DE60316456D1 - Neues verfahren zur herstellung von epothilone-derivaten - Google Patents

Neues verfahren zur herstellung von epothilone-derivaten

Info

Publication number: DE60316456D1
Authority: DE; Germany
Prior art keywords: production; new method; epothilone derivatives; epothilone; derivatives
Prior art date: 2002-09-13
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE60316456T

Other languages

English (en)

Other versions

DE60316456T2 (de

Inventor

Guido Koch

Olivier Loiseleur

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Novartis AG

Original Assignee

Novartis AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-09-13

Filing date

2003-09-12

Publication date

2007-10-31

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9944042&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE60316456(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2003-09-12 Application filed by Novartis AG filed Critical Novartis AG

2007-10-31 Application granted granted Critical

2007-10-31 Publication of DE60316456D1 publication Critical patent/DE60316456D1/de

2008-06-19 Publication of DE60316456T2 publication Critical patent/DE60316456T2/de

2023-09-13 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
- C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/16—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by esterified hydroxyl radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Oncology (AREA)
Tropical Medicine & Parasitology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Communicable Diseases (AREA)
Hospice & Palliative Care (AREA)
Hematology (AREA)
Psychiatry (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Plural Heterocyclic Compounds (AREA)

DE60316456T 2002-09-13 2003-09-12 Neues verfahren zur herstellung von epothilone-derivaten Expired - Lifetime DE60316456T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GBGB0221312.2A GB0221312D0 (en)	2002-09-13	2002-09-13	Organic compounds
GB0221312		2002-09-13
PCT/EP2003/010171 WO2004024735A2 (en)	2002-09-13	2003-09-12	A new process for the preparation of epothilone derivatives, new epothilone derivatives as well as new intermediate products for the process and the methods of preparing same

Publications (2)

Publication Number	Publication Date
DE60316456D1 true DE60316456D1 (de)	2007-10-31
DE60316456T2 DE60316456T2 (de)	2008-06-19

Family

ID=9944042

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE60316456T Expired - Lifetime DE60316456T2 (de)	2002-09-13	2003-09-12	Neues verfahren zur herstellung von epothilone-derivaten

Country Status (29)

Country	Link
US (1)	US7470792B2 (de)
EP (1)	EP1539768B1 (de)
JP (1)	JP4628102B2 (de)
KR (1)	KR20050042500A (de)
CN (1)	CN100522968C (de)
AR (1)	AR041231A1 (de)
AT (1)	ATE373663T1 (de)
AU (2)	AU2003267349B2 (de)
BR (1)	BR0314263A (de)
CA (1)	CA2497119C (de)
CY (1)	CY1107794T1 (de)
DE (1)	DE60316456T2 (de)
DK (1)	DK1539768T3 (de)
EC (1)	ECSP055652A (de)
ES (1)	ES2290489T3 (de)
GB (1)	GB0221312D0 (de)
IL (1)	IL166829A (de)
MX (1)	MXPA05002785A (de)
MY (1)	MY140442A (de)
NO (1)	NO20051794L (de)
NZ (1)	NZ538612A (de)
PE (1)	PE20050052A1 (de)
PL (1)	PL375039A1 (de)
PT (1)	PT1539768E (de)
RU (2)	RU2404985C2 (de)
SG (1)	SG155770A1 (de)
TW (1)	TWI289563B (de)
WO (1)	WO2004024735A2 (de)
ZA (1)	ZA200501008B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE69734362T2 (de)	1996-12-03	2006-07-20	Sloan-Kettering Institute For Cancer Research	Synthese von epothilonen, zwischenprodukte dazu, analoga und verwendungen davon
US7649006B2 (en)	2002-08-23	2010-01-19	Sloan-Kettering Institute For Cancer Research	Synthesis of epothilones, intermediates thereto and analogues thereof
US6921769B2 (en)	2002-08-23	2005-07-26	Sloan-Kettering Institute For Cancer Research	Synthesis of epothilones, intermediates thereto and analogues thereof
ES2281692T3 (es)	2002-08-23	2007-10-01	Sloan-Kettering Institute For Cancer Research	Sintesis de epotilones, sus intermediarios, sus analogos y sus usos.
US20110300150A1 (en)	2010-05-18	2011-12-08	Scott Eliasof	Compositions and methods for treatment of autoimmune and other disease

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU716610B2 (en) *	1996-08-30	2000-03-02	Novartis Ag	Method for producing epothilones, and intermediate products obtained during the production process
US6441186B1 (en) *	1996-12-13	2002-08-27	The Scripps Research Institute	Epothilone analogs
US6380394B1 (en) *	1996-12-13	2002-04-30	The Scripps Research Institute	Epothilone analogs
HU228851B1 (en) *	1997-02-25	2013-06-28	Biotechnolog Forschung Gmbh	Process for preparing epothilones with a modified side chain and compounds prepared by this process
US6498257B1 (en)	1998-04-21	2002-12-24	Bristol-Myers Squibb Company	2,3-olefinic epothilone derivatives
GB9810659D0 (en) *	1998-05-18	1998-07-15	Ciba Geigy Ag	Organic compounds
PT1140944E (pt) *	1998-12-22	2004-01-30	Novartis Pharma Gmbh	Derivados de epotilona e sua utilizacao como agentes antitumorais
EP1226142A2 (de) *	1999-07-22	2002-07-31	Schering Aktiengesellschaft	Verfahren zur herstellung von epothiolon-b und derivaten davon, sowie von zwischenprodukten für dieses verfahren
US6593115B2 (en) *	2000-03-24	2003-07-15	Bristol-Myers Squibb Co.	Preparation of epothilone intermediates
IL155306A0 (en) *	2000-10-13	2003-11-23	Univ Mississippi	Methods for producing epothilone derivatives and analogs and epothilone derivatives and analogs produced thereby
KR20050026033A (ko)	2002-07-31	2005-03-14	쉐링 악티엔게젤샤프트	신규 효과기 접합체, 그의 제조 방법 및 그의 약학적 용도

2002
- 2002-09-13 GB GBGB0221312.2A patent/GB0221312D0/en not_active Ceased
2003
- 2003-09-11 AR ARP030103290A patent/AR041231A1/es active IP Right Grant
- 2003-09-11 PE PE2003000922A patent/PE20050052A1/es not_active Application Discontinuation
- 2003-09-12 RU RU2008129613/04A patent/RU2404985C2/ru not_active IP Right Cessation
- 2003-09-12 RU RU2005110925/04A patent/RU2343155C2/ru not_active IP Right Cessation
- 2003-09-12 ES ES03748015T patent/ES2290489T3/es not_active Expired - Lifetime
- 2003-09-12 CN CNB038215837A patent/CN100522968C/zh not_active Expired - Fee Related
- 2003-09-12 JP JP2004535499A patent/JP4628102B2/ja not_active Expired - Fee Related
- 2003-09-12 BR BR0314263-9A patent/BR0314263A/pt not_active IP Right Cessation
- 2003-09-12 PT PT03748015T patent/PT1539768E/pt unknown
- 2003-09-12 NZ NZ538612A patent/NZ538612A/en not_active IP Right Cessation
- 2003-09-12 AU AU2003267349A patent/AU2003267349B2/en not_active Ceased
- 2003-09-12 WO PCT/EP2003/010171 patent/WO2004024735A2/en not_active Ceased
- 2003-09-12 TW TW092125250A patent/TWI289563B/zh not_active IP Right Cessation
- 2003-09-12 KR KR1020057004237A patent/KR20050042500A/ko not_active Ceased
- 2003-09-12 AT AT03748015T patent/ATE373663T1/de active
- 2003-09-12 EP EP03748015A patent/EP1539768B1/de not_active Expired - Lifetime
- 2003-09-12 CA CA2497119A patent/CA2497119C/en not_active Expired - Fee Related
- 2003-09-12 SG SG200701814-6A patent/SG155770A1/en unknown
- 2003-09-12 US US10/526,283 patent/US7470792B2/en not_active Expired - Fee Related
- 2003-09-12 PL PL03375039A patent/PL375039A1/xx not_active Application Discontinuation
- 2003-09-12 DE DE60316456T patent/DE60316456T2/de not_active Expired - Lifetime
- 2003-09-12 MX MXPA05002785A patent/MXPA05002785A/es active IP Right Grant
- 2003-09-12 DK DK03748015T patent/DK1539768T3/da active
- 2003-09-13 MY MYPI20033494A patent/MY140442A/en unknown
2005
- 2005-02-03 ZA ZA200501008A patent/ZA200501008B/xx unknown
- 2005-02-10 IL IL166829A patent/IL166829A/en not_active IP Right Cessation
- 2005-03-09 EC EC2005005652A patent/ECSP055652A/es unknown
- 2005-04-12 NO NO20051794A patent/NO20051794L/no not_active Application Discontinuation
2007
- 2007-11-08 CY CY20071101447T patent/CY1107794T1/el unknown
2008
- 2008-08-01 AU AU2008203451A patent/AU2008203451A1/en not_active Abandoned

Also Published As

Publication number	Publication date
EP1539768B1 (de)	2007-09-19
ATE373663T1 (de)	2007-10-15
TWI289563B (en)	2007-11-11
AU2003267349B2 (en)	2008-05-01
PT1539768E (pt)	2007-12-17
KR20050042500A (ko)	2005-05-09
ECSP055652A (es)	2005-05-30
RU2404985C2 (ru)	2010-11-27
CY1107794T1 (el)	2013-06-19
JP2006511469A (ja)	2006-04-06
EP1539768A2 (de)	2005-06-15
NZ538612A (en)	2008-01-31
US7470792B2 (en)	2008-12-30
DK1539768T3 (da)	2008-01-07
NO20051794D0 (no)	2005-04-12
PE20050052A1 (es)	2005-03-28
AR041231A1 (es)	2005-05-11
TW200413388A (en)	2004-08-01
CA2497119C (en)	2011-08-02
US20060106073A1 (en)	2006-05-18
JP4628102B2 (ja)	2011-02-09
PL375039A1 (en)	2005-11-14
RU2008129613A (ru)	2010-01-27
WO2004024735A2 (en)	2004-03-25
CN100522968C (zh)	2009-08-05
RU2005110925A (ru)	2006-01-20
DE60316456T2 (de)	2008-06-19
BR0314263A (pt)	2005-07-05
MY140442A (en)	2009-12-31
NO20051794L (no)	2005-04-12
MXPA05002785A (es)	2005-06-03
AU2003267349A1 (en)	2004-04-30
RU2343155C2 (ru)	2009-01-10
CN1681824A (zh)	2005-10-12
GB0221312D0 (en)	2002-10-23
AU2008203451A1 (en)	2008-08-21
ES2290489T3 (es)	2008-02-16
ZA200501008B (en)	2006-12-27
HK1078853A1 (en)	2006-03-24
IL166829A (en)	2011-01-31
WO2004024735A3 (en)	2004-07-22
SG155770A1 (en)	2009-10-29
CA2497119A1 (en)	2004-03-25

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Legal Events

Date	Code	Title	Description
2008-10-09	8364	No opposition during term of opposition
2010-05-20	8328	Change in the person/name/address of the agent	Representative=s name: KROHER, STROBEL RECHTS- UND PATENTANWAELTE, 80336
2011-06-16	8328	Change in the person/name/address of the agent	Representative=s name: DR. SCHOEN & PARTNER, 80336 MUENCHEN