DE60237044D1 - Immunogene peptidzusammensetzung zur prävention und behandlung der alzheimer-krankheit - Google Patents
Immunogene peptidzusammensetzung zur prävention und behandlung der alzheimer-krankheitInfo
- Publication number
- DE60237044D1 DE60237044D1 DE60237044T DE60237044T DE60237044D1 DE 60237044 D1 DE60237044 D1 DE 60237044D1 DE 60237044 T DE60237044 T DE 60237044T DE 60237044 T DE60237044 T DE 60237044T DE 60237044 D1 DE60237044 D1 DE 60237044D1
- Authority
- DE
- Germany
- Prior art keywords
- peptide
- prevention
- treatment
- alzheimer
- soluble
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 9
- 230000002163 immunogen Effects 0.000 title abstract 5
- 208000024827 Alzheimer disease Diseases 0.000 title abstract 4
- 230000002265 prevention Effects 0.000 title abstract 3
- 208000037259 Amyloid Plaque Diseases 0.000 abstract 2
- 210000004556 brain Anatomy 0.000 abstract 2
- 230000001105 regulatory effect Effects 0.000 abstract 2
- 230000002776 aggregation Effects 0.000 abstract 1
- 238000004220 aggregation Methods 0.000 abstract 1
- 210000002443 helper t lymphocyte Anatomy 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 210000004898 n-terminal fragment Anatomy 0.000 abstract 1
- 239000003053 toxin Substances 0.000 abstract 1
- 231100000765 toxin Toxicity 0.000 abstract 1
- 108700012359 toxins Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/806—Antigenic peptides or proteins
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Toxicology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/865,294 US6906169B2 (en) | 2001-05-25 | 2001-05-25 | Immunogenic peptide composition comprising measles virus Fprotein Thelper cell epitope (MUFThl-16) and N-terminus of β-amyloid peptide |
| PCT/US2002/010293 WO2002096350A2 (en) | 2001-05-25 | 2002-04-02 | Immunogenic peptide composition for the prevention and treatment of alzheimer's disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60237044D1 true DE60237044D1 (de) | 2010-08-26 |
Family
ID=25345158
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60237044T Expired - Lifetime DE60237044D1 (de) | 2001-05-25 | 2002-04-02 | Immunogene peptidzusammensetzung zur prävention und behandlung der alzheimer-krankheit |
| DE60239093T Expired - Lifetime DE60239093D1 (de) | 2001-05-25 | 2002-04-02 | Immunogene Peptidzusammensetzung zur Prävention und Behandlung der Alzheimer-Krankheit |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60239093T Expired - Lifetime DE60239093D1 (de) | 2001-05-25 | 2002-04-02 | Immunogene Peptidzusammensetzung zur Prävention und Behandlung der Alzheimer-Krankheit |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US6906169B2 (de) |
| EP (2) | EP1497313B1 (de) |
| JP (3) | JP4440544B2 (de) |
| CN (2) | CN1568329B (de) |
| AT (2) | ATE496937T1 (de) |
| AU (2) | AU2002303211B2 (de) |
| BR (1) | BRPI0210010B8 (de) |
| CA (2) | CA2448171A1 (de) |
| DE (2) | DE60237044D1 (de) |
| DK (2) | DK2123671T3 (de) |
| ES (2) | ES2360465T3 (de) |
| MX (1) | MXPA03010631A (de) |
| TW (1) | TWI252233B (de) |
| WO (1) | WO2002096350A2 (de) |
| ZA (1) | ZA200308767B (de) |
Families Citing this family (89)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6761888B1 (en) | 2000-05-26 | 2004-07-13 | Neuralab Limited | Passive immunization treatment of Alzheimer's disease |
| US7588766B1 (en) | 2000-05-26 | 2009-09-15 | Elan Pharma International Limited | Treatment of amyloidogenic disease |
| US7790856B2 (en) * | 1998-04-07 | 2010-09-07 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize beta amyloid peptide |
| US20080050367A1 (en) * | 1998-04-07 | 2008-02-28 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
| US6913745B1 (en) | 1997-12-02 | 2005-07-05 | Neuralab Limited | Passive immunization of Alzheimer's disease |
| US7179892B2 (en) * | 2000-12-06 | 2007-02-20 | Neuralab Limited | Humanized antibodies that recognize beta amyloid peptide |
| US7964192B1 (en) * | 1997-12-02 | 2011-06-21 | Janssen Alzheimer Immunotherapy | Prevention and treatment of amyloidgenic disease |
| US6743427B1 (en) | 1997-12-02 | 2004-06-01 | Neuralab Limited | Prevention and treatment of amyloidogenic disease |
| US6787523B1 (en) | 1997-12-02 | 2004-09-07 | Neuralab Limited | Prevention and treatment of amyloidogenic disease |
| US6750324B1 (en) | 1997-12-02 | 2004-06-15 | Neuralab Limited | Humanized and chimeric N-terminal amyloid beta-antibodies |
| TWI239847B (en) | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
| US20050059591A1 (en) * | 1998-04-07 | 2005-03-17 | Neuralab Limited | Prevention and treatment of amyloidogenic disease |
| US20030147882A1 (en) * | 1998-05-21 | 2003-08-07 | Alan Solomon | Methods for amyloid removal using anti-amyloid antibodies |
| US6787637B1 (en) | 1999-05-28 | 2004-09-07 | Neuralab Limited | N-Terminal amyloid-β antibodies |
| BR0108566A (pt) * | 2000-02-21 | 2002-11-19 | Pharmexa As | Método para a regulação negativa in vivo de proteìna amilóide em um animal, incluindo um ser humano e para o tratamento e/ou prevenção e/ou melhora da doença de alzheimer ou outras doenças e condições cartacterizadas por depósitos de amilóide, análogo de um polipeptìdeo amiloidogênico,composição imunogênica, fragmento de ácido nucleico, vetor, célula transformada, composição para induzir a produção de anticorpos contra um polipeptìdeo amiloidogênico, linhagem celular estável, métodos para a preparação de uma célula, para a identificação de um polipeptìdeo amiloidogênico modificado, e para preparação de uma composição imunogênica, uso de um polipeptìdeo amiloidogênico ou de uma subsequência do mesmo, e, uso de um análogo de um polipeptìdeo amiloidogênico |
| AU783144B2 (en) * | 2000-02-21 | 2005-09-29 | H. Lundbeck A/S | Novel method for down-regulation of amyloid |
| US7700751B2 (en) | 2000-12-06 | 2010-04-20 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize β-amyloid peptide |
| TWI255272B (en) * | 2000-12-06 | 2006-05-21 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
| US6906169B2 (en) * | 2001-05-25 | 2005-06-14 | United Biomedical, Inc. | Immunogenic peptide composition comprising measles virus Fprotein Thelper cell epitope (MUFThl-16) and N-terminus of β-amyloid peptide |
| MY144532A (en) * | 2001-08-20 | 2011-09-30 | Lundbeck & Co As H | Novel method for down-regulation of amyloid |
| WO2003045128A2 (en) * | 2001-11-21 | 2003-06-05 | New York University | SYNTHETIC IMMUNOGENIC BUT NON-DEPOSIT-FORMING POLYPEPTIDES AND PEPTIDES HOMOLOGOUS TO AMYLOID β, PRION PROTEIN, AMYLIN, α-SYNUCLEIN, OR POLYGLUTAMINE REPEATS FOR INDUCTION OF AN IMMUNE RESPONSE THERETO |
| US8088388B2 (en) * | 2002-02-14 | 2012-01-03 | United Biomedical, Inc. | Stabilized synthetic immunogen delivery system |
| US20040001848A1 (en) * | 2002-03-01 | 2004-01-01 | Szu-Yi Chou | Method of producing disease-specific antigens |
| MY139983A (en) * | 2002-03-12 | 2009-11-30 | Janssen Alzheimer Immunotherap | Humanized antibodies that recognize beta amyloid peptide |
| EP2330113B1 (de) * | 2002-04-19 | 2016-06-29 | The Governing Council Of The University Of Toronto | Immunologisches Verfahren und Zusammensetzungen für die Behandlung der Alzheimer Krankheit |
| AU2003250102B2 (en) * | 2002-07-24 | 2009-09-17 | Innogenetics N.V. | Fragments of beta-amyloid as targets for vaccination against alzheimer disease |
| DE10303974A1 (de) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
| PE20050627A1 (es) | 2003-05-30 | 2005-08-10 | Wyeth Corp | Anticuerpos humanizados que reconocen el peptido beta amiloideo |
| JP4888876B2 (ja) | 2003-06-13 | 2012-02-29 | 田平 武 | アルツハイマー病の治療のための組換えアデノ随伴ウィルスベクター |
| EP1515158B1 (de) * | 2003-09-09 | 2013-07-17 | Esaote S.p.A. | Ultraschall-Bilderzeugungsverfahren mit Kontrastmittel-Anwesenheit in dem Aufnahmeobjekt |
| BRPI0417689A8 (pt) | 2003-12-17 | 2017-04-25 | Elan Pharm Inc | Método para conjugar um imonógeno de peptídeo, composição, conjugado, composição imunogênica, método para induzir uma resposta imune em um indivíduo mamífero, e, uso do conjugado |
| JP2007522119A (ja) * | 2004-01-28 | 2007-08-09 | キュリックス エーピーエス | アミロイド関連疾患用ワクチンとしてのアミロイドタンパク質のコンジュゲート |
| CU23297A1 (es) * | 2004-11-16 | 2008-07-24 | Ct De Inmunologa A Molecular | Formulaciones inmunoterapã0/00uticas para la inducciã"n de autoanticuerpos bloqueadores de la uniã"n de interleucina-2 a su receptor. su uso en el tratamiento del cã ncer |
| GB0427267D0 (en) * | 2004-12-13 | 2005-01-12 | Maria Teresa De Magistris | Peptide adjuvants |
| AR051528A1 (es) * | 2004-12-15 | 2007-01-17 | Neuralab Ltd | Anticuerpos humanizados que reconocen el peptido beta amiloideo |
| US8916165B2 (en) * | 2004-12-15 | 2014-12-23 | Janssen Alzheimer Immunotherapy | Humanized Aβ antibodies for use in improving cognition |
| AR051800A1 (es) * | 2004-12-15 | 2007-02-07 | Wyeth Corp | Anticuerpos a beta usados en mejorar la cognicion |
| AU2006319358B2 (en) | 2005-11-30 | 2012-01-19 | AbbVie Deutschland GmbH & Co. KG | Anti-Abeta globulomer antibodies, antigen-binding moieties thereof, corresponding hybridomas, nucleic acids, vectors, host cells, methods of producing said antibodies, compositions comprising said antibodies, uses of said antibodies and methods of using said antibodies |
| KR20140087058A (ko) | 2005-11-30 | 2014-07-08 | 애브비 인코포레이티드 | 아밀로이드 베타 단백질에 대한 모노클로날 항체 및 이의 용도 |
| NZ568384A (en) * | 2005-12-12 | 2011-09-30 | Ac Immune Sa | Therapeutic vaccine comprising Abeta peptide |
| GB0613977D0 (en) | 2006-02-07 | 2006-08-23 | Peptcell Ltd | Peptide sequences and compositions |
| KR20080103560A (ko) | 2006-02-22 | 2008-11-27 | 가부시끼가이샤 하야시바라 세이부쓰 가가꾸 겐꾸조 | 항 아밀로이드-β-펩티드 항체 생산 유도용 펩티드 백신 |
| US8784810B2 (en) * | 2006-04-18 | 2014-07-22 | Janssen Alzheimer Immunotherapy | Treatment of amyloidogenic diseases |
| CN101058608B (zh) * | 2006-04-21 | 2011-02-23 | 杜如昱 | 人类抗Aβ1-32淀粉样蛋白抗体、其纯化方法及用途 |
| CA2653628C (en) | 2006-06-01 | 2015-07-14 | Elan Pharmaceuticals, Inc. | Neuroactive fragments of app |
| US8455626B2 (en) | 2006-11-30 | 2013-06-04 | Abbott Laboratories | Aβ conformer selective anti-aβ globulomer monoclonal antibodies |
| US8895004B2 (en) | 2007-02-27 | 2014-11-25 | AbbVie Deutschland GmbH & Co. KG | Method for the treatment of amyloidoses |
| US8003097B2 (en) * | 2007-04-18 | 2011-08-23 | Janssen Alzheimer Immunotherapy | Treatment of cerebral amyloid angiopathy |
| CN101970000A (zh) * | 2007-04-18 | 2011-02-09 | 杨森阿尔茨海默氏症免疫治疗公司 | 脑淀粉样血管病的预防和治疗 |
| WO2008133208A1 (ja) * | 2007-04-20 | 2008-11-06 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | ペプチド免疫応答増強方法 |
| DK2182983T3 (da) | 2007-07-27 | 2014-07-14 | Janssen Alzheimer Immunotherap | Behandling af amyloidogene sygdomme med humaniserede anti-abeta antistoffer |
| JO3076B1 (ar) | 2007-10-17 | 2017-03-15 | Janssen Alzheimer Immunotherap | نظم العلاج المناعي المعتمد على حالة apoe |
| EP2106802A1 (de) | 2008-04-02 | 2009-10-07 | SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. | Modifizierte Peptide als synthetische Impfungen bei Amyloid-bedingten Krankheiten |
| CA2739318A1 (en) | 2008-08-07 | 2010-02-11 | Mercia Pharma, Llc | Immunotherapeutic compositions for the treatment of alzheimer's disease |
| WO2010080188A2 (en) * | 2008-10-14 | 2010-07-15 | The Regents Of The University Of Michigan | Epitope targeted anthrax vaccine |
| EP2348042B1 (de) * | 2008-10-16 | 2017-07-05 | The Chemo-Sero-Therapeutic Research Institute | Modifiziertes amyloid-beta-peptid |
| US9067981B1 (en) | 2008-10-30 | 2015-06-30 | Janssen Sciences Ireland Uc | Hybrid amyloid-beta antibodies |
| DE102008037564A1 (de) | 2008-11-19 | 2010-05-20 | Forschungszentrum Jülich GmbH | Zusammensetzung zur Herstellung von anti-Amyloid beta-Peptid-Antikörpern mit D-Peptiden |
| US8748386B2 (en) | 2009-06-10 | 2014-06-10 | New York University | Immunological targeting of pathological Tau proteins |
| US20110221240A1 (en) * | 2010-03-11 | 2011-09-15 | Ziming Shen | Compact children's table and stool set |
| CA2796339C (en) | 2010-04-15 | 2020-03-31 | Abbott Laboratories | Amyloid-beta binding proteins |
| MX352641B (es) | 2010-07-08 | 2017-12-01 | United Biomedical Inc | Vacuna contra pcv2 basada en peptidos de diseño. |
| JP6147665B2 (ja) | 2010-08-14 | 2017-06-14 | アッヴィ・インコーポレイテッド | アミロイドベータ結合タンパク質 |
| US20120321694A1 (en) * | 2010-10-27 | 2012-12-20 | Daniel Larocque | Compositions and uses |
| GB201113570D0 (en) | 2011-08-05 | 2011-09-21 | Glaxosmithkline Biolog Sa | Vaccine |
| CN102775478B (zh) * | 2012-08-10 | 2013-06-19 | 申联生物医药(上海)有限公司 | 口蹄疫病毒抗原多肽及疫苗 |
| JP2015527369A (ja) * | 2012-08-21 | 2015-09-17 | インスティテュート フォー モレキュラー メディシン, インコーポレイテッド | アミロイド、タウおよびα−シヌクレインの沈着に関連する疾患に関する組成物および方法 |
| US9102752B2 (en) * | 2013-03-15 | 2015-08-11 | United Biomedical, Inc. | Peptide vaccine for prevention and immunotherapy of dementia of the Alzheimer's type |
| WO2015017280A1 (en) | 2013-07-28 | 2015-02-05 | Qantu Therapeutics, Inc. | Vaccine formulations that induce a th2 immune response |
| TWI609026B (zh) * | 2014-03-14 | 2017-12-21 | 美國聯合生物醫學公司 | 抑制與免疫治療阿茲海默型癡呆的胜肽疫苗 |
| JP2021508672A (ja) * | 2017-06-16 | 2021-03-11 | ユナイテッド ニューロサイエンスUnited Neuroscience | シヌクレイノパチーの治療のためのアルファ−シヌクレインタンパク質のc末端からのペプチド免疫原及びその製剤 |
| WO2019023247A1 (en) | 2017-07-25 | 2019-01-31 | Immutics, Inc. | TREATMENT OF CANCER BY BLOCKING THE INTERACTION OF TIM-3 AND ITS LIGAND |
| SG11202003624SA (en) * | 2017-10-27 | 2020-05-28 | United Neuroscience | Tau peptide immunogen constructs |
| BR112020013352A2 (pt) * | 2017-12-31 | 2020-12-01 | United Biomedical, Inc. | imunógenos de peptídeo e formulações dos mesmos direcionados a ige ligada a membrana para tratamento de doenças alérgicas mediadas por ige |
| AU2019262609A1 (en) * | 2018-05-04 | 2020-12-03 | Ubi Ip Holdings | Artificial promiscuous T helper cell epitopes that facilitate targeted antibody production with limited T cell inflammatory response |
| EP3861007A4 (de) * | 2018-10-01 | 2022-07-13 | United Neuroscience | Gegen dipeptid-repeat-proteine aus c9orf72 gerichtete peptid-immunogen-konstrukte |
| US20230218748A1 (en) * | 2018-12-19 | 2023-07-13 | United Biomedical, Inc. | Artificial promiscuous t helper cell epitopes as immune stimulators for synthetic peptide immunogens |
| TWI769424B (zh) * | 2018-12-31 | 2022-07-01 | 美商Uns Ip控股公司 | 針對降鈣素基因相關胜肽(cgrp)的胜肽免疫原及其用於預防和治療偏頭痛的製劑 |
| JP2022523333A (ja) | 2019-01-30 | 2022-04-22 | トゥルーバインディング,インコーポレイテッド | 抗gal3抗体およびその使用 |
| CN110684122B (zh) * | 2019-10-29 | 2021-03-02 | 中国人民解放军军事科学院军事医学研究院 | 重组Tau表位嵌合多聚体抗原、其制备方法和应用 |
| EP4153210A4 (de) * | 2020-05-19 | 2024-11-13 | Othair Prothena Limited | Multiepitop-impfstoff zur behandlung von morbus alzheimer |
| EP4157338A4 (de) | 2020-05-26 | 2024-11-13 | TrueBinding, Inc. | Verfahren zur behandlung von entzündungskrankheiten durch galectin-3-blockierung |
| US20220383996A1 (en) * | 2021-05-27 | 2022-12-01 | Amazon Technologies, Inc. | Assigning peptides to peptide groups for vaccine development |
| US12537072B1 (en) | 2021-05-27 | 2026-01-27 | Amazon Technologies, Inc. | Immunogenic response prediction based on major histocompatibility complex (MHC) data |
| CN113603773B (zh) * | 2021-08-17 | 2023-05-09 | 中国医科大学附属第一医院 | 靶向淀粉样蛋白的单克隆抗体7b8、分泌该抗体的杂交瘤细胞株及应用 |
| EP4395894A4 (de) * | 2021-09-01 | 2025-08-06 | Vaxxinity Inc | Verfahren zur prävention und behandlung von synukleinopathien |
| CN117327168A (zh) * | 2022-06-24 | 2024-01-02 | 厦门大学 | B2M-GluN1封闭肽、其药物组合物及用途 |
| CN116063447B (zh) * | 2022-09-13 | 2023-11-03 | 北京湃德智健科技有限公司 | 用于检测adap自身抗体的抗原多肽及其应用 |
| CN121001737A (zh) * | 2023-01-26 | 2025-11-21 | 瓦克西尼提股份有限公司 | Tau和β淀粉样肽免疫原组合物及相关方法 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5753624A (en) * | 1990-04-27 | 1998-05-19 | Milkhaus Laboratory, Inc. | Materials and methods for treatment of plaquing disease |
| ATE153534T1 (de) | 1990-04-27 | 1997-06-15 | John Mcmichael | Verfahren und zusammensetzung zur behandlung von erkrankungen des zns hervorgerufen durch abnormales beta-amyloid-protein |
| US5955317A (en) * | 1993-01-25 | 1999-09-21 | Takeda Chemical Industries, Ltd. | Antibodies to β-amyloids or their derivatives and use thereof |
| EP1308461A3 (de) * | 1993-01-25 | 2004-02-11 | Takeda Chemical Industries, Ltd. | Antikörper gegen Beta-Amyloiden oder deren Abarten, und deren Verwendungen |
| US5759551A (en) * | 1993-04-27 | 1998-06-02 | United Biomedical, Inc. | Immunogenic LHRH peptide constructs and synthetic universal immune stimulators for vaccines |
| ES2180576T3 (es) * | 1993-04-27 | 2003-02-16 | United Biomedical Inc | Construcciones peptidicas de lhrh inmunogenicas y estimuladores de inmunidad universales sinteticos para vacunas. |
| AU7043894A (en) * | 1993-05-28 | 1994-12-20 | Miriam Hospital, The | Composition and method for (in vivo) imaging of amyloid deposits |
| EP0725838A4 (de) | 1993-10-26 | 1997-02-26 | United Biomedical Inc | Strukturierte synthetische antigenbanken als diagnostika, impfstoffe und therapeutische mittel |
| US7964192B1 (en) * | 1997-12-02 | 2011-06-21 | Janssen Alzheimer Immunotherapy | Prevention and treatment of amyloidgenic disease |
| US6787523B1 (en) * | 1997-12-02 | 2004-09-07 | Neuralab Limited | Prevention and treatment of amyloidogenic disease |
| US6750324B1 (en) * | 1997-12-02 | 2004-06-15 | Neuralab Limited | Humanized and chimeric N-terminal amyloid beta-antibodies |
| TWI239847B (en) | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
| TWI229679B (en) | 1998-06-20 | 2005-03-21 | United Biomedical Inc | Artificial T helper cell epitopes as immune stimulators for synthetic peptide immunogens |
| US6025468A (en) * | 1998-06-20 | 2000-02-15 | United Biomedical, Inc. | Artificial T helper cell epitopes as immune stimulators for synthetic peptide immunogens including immunogenic LHRH peptides |
| UA81216C2 (en) * | 1999-06-01 | 2007-12-25 | Prevention and treatment of amyloid disease | |
| ATE461996T1 (de) * | 1999-09-03 | 2010-04-15 | Univ Ramot | Verbindungen, zusammensetzungen und verfahren zur behandlung oder vorsorge von alzheimer erkrankung |
| EP1237930B1 (de) * | 1999-12-08 | 2006-11-08 | Intellect Neurosciences, Inc. | Schimärische amyloid-beta peptide |
| US20030165481A1 (en) | 2000-02-24 | 2003-09-04 | Hersh Louis B. | Amyloid peptide inactivating enzyme to treat Alzheimer's disease |
| US6906169B2 (en) * | 2001-05-25 | 2005-06-14 | United Biomedical, Inc. | Immunogenic peptide composition comprising measles virus Fprotein Thelper cell epitope (MUFThl-16) and N-terminus of β-amyloid peptide |
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2001
- 2001-05-25 US US09/865,294 patent/US6906169B2/en not_active Expired - Lifetime
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2002
- 2002-03-18 TW TW091105087A patent/TWI252233B/zh not_active IP Right Cessation
- 2002-04-02 CA CA002448171A patent/CA2448171A1/en not_active Abandoned
- 2002-04-02 DK DK09168110.6T patent/DK2123671T3/da active
- 2002-04-02 EP EP02731223A patent/EP1497313B1/de not_active Expired - Lifetime
- 2002-04-02 CN CN028106210A patent/CN1568329B/zh not_active Expired - Lifetime
- 2002-04-02 DE DE60237044T patent/DE60237044D1/de not_active Expired - Lifetime
- 2002-04-02 JP JP2002592863A patent/JP4440544B2/ja not_active Expired - Fee Related
- 2002-04-02 DK DK02731223.0T patent/DK1497313T3/da active
- 2002-04-02 ES ES09168110T patent/ES2360465T3/es not_active Expired - Lifetime
- 2002-04-02 CA CA2665748A patent/CA2665748C/en not_active Expired - Fee Related
- 2002-04-02 CN CN2008101692748A patent/CN101372511B/zh not_active Expired - Fee Related
- 2002-04-02 EP EP09168110A patent/EP2123671B1/de not_active Expired - Lifetime
- 2002-04-02 AT AT09168110T patent/ATE496937T1/de active
- 2002-04-02 AU AU2002303211A patent/AU2002303211B2/en not_active Ceased
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- 2002-04-02 BR BR0210010-0 patent/BRPI0210010B8/pt not_active IP Right Cessation
- 2002-04-02 DE DE60239093T patent/DE60239093D1/de not_active Expired - Lifetime
- 2002-04-02 MX MXPA03010631A patent/MXPA03010631A/es active IP Right Grant
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- 2002-04-02 WO PCT/US2002/010293 patent/WO2002096350A2/en not_active Ceased
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2003
- 2003-11-11 ZA ZA2003/08767A patent/ZA200308767B/en unknown
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- 2004-06-04 US US10/861,614 patent/US7951909B2/en not_active Expired - Lifetime
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