DE60316454D1 - Verfahren und dosierformen für die kontrollierte abgabe von paliperidon - Google Patents
Verfahren und dosierformen für die kontrollierte abgabe von paliperidonInfo
- Publication number
- DE60316454D1 DE60316454D1 DE60316454T DE60316454T DE60316454D1 DE 60316454 D1 DE60316454 D1 DE 60316454D1 DE 60316454 T DE60316454 T DE 60316454T DE 60316454 T DE60316454 T DE 60316454T DE 60316454 D1 DE60316454 D1 DE 60316454D1
- Authority
- DE
- Germany
- Prior art keywords
- paliperidone
- forming
- controlled delivery
- delivery
- controlled
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39959002P | 2002-07-29 | 2002-07-29 | |
| US399590P | 2002-07-29 | ||
| US40600502P | 2002-08-26 | 2002-08-26 | |
| US406005P | 2002-08-26 | ||
| PCT/US2003/023433 WO2004010981A1 (en) | 2002-07-29 | 2003-07-28 | Methods and dosage forms for controlled delivery of paliperidone |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60316454D1 true DE60316454D1 (de) | 2007-10-31 |
| DE60316454T2 DE60316454T2 (de) | 2008-06-26 |
Family
ID=31191280
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60316454T Expired - Lifetime DE60316454T2 (de) | 2002-07-29 | 2003-07-28 | Verfahren und dosierformen für die kontrollierte abgabe von paliperidon |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US20040092534A1 (de) |
| EP (1) | EP1539115B1 (de) |
| JP (1) | JP4500679B2 (de) |
| KR (1) | KR100699516B1 (de) |
| CN (1) | CN1684670A (de) |
| AR (1) | AR040721A1 (de) |
| AT (1) | ATE373472T1 (de) |
| AU (1) | AU2003256844A1 (de) |
| BR (1) | BR0313139A (de) |
| CA (1) | CA2494234C (de) |
| CO (1) | CO5580742A2 (de) |
| CY (1) | CY1107096T1 (de) |
| DE (1) | DE60316454T2 (de) |
| DK (1) | DK1539115T3 (de) |
| ES (1) | ES2293039T3 (de) |
| HR (1) | HRP20050077B1 (de) |
| IL (1) | IL166489A (de) |
| MX (1) | MXPA05001191A (de) |
| MY (1) | MY137049A (de) |
| NO (1) | NO324821B1 (de) |
| NZ (1) | NZ570198A (de) |
| PE (1) | PE20040132A1 (de) |
| PL (1) | PL210119B1 (de) |
| PT (1) | PT1539115E (de) |
| RU (1) | RU2321391C2 (de) |
| TW (1) | TWI363637B (de) |
| WO (1) | WO2004010981A1 (de) |
| ZA (1) | ZA200501641B (de) |
Families Citing this family (76)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050232995A1 (en) * | 2002-07-29 | 2005-10-20 | Yam Nyomi V | Methods and dosage forms for controlled delivery of paliperidone and risperidone |
| AU2005271522B2 (en) * | 2004-08-04 | 2011-02-10 | Alza Corporation | Sustained drug release composition demonstrating an ascending zero order release pattern, methods of manufacturing such a composition |
| WO2006085856A1 (en) * | 2005-02-04 | 2006-08-17 | Alza Corporation | Methods and dosage forms for reducing side effects of benzisozazole derivatives |
| US20060189635A1 (en) * | 2005-02-04 | 2006-08-24 | Michelle Kramer | Enhanced efficacy benzisoxazole derivative dosage forms and methods |
| JP2009507774A (ja) * | 2005-08-04 | 2009-02-26 | アルザ・コーポレーシヨン | 改良された性質を提供するポリマー混合物による半透過性膜を含んでなる浸透性用量形態物 |
| WO2007081736A1 (en) * | 2006-01-06 | 2007-07-19 | Alza Corporation | Osmotic dosage form with controlled release and fast release aspects |
