DE60316588D1 - Neue lactame und deren verwendungen - Google Patents
Neue lactame und deren verwendungenInfo
- Publication number
- DE60316588D1 DE60316588D1 DE60316588T DE60316588T DE60316588D1 DE 60316588 D1 DE60316588 D1 DE 60316588D1 DE 60316588 T DE60316588 T DE 60316588T DE 60316588 T DE60316588 T DE 60316588T DE 60316588 D1 DE60316588 D1 DE 60316588D1
- Authority
- DE
- Germany
- Prior art keywords
- lactame
- new
- new lactame
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/10—Seven-membered rings having the hetero atoms in positions 1 and 4 not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D267/14—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/06—Seven-membered rings having the hetero atoms in positions 1 and 4 not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0202929A SE0202929D0 (sv) | 2002-10-03 | 2002-10-03 | Novel benzothiazepines and uses thereof |
| SE0202929 | 2002-10-03 | ||
| SE0203829 | 2002-12-18 | ||
| SE0203829A SE0203829D0 (sv) | 2002-12-18 | 2002-12-18 | Novel lactams and uses thereof |
| PCT/SE2003/001534 WO2004031154A1 (en) | 2002-10-03 | 2003-10-02 | Novel lactams and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60316588D1 true DE60316588D1 (de) | 2007-11-08 |
| DE60316588T2 DE60316588T2 (de) | 2008-07-31 |
Family
ID=32072595
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60316588T Expired - Lifetime DE60316588T2 (de) | 2002-10-03 | 2003-10-02 | Neue lactame und deren verwendungen |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US7294622B2 (de) |
| EP (2) | EP1845089A1 (de) |
| JP (2) | JP4637584B2 (de) |
| AR (1) | AR041440A1 (de) |
| AT (1) | ATE374187T1 (de) |
| AU (1) | AU2003265202A1 (de) |
| DE (1) | DE60316588T2 (de) |
| DK (1) | DK1554250T3 (de) |
| ES (1) | ES2291743T3 (de) |
| PT (1) | PT1554250E (de) |
| TW (1) | TW200502221A (de) |
| WO (1) | WO2004031154A1 (de) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004080983A1 (en) * | 2003-03-14 | 2004-09-23 | Astrazeneca Ab | Novel lactams and uses thereof |
| US7211573B2 (en) * | 2004-12-08 | 2007-05-01 | Hoffmann-La Roche Inc. | Malonamide derivatives |
| WO2006065218A1 (en) * | 2004-12-14 | 2006-06-22 | Astrazeneca Ab | Novel molecular probes |
| GB2423085C (en) | 2005-02-11 | 2011-11-09 | Cambridge Entpr Ltd | Ligands for G-protein coupled receptors |
| ES2537898T3 (es) * | 2005-10-25 | 2015-06-15 | Shionogi & Co., Ltd. | Derivados de aminotiazolidina y aminotetrahidrotiazepina como inhibidores de BACE 1 |
| WO2007104933A1 (en) * | 2006-03-10 | 2007-09-20 | Astrazeneca Ab | Chemical compounds |
| MX2008012136A (es) * | 2006-03-27 | 2008-10-03 | Hoffmann La Roche | Derivados de malonamida como inhibidores de gama secretasa. |
| US7888345B2 (en) * | 2006-06-09 | 2011-02-15 | Merck Sharp & Dohme Corp. | Benzaepinones as sodium channel blockers |
| AR063142A1 (es) * | 2006-10-04 | 2008-12-30 | Pharmacopeia Inc | Derivados de 2-(bencimidazolil) purina y purinonas 6-sustituidas utiles como inmunosupresores,y composiciones farmaceuticas que los contienen. |
| EP2151435A4 (de) | 2007-04-24 | 2011-09-14 | Shionogi & Co | Pharmazeutische zusammensetzung zur behandlung von morbus alzheimer |
| KR20100017255A (ko) | 2007-04-24 | 2010-02-16 | 시오노기 앤드 컴파니, 리미티드 | 환식기로 치환된 아미노다이하이드로싸이아진 유도체 |
| AU2008287124B2 (en) | 2007-08-14 | 2013-06-06 | Eli Lilly And Company | Azepine derivatives as gamma-secretase inhibitors |
| EP2305672B1 (de) | 2008-06-13 | 2019-03-27 | Shionogi & Co., Ltd. | Schwefelhaltiges heterocyclisches derivat mit b-secretase-hemmender wirkung |
| CN102186841A (zh) | 2008-10-22 | 2011-09-14 | 盐野义制药株式会社 | 具有bace1抑制活性的2-氨基嘧啶-4-酮及2-氨基吡啶衍生物 |
| CN101735211B (zh) * | 2008-11-04 | 2012-11-14 | 复旦大学 | 2,3-二氢[1,5]苯并噻氮杂*类化合物或其盐在制备GSK-3β抑制剂中的用途 |
| US9023767B2 (en) * | 2009-05-07 | 2015-05-05 | Memorial Sloan-Kettering Cancer Center | γ-Secretase substrates and methods of use |
| UY32799A (es) * | 2009-07-24 | 2011-02-28 | Novartis Ag | Derivados de oxazina y su uso en el tratamiento de trastornos neurológicos |
| RU2012129168A (ru) | 2009-12-11 | 2014-01-20 | Сионоги Энд Ко. Лтд. | Производные оксазина |
| US9632088B2 (en) | 2010-09-07 | 2017-04-25 | Memorial Sloan-Kettering Cancer Center | Methods and compositions for gamma-secretase assay |
| JP2014001142A (ja) * | 2010-10-05 | 2014-01-09 | Astellas Pharma Inc | シクロアルカン化合物 |
| UY33650A (es) * | 2010-10-07 | 2012-04-30 | Takeda Pharmaceutical | Compuestos heterocíclicos |
| JP5766198B2 (ja) | 2010-10-29 | 2015-08-19 | 塩野義製薬株式会社 | 縮合アミノジヒドロピリミジン誘導体 |
| CN103261199A (zh) | 2010-10-29 | 2013-08-21 | 盐野义制药株式会社 | 萘啶衍生物 |
| WO2012147763A1 (ja) | 2011-04-26 | 2012-11-01 | 塩野義製薬株式会社 | オキサジン誘導体およびそれを含有するｂａｃｅ１阻害剤 |
| EP2882725A1 (de) * | 2012-08-09 | 2015-06-17 | F. Hoffmann-La Roche AG | Substituierte hetero-azepinone |
| EP2912035A4 (de) | 2012-10-24 | 2016-06-15 | Shionogi & Co | Dihydrooxazin- oder oxazepinderivate mit bace1-hemmender wirkung |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2045578A1 (en) | 1989-01-31 | 1990-08-01 | Megumi Kawai | Anaphylatoxin-receptor ligands |
| US5936065A (en) | 1993-12-06 | 1999-08-10 | Cytel Corporation | CS-1 peptidomimetics, compositions and methods of using the same |
| WO1997024339A1 (en) | 1995-12-27 | 1997-07-10 | Ono Pharmaceutical Co., Ltd. | Tetrazole derivatives and drugs containing the same as the active ingredient |
| GB9621836D0 (en) | 1996-10-19 | 1996-12-11 | Zeneca Ltd | Peptide compounds |
| PT951466E (pt) * | 1996-12-23 | 2009-04-09 | Lilly Co Eli | Compostos cicloalquilo, lactama, lactona e relacionados, composições farmacêuticas compreendendo os mesmos, e métodos para a inibição da libertação do péptido β-amilóide e/ou da sua síntese pela utilização de tais compostos |
| EP1089980A1 (de) | 1998-06-22 | 2001-04-11 | Elan Pharmaceuticals, Inc. | Verbindungen zur inhibierung der freisetzung und/oder synthese von beta-amyloidpeptiden |
| AU4707999A (en) * | 1998-06-22 | 2000-01-10 | Elan Pharmaceuticals, Inc. | Compounds for inhibiting beta-amyloid peptide release and/or its synthesis |
| CA2325388A1 (en) * | 1998-06-22 | 1999-12-29 | Elan Pharmaceuticals, Inc. | Compounds for inhibiting beta-amyloid peptide release and/or its synthesis |
| AU1915399A (en) | 1998-07-10 | 2000-02-01 | Cytel Corporation | Cs-1 peptidomimetics, compositions and methods of using the same |
