DE60310733D1 - Prodrug eines beta-lactamase-inhibitors - Google Patents

Prodrug eines beta-lactamase-inhibitors

Info

Publication number: DE60310733D1
Authority: DE; Germany
Prior art keywords: prodrug; lactamase inhibitor; beta lactamase; beta; inhibitor
Prior art date: 2002-08-23
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE60310733T

Other languages

English (en)

Inventor

Anthony Marfat

Dale Gordon Mcleod

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Pfizer Products Inc

Original Assignee

Pfizer Products Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-08-23

Filing date

2003-08-11

Publication date

2007-02-08

2003-08-11 Application filed by Pfizer Products Inc filed Critical Pfizer Products Inc

2007-02-08 Application granted granted Critical

2007-02-08 Publication of DE60310733D1 publication Critical patent/DE60310733D1/de

2023-08-12 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D499/44—Compounds with an amino radical acylated by carboxylic acids, attached in position 6
- C07D499/48—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)

DE60310733T 2002-08-23 2003-08-11 Prodrug eines beta-lactamase-inhibitors Expired - Lifetime DE60310733D1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US40564002P	2002-08-23	2002-08-23
PCT/IB2003/003582 WO2004018484A1 (en)	2002-08-23	2003-08-11	Beta-lactamase inhibitor prodrug

Publications (1)

Publication Number	Publication Date
DE60310733D1 true DE60310733D1 (de)	2007-02-08

Family

ID=31946909

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE60310733T Expired - Lifetime DE60310733D1 (de)	2002-08-23	2003-08-11	Prodrug eines beta-lactamase-inhibitors

Country Status (31)

Country	Link
US (1)	US7091197B2 (de)
EP (1)	EP1534717B1 (de)
JP (1)	JP2005539037A (de)
KR (1)	KR20050037583A (de)
CN (1)	CN1688589A (de)
AP (1)	AP2005003231A0 (de)
AR (1)	AR041028A1 (de)
AT (1)	ATE349452T1 (de)
AU (1)	AU2003250489A1 (de)
BR (1)	BR0313683A (de)
CA (1)	CA2494953A1 (de)
DE (1)	DE60310733D1 (de)
EA (1)	EA007540B1 (de)
EC (1)	ECSP055625A (de)
GT (1)	GT200300179A (de)
HR (1)	HRP20050162A2 (de)
IL (1)	IL166719A0 (de)
IS (1)	IS7693A (de)
MA (1)	MA27387A1 (de)
MX (1)	MXPA05001446A (de)
NO (1)	NO20051497D0 (de)
NZ (1)	NZ538340A (de)
OA (1)	OA12909A (de)
PA (1)	PA8579701A1 (de)
PE (1)	PE20040899A1 (de)
PL (1)	PL375988A1 (de)
TN (1)	TNSN05054A1 (de)
TW (1)	TWI250162B (de)
UY (1)	UY27947A1 (de)
WO (1)	WO2004018484A1 (de)
ZA (1)	ZA200501513B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1636240A1 (de) *	2003-06-05	2006-03-22	Pfizer Products Inc.	Beta-lactamasehemmer prodrug
US20060105941A1 (en) *	2004-11-12	2006-05-18	Allergan, Inc.	Mixed antibiotic codrugs
WO2007012319A1 (de) *	2005-07-29	2007-02-01	Sigma-Aldrich Production Gmbh	Ionisierungsadditive enthaltende lc/ms-blends
WO2010118968A1 (en)	2009-04-16	2010-10-21	Nicox S.A.	No-donor aspirin derivatives
WO2013056163A1 (en)	2011-10-14	2013-04-18	The Regents Of The University Of California	Beta-lactamase inhibitors
CN104159587A (zh)	2012-01-06	2014-11-19	南佛罗里达大学	组合物、使用方法、以及治疗方法
CN109422765B (zh) *	2017-09-05	2020-08-28	香港理工大学深圳研究院	C类β-内酰胺酶抑制剂及其制备方法和应用

