DE60309349D1 - Propanamine derivate als serotonin und norepinephrin reuptake-inhibitoren - Google Patents
Propanamine derivate als serotonin und norepinephrin reuptake-inhibitorenInfo
- Publication number
- DE60309349D1 DE60309349D1 DE60309349T DE60309349T DE60309349D1 DE 60309349 D1 DE60309349 D1 DE 60309349D1 DE 60309349 T DE60309349 T DE 60309349T DE 60309349 T DE60309349 T DE 60309349T DE 60309349 D1 DE60309349 D1 DE 60309349D1
- Authority
- DE
- Germany
- Prior art keywords
- sub
- alkyl
- halo
- substituents
- optionally substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000002767 noradrenalin uptake inhibitor Substances 0.000 title 1
- 229940127221 norepinephrine reuptake inhibitor Drugs 0.000 title 1
- WGYKZJWCGVVSQN-UHFFFAOYSA-N propylamine Chemical class CCCN WGYKZJWCGVVSQN-UHFFFAOYSA-N 0.000 title 1
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 9
- 125000001475 halogen functional group Chemical group 0.000 abstract 4
- 125000001424 substituent group Chemical group 0.000 abstract 4
- -1 thio 3-substituted propanamine compound Chemical class 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 abstract 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000004582 dihydrobenzothienyl group Chemical group S1C(CC2=C1C=CC=C2)* 0.000 abstract 1
- 125000005956 isoquinolyl group Chemical group 0.000 abstract 1
- 125000005493 quinolyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000004588 thienopyridyl group Chemical group S1C(=CC2=C1C=CC=N2)* 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42412602P | 2002-11-05 | 2002-11-05 | |
| US424126P | 2002-11-05 | ||
| PCT/US2003/031512 WO2004043931A1 (en) | 2002-11-05 | 2003-10-24 | Propanamine derivatives as serotonin and norepinephrine reuptake inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60309349D1 true DE60309349D1 (de) | 2006-12-07 |
| DE60309349T2 DE60309349T2 (de) | 2007-05-10 |
Family
ID=32312755
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60309349T Expired - Fee Related DE60309349T2 (de) | 2002-11-05 | 2003-10-24 | Propanamine derivate als serotonin und norepinephrin reuptake-inhibitoren |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7410982B2 (de) |
| EP (1) | EP1567501B1 (de) |
| AT (1) | ATE343566T1 (de) |
| AU (1) | AU2003287022A1 (de) |
| DE (1) | DE60309349T2 (de) |
| ES (1) | ES2274286T3 (de) |
| WO (1) | WO2004043931A1 (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7410996B2 (en) | 2002-11-05 | 2008-08-12 | Eli Lilly And Company | 3-aryloxy/thio-2,3-substituted propanamines and their use in inhibiting serotonin and norepinephrine reuptake |
| AU2003287024A1 (en) | 2002-11-05 | 2004-06-03 | Eli Lilly And Company | 3-aryloxy/thio-3-substituted propanamines and their use in inhibiting serotonin and norephinephrine reuptake |
| US20050008607A1 (en) * | 2003-06-05 | 2005-01-13 | L'oreal | Composition containing a carbonyl amine |
| EP1789050A1 (de) * | 2004-08-09 | 2007-05-30 | Warner-Lambert Company LLC | Neue chinoxalinon-norepinephrin-wiederaufnahmehemmer zur behandlung von erkrankungen des zentralnervensystems |
| EP1786778A1 (de) * | 2004-08-26 | 2007-05-23 | Neurosearch A/S | Neue substituierte heteroaryloxyalkylamine und deren verwendung als monoamin neurotransmitter wiederaufnahmehemmer |
| US8690831B2 (en) * | 2008-04-25 | 2014-04-08 | Ethicon Endo-Surgery, Inc. | Gas jet fluid removal in a trocar |
| US20100051879A1 (en) * | 2006-11-22 | 2010-03-04 | The Regents od the Univesity of California | Functionalized Boron Nitride Nanotubes |
| WO2008150528A1 (en) * | 2007-06-04 | 2008-12-11 | Intra-Cellular Therapies, Inc. | Novel methods |
| US8101642B2 (en) | 2008-06-05 | 2012-01-24 | Sk Biopharmaceuticals Co., Ltd. | 3-substituted propanamine compounds |
| EP3339307A1 (de) * | 2016-12-20 | 2018-06-27 | Laboratorios del Dr. Esteve, S.A. | Stickstoffhaltige bicyclische derivate zur behandlung von schmerzen und schmerzbedingten leiden |
| EP3339304A1 (de) | 2016-12-20 | 2018-06-27 | Laboratorios del Dr. Esteve, S.A. | Neue chinolin- und isochinolinderivate zur behandlung von schmerzen und schmerzbedingten leiden |
| CN113214182B (zh) * | 2021-05-19 | 2022-12-23 | 佛山湘潭大学绿色智造研究院 | 一种苯并异噻唑类化合物及其制备方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2060622B (en) | 1979-09-14 | 1983-05-25 | Wyeth John & Brother Ltd | 3-aryl-3-aryloxyalkylamines |
| US4956388A (en) * | 1986-12-22 | 1990-09-11 | Eli Lilly And Company | 3-aryloxy-3-substituted propanamines |
| US4902710A (en) | 1988-12-14 | 1990-02-20 | Eli Lilly And Company | Serotonin and norepinephrine uptake inhibitors |
| GB0112122D0 (en) | 2001-05-18 | 2001-07-11 | Lilly Co Eli | Heteroaryloxy 3-substituted propanamines |
| AU2003287024A1 (en) | 2002-11-05 | 2004-06-03 | Eli Lilly And Company | 3-aryloxy/thio-3-substituted propanamines and their use in inhibiting serotonin and norephinephrine reuptake |
-
2003
- 2003-10-24 AU AU2003287022A patent/AU2003287022A1/en not_active Abandoned
- 2003-10-24 ES ES03777542T patent/ES2274286T3/es not_active Expired - Lifetime
- 2003-10-24 US US10/532,765 patent/US7410982B2/en not_active Expired - Fee Related
- 2003-10-24 EP EP03777542A patent/EP1567501B1/de not_active Expired - Lifetime
- 2003-10-24 WO PCT/US2003/031512 patent/WO2004043931A1/en not_active Ceased
- 2003-10-24 AT AT03777542T patent/ATE343566T1/de not_active IP Right Cessation
- 2003-10-24 DE DE60309349T patent/DE60309349T2/de not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1567501B1 (de) | 2006-10-25 |
| DE60309349T2 (de) | 2007-05-10 |
| US20060058360A1 (en) | 2006-03-16 |
| WO2004043931A1 (en) | 2004-05-27 |
| EP1567501A1 (de) | 2005-08-31 |
| US7410982B2 (en) | 2008-08-12 |
| AU2003287022A1 (en) | 2004-06-03 |
| ATE343566T1 (de) | 2006-11-15 |
| ES2274286T3 (es) | 2007-05-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8328 | Change in the person/name/address of the agent |
Representative=s name: KROHER, STROBEL RECHTS- UND PATENTANWAELTE, 80336 |
|
| 8339 | Ceased/non-payment of the annual fee |