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DE602007004333D1 - Inhibitoren von akt (proteinkinase b) - Google Patents

Inhibitoren von akt (proteinkinase b)

Info

Publication number
DE602007004333D1
DE602007004333D1 DE602007004333T DE602007004333T DE602007004333D1 DE 602007004333 D1 DE602007004333 D1 DE 602007004333D1 DE 602007004333 T DE602007004333 T DE 602007004333T DE 602007004333 T DE602007004333 T DE 602007004333T DE 602007004333 D1 DE602007004333 D1 DE 602007004333D1
Authority
DE
Germany
Prior art keywords
inhibitors
act
protein kinase
kinase
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602007004333T
Other languages
English (en)
Inventor
Sajan Joseph
Renhua Li
Michael Ray Myers
Aktham Aburub
Jenny Pingqi Dai
Christopher Randall Schmid
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of DE602007004333D1 publication Critical patent/DE602007004333D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • AIDS & HIV (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE602007004333T 2006-06-20 2007-06-12 Inhibitoren von akt (proteinkinase b) Active DE602007004333D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US80526006P 2006-06-20 2006-06-20
US88576507P 2007-01-19 2007-01-19
PCT/US2007/070945 WO2007149730A2 (en) 2006-06-20 2007-06-12 Inhibitors of akt (protein kinase b)

Publications (1)

Publication Number Publication Date
DE602007004333D1 true DE602007004333D1 (de) 2010-03-04

Family

ID=38834248

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602007004333T Active DE602007004333D1 (de) 2006-06-20 2007-06-12 Inhibitoren von akt (proteinkinase b)

Country Status (28)

Country Link
US (1) US7998977B2 (de)
EP (1) EP2035385B1 (de)
JP (1) JP2009541335A (de)
KR (1) KR101067551B1 (de)
AR (1) AR061240A1 (de)
AT (1) ATE455102T1 (de)
AU (1) AU2007261120A1 (de)
BR (1) BRPI0713136A2 (de)
CA (1) CA2652612A1 (de)
CL (1) CL2007001752A1 (de)
DE (1) DE602007004333D1 (de)
DK (1) DK2035385T3 (de)
DO (1) DOP2008000053A (de)
EA (1) EA015712B1 (de)
EC (1) ECSP088992A (de)
ES (1) ES2336630T3 (de)
HR (1) HRP20100147T1 (de)
IL (1) IL195005A0 (de)
MA (1) MA30757B1 (de)
MX (1) MX2008015904A (de)
NO (1) NO20090289L (de)
PE (1) PE20080338A1 (de)
PL (1) PL2035385T3 (de)
PT (1) PT2035385E (de)
SI (1) SI2035385T1 (de)
TN (1) TNSN08529A1 (de)
TW (1) TW200812970A (de)
WO (1) WO2007149730A2 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009146320A1 (en) 2008-05-27 2009-12-03 Dmi Life Sciences, Inc. Therapeutic methods and compounds
CA2810844C (en) 2010-09-07 2017-03-21 Dmi Acquisition Corp. Diketopiperazine compositions for the treatment of metabolic syndrome and related conditions
PH12014500686A1 (en) 2011-10-10 2020-12-18 Ampio Pharmaceuticals Inc Implantable medical devices with increased immune tolerance, and methods for making and implanting
JP6203734B2 (ja) 2011-10-10 2017-09-27 アンピオ ファーマシューティカルズ，インコーポレイテッド 変形性関節疾患の治療
HK1198812A1 (en) 2011-10-28 2015-06-12 Ampio Pharmaceuticals, Inc. Treatment of rhinitis
MX2015010937A (es) 2013-03-15 2015-10-29 Ampio Pharmaceuticals Inc Composiciones para la movilizacion, autodireccion, expansion y diferenciacion de celulas madre y metodos para usar las mismas.
AU2014293011A1 (en) 2013-07-26 2016-03-17 Race Oncology Ltd. Compositions to improve the therapeutic benefit of bisantrene
EP3183240A4 (de) 2014-08-18 2018-06-27 Ampio Pharmaceuticals, Inc. Behandlung von gelenkerkrankungen
US10123997B2 (en) * 2015-06-15 2018-11-13 Yong Liao Target for treating hepatitis B virus
HK1246669A1 (zh) 2015-06-22 2018-09-14 Ampio Pharmaceuticals, Inc. 人血清白蛋白低分子量组分在疾病治疗中的应用
WO2017156350A1 (en) 2016-03-09 2017-09-14 K-Gen, Inc. Methods of cancer treatment
CN115916350B (zh) * 2020-07-22 2024-11-05 南京正大天晴制药有限公司 Akt抑制剂的单位剂量组合物
WO2022017448A1 (zh) * 2020-07-22 2022-01-27 南京正大天晴制药有限公司 一种二氢吡啶并[2,3-d]嘧啶酮衍生物的盐及晶型

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL152807A0 (en) 2000-05-30 2003-06-24 Peptor Ltd Protein kinase inhibitors
EP1611105A1 (de) 2003-03-28 2006-01-04 Eli Lilly And Company Isochinolin-5-sulfonsäureamide als inhibitoren von akt (proteinkinase b)
GB0317315D0 (en) 2003-07-24 2003-08-27 Astex Technology Ltd Pharmaceutical compounds
EP1689719A1 (de) 2003-11-25 2006-08-16 Eli Lilly And Company 7-phenylisochinolin-5-sulfonylaminoderivate als inhibitoren von akt (proteinkinase b)

Also Published As

Publication number Publication date
PE20080338A1 (es) 2008-04-25
EA200970041A1 (ru) 2009-06-30
MX2008015904A (es) 2009-01-12
PL2035385T3 (pl) 2010-06-30
KR20090015978A (ko) 2009-02-12
KR101067551B1 (ko) 2011-09-27
US20090221633A1 (en) 2009-09-03
AU2007261120A1 (en) 2007-12-27
TW200812970A (en) 2008-03-16
EA015712B1 (ru) 2011-10-31
NO20090289L (no) 2009-01-19
EP2035385B1 (de) 2010-01-13
ECSP088992A (es) 2009-01-30
DOP2008000053A (es) 2009-01-15
ATE455102T1 (de) 2010-01-15
PT2035385E (pt) 2010-03-01
AR061240A1 (es) 2008-08-13
JP2009541335A (ja) 2009-11-26
DK2035385T3 (da) 2010-03-22
ES2336630T3 (es) 2010-04-14
HRP20100147T1 (hr) 2010-04-30
TNSN08529A1 (en) 2010-04-14
SI2035385T1 (sl) 2010-05-31
MA30757B1 (fr) 2009-10-01
BRPI0713136A2 (pt) 2012-04-17
CA2652612A1 (en) 2007-12-27
CL2007001752A1 (es) 2008-01-18
WO2007149730A3 (en) 2008-04-24
US7998977B2 (en) 2011-08-16
WO2007149730A2 (en) 2007-12-27
EP2035385A2 (de) 2009-03-18
IL195005A0 (en) 2009-08-03

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: DR. SCHOEN & PARTNER, 80336 MUENCHEN