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DE602008006054D1 - Laserdesorptions-elektrospray-ionenquelle für massenspektrometer - Google Patents

Laserdesorptions-elektrospray-ionenquelle für massenspektrometer

Info

Publication number
DE602008006054D1
DE602008006054D1 DE602008006054T DE602008006054T DE602008006054D1 DE 602008006054 D1 DE602008006054 D1 DE 602008006054D1 DE 602008006054 T DE602008006054 T DE 602008006054T DE 602008006054 T DE602008006054 T DE 602008006054T DE 602008006054 D1 DE602008006054 D1 DE 602008006054D1
Authority
DE
Germany
Prior art keywords
ion source
sample
laser desorption
mass spectrometers
electrospray ion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602008006054T
Other languages
English (en)
Inventor
Viatcheslav V Kovtoun
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Thermo Finnigan LLC
Original Assignee
Thermo Finnigan LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thermo Finnigan LLC filed Critical Thermo Finnigan LLC
Publication of DE602008006054D1 publication Critical patent/DE602008006054D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
    • H01J49/165—Electrospray ionisation
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0459—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for solid samples
    • H01J49/0463—Desorption by laser or particle beam, followed by ionisation as a separate step

Landscapes

  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Plasma & Fusion (AREA)
  • Optics & Photonics (AREA)
  • Electron Tubes For Measurement (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
DE602008006054T 2007-05-03 2008-04-30 Laserdesorptions-elektrospray-ionenquelle für massenspektrometer Active DE602008006054D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/799,910 US7525105B2 (en) 2007-05-03 2007-05-03 Laser desorption—electrospray ion (ESI) source for mass spectrometers
PCT/US2008/062106 WO2008137484A2 (en) 2007-05-03 2008-04-30 Laser desorption - electrospray ion (esi) source for mass spectrometers

Publications (1)

Publication Number Publication Date
DE602008006054D1 true DE602008006054D1 (de) 2011-05-19

Family

ID=39832314

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602008006054T Active DE602008006054D1 (de) 2007-05-03 2008-04-30 Laserdesorptions-elektrospray-ionenquelle für massenspektrometer

Country Status (6)

Country Link
US (1) US7525105B2 (de)
EP (1) EP2140478B1 (de)
AT (1) ATE504938T1 (de)
CA (1) CA2683985A1 (de)
DE (1) DE602008006054D1 (de)
WO (1) WO2008137484A2 (de)

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DE102006056929B4 (de) * 2006-12-04 2010-09-02 Bruker Daltonik Gmbh Massenspektrometrie mit Laser-Ablation
US8067730B2 (en) 2007-07-20 2011-11-29 The George Washington University Laser ablation electrospray ionization (LAESI) for atmospheric pressure, In vivo, and imaging mass spectrometry
US8901487B2 (en) * 2007-07-20 2014-12-02 George Washington University Subcellular analysis by laser ablation electrospray ionization mass spectrometry
US7964843B2 (en) 2008-07-18 2011-06-21 The George Washington University Three-dimensional molecular imaging by infrared laser ablation electrospray ionization mass spectrometry
US20100285446A1 (en) * 2007-07-20 2010-11-11 Akos Vertes Methods for Detecting Metabolic States by Laser Ablation Electrospray Ionization Mass Spectrometry
US7915579B2 (en) * 2008-09-05 2011-03-29 Ohio University Method and apparatus of liquid sample-desorption electrospray ionization-mass specrometry (LS-DESI-MS)
WO2010114976A1 (en) * 2009-04-01 2010-10-07 Prosolia, Inc. Method and system for surface sampling
EP4152360A1 (de) 2009-04-30 2023-03-22 Purdue Research Foundation Ionenerzeugung mit einem befeuchteten porösen material
US9500572B2 (en) 2009-04-30 2016-11-22 Purdue Research Foundation Sample dispenser including an internal standard and methods of use thereof
US8704167B2 (en) 2009-04-30 2014-04-22 Purdue Research Foundation Mass spectrometry analysis of microorganisms in samples
WO2010135246A1 (en) * 2009-05-18 2010-11-25 Jeol Usa, Inc. Method of surface ionization with solvent spray and excited-state neutrals
EP2467868A1 (de) * 2009-08-17 2012-06-27 Temple University Of The Commonwealth System Of Higher Education Verdampfungsvorrichtung und vorrichtung für bildgebende massenspektrometrie
GB2475742B (en) * 2009-11-30 2014-02-12 Microsaic Systems Plc Sample collection and detection system
US8097845B2 (en) 2010-03-11 2012-01-17 Battelle Memorial Institute Focused analyte spray emission apparatus and process for mass spectrometric analysis
JP5819943B2 (ja) 2010-05-07 2015-11-24 ユーティ—バテル エルエルシー 表面からサンプルを抽出するためのシステムおよび方法
US20140166875A1 (en) * 2010-09-02 2014-06-19 Wayne State University Systems and methods for high throughput solvent assisted ionization inlet for mass spectrometry
US8486703B2 (en) 2010-09-30 2013-07-16 Ut-Battelle, Llc Surface sampling concentration and reaction probe
US8637813B2 (en) 2010-10-01 2014-01-28 Ut-Battelle, Llc System and method for laser assisted sample transfer to solution for chemical analysis
US8519330B2 (en) 2010-10-01 2013-08-27 Ut-Battelle, Llc Systems and methods for laser assisted sample transfer to solution for chemical analysis
US8853621B2 (en) * 2010-10-25 2014-10-07 Wayne State University Systems and methods extending the laserspray ionization mass spectrometry concept from atmospheric pressure to vacuum
TWI510781B (zh) * 2010-10-29 2015-12-01 Scinopharm Taiwan Ltd 即時監測固相胜肽合成反應之質譜系統
CA3023911C (en) 2011-01-05 2021-09-07 Purdue Research Foundation (Prf) Systems and methods for sample analysis
US9157921B2 (en) 2011-05-18 2015-10-13 Purdue Research Foundation Method for diagnosing abnormality in tissue samples by combination of mass spectral and optical imaging
US9546979B2 (en) 2011-05-18 2017-01-17 Purdue Research Foundation Analyzing a metabolite level in a tissue sample using DESI
WO2012167126A1 (en) 2011-06-03 2012-12-06 Purdue Research Foundation Ion generation using modified wetted porous materials
JP2014524121A (ja) 2011-07-14 2014-09-18 ザ・ジョージ・ワシントン・ユニバーシティ レーザアブレーション・エレクトロスプレイイオン化質量分析用のプルームコリメーション
US8648297B2 (en) 2011-07-21 2014-02-11 Ohio University Coupling of liquid chromatography with mass spectrometry by liquid sample desorption electrospray ionization (DESI)
US8664589B2 (en) 2011-12-29 2014-03-04 Electro Scientific Industries, Inc Spectroscopy data display systems and methods
WO2014114808A2 (en) * 2013-01-28 2014-07-31 Westfälische Wilhelms-Universität Münster Laser ablation atmospheric pressure ionization mass spectrometry
CN104956463B (zh) 2013-01-31 2018-04-06 普度研究基金会 分析原油的方法
EP2951852B1 (de) 2013-01-31 2020-07-22 Purdue Research Foundation Systeme zur analyse einer extrahierten probe
EP4099363A1 (de) 2013-06-25 2022-12-07 Purdue Research Foundation Massenspektrometrieanalyse von mikroorganismen in proben
US11293872B2 (en) 2014-09-18 2022-04-05 Universiteit Gent Laser ablation probe
US9390901B2 (en) * 2014-10-31 2016-07-12 Ut-Battelle, Llc System and method for liquid extraction electrospray-assisted sample transfer to solution for chemical analysis
US9786478B2 (en) 2014-12-05 2017-10-10 Purdue Research Foundation Zero voltage mass spectrometry probes and systems
JP6948266B2 (ja) 2015-02-06 2021-10-13 パーデュー・リサーチ・ファウンデーションＰｕｒｄｕｅ Ｒｅｓｅａｒｃｈ Ｆｏｕｎｄａｔｉｏｎ プローブ、システム、カートリッジ、およびその使用方法
US9632066B2 (en) * 2015-04-09 2017-04-25 Ut-Battelle, Llc Open port sampling interface
US10060838B2 (en) 2015-04-09 2018-08-28 Ut-Battelle, Llc Capture probe
US11125657B2 (en) 2018-01-30 2021-09-21 Ut-Battelle, Llc Sampling probe
CN110416059B (zh) 2018-04-27 2020-09-11 岛津分析技术研发（上海）有限公司 样本解吸及电离装置以及应用该装置的质谱仪及分析方法
CN118311128B (zh) * 2024-04-15 2025-01-24 合肥谱佳医学检验实验室有限公司 一种紫外光辅助电喷雾装置及方法

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10158860B4 (de) 2001-11-30 2007-04-05 Bruker Daltonik Gmbh Massenspektrometrische Proteingemischanalyse
DE102004002729B4 (de) 2004-01-20 2008-11-27 Bruker Daltonik Gmbh Ionisierung desorbierter Analytmoleküle bei Atmosphärendruck
US7335897B2 (en) * 2004-03-30 2008-02-26 Purdue Research Foundation Method and system for desorption electrospray ionization
TWI271771B (en) * 2006-01-27 2007-01-21 Univ Nat Sun Yat Sen Electrospray-assisted laser desorption ionization devices, mass spectrometers, and methods for mass spectrometry

Also Published As

Publication number Publication date
US7525105B2 (en) 2009-04-28
EP2140478A2 (de) 2010-01-06
WO2008137484A2 (en) 2008-11-13
WO2008137484A3 (en) 2009-08-06
EP2140478B1 (de) 2011-04-06
CA2683985A1 (en) 2008-11-13
US20080272294A1 (en) 2008-11-06
ATE504938T1 (de) 2011-04-15

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