DE602007007211D1 - Inhibitoren von11-beta-hydroxysteroiddehydrogenase 1 - Google Patents
Inhibitoren von11-beta-hydroxysteroiddehydrogenase 1Info
- Publication number
- DE602007007211D1 DE602007007211D1 DE602007007211T DE602007007211T DE602007007211D1 DE 602007007211 D1 DE602007007211 D1 DE 602007007211D1 DE 602007007211 T DE602007007211 T DE 602007007211T DE 602007007211 T DE602007007211 T DE 602007007211T DE 602007007211 D1 DE602007007211 D1 DE 602007007211D1
- Authority
- DE
- Germany
- Prior art keywords
- compounds
- hydroxysteroiddehydrogenase
- inhibitors
- beta
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 102100036506 11-beta-hydroxysteroid dehydrogenase 1 Human genes 0.000 title 1
- 101710186107 11-beta-hydroxysteroid dehydrogenase 1 Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 230000000694 effects Effects 0.000 abstract 2
- 208000031226 Hyperlipidaemia Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 208000001145 Metabolic Syndrome Diseases 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 201000001421 hyperglycemia Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74557406P | 2006-04-25 | 2006-04-25 | |
| PCT/US2007/067350 WO2007127763A2 (en) | 2006-04-25 | 2007-04-25 | Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE602007007211D1 true DE602007007211D1 (de) | 2010-07-29 |
Family
ID=38541939
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602007007211T Active DE602007007211D1 (de) | 2006-04-25 | 2007-04-25 | Inhibitoren von11-beta-hydroxysteroiddehydrogenase 1 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US7968585B2 (de) |
| JP (1) | JP5324427B2 (de) |
| CN (1) | CN101432265B (de) |
| AT (1) | ATE471311T1 (de) |
| AU (1) | AU2007244861B2 (de) |
| BR (1) | BRPI0710231A2 (de) |
| CA (1) | CA2648019C (de) |
| DE (1) | DE602007007211D1 (de) |
| DK (1) | DK2035379T3 (de) |
| EA (1) | EA015499B1 (de) |
| ES (1) | ES2344616T3 (de) |
| MX (1) | MX2008013650A (de) |
| PT (1) | PT2035379E (de) |
| WO (1) | WO2007127763A2 (de) |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2016047B1 (de) * | 2006-04-21 | 2013-08-28 | Eli Lilly And Company | Biphenylamid-lactam-derivate als inhibitoren von 11-beta-hydroxysteroiddehydrogenase 1 |
| MX2008013484A (es) | 2006-04-21 | 2008-10-30 | Lilly Co Eli | Derivados de lactamas de ciclohexilpirazol como inhibidores de 11-beta-hidroxiesteroide deshidrogenasa 1. |
| BRPI0710273A2 (pt) | 2006-04-21 | 2011-08-09 | Lilly Co Eli | composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, e, intermediário |
| EA015106B1 (ru) | 2006-04-24 | 2011-06-30 | Эли Лилли Энд Компани | Ингибиторы 11-бета-гидроксистероид дегидрогеназы 1 |
| ES2346925T3 (es) | 2006-04-24 | 2010-10-21 | ELI LILLY & COMPANY | Pirrolidinonas sustituidas como inhibidores de la 11 beta-dihidroesteroide deshidrogenasa 1. |
| WO2007127704A1 (en) | 2006-04-24 | 2007-11-08 | Eli Lilly And Company | Cyclohexyl substituted pyrrolidinones as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| EP2016071B1 (de) | 2006-04-25 | 2013-07-24 | Eli Lilly And Company | 11-beta-hydroxysteroid-dehydrogenase-1-hemmer |
| DK2021337T3 (da) | 2006-04-25 | 2010-03-29 | Lilly Co Eli | Inhibitorer af 11-beta-hydroxysteroid-dehydrogenase-1 |
| EA014719B1 (ru) * | 2006-04-28 | 2011-02-28 | Эли Лилли Энд Компани | Пиперидинилзамещённые пирролидиноны в качестве ингибиторов 11-бета-гидроксистероид дегидрогеназы 1 |
| EP2183229B1 (de) | 2007-07-26 | 2012-04-18 | Vitae Pharmaceuticals, Inc. | Synthese von 11-beta-hydroxysteroid-dehydrogenase-1-hemmern |
| EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| AR069207A1 (es) | 2007-11-07 | 2010-01-06 | Vitae Pharmaceuticals Inc | Ureas ciclicas como inhibidores de la 11 beta - hidroxi-esteroide deshidrogenasa 1 |
| TW200927115A (en) | 2007-11-16 | 2009-07-01 | Boehringer Ingelheim Int | Aryl-and heteroarylcarbonyl derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use |
| WO2009075835A1 (en) | 2007-12-11 | 2009-06-18 | Vitae Pharmaceutical, Inc | CYCLIC UREA INHIBITORS OF 11β-HYDROXYSTEROID DEHYDROGENASE 1 |
| TW200934490A (en) | 2008-01-07 | 2009-08-16 | Vitae Pharmaceuticals Inc | Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1 |
| WO2009094169A1 (en) | 2008-01-24 | 2009-07-30 | Vitae Pharmaceuticals, Inc. | Cyclic carbazate and semicarbazide inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| US8598160B2 (en) | 2008-02-15 | 2013-12-03 | Vitae Pharmaceuticals, Inc. | Cycloalkyl lactame derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| CA2723039A1 (en) | 2008-05-01 | 2009-11-05 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| ES2421537T3 (es) | 2008-05-01 | 2013-09-03 | Vitae Pharmaceuticals Inc | Inhibidores cíclicos de la 11beta-hidroxiesteroide deshidrogenasa 1 |
| CA2723034A1 (en) | 2008-05-01 | 2009-11-05 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| JP5711115B2 (ja) | 2008-05-13 | 2015-04-30 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ベンゾモルファン及び関連骨格のアリサイクリックカルボン酸誘導体、そのような化合物を含有する医薬及びその使用 |
| US8846668B2 (en) | 2008-07-25 | 2014-09-30 | Vitae Pharmaceuticals, Inc. | Inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| DK2324018T3 (da) | 2008-07-25 | 2013-10-14 | Boehringer Ingelheim Int | Cykliske inhibitorer af 11 beta-hydroxysteroid dehydrogenase 1 |
| JP5390610B2 (ja) | 2008-07-25 | 2014-01-15 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | １１β−ヒドロキシステロイドデヒドロゲナーゼ１型の阻害剤の合成 |
| EP2393807B1 (de) | 2009-02-04 | 2013-08-14 | Boehringer Ingelheim International GmbH | Zyklische 11beta-hydroxysteroid-dehydrogenase-1-hemmer |
| EP2243479A3 (de) | 2009-04-20 | 2011-01-19 | Abbott Laboratories | Neuartige Amid- und Amidinderivate und deren Verwendungen |
| US8680093B2 (en) | 2009-04-30 | 2014-03-25 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| EP2440537A1 (de) | 2009-06-11 | 2012-04-18 | Vitae Pharmaceuticals, Inc. | Cyclische hemmer der 11beta-hydroxysteroiddehydrogenase 1 auf basis der 1,3 -oxazinan- 2 -on-struktur |
| US8440710B2 (en) | 2009-10-15 | 2013-05-14 | Hoffmann-La Roche Inc. | HSL inhibitors useful in the treatment of diabetes |
| TW201118069A (en) | 2009-10-28 | 2011-06-01 | Lundbeck & Co As H | Spirolactam derivatives and uses of same |
| WO2011056737A1 (en) | 2009-11-05 | 2011-05-12 | Boehringer Ingelheim International Gmbh | Novel chiral phosphorus ligands |
| TWI531571B (zh) | 2009-11-06 | 2016-05-01 | 維它藥物公司 | 六氫茚并吡啶及八氫苯并喹啉之芳基－及雜芳基羰基衍生物 |
| US8871208B2 (en) * | 2009-12-04 | 2014-10-28 | Abbvie Inc. | 11-β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors and uses thereof |
| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| US8648192B2 (en) | 2010-05-26 | 2014-02-11 | Boehringer Ingelheim International Gmbh | 2-oxo-1,2-dihydropyridin-4-ylboronic acid derivatives |
| WO2011159760A1 (en) | 2010-06-16 | 2011-12-22 | Vitae Pharmaceuticals, Inc. | Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use |
| WO2011157827A1 (de) | 2010-06-18 | 2011-12-22 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
| JP5813106B2 (ja) * | 2010-06-25 | 2015-11-17 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 代謝障害の処置のための１１−β−ＨＳＤ１のインヒビターとしてのアザスピロヘキサノン |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
| TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
| TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| EA201300522A1 (ru) | 2010-11-02 | 2013-11-29 | Бёрингер Ингельхайм Интернациональ Гмбх | Фармацевтические комбинации для лечения метаболических нарушений |
| TWI537258B (zh) | 2010-11-05 | 2016-06-11 | 百靈佳殷格翰國際股份有限公司 | 六氫茚并吡啶及八氫苯并喹啉之芳基－及雜環芳基羰基衍生物 |
| WO2012120056A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| EP2766349B1 (de) | 2011-03-08 | 2016-06-01 | Sanofi | Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
| US8828994B2 (en) | 2011-03-08 | 2014-09-09 | Sanofi | Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
| US8828995B2 (en) | 2011-03-08 | 2014-09-09 | Sanofi | Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
| WO2012120055A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| US8722721B2 (en) * | 2011-03-16 | 2014-05-13 | Hoffmann-La Roche Inc. | SEC-hydroxycyclohexyl derivatives |
| US8703807B2 (en) * | 2011-03-17 | 2014-04-22 | Hoffmann-La Roche Inc. | Azaspirodecanone compounds |
| US8809384B2 (en) * | 2011-03-25 | 2014-08-19 | Hoffmann-La Roche Inc. | Azaspirodecanone compounds |
| US8501768B2 (en) * | 2011-05-17 | 2013-08-06 | Hoffmann-La Roche Inc. | Hexahydrocyclopentapyrrolone, hexahydropyrrolopyrrolone, octahydropyrrolopyridinone and octahydropyridinone compounds |
| EP2554539B1 (de) | 2011-08-02 | 2014-12-10 | Universität Potsdam | Verfahren zur Herstellung von gamma-Spirolactamen aus zyklischen ungesättigten Carbonsäuren |
| JP2014524438A (ja) | 2011-08-17 | 2014-09-22 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | インデノピリジン誘導体 |
| WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| EP2760862B1 (de) | 2011-09-27 | 2015-10-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridin-4-carbonsäureamidderivate als kinaseinhibitoren |
| HUE040133T2 (hu) | 2014-07-15 | 2019-02-28 | Gruenenthal Gmbh | Szubsztituált azaspiro(4.5)dekán származékok |
| TW201607923A (zh) | 2014-07-15 | 2016-03-01 | 歌林達有限公司 | 被取代之氮螺環（４．５）癸烷衍生物 |
| WO2019099760A1 (en) | 2017-11-16 | 2019-05-23 | University Of Houston System | Aryl-substituted acetamide and pyrrolidin-2-one derivatives and their use for the treatment of seizures |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004056744A1 (en) | 2002-12-23 | 2004-07-08 | Janssen Pharmaceutica N.V. | Adamantyl acetamides as hydroxysteroid dehydrogenase inhibitors |
| WO2005108361A1 (en) | 2004-05-07 | 2005-11-17 | Janssen Pharmaceutica N.V. | Adamantyl pyrrolidin-2-one derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors |
| NZ551077A (en) * | 2004-05-07 | 2009-05-31 | Janssen Pharmaceutica Nv | Pyrrolidin-2-one and piperidin-2-one derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors |
| WO2006024628A1 (en) * | 2004-08-30 | 2006-03-09 | Janssen Pharmaceutica N.V. | Tricyclic lactam derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors |
| WO2006040329A1 (en) * | 2004-10-12 | 2006-04-20 | Novo Nordisk A/S | 1 ibeta- hydroxysteroid dehydrogenase type 1 active spiro compounds |
| PL1807072T3 (pl) * | 2004-10-29 | 2009-06-30 | Lilly Co Eli | Cykloalkilowe pochodne laktamów jako inhibitory 11-ß-HSD1 |
| US20060116382A1 (en) | 2004-11-10 | 2006-06-01 | Wenqing Yao | Lactam compounds and their use as pharmaceuticals |
| ES2308602T3 (es) | 2004-12-20 | 2008-12-01 | Eli Lilly And Company | Derivados de cicloalquil lactamas como inhibidores de la 11-beta-hidroxiesteroide deshidrogenasa 1. |
| EP1830840B1 (de) | 2004-12-21 | 2008-07-16 | Eli Lilly And Company | Cycloalkyl-lactam-derivate als inhibitoren von 11-beta-hydroxysteroiddehydrogenase 1 |
| US20090264650A1 (en) | 2005-03-31 | 2009-10-22 | Nobuo Cho | Prophylactic/Therapeutic Agent for Diabetes |
| US7998959B2 (en) | 2006-01-12 | 2011-08-16 | Incyte Corporation | Modulators of 11-β hydroxyl steroid dehydrogenase type 1, pharmaceutical compositions thereof, and methods of using the same |
| MX2008013484A (es) | 2006-04-21 | 2008-10-30 | Lilly Co Eli | Derivados de lactamas de ciclohexilpirazol como inhibidores de 11-beta-hidroxiesteroide deshidrogenasa 1. |
| BRPI0710273A2 (pt) | 2006-04-21 | 2011-08-09 | Lilly Co Eli | composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, e, intermediário |
| EP2016047B1 (de) | 2006-04-21 | 2013-08-28 | Eli Lilly And Company | Biphenylamid-lactam-derivate als inhibitoren von 11-beta-hydroxysteroiddehydrogenase 1 |
| EA015106B1 (ru) | 2006-04-24 | 2011-06-30 | Эли Лилли Энд Компани | Ингибиторы 11-бета-гидроксистероид дегидрогеназы 1 |
| WO2007127704A1 (en) | 2006-04-24 | 2007-11-08 | Eli Lilly And Company | Cyclohexyl substituted pyrrolidinones as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| ES2346925T3 (es) | 2006-04-24 | 2010-10-21 | ELI LILLY & COMPANY | Pirrolidinonas sustituidas como inhibidores de la 11 beta-dihidroesteroide deshidrogenasa 1. |
| EP2016071B1 (de) | 2006-04-25 | 2013-07-24 | Eli Lilly And Company | 11-beta-hydroxysteroid-dehydrogenase-1-hemmer |
| DK2021337T3 (da) | 2006-04-25 | 2010-03-29 | Lilly Co Eli | Inhibitorer af 11-beta-hydroxysteroid-dehydrogenase-1 |
| EA014719B1 (ru) | 2006-04-28 | 2011-02-28 | Эли Лилли Энд Компани | Пиперидинилзамещённые пирролидиноны в качестве ингибиторов 11-бета-гидроксистероид дегидрогеназы 1 |
| CL2008001839A1 (es) | 2007-06-21 | 2009-01-16 | Incyte Holdings Corp | Compuestos derivados de 2,7-diazaespirociclos, inhibidores de 11-beta hidroxil esteroide deshidrogenasa tipo 1; composicion farmaceutica que comprende a dichos compuestos; utiles para tratar la obesidad, diabetes, intolerancia a la glucosa, diabetes tipo ii, entre otras enfermedades. |
-
2007
- 2007-04-25 AT AT07782529T patent/ATE471311T1/de active
- 2007-04-25 BR BRPI0710231-3A patent/BRPI0710231A2/pt not_active IP Right Cessation
- 2007-04-25 DE DE602007007211T patent/DE602007007211D1/de active Active
- 2007-04-25 CN CN2007800148399A patent/CN101432265B/zh not_active Expired - Fee Related
- 2007-04-25 WO PCT/US2007/067350 patent/WO2007127763A2/en not_active Ceased
- 2007-04-25 ES ES07782529T patent/ES2344616T3/es active Active
- 2007-04-25 JP JP2009507936A patent/JP5324427B2/ja not_active Expired - Fee Related
- 2007-04-25 US US12/297,906 patent/US7968585B2/en not_active Expired - Fee Related
- 2007-04-25 EA EA200870475A patent/EA015499B1/ru not_active IP Right Cessation
- 2007-04-25 DK DK07782529.7T patent/DK2035379T3/da active
- 2007-04-25 AU AU2007244861A patent/AU2007244861B2/en not_active Ceased
- 2007-04-25 CA CA2648019A patent/CA2648019C/en not_active Expired - Fee Related
- 2007-04-25 PT PT07782529T patent/PT2035379E/pt unknown
- 2007-04-25 MX MX2008013650A patent/MX2008013650A/es active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| US7968585B2 (en) | 2011-06-28 |
| PT2035379E (pt) | 2010-07-13 |
| WO2007127763A3 (en) | 2007-12-13 |
| EA200870475A1 (ru) | 2009-06-30 |
| CA2648019C (en) | 2014-04-01 |
| CN101432265B (zh) | 2011-12-14 |
| DK2035379T3 (da) | 2010-09-06 |
| WO2007127763A2 (en) | 2007-11-08 |
| ATE471311T1 (de) | 2010-07-15 |
| CN101432265A (zh) | 2009-05-13 |
| EA015499B1 (ru) | 2011-08-30 |
| AU2007244861B2 (en) | 2012-03-15 |
| MX2008013650A (es) | 2008-11-04 |
| US20090099180A1 (en) | 2009-04-16 |
| JP5324427B2 (ja) | 2013-10-23 |
| ES2344616T3 (es) | 2010-09-01 |
| BRPI0710231A2 (pt) | 2011-08-02 |
| CA2648019A1 (en) | 2007-11-08 |
| JP2009535357A (ja) | 2009-10-01 |
| AU2007244861A1 (en) | 2007-11-08 |
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