| HRP990246A2 (en) | 1998-08-07 | 2000-06-30 | Du Pont Pharm Co | Succinoylamino benzodiazepines as inhibitors of a beta protein production |
| EP1131634A2 (de) | 1998-09-30 | 2001-09-12 | Elan Pharmaceuticals, Inc. | Bestimmung des mechanismus der beta-amyloid-peptid-erzeugung |
| CA2347671A1 (en) * | 1998-12-24 | 2000-07-06 | Dupont Pharmaceuticals Company | Succinoylamino benzodiazepines as inhibitors of a.beta. protein production |
| JP2001030342A (ja) | 1999-07-23 | 2001-02-06 | Japan Polychem Corp | ポリオレフィン製延伸ブロー成形用インモールドラベル及びそのラベルを熱融着させた成形体 |
| JP2003509411A (ja) * | 1999-09-13 | 2003-03-11 | デュポン ファーマシューティカルズ カンパニー | Ａβタンパク質の産生阻害剤としてのヒドロキシアルカノイルアミノラクタムおよび関連構造体 |
| WO2001068655A2 (en) | 2000-03-10 | 2001-09-20 | Ariad Pharmaceuticals, Inc. | Caprolactam derivatives and uses thereof |
| WO2001072324A1 (en) * | 2000-03-28 | 2001-10-04 | Bristol-Myers Squibb Pharma Company | Lactams as inhibitors of a-beta protein production |
| WO2004080983A1 (en) | 2003-03-14 | 2004-09-23 | Astrazeneca Ab | Novel lactams and uses thereof |
| US7060698B2 (en) | 2003-05-19 | 2006-06-13 | Hoffmann-La Roche Inc. | Benzoxazepinone derivatives |
| WO2006065218A1 (en) | 2004-12-14 | 2006-06-22 | Astrazeneca Ab | Novel molecular probes |
-
2003
- 2003-09-29 TW TW092126851A patent/TW200502221A/zh unknown
- 2003-09-30 AR ARP030103560A patent/AR041440A1/es not_active Application Discontinuation
- 2003-10-02 EP EP07012660A patent/EP1845089A1/de not_active Withdrawn
- 2003-10-02 WO PCT/SE2003/001534 patent/WO2004031154A1/en not_active Ceased
- 2003-10-02 US US10/528,640 patent/US7294622B2/en not_active Expired - Fee Related
- 2003-10-02 JP JP2004541383A patent/JP4637584B2/ja not_active Expired - Fee Related
- 2003-10-02 EP EP03799234A patent/EP1554250B1/de not_active Expired - Lifetime
- 2003-10-02 ES ES03799234T patent/ES2291743T3/es not_active Expired - Lifetime
- 2003-10-02 AU AU2003265202A patent/AU2003265202A1/en not_active Abandoned
- 2003-10-02 DK DK03799234T patent/DK1554250T3/da active
- 2003-10-02 PT PT03799234T patent/PT1554250E/pt unknown
- 2003-10-02 DE DE60316588T patent/DE60316588T2/de not_active Expired - Lifetime
- 2003-10-02 AT AT03799234T patent/ATE374187T1/de not_active IP Right Cessation
-
2007
- 2007-08-24 US US11/844,451 patent/US20080076752A1/en not_active Abandoned
-
2009
- 2009-01-26 US US12/359,465 patent/US7858776B2/en not_active Expired - Fee Related
-
2010
- 2010-06-15 JP JP2010136105A patent/JP2010248216A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| ES2291743T3 (es) | 2008-03-01 |
| AR041440A1 (es) | 2005-05-18 |
| EP1845089A1 (de) | 2007-10-17 |
| TW200502221A (en) | 2005-01-16 |
| ATE374187T1 (de) | 2007-10-15 |
| US20100160627A1 (en) | 2010-06-24 |
| JP4637584B2 (ja) | 2011-02-23 |
| US7294622B2 (en) | 2007-11-13 |
| US7858776B2 (en) | 2010-12-28 |
| AU2003265202A1 (en) | 2004-04-23 |
| EP1554250B1 (de) | 2007-09-26 |
| WO2004031154A1 (en) | 2004-04-15 |
| JP2010248216A (ja) | 2010-11-04 |
| US20080076752A1 (en) | 2008-03-27 |
| PT1554250E (pt) | 2007-11-15 |
| US20060089346A1 (en) | 2006-04-27 |
| DK1554250T3 (da) | 2007-12-17 |
| DE60316588T2 (de) | 2008-07-31 |
| EP1554250A1 (de) | 2005-07-20 |
| JP2006503862A (ja) | 2006-02-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |