DE60316423D1 - Tyrosinkinase-hemmer - Google Patents

Tyrosinkinase-hemmer

Info

Publication number: DE60316423D1
Authority: DE; Germany
Prior art keywords: compounds; tyrosine kinase; kinase inhibitor; present; receptor
Prior art date: 2002-04-12
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE60316423T

Other languages

English (en)

Other versions

DE60316423T2 (de

Inventor

B Wesley Trotter

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Merck Sharp and Dohme LLC

Original Assignee

Merck and Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-04-12

Filing date

2003-04-08

Publication date

2007-10-31

2003-04-08 Application filed by Merck and Co Inc filed Critical Merck and Co Inc

2007-10-31 Application granted granted Critical

2007-10-31 Publication of DE60316423D1 publication Critical patent/DE60316423D1/de

2008-06-12 Publication of DE60316423T2 publication Critical patent/DE60316423T2/de

2023-04-09 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Immunology (AREA)
Biomedical Technology (AREA)
Diabetes (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Rheumatology (AREA)
Endocrinology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Hematology (AREA)
Dermatology (AREA)
Vascular Medicine (AREA)
Emergency Medicine (AREA)
Pain & Pain Management (AREA)
Transplantation (AREA)
Ophthalmology & Optometry (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Obesity (AREA)
Orthopedic Medicine & Surgery (AREA)
Urology & Nephrology (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DE60316423T 2002-04-12 2003-04-08 Tyrosinkinase-hemmer Expired - Lifetime DE60316423T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US37223202P	2002-04-12	2002-04-12
US372232P		2002-04-12
PCT/US2003/012457 WO2003086315A2 (en)	2002-04-12	2003-04-08	Tyrosine kinase inhibitors

Publications (2)

Publication Number	Publication Date
DE60316423D1 true DE60316423D1 (de)	2007-10-31
DE60316423T2 DE60316423T2 (de)	2008-06-12

Family

ID=29250816

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE60316423T Expired - Lifetime DE60316423T2 (de)	2002-04-12	2003-04-08	Tyrosinkinase-hemmer

Country Status (9)

Country	Link
US (1)	US7371754B2 (de)
EP (1)	EP1496907B1 (de)
JP (1)	JP4475389B2 (de)
AT (1)	ATE373662T1 (de)
AU (1)	AU2003223689B2 (de)
CA (1)	CA2480758A1 (de)
DE (1)	DE60316423T2 (de)
ES (1)	ES2292956T3 (de)
WO (1)	WO2003086315A2 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE60321330D1 (de)	2002-04-12	2008-07-10	Merck & Co Inc	Tyrosinkinase-hemmer
EP1496897A4 (de) *	2002-04-12	2006-05-10	Merck & Co Inc	Tyrosinkinase-hemmer
EP1993292B1 (de)	2006-03-09	2013-05-15	NEC Corporation	Verfahren und vorrichtung für dynamische bildkodierung und programm damit
US8530475B2 (en)	2006-05-18	2013-09-10	Janssen Pharmaceutica Nv	Bridged aryl piperazines derivatives useful for the treatment of CNS, GI-urinary and reproductive disorders
US8642067B2 (en)	2007-04-02	2014-02-04	Allergen, Inc.	Methods and compositions for intraocular administration to treat ocular conditions
CN117257805B (zh) *	2023-11-10	2024-03-12	中山大学附属第八医院（深圳福田）	核苷类逆转录酶抑制剂在制备抗血管钙化药物中的应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4332810A (en)	1981-01-26	1982-06-01	Merck & Co., Inc.	N-(Substituted)-2,5-ethano-8-hydroxy (or methoxy)-1,2,3,4,5,6-hexahydro-3 (or 4)-benzazocine centrally-acting analgesics
DK1319000T3 (da)	2000-09-20	2009-02-16	Aprea Ab	Anvendelse af 1-azabicyclo(2,2,2)oktan-3-on-derivater til behandling af cancertumorer
GB0110797D0 (en) *	2001-05-02	2001-06-27	Celltech R&D Ltd	Chemical compounds
DE60321330D1 (de)	2002-04-12	2008-07-10	Merck & Co Inc	Tyrosinkinase-hemmer
EP1496897A4 (de)	2002-04-12	2006-05-10	Merck & Co Inc	Tyrosinkinase-hemmer

2003
- 2003-04-08 DE DE60316423T patent/DE60316423T2/de not_active Expired - Lifetime
- 2003-04-08 JP JP2003583340A patent/JP4475389B2/ja not_active Expired - Lifetime
- 2003-04-08 EP EP03719886A patent/EP1496907B1/de not_active Expired - Lifetime
- 2003-04-08 AU AU2003223689A patent/AU2003223689B2/en not_active Ceased
- 2003-04-08 US US10/510,610 patent/US7371754B2/en not_active Expired - Fee Related
- 2003-04-08 AT AT03719886T patent/ATE373662T1/de not_active IP Right Cessation
- 2003-04-08 WO PCT/US2003/012457 patent/WO2003086315A2/en not_active Ceased
- 2003-04-08 ES ES03719886T patent/ES2292956T3/es not_active Expired - Lifetime
- 2003-04-08 CA CA002480758A patent/CA2480758A1/en not_active Abandoned

Also Published As

Publication number	Publication date
JP2005528387A (ja)	2005-09-22
WO2003086315A3 (en)	2004-01-08
ES2292956T3 (es)	2008-03-16
CA2480758A1 (en)	2003-10-23
EP1496907A2 (de)	2005-01-19
AU2003223689A1 (en)	2003-10-27
WO2003086315A2 (en)	2003-10-23
US20050227988A1 (en)	2005-10-13
DE60316423T2 (de)	2008-06-12
EP1496907B1 (de)	2007-09-19
AU2003223689B2 (en)	2009-08-20
US7371754B2 (en)	2008-05-13
JP4475389B2 (ja)	2010-06-09
ATE373662T1 (de)	2007-10-15
EP1496907A4 (de)	2006-05-10

Publication	Publication Date	Title
ATE482938T1 (de)	2010-10-15	Tyrosinkinaseinhibitoren
WO2004014300A3 (en)	2004-04-22	Tyrosine kinase inhibitors
WO2003035615A3 (en)	2004-03-18	Tyrosine kinase inhibitors
DK1362047T3 (da)	2006-09-04	Indazolylsubstituerede pyrrolinforbindelser som kinaseinhibitorer
WO2004031401A3 (en)	2004-07-29	Novel tyrosine kinases inhibitors
AU2001241798A1 (en)	2001-09-12	3-(pyrolyllactone)-2-indolinone compounds as kinase inhibitors
WO2004096795A3 (en)	2005-03-10	C-fms kinase inhibitors
WO2003035616A3 (en)	2003-10-23	Tyrosine kinase inhibitors
CA2400447A1 (en)	2001-08-23	Kinase inhibitors
WO2003035619A8 (en)	2003-07-03	Tyrosine kinase inhibitors
SG132683A1 (en)	2007-06-28	Imidazopyrazine tyrosine kinase inhibitors
PL361404A1 (en)	2004-10-04	Synergistic combinations comprising a renin inhibitor for cardiovascular diseases
WO2001019828A3 (en)	2001-10-04	Kinase inhibitors as therapeutic agents
IL163781A0 (en)	2005-12-18	Purine derivatives as kinase inhibitors
MY139689A (en)	2009-10-30	Imidazotriazines as protein kinase inhibitors
WO2003035614A3 (en)	2004-03-18	Tyrosine kinase inhibitors
IL163777A0 (en)	2005-12-18	Kinase inhibitors
WO2006047479A3 (en)	2007-01-04	C-fms kinase inhibitors
MXPA05013076A (es)	2006-03-09	Compuestos de isoindolina-1-ona como inhibidores de cinasa.
WO2006047503A3 (en)	2006-09-28	Inhibitors of c-fms kinase
AU2001230395A1 (en)	2001-08-14	Use of cox-2 inhibitors as gastroprokinetics
DE60316423D1 (de)	2007-10-31	Tyrosinkinase-hemmer
TW200628153A (en)	2006-08-16	Novel compounds
DE60321330D1 (de)	2008-07-10	Tyrosinkinase-hemmer
WO2005009373A3 (en)	2005-09-09	Tyrosine kinase inhibitors

Legal Events

Date	Code	Title	Description
2008-10-09	8364	No opposition during term of opposition
2010-08-12	8327	Change in the person/name/address of the patent owner	Owner name: MERCK SHARP & DOHME CORP., RAHWAY, N.J., US
2010-08-12	8328	Change in the person/name/address of the agent	Representative=s name: MARKS & CLERK (LUXEMBOURG) LLP, LUXEMBOURG, LU