DE60316410D1 - N-substituierte 3-hydroxy-4-pyridinone und diese enthaltende pharmazeutika - Google Patents
N-substituierte 3-hydroxy-4-pyridinone und diese enthaltende pharmazeutikaInfo
- Publication number
- DE60316410D1 DE60316410D1 DE60316410T DE60316410T DE60316410D1 DE 60316410 D1 DE60316410 D1 DE 60316410D1 DE 60316410 T DE60316410 T DE 60316410T DE 60316410 T DE60316410 T DE 60316410T DE 60316410 D1 DE60316410 D1 DE 60316410D1
- Authority
- DE
- Germany
- Prior art keywords
- hydroxy
- substituted
- pyridinones
- metal chelates
- pyridinone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- -1 N-SUBSTITUTED 3-HYDROXY-4-PYRIDINONE Chemical class 0.000 title abstract 5
- 239000003814 drug Substances 0.000 title 1
- 239000002184 metal Substances 0.000 abstract 4
- 102000008186 Collagen Human genes 0.000 abstract 1
- 108010035532 Collagen Proteins 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 208000030852 Parasitic disease Diseases 0.000 abstract 1
- 208000036142 Viral infection Diseases 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 230000004663 cell proliferation Effects 0.000 abstract 1
- 229920001436 collagen Polymers 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 230000003071 parasitic effect Effects 0.000 abstract 1
- 239000008177 pharmaceutical agent Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000009385 viral infection Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0476—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from monodendate ligands, e.g. sestamibi
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Nutrition Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35433902P | 2002-02-05 | 2002-02-05 | |
| US354339P | 2002-02-05 | ||
| PCT/US2003/003375 WO2003065991A2 (en) | 2002-02-05 | 2003-02-05 | N-substituted3-hydroxy-4-pyridinones and pharmaceuticals containing thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60316410D1 true DE60316410D1 (de) | 2007-10-31 |
| DE60316410T2 DE60316410T2 (de) | 2008-06-19 |
Family
ID=27734359
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60316410T Expired - Fee Related DE60316410T2 (de) | 2002-02-05 | 2003-02-05 | N-substituierte 3-hydroxy-4-pyridinone und diese enthaltende pharmazeutika |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US6825204B2 (de) |
| EP (1) | EP1474396B9 (de) |
| JP (1) | JP2005516987A (de) |
| AT (1) | ATE373644T1 (de) |
| AU (1) | AU2003210850A1 (de) |
| DE (1) | DE60316410T2 (de) |
| PL (1) | PL371746A1 (de) |
| WO (1) | WO2003065991A2 (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005110399A2 (en) * | 2004-04-29 | 2005-11-24 | The Regents Of The University Of California | Zinc-binding groups for metalloprotein inhibitors |
| US20100166662A1 (en) * | 2006-03-27 | 2010-07-01 | The University Of Chicago | Magnetic resonance imaging method using vanadyl-based contrast agents |
| WO2008020920A1 (en) * | 2006-08-15 | 2008-02-21 | Duke University | Ros-sensitive iron chelators and methods of using the same |
| US8217173B2 (en) * | 2007-02-13 | 2012-07-10 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Fluoride-releasing compositions |
| US8916163B1 (en) * | 2007-12-21 | 2014-12-23 | Vanderbilt University | Method for treating microbial infections |
| WO2009143297A1 (en) | 2008-05-20 | 2009-11-26 | Neurogesx, Inc. | Carbonate prodrugs and methods of using the same |
| BRPI0912326A2 (pt) | 2008-05-20 | 2015-10-06 | Neurogesx Inc | análogos de acetaminofeno hidrossolúveis |
| CA2919268C (en) | 2013-07-25 | 2023-09-05 | Exicure, Inc. | Spherical nucleic acid-based constructs as immunostimulatory agents for prophylactic and therapeutic use |
