DE60315288D1 - Cyanoguanidin prodrugs - Google Patents
Cyanoguanidin prodrugsInfo
- Publication number
- DE60315288D1 DE60315288D1 DE60315288T DE60315288T DE60315288D1 DE 60315288 D1 DE60315288 D1 DE 60315288D1 DE 60315288 T DE60315288 T DE 60315288T DE 60315288 T DE60315288 T DE 60315288T DE 60315288 D1 DE60315288 D1 DE 60315288D1
- Authority
- DE
- Germany
- Prior art keywords
- sub
- prodrugs
- cyanoguanidine
- cyanoguanidine prodrugs
- cancers
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 229940002612 prodrug Drugs 0.000 title abstract 2
- 239000000651 prodrug Substances 0.000 title abstract 2
- QGBSISYHAICWAH-UHFFFAOYSA-N dicyandiamide Chemical compound NC(N)=NC#N QGBSISYHAICWAH-UHFFFAOYSA-N 0.000 title 1
- CPFPCHSTLBKFPH-UHFFFAOYSA-N 1-cyano-1-pyridin-2-ylguanidine Chemical class NC(=N)N(C#N)C1=CC=CC=N1 CPFPCHSTLBKFPH-UHFFFAOYSA-N 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4425—Pyridinium derivatives, e.g. pralidoxime, pyridostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Gastroenterology & Hepatology (AREA)
- Oncology (AREA)
- Dermatology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Neurology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Adhesives Or Adhesive Processes (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38083602P | 2002-05-17 | 2002-05-17 | |
| US380836P | 2002-05-17 | ||
| PCT/DK2003/000318 WO2003097601A1 (en) | 2002-05-17 | 2003-05-15 | Cyanoguanidine prodrugs |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60315288D1 true DE60315288D1 (de) | 2007-09-13 |
| DE60315288T2 DE60315288T2 (de) | 2008-04-10 |
Family
ID=29550021
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60315288T Expired - Lifetime DE60315288T2 (de) | 2002-05-17 | 2003-05-15 | Cyanoguanidin prodrugs |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20070249676A1 (de) |
| EP (1) | EP1507760B1 (de) |
| JP (1) | JP4625694B2 (de) |
| KR (1) | KR101010871B1 (de) |
| CN (1) | CN100503570C (de) |
| AT (1) | ATE368649T1 (de) |
| AU (1) | AU2003229534B2 (de) |
| BR (1) | BR0309996A (de) |
| CA (1) | CA2485351C (de) |
| DE (1) | DE60315288T2 (de) |
| ES (1) | ES2290454T3 (de) |
| IL (1) | IL165086A (de) |
| IS (1) | IS7562A (de) |
| MX (1) | MXPA04011322A (de) |
| NO (1) | NO330183B1 (de) |
| PL (1) | PL228742B1 (de) |
| RU (1) | RU2326867C2 (de) |
| WO (1) | WO2003097601A1 (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7253193B2 (en) | 2002-05-17 | 2007-08-07 | Leo Pharma A/S | Cyanoguanidine prodrugs |
| WO2006066584A1 (en) | 2004-12-22 | 2006-06-29 | Leo Pharma A/S | Novel cyanoguanidine compounds |
| WO2007022964A2 (de) | 2005-08-24 | 2007-03-01 | Abbott Gmbh & Co. Kg | Hetaryl substituierte guanidinverbindungen und ihre verwendung als bindungspartner für 5-ht5-rezeptoren |
| CA2701071C (en) * | 2007-09-26 | 2018-03-27 | Gemin X Pharmaceuticals Canada Inc. | Compositions and methods for effecting nad+ levels using a nicotinamide phosphoribosyl transferase inhibitor |
| RU2011111728A (ru) | 2008-08-29 | 2012-10-10 | Топотаргет А/С (Dk) | Новые производные мочевины и тиомочевины |
| WO2010088842A1 (zh) | 2009-02-06 | 2010-08-12 | 天津和美生物技术有限公司 | 含有吡啶基氰基胍的药物组合物及其制备和应用 |
| EP2453883A1 (de) | 2009-07-17 | 2012-05-23 | Topo Target A/S | Verfahren zur prognose des nutzens der verabreichung von nikotinsäure bzw. einem vorläufer oder prodrug daraus zur minderung des schweregrades der nebenwirkungen einer krebsbehandlung mit nikotinamid-phosphoribosyltransferase-hemmern |
| US8912184B1 (en) | 2010-03-01 | 2014-12-16 | Alzheimer's Institute Of America, Inc. | Therapeutic and diagnostic methods |
| WO2011121055A1 (en) | 2010-03-31 | 2011-10-06 | Topotarget A/S | Pyridinyl derivatives comprising a cyanoguanidine or squaric acid moiety |
| CN109608436B (zh) * | 2011-04-08 | 2022-10-11 | 斯法尔制药私人有限公司 | 取代的甲基甲酰基试剂及使用所述试剂改进化合物物理化学和/或药代动力学性质的方法 |
| MA37808A1 (fr) * | 2012-06-27 | 2018-03-30 | Alzheimers Institute Of America Inc | Composés et leurs utilisations thérapeutiques |
| CN116640238B (zh) * | 2023-05-30 | 2024-05-03 | 华侨大学 | 一种胍基吡啶壳聚糖鎓盐及其制备方法和应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9219472D0 (en) * | 1992-09-15 | 1992-10-28 | Leo Pharm Prod Ltd | Chemical compounds |
| US5919816A (en) * | 1994-11-14 | 1999-07-06 | Bionumerik Pharmaceuticals, Inc. | Formulations and methods of reducing toxicity of antineoplastic agents |
| GB9711123D0 (en) * | 1997-05-29 | 1997-07-23 | Leo Pharm Prod Ltd | Novel cyanoguanidines |
| GB9711125D0 (en) * | 1997-05-29 | 1997-07-23 | Leo Pharm Prod Ltd | Novel cyanoguanidines |
| GB9711124D0 (en) * | 1997-05-29 | 1997-07-23 | Leo Pharm Prod Ltd | Novel cyanoguanidines |
| WO2000061559A1 (en) * | 1999-04-09 | 2000-10-19 | Shionogi Bioresearch Corp. | N-substituted cyanoguanidine compounds |
| AU1494702A (en) * | 2000-11-21 | 2002-06-03 | Leo Pharma As | Cyanoguanidine prodrugs |
| US20030045515A1 (en) * | 2001-05-24 | 2003-03-06 | Lise Binderup | Combination medicament for treatment of neoplastic diseases |
| JP2005531560A (ja) * | 2002-05-17 | 2005-10-20 | レオ・ファーマ・アクティーゼルスカブ | シアノグアニジンプロドラッグ |
-
2003
- 2003-05-15 PL PL372769A patent/PL228742B1/pl unknown
- 2003-05-15 DE DE60315288T patent/DE60315288T2/de not_active Expired - Lifetime
- 2003-05-15 JP JP2004505334A patent/JP4625694B2/ja not_active Expired - Fee Related
- 2003-05-15 MX MXPA04011322A patent/MXPA04011322A/es active IP Right Grant
- 2003-05-15 RU RU2004136991/04A patent/RU2326867C2/ru active
- 2003-05-15 BR BR0309996-2A patent/BR0309996A/pt not_active Application Discontinuation
- 2003-05-15 CN CNB038140772A patent/CN100503570C/zh not_active Expired - Fee Related
- 2003-05-15 ES ES03722311T patent/ES2290454T3/es not_active Expired - Lifetime
- 2003-05-15 CA CA2485351A patent/CA2485351C/en not_active Expired - Lifetime
- 2003-05-15 KR KR1020047018603A patent/KR101010871B1/ko not_active Expired - Fee Related
- 2003-05-15 WO PCT/DK2003/000318 patent/WO2003097601A1/en not_active Ceased
- 2003-05-15 AU AU2003229534A patent/AU2003229534B2/en not_active Ceased
- 2003-05-15 AT AT03722311T patent/ATE368649T1/de not_active IP Right Cessation
- 2003-05-15 EP EP03722311A patent/EP1507760B1/de not_active Expired - Lifetime
-
2004
- 2004-11-08 IL IL165086A patent/IL165086A/en active IP Right Grant
- 2004-11-29 IS IS7562A patent/IS7562A/is unknown
- 2004-12-08 NO NO20045374A patent/NO330183B1/no not_active IP Right Cessation
-
2007
- 2007-06-28 US US11/823,571 patent/US20070249676A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2485351C (en) | 2011-12-06 |
| EP1507760B1 (de) | 2007-08-01 |
| ATE368649T1 (de) | 2007-08-15 |
| IS7562A (is) | 2004-11-29 |
| HK1076812A1 (zh) | 2006-01-27 |
| US20070249676A1 (en) | 2007-10-25 |
| CN1662501A (zh) | 2005-08-31 |
| JP4625694B2 (ja) | 2011-02-02 |
| DE60315288T2 (de) | 2008-04-10 |
| CN100503570C (zh) | 2009-06-24 |
| IL165086A0 (en) | 2005-12-18 |
| CA2485351A1 (en) | 2003-11-27 |
| AU2003229534A1 (en) | 2003-12-02 |
| ES2290454T3 (es) | 2008-02-16 |
| MXPA04011322A (es) | 2005-02-17 |
| JP2005538949A (ja) | 2005-12-22 |
| EP1507760A1 (de) | 2005-02-23 |
| NO330183B1 (no) | 2011-02-28 |
| RU2326867C2 (ru) | 2008-06-20 |
| BR0309996A (pt) | 2005-02-22 |
| WO2003097601A1 (en) | 2003-11-27 |
| KR20050016412A (ko) | 2005-02-21 |
| RU2004136991A (ru) | 2005-06-10 |
| IL165086A (en) | 2011-11-30 |
| NO20045374L (no) | 2004-12-08 |
| PL372769A1 (en) | 2005-08-08 |
| PL228742B1 (pl) | 2018-05-30 |
| AU2003229534B2 (en) | 2009-08-27 |
| KR101010871B1 (ko) | 2011-01-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |