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DE60321774D1 - Aerosol-formulierungen von formoterol und mometason - Google Patents

Aerosol-formulierungen von formoterol und mometason

Info

Publication number
DE60321774D1
DE60321774D1 DE60321774T DE60321774T DE60321774D1 DE 60321774 D1 DE60321774 D1 DE 60321774D1 DE 60321774 T DE60321774 T DE 60321774T DE 60321774 T DE60321774 T DE 60321774T DE 60321774 D1 DE60321774 D1 DE 60321774D1
Authority
DE
Germany
Prior art keywords
formoterol
mometason
aerosol formulations
solvate
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60321774T
Other languages
English (en)
Inventor
Alexander D Slowey
Susannah C Boswell
Philip A Jinks
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
3M Innovative Properties Co
Original Assignee
3M Innovative Properties Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 3M Innovative Properties Co filed Critical 3M Innovative Properties Co
Application granted granted Critical
Publication of DE60321774D1 publication Critical patent/DE60321774D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L9/00Disinfection, sterilisation or deodorisation of air
    • A61L9/14Disinfection, sterilisation or deodorisation of air using sprayed or atomised substances including air-liquid contact processes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/12Aerosols; Foams
    • A61K9/124Aerosols; Foams characterised by the propellant

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
DE60321774T 2002-04-05 2003-03-21 Aerosol-formulierungen von formoterol und mometason Expired - Lifetime DE60321774D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0207906.9A GB0207906D0 (en) 2002-04-05 2002-04-05 Formoterol and mometasone aerosol formulations
PCT/US2003/008710 WO2003086350A1 (en) 2002-04-05 2003-03-21 Formoterol and mometasone aerosol formulations

Publications (1)

Publication Number Publication Date
DE60321774D1 true DE60321774D1 (de) 2008-08-07

Family

ID=9934328

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60321774T Expired - Lifetime DE60321774D1 (de) 2002-04-05 2003-03-21 Aerosol-formulierungen von formoterol und mometason

Country Status (7)

Country Link
US (1) US8252268B2 (de)
EP (1) EP1492499B1 (de)
AT (1) ATE398999T1 (de)
AU (1) AU2003225915A1 (de)
DE (1) DE60321774D1 (de)
GB (1) GB0207906D0 (de)
WO (1) WO2003086350A1 (de)

Families Citing this family (34)

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WO2004020289A1 (en) * 2002-08-27 2004-03-11 Schering Corporation Process for producing metered dose inhaler formulations
SE0301260D0 (sv) * 2003-04-29 2003-04-29 Astrazeneca Ab Novel equipment
ES2544477T3 (es) 2003-10-03 2015-08-31 3M Innovative Properties Company Imidazoquinolinas sustituidas con alcoxi
MXPA06005910A (es) 2003-11-25 2006-08-23 3M Innovative Properties Co Sistemas de anillo imidazo sustituido y metodos.
JP2008530022A (ja) 2005-02-04 2008-08-07 コーリー ファーマシューティカル グループ,インコーポレイテッド 免疫反応調節物質を含む水性ゲル処方物
JP5107933B2 (ja) * 2005-12-21 2012-12-26 メダ ファーマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト 炎症性疾患の治療に使用する、抗コリン作用薬類、β2−アドレナリン受容体のアゴニスト類、抗ロイコトリエン(ロイコトリエン受容体のアンタゴニスト)類、グルココルチコイド類および/またはPDE4阻害剤類の新規配合薬
EP1894568A1 (de) * 2006-08-31 2008-03-05 Novartis AG Pharmazeutische Zusammensetzungen zur Behandlung von entzündlichen oder obstruktiven Atemwegserkrankungen
WO2008097233A1 (en) * 2007-02-09 2008-08-14 Schering Corporation Stable pharmaceutical drug aerosols
CN108434126B (zh) 2009-03-26 2021-11-19 普马特里克斯营业公司 治疗肺病的干粉配方与方法
CA2754684A1 (en) * 2009-03-26 2010-09-30 Pulmatrix, Inc. Calcium citrate and calcium lactate formulations for alteration of biophysical properties of mucosal lining
PL2435024T3 (pl) * 2009-05-29 2017-01-31 Pearl Therapeutics, Inc. Dostarczanie substancji czynnych do dróg oddechowych oraz powiązane sposoby i systemy
US8815258B2 (en) 2009-05-29 2014-08-26 Pearl Therapeutics, Inc. Compositions, methods and systems for respiratory delivery of two or more active agents
WO2011015226A1 (en) * 2009-08-03 2011-02-10 Pharmatex Italia Srl Process for the preparation of sterile powdered pharmaceutical compounds in the form of micro and nanoparticles
EP2533765A2 (de) * 2010-01-29 2012-12-19 Mahmut Bilgic Pharmazeutische zusammensetzungen mit formoterol und mometason
WO2012030645A1 (en) 2010-08-30 2012-03-08 Pulmatrix, Inc. Respirably dry powder comprising calcium lactate, sodium chloride and leucine
AU2011296343B2 (en) 2010-08-30 2015-12-10 Pulmatrix Operating Company, Inc. Dry powder formulations and methods for treating pulmonary diseases
ES2710537T3 (es) 2010-09-29 2019-04-25 Pulmatrix Operating Co Inc Polvos secos catiónicos
IL286573B (en) 2010-09-29 2022-08-01 Pulmatrix Operating Co Inc Monovalent metal cation dry powders for inhalation
NZ629722A (en) 2012-02-29 2017-03-31 Pulmatrix Operating Co Inc Inhalable dry powders
CA2905542C (en) 2013-03-15 2022-05-03 Pearl Therapeutics, Inc. Methods and systems for conditioning of particulate crystalline materials
CA2907566C (en) 2013-04-01 2023-08-22 Pulmatrix, Inc. Tiotropium dry powders
WO2015199626A1 (en) * 2014-06-27 2015-12-30 World Medicine İlaç Sanayi̇ Ve Ti̇caret Anoni̇m Şi̇rketi̇ STABLE AEROSOL FORMULATIONS OF β2- ADRENERGIC AGONISTS
EP3174522A1 (de) 2014-07-29 2017-06-07 3M Innovative Properties Company Verfahren zur herstellung einer pharmazeutischen zusammensetzung
EP3383366B2 (de) 2015-12-04 2024-06-05 Mexichem Fluor S.A. de C.V. Pharmazeutische zusammensetzung
GB2545025A (en) * 2015-12-04 2017-06-07 Mexichem Fluor Sa De Cv Pharmaceutical composition
US20240189244A1 (en) * 2021-04-09 2024-06-13 Arizona Board Of Regents On Behalf Of The University Of Arizona Compositions and methods for delivering pharmaceutical agents
US11964121B2 (en) 2021-10-13 2024-04-23 Satio, Inc. Mono dose dermal patch for pharmaceutical delivery
US12048543B2 (en) 2021-11-08 2024-07-30 Satio, Inc. Dermal patch for collecting a physiological sample with removable vial
US12178979B2 (en) 2021-10-13 2024-12-31 Satio, Inc. Dermal patch for delivering a pharmaceutical
US12023156B2 (en) 2021-10-13 2024-07-02 Satio, Inc. Dermal patch for collecting a physiological sample
US12214346B2 (en) 2021-10-13 2025-02-04 Satio, Inc. Dermal patch with a diagnostic test strip
US11877848B2 (en) 2021-11-08 2024-01-23 Satio, Inc. Dermal patch for collecting a physiological sample
US11452474B1 (en) 2021-04-14 2022-09-27 Satio, Inc. Dual lever dermal patch system
US12053284B2 (en) 2021-11-08 2024-08-06 Satio, Inc. Dermal patch for collecting a physiological sample

Family Cites Families (22)

* Cited by examiner, † Cited by third party
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ATE8790T1 (de) 1981-02-02 1984-08-15 Schering Corporation Aromatische heterocyclische steroidester, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen, die sie enthalten.
DE69104991T2 (de) * 1990-09-10 1995-04-20 Schering Corp Mometason-furoate-monohydrat, verfahren zu seiner herstellung und das enthaltende pharmazeutische zusammensetzungen.
US5795564A (en) 1991-04-05 1998-08-18 Sepracor, Inc. Methods and compositions for treating pulmonary disorders using optically pure (R,R)-formoterol
EP0689424B1 (de) 1993-03-17 1998-10-14 Minnesota Mining And Manufacturing Company Aerosolzusammensetzung enthaltend einen aus ester-, amid- oder merkaptoester- derivat dispergiermittel
JPH08507792A (ja) 1993-03-17 1996-08-20 ミネソタ マイニング アンド マニュファクチャリング カンパニー ジオール−二酸から誘導される分散助剤を含むエーロゾル配合物
PE44995A1 (es) 1994-01-27 1995-12-18 Schering Corp Furoato de mometasona para el tratamiento de las enfermedades pulmonares y de las vias respiratorias
CA2217950C (en) * 1995-04-14 2001-12-25 Glaxo Wellcome Inc. Metered dose inhaler for albuterol
GB9612297D0 (en) * 1996-06-11 1996-08-14 Minnesota Mining & Mfg Medicinal aerosol formulations
TW475901B (en) 1996-08-29 2002-02-11 Schering Corp Chlorofluorocarbon-free mometasone furoate aerosol formulations
CA2271004C (en) 1996-11-11 2007-05-01 Sepracor Inc. Process for the preparation of optically pure isomers of formoterol
US6129905A (en) 1997-04-21 2000-10-10 Aeropharm Technology, Inc. Aerosol formulations containing a sugar as a dispersant
US6264923B1 (en) 1998-05-13 2001-07-24 3M Innovative Properties Company Medicinal aerosol formulation of ciclesonide and related compounds
DK1102579T3 (da) 1998-08-04 2003-07-14 Jago Res Ag Medicinske aerosolformuleringer
GB9904919D0 (en) 1999-03-03 1999-04-28 Novartis Ag Organic compounds
SE9900833D0 (sv) * 1999-03-09 1999-03-09 Astra Ab Novel combination
GB0009609D0 (en) * 2000-04-18 2000-06-07 Glaxo Group Ltd Therapeutic compositions
GB0009612D0 (en) 2000-04-18 2000-06-07 Glaxo Group Ltd Therapeutic formulations
US20020076382A1 (en) 2000-08-04 2002-06-20 Kaplan Leonard W. Formulations of mometasone and a bronchodilator for pulmonary administration
CZ2003983A3 (cs) * 2000-10-09 2003-09-17 3M Innovative Properties Company Léčivé aerosolové přípravky
US20040081627A1 (en) * 2000-10-09 2004-04-29 Jinks Phillip A Medicinal aerosol formulations
AR036358A1 (es) * 2001-08-28 2004-09-01 Schering Corp Un inhalador de dosis medidas que contiene una formulacion de suspension en aerosol para inhalacion, un proceso para la produccion de la formulacion, el producto y el uso de una formulacion para la manufactura de un medicamento de asma
WO2004020289A1 (en) 2002-08-27 2004-03-11 Schering Corporation Process for producing metered dose inhaler formulations

Also Published As

Publication number Publication date
ATE398999T1 (de) 2008-07-15
GB0207906D0 (en) 2002-05-15
AU2003225915A1 (en) 2003-10-27
US8252268B2 (en) 2012-08-28
EP1492499A1 (de) 2005-01-05
EP1492499B1 (de) 2008-06-25
US20050255049A1 (en) 2005-11-17
WO2003086350A1 (en) 2003-10-23

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Legal Events

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