| SI3095447T1 (sl) | 2006-02-03 | 2022-02-28 | Opko Renal, Llc | Zdravljenje pomanjkanja vitamina D s 25-hidroksivitaminom D2 in 25-hidroksivitaminom D3 |
| US20070232624A1 (en) * | 2006-04-03 | 2007-10-04 | Palumbo Joseph M | Use of paliperidone for the treatment of sleep disturbances and/or excessive daytime sleepiness in psychiatric patients |
| CA2655499C (en) | 2006-06-21 | 2015-10-27 | Proventiv Therapeutics, Llc | Method of treating and preventing secondary hyperparathyroidism_with vitamin d repletion and vitamin d replacemnt therapies |
| US8524749B2 (en) * | 2007-02-09 | 2013-09-03 | Alza Corporation | Controlled release compositions of tizanidine |
| WO2009047644A2 (en) | 2007-04-25 | 2009-04-16 | Cytochroma Inc. | Method of treating vitamin d insufficiency and deficiency |
| PL3542792T3 (pl) | 2007-04-25 | 2023-11-20 | Eirgen Pharma Ltd. | 25-hydroksywitamina d o kontrolowanym uwalnianiu |
| EP3225243B1 (de) * | 2007-04-25 | 2025-09-03 | Opko Renal, LLC | Verfahren zur sicheren und effektiven behandlung und vorbeugung von sekundärem hyperparathyroidismus für chronische nierenerkrankung |
| PL2079446T3 (pl) * | 2007-08-21 | 2012-04-30 | Teva Pharma | Preparat paliperidonu o przedłużonym uwalnianiu |
| BRPI0817946A2 (pt) | 2007-09-25 | 2015-05-05 | Teva Pharma | Composições de imatinibe estável |
| EP3909585A1 (de) * | 2007-12-19 | 2021-11-17 | Janssen Pharmaceutica NV | Dosierplan im zusammenhang mit langwirkenden injizierbaren paliperidonestern |
| EP2280967A2 (de) * | 2008-03-27 | 2011-02-09 | Actavis Group PTC EHF | Hochreines paliperidon oder ein pharmazeutisch unbedenkliches salz davon, welches im wesentlichen frei von keto-verunreinigungen ist |
| EP2326312A1 (de) * | 2008-07-25 | 2011-06-01 | KRKA, D.D., Novo Mesto | Paliperidon-zusammensetzung mit festen matrixteilchen |
| EP2161019A1 (de) | 2008-09-05 | 2010-03-10 | KRKA, D.D., Novo Mesto | Verlängerte Freisetzung von einer pharmazeutischen Mehrteilchenzusammensetzung mit Paliperidon |
| WO2010044097A2 (en) | 2008-09-15 | 2010-04-22 | Intas Pharmaceuticals Limited | Novel dosage form of paliperidone and process for preparing the same |
| CA2739181C (en) * | 2008-09-30 | 2017-03-14 | Endo Pharmaceuticals Solutions Inc. | Implantable device for the delivery of risperidone and methods of use thereof |
| WO2011018246A2 (en) | 2009-08-13 | 2011-02-17 | Synthon B.V. | Controlled release paliperidone composition |
| US20110052687A1 (en) * | 2009-08-26 | 2011-03-03 | Glenmark Generics Ltd | Extended release pharmaceutical composition of paliperidone |
| CA2777856A1 (en) * | 2009-10-16 | 2011-04-21 | Ranbaxy Laboratories Limited | Extended release pharmaceutical compositions of paliperidone and processes of preparation thereof |
| US9271939B2 (en) | 2010-03-15 | 2016-03-01 | Inventia Healthcare Private Limited | Stabilized prolonged release pharmaceutical composition comprising atypical antipsychotic |
| RS60087B1 (sr) | 2010-03-29 | 2020-05-29 | Opko Ireland Global Holdings Ltd | Postupci i kompozicije za snižavanje nivoa paratireoidnog hormona |
| ES2602503T3 (es) | 2010-04-22 | 2017-02-21 | Intra-Cellular Therapies, Inc. | Compuestos orgánicos |
| US20120201886A1 (en) | 2010-07-30 | 2012-08-09 | Micro Labs Limited | Coated Extended Release Pharmaceutical Compositions Containing Paliperidone |
| CN102058517A (zh) * | 2010-12-31 | 2011-05-18 | 泰州万全医药科技有限公司 | 一种帕潘立酮缓释剂及其制备方法 |
| US20130034605A1 (en) | 2011-08-01 | 2013-02-07 | Micro Labs Limited | Extended release pharmaceutical compositions containing paliperidone |
| CN102274164B (zh) * | 2011-08-22 | 2014-07-02 | 长春健欣生物医药科技开发有限公司 | 帕潘立酮及帕潘立酮衍生物的注射用缓释凝胶剂 |
| US20150080404A1 (en) | 2012-04-14 | 2015-03-19 | Intra-Cellular Therapies, Inc. | Novel compositions and methods |
| WO2014102741A2 (en) * | 2012-12-28 | 2014-07-03 | University Of The Witwatersrand, Johannesburg | Pharmaceutical dosage form |
| PT2968320T (pt) | 2013-03-15 | 2021-01-28 | Intra Cellular Therapies Inc | Compostos orgânicos |
| KR101847947B1 (ko) | 2013-03-15 | 2018-05-28 | 옵코 아이피 홀딩스 Ⅱ 인코포레이티드 | 안정화되고 변형된 비타민 d 방출 제형 |
| CN103271889B (zh) * | 2013-05-23 | 2015-10-28 | 沈阳药科大学 | 帕利哌酮新型递增释放渗透泵制剂及其制备方法 |
| CN103385857A (zh) * | 2013-06-29 | 2013-11-13 | 北京万全德众医药生物技术有限公司 | 帕利哌酮的药物组合物 |
| WO2015001488A1 (en) | 2013-07-01 | 2015-01-08 | Ranbaxy Laboratories Limited | Extended-release tablets of paliperidone and processes of preparation thereof |
| KR102692169B1 (ko) | 2013-12-03 | 2024-08-05 | 인트라-셀룰라 써래피스, 인코퍼레이티드. | 신규한 방법 |
| ES2961843T3 (es) | 2014-04-04 | 2024-03-14 | Intra Cellular Therapies Inc | Gamma-carbolinas condensadas con heterociclo deuteradas como antagonistas de los receptores de 5-HT2A |
| CN106456638A (zh) | 2014-04-04 | 2017-02-22 | 细胞内治疗公司 | 有机化合物 |
| US10179776B2 (en) | 2014-06-09 | 2019-01-15 | Intra-Cellular Therapies, Inc. | Compounds and methods of use to treat schizophrenia |
| US20160000654A1 (en) * | 2014-07-07 | 2016-01-07 | Cadila Healthcare Limited | Method for determining formulation orientation of asymmetric multi-layered osmotic tablets |
| US10220047B2 (en) | 2014-08-07 | 2019-03-05 | Opko Ireland Global Holdings, Ltd. | Adjunctive therapy with 25-hydroxyvitamin D and articles therefor |
| CN104257622B (zh) * | 2014-10-01 | 2020-02-07 | 浙江华海药业股份有限公司 | 一种帕利哌酮控释片及其制备方法 |
| US9844551B2 (en) | 2015-01-14 | 2017-12-19 | Children's Hospital Medical Center | Compositions and methods for treatment of fragile X syndrome |
| GR1008842B (el) | 2015-08-06 | 2016-09-05 | Φαρματεν Ανωνυμος Βιομηχανικη Και Εμπορικη Εταιρεια Φαρμακευτικων Ιατρικων Και Καλλυντικων Προϊοντων | Φαρμακευτικο σκευασμα περιεχον εναν ατυπο αντιψυχωσιμο παραγοντα και μεθοδος για την παρασκευη αυτου |
| CN105147629B (zh) * | 2015-09-24 | 2017-08-25 | 吉林大学 | 一种异丁利酮片剂及制备方法 |
| HUE053737T2 (hu) | 2016-01-26 | 2021-07-28 | Intra Cellular Therapies Inc | Piridopirrolokinoxalin vegyületek, készítményeik és alkalmazásaik |
| KR102483124B1 (ko) | 2016-03-25 | 2022-12-29 | 인트라-셀룰라 써래피스, 인코퍼레이티드. | 유기 화합물 |
| AU2017253821B2 (en) | 2016-03-28 | 2022-11-03 | Opko Ireland Global Holdings, Limited | Methods of vitamin D treatment |
| US10682354B2 (en) | 2016-03-28 | 2020-06-16 | Intra-Cellular Therapies, Inc. | Compositions and methods |
| WO2017174096A1 (en) | 2016-04-05 | 2017-10-12 | Pharmathen S.A. | Pharmaceutical composition comprising an atypical antipsychotic agent and method for the preparation thereof |
| WO2018071233A1 (en) | 2016-10-12 | 2018-04-19 | Intra-Cellular Therapies, Inc. | Amorphous solid dispersions |
| WO2018098115A1 (en) * | 2016-11-23 | 2018-05-31 | Children's Hospital Medical Center | Paliperidone for treatment of drug refractory irritability and autism spectrum disorder |
| CN106727392A (zh) * | 2016-12-15 | 2017-05-31 | 上海奕利制药有限公司 | 一种帕利哌酮缓释片剂及其制备方法 |
| WO2018126143A1 (en) | 2016-12-29 | 2018-07-05 | Intra-Cellular Therapies, Inc. | Organic compounds |
| US10961245B2 (en) | 2016-12-29 | 2021-03-30 | Intra-Cellular Therapies, Inc. | Substituted heterocycle fused gamma-carbolines for treatment of central nervous system disorders |
| JP7132939B2 (ja) | 2017-03-24 | 2022-09-07 | イントラ-セルラー・セラピーズ・インコーポレイテッド | 新規組成物および方法 |
| AU2018307479B2 (en) | 2017-07-26 | 2024-06-20 | Intra-Cellular Therapies, Inc. | Organic compounds |
| CA3071137A1 (en) | 2017-07-26 | 2019-01-31 | Intra-Cellular Therapies, Inc. | Prodrugs of substituted heterocycle fused gamma-carbolines |
| BR112020019181A2 (pt) | 2018-03-23 | 2021-01-05 | Intra-Cellular Therapies, Inc. | Compostos orgânicos |
| CN112040940A (zh) | 2018-03-23 | 2020-12-04 | 细胞内治疗公司 | 有机化合物 |
| WO2019237037A1 (en) | 2018-06-08 | 2019-12-12 | Intra-Cellular Therapies, Inc. | Novel methods |
| US12144808B2 (en) | 2018-08-29 | 2024-11-19 | Intra-Cellular Therapies, Inc. | Compositions and methods |
| US10695345B2 (en) | 2018-08-31 | 2020-06-30 | Intra-Cellular Therapies, Inc. | Pharmaceutical capsule compositions comprising lumateperone mono-tosylate |
| KR102906995B1 (ko) | 2018-08-31 | 2025-12-31 | 인트라-셀룰라 써래피스, 인코퍼레이티드. | 신규한 방법 |
| EP3993798A4 (de) | 2019-07-07 | 2023-04-26 | Intra-Cellular Therapies, Inc. | Neuartige verfahren |
| KR102285510B1 (ko) | 2019-10-29 | 2021-08-04 | 강동국 | 양액 농도조절용 캡슐 및 그 용도 |
| EP4329734A4 (de) | 2021-04-26 | 2025-04-02 | Celanese EVA Performance Polymers LLC | Implantierbare vorrichtung zur verzögerten freisetzung einer makromolekularen arzneimittelverbindung |
| CN113616610B (zh) * | 2021-07-30 | 2023-05-12 | 石药集团欧意药业有限公司 | 一种帕利哌酮缓释片及其制备方法 |
| US20230364009A1 (en) * | 2022-05-12 | 2023-11-16 | Celanese Eva Performance Polymers Llc | Implantable Medical Device for the Delivery of an Antipsychotic |
| US12414948B2 (en) | 2022-05-18 | 2025-09-16 | Intra-Cellular Therapies, Inc. | Methods |
| CN120417904A (zh) | 2022-12-30 | 2025-08-01 | 细胞内治疗公司 | 作用于血清素5-HT2A受体的杂环稠合γ-咔啉 |
| WO2026011166A1 (en) | 2024-07-03 | 2026-01-08 | Intra-Cellular Therapies, Inc. | Substituted heterocycles for use in the treatment of diseases involving the 5-ht2a receptor |
| WO2026011136A1 (en) | 2024-07-03 | 2026-01-08 | Intra-Cellular Therapies, Inc. | Organic compounds |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4656092A (en) * | 1985-10-15 | 1987-04-07 | R. P. Scherer Corporation | Target shooting capsules |
| GB8613688D0 (en) * | 1986-06-05 | 1986-07-09 | Euro Celtique Sa | Pharmaceutical composition |
| IL92966A (en) * | 1989-01-12 | 1995-07-31 | Pfizer | Dispensing devices powered by hydrogel |
| US5156850A (en) * | 1990-08-31 | 1992-10-20 | Alza Corporation | Dosage form for time-varying patterns of drug delivery |
| TW376319B (en) * | 1993-04-28 | 1999-12-11 | Janssen Pharmaceutica Nv | Pharmaceutical composition containing risperidone pamoate and having a long acting activity for treating psychoses induced by the release of dopamine |
| EP1029538A3 (de) * | 1993-09-28 | 2003-10-15 | R.P. Scherer GmbH | Herstellung von Weichgelatinekapseln |
| SK282231B6 (sk) * | 1993-11-19 | 2001-12-03 | Janssen Pharmaceutica N. V. | Farmaceutický prostriedok na liečenie psychotických porúch |
| TW487572B (en) * | 1996-05-20 | 2002-05-21 | Janssen Pharmaceutica Nv | Aqueous suspensions of 9-hydroxyrisperidone fatty acid esters |
| CA2263558A1 (en) * | 1996-08-16 | 1998-02-19 | Alza Corporation | Dosage form for providing ascending dose of drug |
| US6919373B1 (en) * | 1996-11-12 | 2005-07-19 | Alza Corporation | Methods and devices for providing prolonged drug therapy |
| WO1999062496A1 (en) * | 1998-06-03 | 1999-12-09 | Alza Corporation | Methods and devices for providing prolonged drug therapy |
| US6706282B1 (en) * | 1998-11-02 | 2004-03-16 | Evangeline Cruz | Controlled delivery of phenoxyethyl-substituted 1,2,4-triazolones |
| DK1126853T3 (da) * | 1998-11-02 | 2006-08-14 | Alza Corp | Kontrolleret levering af antidepressine midler |
| CA2354472C (en) * | 1998-12-17 | 2009-02-24 | Alza Corporation | Conversion of liquid filled gelatin capsules into controlled release systems by multiple coatings |
| ES2255490T3 (es) * | 1999-03-31 | 2006-07-01 | Janssen Pharmaceutica N.V. | Almidon pregelatinizado en una formulacion de liberacion controlada. |
| US6599532B2 (en) * | 2000-01-13 | 2003-07-29 | Osmotica Corp. | Osmotic device containing alprazolam and an antipsychotic agent |
| US6491949B2 (en) * | 2000-01-14 | 2002-12-10 | Osmotica Corp. | Osmotic device within an osmotic device |
| US6375981B1 (en) * | 2000-06-01 | 2002-04-23 | A. E. Staley Manufacturing Co. | Modified starch as a replacement for gelatin in soft gel films and capsules |
| US6530962B1 (en) * | 2001-08-31 | 2003-03-11 | R.P. Scherer Technologies, Inc. | Emulsion of water soluble dyes in a lipophilic carrier |
-
2003
- 2003-07-28 PT PT03771910T patent/PT1539115E/pt unknown
- 2003-07-28 AT AT03771910T patent/ATE373472T1/de active
- 2003-07-28 KR KR1020057001460A patent/KR100699516B1/ko not_active Expired - Lifetime
- 2003-07-28 BR BR0313139-4A patent/BR0313139A/pt not_active Application Discontinuation
- 2003-07-28 ES ES03771910T patent/ES2293039T3/es not_active Expired - Lifetime
- 2003-07-28 DK DK03771910T patent/DK1539115T3/da active
- 2003-07-28 WO PCT/US2003/023433 patent/WO2004010981A1/en not_active Ceased
- 2003-07-28 DE DE60316454T patent/DE60316454T2/de not_active Expired - Lifetime
- 2003-07-28 RU RU2005102105/15A patent/RU2321391C2/ru not_active Application Discontinuation
- 2003-07-28 NZ NZ570198A patent/NZ570198A/en not_active IP Right Cessation
- 2003-07-28 EP EP03771910A patent/EP1539115B1/de not_active Revoked
- 2003-07-28 PL PL376258A patent/PL210119B1/pl unknown
- 2003-07-28 AU AU2003256844A patent/AU2003256844A1/en not_active Abandoned
- 2003-07-28 CN CNA03822948XA patent/CN1684670A/zh active Pending
- 2003-07-28 US US10/629,211 patent/US20040092534A1/en not_active Abandoned
- 2003-07-28 JP JP2004524886A patent/JP4500679B2/ja not_active Expired - Lifetime
- 2003-07-28 HR HRP20050077AA patent/HRP20050077B1/hr not_active IP Right Cessation
- 2003-07-28 CA CA002494234A patent/CA2494234C/en not_active Expired - Lifetime
- 2003-07-28 MX MXPA05001191A patent/MXPA05001191A/es active IP Right Grant
- 2003-07-29 TW TW092120703A patent/TWI363637B/zh not_active IP Right Cessation
- 2003-07-29 MY MYPI20032846A patent/MY137049A/en unknown
- 2003-07-29 AR AR20030102717A patent/AR040721A1/es unknown
- 2003-07-30 PE PE2003000749A patent/PE20040132A1/es not_active Application Discontinuation
-
2005
- 2005-01-25 IL IL166489A patent/IL166489A/en active IP Right Grant
- 2005-02-22 NO NO20050956A patent/NO324821B1/no not_active IP Right Cessation
- 2005-02-24 ZA ZA2005/01641A patent/ZA200501641B/en unknown
- 2005-02-28 CO CO05018509A patent/CO5580742A2/es not_active Application Discontinuation
-
2007
- 2007-12-18 CY CY20071101601T patent/CY1107096T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE60316454D1 (de) | Verfahren und dosierformen für die kontrollierte abgabe von paliperidon | |
| DE60324376D1 (de) | Halbleiterbauelement und Verfahren zu dessen Herstellung | |
| DE60325690D1 (de) | Halbleiterbauelement und verfahren zu seiner herstellung | |
| DE50212077D1 (de) | Piezoelektrisches bauelement und verfahren zu dessen herstellung | |
| DE60326628D1 (de) | Dorn und verfahren zur herstellung von stents | |
| DE50213224D1 (de) | Induktives bauelement und verfahren zu seiner herstellung | |
| DE602004021927D1 (de) | Halbleiterbauelement und verfahren zu seiner herstellung | |
| DE602004002195D1 (de) | Verfahren und apparat für die ablauffolgesteuerung von paketen | |
| DE60305105D1 (de) | Aluminiumbeschichtetes Bauteil und Verfahren zu dessen Herstellung | |
| DE60327225D1 (de) | Aripiprazol-komplex-formulierung und verfahren | |
| DE60239464D1 (de) | Piezoelektrisches porzellan und verfahren zu seiner herstellung | |
| DE50310782D1 (de) | Piezoaktor und verfahren zu dessen herstellung | |
| DE60337036D1 (de) | Halbleiterbauelement und verfahren zu seiner herstellung | |
| DE60303268D1 (de) | Verfahren und Vorrichtung zur Herstellung von Microarrays | |
| DE50214272D1 (de) | Piezoelektrisches bauelement und verfahren zu dessen herstellung | |
| DE50307832D1 (de) | Schichtsystem und verfahren zu dessen herstellung | |
| DE60239493D1 (de) | Halbleiterbauelement und verfahren zu seiner herstellung | |
| DE60314817D1 (de) | Gatewaykarte, Gatewayvorrichtung, Verfahren zur Steuerung der Gatewaykarte und Computerprodukt | |
| DE60329744D1 (de) | Aminosäurepulver und verfahren zu seiner herstellung | |
| DE602004010241D1 (de) | Mehrschichtprodukt und verfahren zu seiner herstellung | |
| DE60236790D1 (de) | Piezoelektrischer oszillator und verfahren zu seiner herstellung | |
| EP1599904A4 (de) | Laterale lubistorstruktur und verfahren | |
| DE60233077D1 (de) | Halbleiterbauelement und verfahren zu seiner herstellung | |
| DE60229488D1 (de) | Piezoelektrisches Bauelement und Verfahren zu dessen Herstellung | |
| DE60323689D1 (de) | Schräg geschichtetes furniermaterial und verfahren zu dessen herstellung |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8363 | Opposition against the patent |