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IE34011B1 (en) *	1969-03-13	1975-01-08	Leo Pharm Prod Ltd	New penicillin esters
IE34019B1 (en) *	1969-03-18	1975-01-08	Leo Pharm Prod Ltd	New semi-synthetic penicillin esters
GB1267936A (en)	1969-05-28	1972-03-22	Beecham Group Ltd	DERIVATIVES OF alpha-AMINOPENICILLINS
US3957764A (en) *	1969-11-11	1976-05-18	Lovens Kemiske Fabrik Produktionsaktieselskab	6-aminopenicillanic acid derivatives
US3862181A (en) *	1970-10-28	1975-01-21	Squibb & Sons Inc	Process for preparing cephalosporins
GB1315566A (en)	1970-11-06	1973-05-02	Leo Pharm Prod Ltd	Penicillanic acid derivatives
CA996929A (en)	1971-04-05	1976-09-14	Kohzi Nakano	Acyloxyalkyl ester derivatives of penicillin
GB1433131A (en) *	1972-03-13	1976-04-22	Astra Laekemedel Ab	Penicillins
GB1426717A (en)	1972-03-13	1976-03-03	Astra Laekemedel Ab	Penicillins
US4397783A (en) *	1979-03-05	1983-08-09	Pfizer Inc.	Process for converting 6,6-disubstituted penicillanic acid derivatives to the 6-β-congeners
DE2927004A1 (de) *	1979-07-04	1981-05-27	Bayer Ag, 5090 Leverkusen	Penicillansaeure-1,1-dioxide, ihre herstellung und ihre verwendung als arzneimittel als arzneimittel
US4287181A (en) *	1979-10-22	1981-09-01	Pfizer Inc.	Derivatives of 6β-hydroxyalkylpenicillanic acids as β-lactamase inhibitors
US4432970A (en) *	1979-11-23	1984-02-21	Pfizer Inc.	6-beta-Halopenicillanic acid 1,1-dioxides as beta-lactamase inhibitors
GB2076812A (en) *	1980-05-22	1981-12-09	Ciba Geigy Ag	Penam-dioxide compounds, processes for their manufacture, and their use
JPS5849387A (ja)	1981-09-17	1983-03-23	Sankyo Co Ltd	７−メトキシセフアロスポリン化合物およびその製法
EP0076066B1 (de) *	1981-09-22	1986-11-26	Kureha Kagaku Kogyo Kabushiki Kaisha	Penicillin-Derivate
US4406887A (en) *	1981-10-13	1983-09-27	Bristol-Myers Company	Method for treating resistant bacteria including anaerobes
US4428935A (en) *	1982-05-24	1984-01-31	Pfizer Inc.	Penicillanic acid dioxide prodrug
US4521533A (en) *	1984-07-12	1985-06-04	Pfizer Inc.	Salts of 6-alpha-(aminomethyl)penicillanic acid 1,1-dioxide esters and beta-lactam antibiotics
DE3901405A1 (de)	1989-01-19	1990-07-26	Hoechst Ag	Cephalosporinderivate und verfahren zu ihrer herstellung
JPH03206038A (ja)	1990-01-08	1991-09-09	Yoshitomi Pharmaceut Ind Ltd	抗菌剤
GB9001405D0 (en) *	1990-01-22	1990-03-21	Leo Pharm Prod Ltd	New intermediates,their production and use
GB9208492D0 (en) *	1992-04-16	1992-06-03	Glaxo Spa	Heterocyclic compounds
EP1636240A1 (de) *	2003-06-05	2006-03-22	Pfizer Products Inc.	Beta-lactamasehemmer prodrug

2003
- 2003-08-06 PA PA20038579701A patent/PA8579701A1/es unknown
- 2003-08-11 CN CNA038243164A patent/CN1688589A/zh active Pending
- 2003-08-11 DE DE60310733T patent/DE60310733D1/de not_active Expired - Lifetime
- 2003-08-11 AU AU2003250489A patent/AU2003250489A1/en not_active Abandoned
- 2003-08-11 MX MXPA05001446A patent/MXPA05001446A/es unknown
- 2003-08-11 AT AT03792574T patent/ATE349452T1/de not_active IP Right Cessation
- 2003-08-11 KR KR1020057002983A patent/KR20050037583A/ko not_active Abandoned
- 2003-08-11 WO PCT/IB2003/003582 patent/WO2004018484A1/en not_active Ceased
- 2003-08-11 EA EA200500398A patent/EA007540B1/ru unknown
- 2003-08-11 NZ NZ538340A patent/NZ538340A/en unknown
- 2003-08-11 HR HR20050162A patent/HRP20050162A2/xx not_active Application Discontinuation
- 2003-08-11 AP AP2005003231A patent/AP2005003231A0/xx unknown
- 2003-08-11 CA CA002494953A patent/CA2494953A1/en not_active Abandoned
- 2003-08-11 PL PL03375988A patent/PL375988A1/xx unknown
- 2003-08-11 EP EP03792574A patent/EP1534717B1/de not_active Expired - Lifetime
- 2003-08-11 OA OA1200500051A patent/OA12909A/en unknown
- 2003-08-11 JP JP2004530453A patent/JP2005539037A/ja not_active Abandoned
- 2003-08-11 BR BR0313683-3A patent/BR0313683A/pt not_active IP Right Cessation
- 2003-08-19 PE PE2003000840A patent/PE20040899A1/es not_active Application Discontinuation
- 2003-08-21 UY UY27947A patent/UY27947A1/es not_active Application Discontinuation
- 2003-08-21 AR ARP030103023A patent/AR041028A1/es unknown
- 2003-08-22 GT GT200300179A patent/GT200300179A/es unknown
- 2003-08-22 TW TW092123156A patent/TWI250162B/zh not_active IP Right Cessation
- 2003-08-25 US US10/648,408 patent/US7091197B2/en not_active Expired - Fee Related
2005
- 2005-02-07 IL IL16671905A patent/IL166719A0/xx unknown
- 2005-02-10 IS IS7693A patent/IS7693A/is unknown
- 2005-02-21 ZA ZA200501513A patent/ZA200501513B/en unknown
- 2005-02-23 TN TNP2005000054A patent/TNSN05054A1/fr unknown
- 2005-02-23 MA MA28119A patent/MA27387A1/fr unknown
- 2005-02-23 EC EC2005005625A patent/ECSP055625A/es unknown
- 2005-03-21 NO NO20051497A patent/NO20051497D0/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
OA12909A (en)	2006-10-13
US20040110740A1 (en)	2004-06-10
NZ538340A (en)	2006-10-27
IS7693A (is)	2005-02-10
TWI250162B (en)	2006-03-01
ZA200501513B (en)	2006-09-27
AU2003250489A1 (en)	2004-03-11
IL166719A0 (en)	2006-01-15
PL375988A1 (en)	2005-12-12
UY27947A1 (es)	2004-03-31
AP2005003231A0 (en)	2005-03-31
TNSN05054A1 (fr)	2007-05-14
ECSP055625A (es)	2005-04-18
ATE349452T1 (de)	2007-01-15
MA27387A1 (fr)	2005-06-01
KR20050037583A (ko)	2005-04-22
NO20051497L (no)	2005-03-21
EA007540B1 (ru)	2006-10-27
TW200417548A (en)	2004-09-16
JP2005539037A (ja)	2005-12-22
GT200300179A (es)	2004-05-18
EP1534717B1 (de)	2006-12-27
EA200500398A1 (ru)	2005-08-25
NO20051497D0 (no)	2005-03-21
MXPA05001446A (es)	2005-06-06
WO2004018484A1 (en)	2004-03-04
BR0313683A (pt)	2005-06-21
PA8579701A1 (es)	2005-05-24
CN1688589A (zh)	2005-10-26
US7091197B2 (en)	2006-08-15
EP1534717A1 (de)	2005-06-01
AR041028A1 (es)	2005-04-27
HRP20050162A2 (en)	2005-06-30
CA2494953A1 (en)	2004-03-04
PE20040899A1 (es)	2004-12-28

Publication	Publication Date	Title
NO20045220L (no)	2005-01-19	Heterocykliske inhibitorer for kinaser
DK1534290T3 (da)	2012-04-10	Hidtil ukendte kinasehæmmere
AP1967A (en)	2009-03-10	Thiazolidinone compounds as inhibitors of Hyak3
DK1501508T3 (da)	2007-05-21	Inhibitorer af histondeatylase
DE60320933D1 (de)	2008-06-26	Rho-kinase inhibitoren
DK1562589T3 (da)	2009-02-16	Diaminotriazoler der er nyttige som inhibitorer af proteinkinaser
DE60319430D1 (de)	2008-04-10	R- und fgfr-inhibitoren
EP1549316A4 (de)	2008-04-09	HEMMER VON TFGbeta
EP1656133A4 (de)	2008-10-29	Inhibitoren von mitotischem kinesin
EP1765336A4 (de)	2010-03-10	Angiogenesehemmer
EP1656146A4 (de)	2009-04-15	Inhibitoren von mitotischem kinesin
DE602004018837D1 (de)	2009-02-12	Ptidase-iv-inhibitoren
EP1499336A4 (de)	2005-06-01	Proteasehemmer
AU2003302238A8 (en)	2004-06-23	2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidine derivatives as factor viia inhibitors
IS7456A (is)	2004-09-17	Fosfat forlyf flúoróoxindóla
EP1660436A4 (de)	2006-11-22	Cathepsininhibitoren
EP1556089A4 (de)	2008-01-09	Hemmung der gen-expression mitrna-beeinflussenden mitteln
EP1697331A4 (de)	2010-08-04	Inhibitoren von mitotischem kinesin
IL165475A0 (en)	2006-01-15	Nitrooxyderivatives of eyclooxygenase-2 inhibitors
DK1536796T3 (da)	2008-06-09	N-arylpiperidinsubstituerede biphenylcarboxamider som inhibitorer af apolipoprotein B-sektion
PL378760A1 (pl)	2006-05-15	Pochodne oksazoli jako inhibitory cyklooksygenazy
DE60310733D1 (de)	2007-02-08	Prodrug eines beta-lactamase-inhibitors
NO20054188D0 (no)	2005-09-09	Et arrangement av fagverksstag
DK1461326T3 (da)	2007-12-10	Benzothiazol og benzoxazol-4,7 -dion-derivater og anvendelse heraf som inhibitorer for cdc25-phosphataser
NO20054837D0 (no)	2005-10-19	Formulering for inhibering av korrosjon og avleiringer

Legal Events

Date	Code	Title	Description
2007-11-29	8332	No legal effect for de