DE60313634D1 - Piperazinsubstituierte arylbenzodiazepine - Google Patents
Piperazinsubstituierte arylbenzodiazepineInfo
- Publication number
- DE60313634D1 DE60313634D1 DE60313634T DE60313634T DE60313634D1 DE 60313634 D1 DE60313634 D1 DE 60313634D1 DE 60313634 T DE60313634 T DE 60313634T DE 60313634 T DE60313634 T DE 60313634T DE 60313634 D1 DE60313634 D1 DE 60313634D1
- Authority
- DE
- Germany
- Prior art keywords
- sup
- sub
- alkyl
- optionally substituted
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 125000000217 alkyl group Chemical group 0.000 abstract 10
- 125000003118 aryl group Chemical group 0.000 abstract 7
- 229910052739 hydrogen Inorganic materials 0.000 abstract 7
- 239000001257 hydrogen Substances 0.000 abstract 7
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 6
- 125000003709 fluoroalkyl group Chemical group 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 208000020925 Bipolar disease Diseases 0.000 abstract 1
- 102000004980 Dopamine D2 Receptors Human genes 0.000 abstract 1
- 108090001111 Dopamine D2 Receptors Proteins 0.000 abstract 1
- 208000028017 Psychotic disease Diseases 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- -1 hydroxy, methoxy, ethoxy Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 239000011593 sulfur Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Psychiatry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40129702P | 2002-08-05 | 2002-08-05 | |
| US401297P | 2002-08-05 | ||
| PCT/IB2003/003583 WO2004014895A1 (en) | 2002-08-05 | 2003-07-28 | Piperazine substituted aryl benzodiazepines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60313634D1 true DE60313634D1 (de) | 2007-06-14 |
| DE60313634T2 DE60313634T2 (de) | 2008-01-31 |
Family
ID=31715704
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60313634T Expired - Lifetime DE60313634T2 (de) | 2002-08-05 | 2003-07-28 | Piperazinsubstituierte arylbenzodiazepine |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7384934B2 (de) |
| EP (1) | EP1546134B1 (de) |
| AT (1) | ATE361289T1 (de) |
| AU (1) | AU2003264915A1 (de) |
| CY (1) | CY1110382T1 (de) |
| DE (1) | DE60313634T2 (de) |
| DK (1) | DK1546134T3 (de) |
| ES (1) | ES2285227T3 (de) |
| PT (1) | PT1546134E (de) |
| WO (1) | WO2004014895A1 (de) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1243262E (pt) | 2001-03-20 | 2006-10-31 | Sanol Arznei Schwarz Gmbh | Nova utilizacao de uma classe de compostos peptideos para o tratamento da dor inflamatoria nao neuropatica |
| ES2185606T3 (es) | 2001-03-21 | 2003-05-01 | Sanol Arznei Schwarz Gmbh | Nuevo uso de una clase de compuestos peptidicos para tratamiento de la alodinia u otros tipos diferentes de dolor cronico o fantasma. |
| WO2005026177A1 (en) * | 2003-09-09 | 2005-03-24 | Eli Lilly And Company | Substituted piperazines of azepines, oxazepines, and thiazepines |
| AR048272A1 (es) * | 2004-03-18 | 2006-04-12 | Lek Pharmaceuticals | Sintesis de 2 metil - 4- (4- metil -1- piperazinil) - 10 h- tieno ( 2,3-b) (1,5) benzodiazepina y sus sales, metodos para su preparacion, composiciones farmaceuticas que la contienen y su uso en la fabricacion de medicamentos para el tratamiento de enfermedades mentales. |
| EP1781276B1 (de) | 2004-08-27 | 2010-06-23 | UCB Pharma GmbH | Verwendung von peptidverbindungen zur behandlung von schmerzen durch knochenkrebs, chemotherapie- und nucleosid-bedingten schmerzen |
| EP1642889A1 (de) * | 2004-10-02 | 2006-04-05 | Schwarz Pharma Ag | Verbessertes Syntheseschema für Lacosamid |
| MY147756A (en) | 2005-05-25 | 2013-01-15 | Theravance Inc | Benzimidazole-carboxamide compounds as 5-ht4 receptor agonists |
| PT2462990E (pt) | 2006-06-15 | 2014-04-02 | Ucb Pharma Gmbh | Composição farmacêutica com efeito anticonvulsivo sinergístico |
| RU2469033C2 (ru) | 2007-03-15 | 2012-12-10 | Арикс Терапьютикс, Инк. | СОЕДИНЕНИЯ ДИБЕНЗО[b,f][1,4]ОКСАЗАПИНА |
| US8420807B2 (en) * | 2008-01-31 | 2013-04-16 | Fermion Oy | Process for the preparation of quetiapine |
| PL395468A1 (pl) * | 2011-06-29 | 2013-01-07 | Adamed Spólka Z Ograniczona Odpowiedzialnoscia | Zwiazki amidoalkilopiperazynylowe do leczenia chorób osrodkowego ukladu nerwowego |
| PT3663317T (pt) | 2012-08-21 | 2023-01-23 | Janssen Pharmaceutica Nv | Anticorpos para haptenos de quetiapina e sua utilização |
| EP3581195B1 (de) | 2012-08-21 | 2025-10-01 | Janssen Pharmaceutica NV | Antikörper gegen olanzapinhaptene und verwendung davon |
| CN104736566A (zh) | 2012-08-21 | 2015-06-24 | 奥索临床诊断有限公司 | 帕潘立酮半抗原的抗体及其用途 |
| ES2822004T3 (es) | 2012-08-21 | 2021-04-28 | Janssen Pharmaceutica Nv | Anticuerpos contra quetiapina y uso de los mismos |
| ES2666000T3 (es) | 2012-08-21 | 2018-04-30 | Janssen Pharmaceutica, N.V. | Anticuerpos para aripiprazol y uso de los mismos |
| PL2888258T3 (pl) | 2012-08-21 | 2019-10-31 | Janssen Pharmaceutica Nv | Hapteny paliperydonu |
| EP2888263B1 (de) | 2012-08-21 | 2018-05-09 | Janssen Pharmaceutica NV | Haptene aus risperidon und paliperidon |
| AU2013306018B2 (en) * | 2012-08-21 | 2017-08-10 | Saladax Biomedical Inc. | Haptens of olanzapine |
| US9611332B2 (en) | 2012-08-21 | 2017-04-04 | Janssen Pharmaceutica Nv | Antibodies to aripiprazole haptens and use thereof |
| ES2691092T3 (es) | 2012-08-21 | 2018-11-23 | Janssen Pharmaceutica Nv | Anticuerpos contra la risperidona y uso de los mismos |
| EP3305784B1 (de) | 2012-08-21 | 2020-08-12 | Janssen Pharmaceutica NV | Haptene von quetiapin zur verwendung bei immunoassays |
| CN104755928B (zh) | 2012-08-21 | 2017-05-10 | 詹森药业有限公司 | 奥氮平的抗体及其用途 |
| ES2926662T3 (es) | 2012-08-21 | 2022-10-27 | Janssen Pharmaceutica Nv | Anticuerpos contra haptenos de risperidona y uso de los mismos |
| AU2013305965B2 (en) | 2012-08-21 | 2017-08-24 | Saladax Biomedical Inc. | Antibodies to paliperidone and use thereof |
| CN104822660A (zh) | 2012-08-21 | 2015-08-05 | 詹森药业有限公司 | 阿立哌唑半抗原及其在免疫测定中的应用 |
| US9346743B2 (en) | 2012-10-15 | 2016-05-24 | Albemarle Corporation | Processes for the synthesis of 2-amino-4,6-dimethoxybenzamide and other benzamide compounds |
| US20140206667A1 (en) | 2012-11-14 | 2014-07-24 | Michela Gallagher | Methods and compositions for treating schizophrenia |
| RU2610169C2 (ru) | 2014-09-11 | 2017-02-08 | Общество С Ограниченной Ответственностью "Валентек" | ПРОИЗВОДНЫЕ 7-ФТОРО-8-ХЛОРО-5Н-ДИБЕНЗО[b, е][1, 4]ДИАЗЕПИНА И ИХ ПРИМЕНЕНИЕ |
| CN104530077A (zh) * | 2014-12-29 | 2015-04-22 | 杭州师范大学 | 一种奥氮平中间体的合成方法 |
| GB201510010D0 (en) | 2015-06-09 | 2015-07-22 | King S College London | PDD and BPD compounds |
| GB201514928D0 (en) | 2015-08-21 | 2015-10-07 | King S College London | PDD compounds |
| US20180339985A1 (en) | 2015-08-21 | 2018-11-29 | Femtogenix Limited | Pdd compounds |
| WO2017106501A1 (en) | 2015-12-17 | 2017-06-22 | Janssen Pharmaceutica Nv | Antibodies to risperidone and use thereof |
| EP3390455A1 (de) | 2015-12-17 | 2018-10-24 | Janssen Pharmaceutica NV | Antikörper gegen quetiapin und verwendung davon |
| RU2667954C2 (ru) | 2016-03-04 | 2018-09-25 | Общество С Ограниченной Ответственностью "Валентек" | Фармацевтическая композиция для лечения функциональных психических расстройств |
| CN110452183B (zh) * | 2019-09-04 | 2023-03-14 | 中国科学院上海有机化学研究所 | 一种手性杂环化合物的制备方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4115568A (en) * | 1974-11-26 | 1978-09-19 | Lilly Industries Limited | Thieno[3,2-b]-[1,5]benzodiazepines |
| GB8819059D0 (en) * | 1988-08-11 | 1988-09-14 | Lilly Industries Ltd | Benzodiazepine compounds & their use as pharmaceuticals |
| US5602124A (en) * | 1994-12-12 | 1997-02-11 | Allelix Biopharmaceuticals, Inc. | 5-HT2 receptor ligands |
| US5602121A (en) * | 1994-12-12 | 1997-02-11 | Allelix Biopharmaceuticals, Inc. | Alkyl-substituted compounds having dopamine receptor affinity |
| KR20010021989A (ko) * | 1997-09-02 | 2001-03-15 | 가마후라 아키오 | 축합 티오펜 화합물 및 이의 의약 용도 |
| CA2479932A1 (en) * | 2002-03-28 | 2003-10-09 | Eli Lilly And Company | Piperazine substituted aryl benzodiazepines and their use as dopamine receptor antagonists for the treatment of psychotic disorders |
-
2003
- 2003-07-28 WO PCT/IB2003/003583 patent/WO2004014895A1/en not_active Ceased
- 2003-07-28 AU AU2003264915A patent/AU2003264915A1/en not_active Abandoned
- 2003-07-28 DE DE60313634T patent/DE60313634T2/de not_active Expired - Lifetime
- 2003-07-28 AT AT03784411T patent/ATE361289T1/de active
- 2003-07-28 US US10/523,147 patent/US7384934B2/en not_active Expired - Fee Related
- 2003-07-28 EP EP03784411A patent/EP1546134B1/de not_active Expired - Lifetime
- 2003-07-28 PT PT03784411T patent/PT1546134E/pt unknown
- 2003-07-28 DK DK03784411T patent/DK1546134T3/da active
- 2003-07-28 ES ES03784411T patent/ES2285227T3/es not_active Expired - Lifetime
-
2007
- 2007-08-02 CY CY20071101030T patent/CY1110382T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20060084643A1 (en) | 2006-04-20 |
| CY1110382T1 (el) | 2015-04-29 |
| WO2004014895A1 (en) | 2004-02-19 |
| DK1546134T3 (da) | 2007-09-10 |
| ES2285227T3 (es) | 2007-11-16 |
| AU2003264915A1 (en) | 2004-02-25 |
| DE60313634T2 (de) | 2008-01-31 |
| PT1546134E (pt) | 2007-08-10 |
| EP1546134B1 (de) | 2007-05-02 |
| EP1546134A1 (de) | 2005-06-29 |
| US7384934B2 (en) | 2008-06-10 |
| ATE361289T1 (de) | 2007-05-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8328 | Change in the person/name/address of the agent |
Representative=s name: KROHER, STROBEL RECHTS- UND PATENTANWAELTE, 80336 |
|
| 8328 | Change in the person/name/address of the agent |
Representative=s name: DR. SCHOEN & PARTNER, 80336 MUENCHEN |