DE60320952D1 - Kontrastmittel zur nahes-infrarot-fluoreszenz und methode zur fluoreszenzabbildung - Google Patents
Kontrastmittel zur nahes-infrarot-fluoreszenz und methode zur fluoreszenzabbildungInfo
- Publication number
- DE60320952D1 DE60320952D1 DE60320952T DE60320952T DE60320952D1 DE 60320952 D1 DE60320952 D1 DE 60320952D1 DE 60320952 T DE60320952 T DE 60320952T DE 60320952 T DE60320952 T DE 60320952T DE 60320952 D1 DE60320952 D1 DE 60320952D1
- Authority
- DE
- Germany
- Prior art keywords
- represent
- alkyl group
- formation method
- infrared fluorescence
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 230000015572 biosynthetic process Effects 0.000 title 1
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 1
- 125000006732 (C1-C15) alkyl group Chemical group 0.000 abstract 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 210000004204 blood vessel Anatomy 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000002872 contrast media Substances 0.000 abstract 1
- 238000003384 imaging method Methods 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 125000001434 methanylylidene group Chemical group [H]C#[*] 0.000 abstract 1
- 230000003472 neutralizing effect Effects 0.000 abstract 1
- 230000035699 permeability Effects 0.000 abstract 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/0032—Methine dyes, e.g. cyanine dyes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0052—Small organic molecules
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- General Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Indole Compounds (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Endoscopes (AREA)
- Investigating Materials By The Use Of Optical Means Adapted For Particular Applications (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2002109794A JP2003261464A (ja) | 2002-03-07 | 2002-03-07 | 近赤外蛍光造影剤および蛍光造影法 |
| PCT/EP2003/002358 WO2003074091A2 (en) | 2002-03-07 | 2003-03-07 | Near infrared fluorescent contrast agent and method for fluorescence imaging |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60320952D1 true DE60320952D1 (de) | 2008-06-26 |
Family
ID=27785574
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60320952T Expired - Fee Related DE60320952D1 (de) | 2002-03-07 | 2003-03-07 | Kontrastmittel zur nahes-infrarot-fluoreszenz und methode zur fluoreszenzabbildung |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US7473415B2 (de) |
| EP (1) | EP1480683B1 (de) |
| JP (2) | JP2003261464A (de) |
| KR (1) | KR20040099301A (de) |
| CN (1) | CN100340298C (de) |
| AT (1) | ATE395088T1 (de) |
| AU (1) | AU2003208700B2 (de) |
| BR (1) | BR0308217A (de) |
| CA (1) | CA2478272A1 (de) |
| DE (1) | DE60320952D1 (de) |
| DK (1) | DK1480683T3 (de) |
| ES (1) | ES2305444T3 (de) |
| MX (1) | MXPA04008664A (de) |
| NO (1) | NO20044244L (de) |
| PL (1) | PL370918A1 (de) |
| PT (1) | PT1480683E (de) |
| RU (1) | RU2350355C9 (de) |
| WO (1) | WO2003074091A2 (de) |
| ZA (1) | ZA200408072B (de) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4445065A1 (de) * | 1994-12-07 | 1996-06-13 | Diagnostikforschung Inst | Verfahren zur In-vivo-Diagnostik mittels NIR-Strahlung |
| JP2003261464A (ja) * | 2002-03-07 | 2003-09-16 | Fuji Photo Film Co Ltd | 近赤外蛍光造影剤および蛍光造影法 |
| US7682602B2 (en) * | 2003-12-19 | 2010-03-23 | Konica Minolta Medical & Graphic, Inc. | Near-infrared fluorescent contrast medium |
| US7233392B2 (en) * | 2004-03-25 | 2007-06-19 | Opotek, Inc. | Spectral imaging device with tunable light source |
| US7910753B2 (en) * | 2004-09-10 | 2011-03-22 | Anaspec Incorporated | Cyanine dyes and their applications as luminescence quenching compounds |
| US8227621B2 (en) | 2005-06-30 | 2012-07-24 | Li-Cor, Inc. | Cyanine dyes and methods of use |
| US20110262354A1 (en) * | 2007-07-13 | 2011-10-27 | Emory University | Cyanine-containing compounds for cancer imaging and treatment |