| DE102013217034A1 (de) * | 2013-08-27 | 2015-03-05 | Henkel Ag & Co. Kgaa | Wasch- und Reinigungsmittel mit verbesserter Leistung |
| KR20170042758A (ko) * | 2014-08-20 | 2017-04-19 | 노오쓰웨스턴 유니버시티 | 안티센스 유전자 조절을 위한 생체에 적합한 무한 배위 중합체 나노입자-핵산 컨쥬게이트 |
| CN111995567B (zh) * | 2020-07-24 | 2022-11-25 | 浙江工业大学 | 具潜在多靶点抗ad活性的甲酰胺吡啶酮类铁螯合剂衍生物及其制备方法与应用 |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2136807A (en) * | 1934-12-17 | 1938-11-15 | John S Skelly | Side retort stoker |
| JPH07110815B2 (ja) | 1985-11-18 | 1995-11-29 | ボ−ド・オブ・リ−ジェンツ、ザ・ユニバ−シティ−・オブ・テキサス・システム | 画像及びスペクトル向上（およびスペクトルシフト）のためのポリキレ−ト剤 |
| US4908371A (en) | 1987-11-10 | 1990-03-13 | Ciba-Geigy Corporation | Esterified hydroxy dihydropyridinones for treating diseases associated with trivalent metal ion overload |
| EP0335745A1 (de) | 1988-03-31 | 1989-10-04 | The Royal Free Hospital School Of Medicine | Verfahren zur Herstellung von Pyridin-4-onen |
| US5087440A (en) | 1989-07-31 | 1992-02-11 | Salutar, Inc. | Heterocyclic derivatives of DTPA used for magnetic resonance imaging |
| AU7346091A (en) | 1990-03-02 | 1991-09-18 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Preparations for mr diagnosis |
| US5143716A (en) | 1991-02-01 | 1992-09-01 | Unger Evan C | Phosphorylated sugar alcohols, Mono- and Di-Saccharides as contrast agents for use in magnetic resonance imaging of the gastrointestinal region |
| US5527790A (en) | 1991-09-30 | 1996-06-18 | The University Of British Columbia | Bis(maltolato)oxovanadium compositions for the treatment of elevated blood sugar |
| US5866563A (en) | 1991-09-30 | 1999-02-02 | The University Of British Columbia | Vanadium compositions |
| US5336482A (en) * | 1991-12-05 | 1994-08-09 | The Du Pont Merck Pharmaceutical Company | Technetium-99m complexes with N-substituted 3-hydroxy-4-pyridinones |
| GB9209078D0 (en) | 1992-04-27 | 1992-06-10 | Hider Robert C | Pharmaceutical compositions |
| GB9217099D0 (en) | 1992-08-12 | 1992-09-23 | British Tech Group | Pharmaceutical compositions |
| JPH07179474A (ja) * | 1993-10-05 | 1995-07-18 | Takeda Chem Ind Ltd | 新規セフェム化合物、その製造法およびその抗菌組成物 |
| US5565491A (en) | 1994-01-31 | 1996-10-15 | Bristol-Myers Squibb Company | Use of phosphotyrosine phospatase inhibitors for controlling cellular proliferation |
| GB9416768D0 (en) | 1994-08-18 | 1994-10-12 | Nycomed Innovation Ab | Compositions |
| WO1996005867A2 (en) | 1994-08-18 | 1996-02-29 | Nycomed Imaging A/S | Compositions |
| US5789426A (en) | 1995-01-20 | 1998-08-04 | Cornell Research Foundation, Inc. | Method for the treatment of fibroproliferative disorders by application of inhibitors of protein hydroxylation |
| US6046219A (en) | 1995-01-20 | 2000-04-04 | Cornell Research Foundation, Inc. | Method for the treatment of conditions mediated by collagen formation together with cell proliferation by application of inhibitors of protein hydroxylation |
| US5849587A (en) | 1995-06-09 | 1998-12-15 | Cornell Research Foundation, Inc. | Method of inhibiting viral replication in eukaryotic cells and of inducing apoptosis of virally-infected cells |
| DK81095A (da) | 1995-07-11 | 1997-01-12 | Henrik S Thomsen | Peroralt MR-kontraststof til lever og øvre tarmkanal |
| DE59611243D1 (de) | 1995-09-29 | 2005-08-11 | Novartis Ag | Hydroxypyridinone |
| FR2750699B1 (fr) | 1996-07-05 | 1998-12-04 | Univ Picardie | Procede de synthese regiospecifique de nouveaux derives 3-hydroxypydirin-4(1h)-ones a partir d'aminomonosaccharides ou d'aminoitols. produits obtenus par ce procede et leurs applications |
| US6232340B1 (en) | 1997-04-24 | 2001-05-15 | Angiotech Pharmaceuticals, Inc. | Vanadium complexes and derivatives thereof and methods related thereto |
| GB9711093D0 (en) | 1997-05-29 | 1997-07-23 | British Tech Group | Novel orally active iron (III) chelators |
| GB9723078D0 (en) | 1997-10-31 | 1998-01-07 | Cerebrus Ltd | Chemical compounds |
| US6248579B1 (en) | 1998-02-13 | 2001-06-19 | Pfizer Inc | Streptomyces avermitilis gene directing the ratio of B2:B1 avermectins |
| WO2000016782A1 (en) | 1998-09-18 | 2000-03-30 | The University Of British Columbia | Pharmaceutical compositions of vanadium biguanide complexes and their use |
| ID28630A (id) | 1998-09-23 | 2001-06-21 | Unilever Nv | Komposisi-komposisi perawatan oral |
| WO2000024730A1 (en) | 1998-10-28 | 2000-05-04 | The University Of British Columbia | Organic vanadium(iii) complexes and their use |
| US5980863A (en) | 1998-11-02 | 1999-11-09 | Eagle Vision Pharmaceutical Corporation | Manganese compositions and methods for MRI |
| EP1006112A1 (de) | 1998-12-01 | 2000-06-07 | Cerebrus Pharmaceuticals Limited | 3-Hydroxy-2(1H)-pyridinon- oder 3-hydroxy-4(1H)-pyridinon- Derivate verwendbar als reaktive Sauerstoffspezies-Fänger (ROS) |
| EP1006108A1 (de) | 1998-12-01 | 2000-06-07 | Cerebrus Pharmaceuticals Limited | 3-Hydroxy-2(1H)-pyridinon- oder 3-hydroxy-4(1H)-pyridinon- Derivate verwendbar als reaktive Sauerstoffspezies-Fänger (ROS) |
| GB2345058A (en) | 1998-12-01 | 2000-06-28 | Cerebrus Pharm Ltd | Hydroxypyridone compounds useful in the treatment of oxidative damage to the central nervous system |
| US6294152B1 (en) * | 1999-01-11 | 2001-09-25 | The University Of Toledo | Iron(III) complexes as contrast agents for image enhancement in magnetic resonance imaging |
| US6323340B1 (en) * | 1999-07-30 | 2001-11-27 | Nippon Shobukai Co., Ltd. | Phthalocyanine compound, method for production thereof, and near infrared absorption dye using the compound |
| NL1012825C2 (nl) | 1999-08-13 | 2001-02-23 | Faculteit Geneeskunde Universi | Farmaceuticum voor de behandeling van virale infecties in het bijzonder van het humane immunodeficiency virus (HIV). |
-
2003
- 2003-02-05 EP EP03737635A patent/EP1474396B9/de not_active Expired - Lifetime
- 2003-02-05 AT AT03737635T patent/ATE373644T1/de not_active IP Right Cessation
- 2003-02-05 AU AU2003210850A patent/AU2003210850A1/en not_active Abandoned
- 2003-02-05 US US10/358,835 patent/US6825204B2/en not_active Expired - Fee Related
- 2003-02-05 WO PCT/US2003/003375 patent/WO2003065991A2/en not_active Ceased
- 2003-02-05 JP JP2003565417A patent/JP2005516987A/ja active Pending
- 2003-02-05 DE DE60316410T patent/DE60316410T2/de not_active Expired - Fee Related
- 2003-02-05 PL PL03371746A patent/PL371746A1/xx not_active Application Discontinuation
-
2004
- 2004-03-18 US US10/803,724 patent/US6932960B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1474396B9 (de) | 2008-07-09 |
| EP1474396B1 (de) | 2007-09-19 |
| AU2003210850A8 (en) | 2003-09-02 |
| PL371746A1 (en) | 2005-06-27 |
| US6825204B2 (en) | 2004-11-30 |
| JP2005516987A (ja) | 2005-06-09 |
| EP1474396A2 (de) | 2004-11-10 |
| AU2003210850A1 (en) | 2003-09-02 |
| US6932960B2 (en) | 2005-08-23 |
| ATE373644T1 (de) | 2007-10-15 |
| EP1474396A4 (de) | 2006-01-18 |
| DE60316410T2 (de) | 2008-06-19 |
| US20030170174A1 (en) | 2003-09-11 |
| WO2003065991A3 (en) | 2003-12-31 |
| WO2003065991A2 (en) | 2003-08-14 |
| US20040176326A1 (en) | 2004-09-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |