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AR057023A1 - Compuestos heterociclicos con propiedades inhibidoras de hiv-integrasa - Google Patents

Compuestos heterociclicos con propiedades inhibidoras de hiv-integrasa

Info

Publication number
AR057023A1
AR057023A1 ARP060101971A ARP060101971A AR057023A1 AR 057023 A1 AR057023 A1 AR 057023A1 AR P060101971 A ARP060101971 A AR P060101971A AR P060101971 A ARP060101971 A AR P060101971A AR 057023 A1 AR057023 A1 AR 057023A1
Authority
AR
Argentina
Prior art keywords
group
hiv
integrasa
inhibiting properties
pending
Prior art date
Application number
ARP060101971A
Other languages
English (en)
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of AR057023A1 publication Critical patent/AR057023A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Se describen compuesto tricíclicos, intermediarios protegidos de éstos, y métodos para la inhibicion de HIV-integrasa. Reivindicacion 1: Un compuesto que tiene la formula (1) o su sal farmacéuticamente aceptable, donde, cada Ra está independientemente seleccionado del grupo que consiste en H, Cl, F, CH3HNC(O)-, (CH3)2NC(O)-, (CH3)2NS(O)2-, CH3S(O)2-, ciano y amino; m es 0, 1, 2, 3, 4 o 5; R1 y R2 están independientemente seleccionados del grupo que consiste en H y alquilo C1-4; R3 está seleccionado del grupo que consiste en H, metilo y etilo, y R4 es alquilo C1-4, N-etilamino o N,N-dimetilamino; R3 y R4 se ciclan para formar, conjuntamente con el átomo de N pendiente del grupo R3 y el grupo SO2 pendiente del grupo R4 un grupo heterocíclico o heterocíclico sustituido.
ARP060101971A 2005-05-16 2006-05-16 Compuestos heterociclicos con propiedades inhibidoras de hiv-integrasa AR057023A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US68169005P 2005-05-16 2005-05-16

Publications (1)

Publication Number Publication Date
AR057023A1 true AR057023A1 (es) 2007-11-14

Family

ID=37432118

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP060101971A AR057023A1 (es) 2005-05-16 2006-05-16 Compuestos heterociclicos con propiedades inhibidoras de hiv-integrasa

Country Status (5)

Country Link
US (1) US20070072831A1 (es)
EP (1) EP1888581A2 (es)
AR (1) AR057023A1 (es)
TW (1) TW200716632A (es)
WO (1) WO2006125048A2 (es)

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Also Published As

Publication number Publication date
WO2006125048A2 (en) 2006-11-23
TW200716632A (en) 2007-05-01
WO2006125048A3 (en) 2007-08-09
EP1888581A2 (en) 2008-02-20
US20070072831A1 (en) 2007-03-29

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