| GB0718957D0 (en) * | 2007-09-28 | 2007-11-07 | Ge Healthcare Ltd | Optical imaging agents |
| US20090214436A1 (en) * | 2008-02-18 | 2009-08-27 | Washington University | Dichromic fluorescent compounds |
| US20090240143A1 (en) * | 2008-03-12 | 2009-09-24 | Mauna Kea Technologies | Method and an optical probe for in vivo imaging of a mucosa in a biliary or pancreatic system and a method for selectively operating a tissue sampling of a mucosa in a biliary or pancreatic system |
| EP2303337A4 (de) * | 2008-06-13 | 2014-09-03 | Cedars Sinai Medical Center | Kleinmolekülige liganden-arzneimittel-konjugate für die gezielte krebstherapie |
| EP2419478B1 (de) * | 2009-04-17 | 2018-02-28 | Li-Cor, Inc. | Fluoreszenzbasierte bildgebung mit substituierten cyaninfarbstoffen |
| CN101574529B (zh) * | 2009-06-04 | 2011-04-20 | 中国人民解放军第三军医大学 | 近红外荧光化合物在制备用于淋巴结成像和血管造影的药物中的用途 |
| CA2809798C (en) | 2009-08-28 | 2018-09-18 | Visen Medical, Inc. | Systems and methods for tomographic imaging in diffuse media using a hybrid inversion technique |
| JP2011046663A (ja) * | 2009-08-28 | 2011-03-10 | Fujifilm Corp | 近赤外蛍光造影剤 |
| JP2011046662A (ja) * | 2009-08-28 | 2011-03-10 | Fujifilm Corp | 近赤外蛍光造影剤 |
| WO2011038006A1 (en) | 2009-09-22 | 2011-03-31 | Visen Medical, Inc. | Systems and methods for virtual index-matching of diffusive media |
| JP5462596B2 (ja) * | 2009-11-12 | 2014-04-02 | 富士フイルム株式会社 | 蛍光画像撮像装置 |
| US8273875B2 (en) | 2009-11-16 | 2012-09-25 | University Of Notre Dame Du Lac | High performance luminescent compounds |
| WO2012054749A1 (en) | 2010-10-20 | 2012-04-26 | Li-Cor, Inc. | Cyanine dyes and their conjugates |
| JP5200193B2 (ja) * | 2011-03-15 | 2013-05-15 | オリンパスメディカルシステムズ株式会社 | 医療装置 |
| EP2599428B1 (de) * | 2011-03-15 | 2017-09-06 | Olympus Corporation | Medizinische vorrichtung |
| EP3553075B1 (de) | 2012-01-23 | 2025-01-08 | Washington University | Brillenbildgebungssysteme und -verfahren |
| EP2906106B1 (de) | 2012-10-15 | 2023-06-14 | VisEn Medical, Inc. | Systeme, verfahren, und vorrichtung zur abbildung von diffusen medien mit modalitätsübergreifender gewichtung von fluoreszierenden und biolumineszierenden quellen |
| JP6244004B2 (ja) | 2013-03-14 | 2017-12-06 | プロフサ，インコーポレイテッド | 酸素センサ |
| BR112016015198A2 (pt) | 2013-12-31 | 2017-08-08 | Memorial Sloan Kettering Cancer Center | Sistemas, métodos e aparelho para a produção de imagens multicanal de fontes fluorescentes em tempo real |
| US10335501B2 (en) | 2014-12-15 | 2019-07-02 | Memorial Sloan Kettering Cancer Center | Cyclic peptides with enhanced nerve-binding selectively, nanoparticles bound with said cyclic peptides, and use of same for real-time in vivo nerve tissue imaging |
| KR20160086481A (ko) * | 2015-01-09 | 2016-07-20 | 차의과학대학교 산학협력단 | 신규 유기 화합물 및 이를 포함하는 근적외선 형광 조영제, 그리고 조영제의 나노입자화 방법 |
| WO2016179350A1 (en) | 2015-05-06 | 2016-11-10 | Washington University | Compounds having rd targeting motifs and methods of use thereof |
| CN108495655A (zh) | 2015-12-15 | 2018-09-04 | 纪念斯隆凯特琳癌症中心 | 用于组织区分例如用于术中可视化的成像系统和方法 |
| JP6752582B2 (ja) * | 2016-02-08 | 2020-09-09 | キヤノン株式会社 | 光音響イメージング用造影剤 |
| CA3045007A1 (en) | 2016-11-30 | 2018-06-07 | Memorial Sloan Kettering Cancer Center | Inhibitor-functionalized ultrasmall nanoparticles and methods thereof |
| EP3558118A4 (de) | 2016-12-21 | 2021-02-24 | Profusa, Inc. | Polymerisierbare nahinfrarot-farbstoffe |
| CA3095410A1 (en) | 2018-03-30 | 2019-10-03 | Perkinelmer Health Sciences, Inc. | Systems and methods for 3d reconstruction of anatomical organs and inclusions using short-wave infrared (swir) projection tomography |
| US12285250B2 (en) | 2018-06-27 | 2025-04-29 | Profusa, Inc | Near-IR glucose sensors |
| CN109824871B (zh) * | 2019-01-08 | 2021-04-16 | 南京邮电大学 | 一种近红外二区荧光醌式聚合物、制备方法及其应用 |
| EP4072598A4 (de) | 2019-12-13 | 2024-02-21 | Washington University | Nahinfrarot-fluoreszierende farbstoffe, formulierungen und zugehörige verfahren |
| EP4015004A1 (de) | 2020-12-18 | 2022-06-22 | Phi Pharma SA | Proteoglykanspezifische verzweigte peptide |
| CN119183454A (zh) * | 2022-04-27 | 2024-12-24 | 卫材R&D管理有限公司 | Icg脂质衍生物和包含其的基于脂质的颗粒 |
| US20240361241A1 (en) * | 2023-04-26 | 2024-10-31 | California Institute Of Technology | Methods and systems for bond-selective fluorescence-detected infrared-excited imaging |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2077342C1 (ru) * | 1994-06-09 | 1997-04-20 | Николай Сергеевич Воробьев | Способ определения онкологических заболеваний |
| DE19539409C2 (de) * | 1995-10-11 | 1999-02-18 | Diagnostikforschung Inst | Kontrastmittel für die Nahinfrarot-Diagnostik |
| DE19957007A1 (de) * | 1999-11-26 | 2001-05-31 | Few Chemicals Gmbh Wolfen | Cyaninfarbstoffe |
| US6395257B1 (en) * | 2000-01-18 | 2002-05-28 | Mallinckrodt Inc. | Dendrimer precursor dyes for imaging |
| JP2001288197A (ja) * | 2000-04-10 | 2001-10-16 | Fuji Photo Film Co Ltd | 蛍光ヌクレオチド |
| DE60140452D1 (de) * | 2000-08-08 | 2009-12-24 | Fujifilm Corp | Cyaninfarbstoffe |
| US6663847B1 (en) * | 2000-10-13 | 2003-12-16 | Mallinckrodt Inc. | Dynamic organ function monitoring agents |
| JP2003261464A (ja) * | 2002-03-07 | 2003-09-16 | Fuji Photo Film Co Ltd | 近赤外蛍光造影剤および蛍光造影法 |
-
2002
- 2002-03-07 JP JP2002109794A patent/JP2003261464A/ja active Pending
-
2003
- 2003-03-07 AT AT03706606T patent/ATE395088T1/de not_active IP Right Cessation
- 2003-03-07 JP JP2003579524A patent/JP2005519977A/ja active Pending
- 2003-03-07 KR KR10-2004-7013937A patent/KR20040099301A/ko not_active Ceased
- 2003-03-07 WO PCT/EP2003/002358 patent/WO2003074091A2/en not_active Ceased
- 2003-03-07 PT PT03706606T patent/PT1480683E/pt unknown
- 2003-03-07 DK DK03706606T patent/DK1480683T3/da active
- 2003-03-07 AU AU2003208700A patent/AU2003208700B2/en not_active Ceased
- 2003-03-07 EP EP03706606A patent/EP1480683B1/de not_active Expired - Lifetime
- 2003-03-07 MX MXPA04008664A patent/MXPA04008664A/es active IP Right Grant
- 2003-03-07 CN CNB038054604A patent/CN100340298C/zh not_active Expired - Fee Related
- 2003-03-07 DE DE60320952T patent/DE60320952D1/de not_active Expired - Fee Related
- 2003-03-07 RU RU2004129766/15A patent/RU2350355C9/ru not_active IP Right Cessation
- 2003-03-07 CA CA002478272A patent/CA2478272A1/en not_active Abandoned
- 2003-03-07 PL PL03370918A patent/PL370918A1/xx not_active Application Discontinuation
- 2003-03-07 ES ES03706606T patent/ES2305444T3/es not_active Expired - Lifetime
- 2003-03-07 BR BR0308217-2A patent/BR0308217A/pt not_active IP Right Cessation
- 2003-03-07 US US10/506,819 patent/US7473415B2/en not_active Expired - Fee Related
-
2004
- 2004-10-06 ZA ZA200408072A patent/ZA200408072B/en unknown
- 2004-10-06 NO NO20044244A patent/NO20044244L/no not_active Application Discontinuation
-
2008
- 2008-06-27 US US12/147,717 patent/US20090041670A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| KR20040099301A (ko) | 2004-11-26 |
| ATE395088T1 (de) | 2008-05-15 |
| MXPA04008664A (es) | 2004-12-06 |
| CA2478272A1 (en) | 2003-09-12 |
| PL370918A1 (en) | 2005-06-13 |
| CN1638810A (zh) | 2005-07-13 |
| EP1480683A2 (de) | 2004-12-01 |
| AU2003208700B2 (en) | 2007-12-20 |
| RU2350355C2 (ru) | 2009-03-27 |
| RU2350355C9 (ru) | 2009-05-27 |
| BR0308217A (pt) | 2004-12-21 |
| JP2003261464A (ja) | 2003-09-16 |
| ES2305444T3 (es) | 2008-11-01 |
| RU2004129766A (ru) | 2005-08-10 |
| US20050226815A1 (en) | 2005-10-13 |
| WO2003074091A2 (en) | 2003-09-12 |
| US20090041670A1 (en) | 2009-02-12 |
| DK1480683T3 (da) | 2008-08-18 |
| US7473415B2 (en) | 2009-01-06 |
| WO2003074091A3 (en) | 2004-03-11 |
| HK1079110A1 (en) | 2006-03-31 |
| CN100340298C (zh) | 2007-10-03 |
| PT1480683E (pt) | 2008-07-24 |
| NO20044244L (no) | 2004-12-06 |
| AU2003208700A1 (en) | 2003-09-16 |
| ZA200408072B (en) | 2006-06-28 |
| EP1480683B1 (de) | 2008-05-14 |
| JP2005519977A (ja) | 2005-07-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |