[go: up one dir, main page]

DE602004031301D1 - Nichtsymmetrisches geliermittel - Google Patents

Nichtsymmetrisches geliermittel

Info

Publication number
DE602004031301D1
DE602004031301D1 DE602004031301T DE602004031301T DE602004031301D1 DE 602004031301 D1 DE602004031301 D1 DE 602004031301D1 DE 602004031301 T DE602004031301 T DE 602004031301T DE 602004031301 T DE602004031301 T DE 602004031301T DE 602004031301 D1 DE602004031301 D1 DE 602004031301D1
Authority
DE
Germany
Prior art keywords
gelator
thickener
gelier
symmetrical
present
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE602004031301T
Other languages
English (en)
Inventor
Bommel Kjeld Jacobus Van
Esch Johannes Henricus Van
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Applied Nanosystems BV
Original Assignee
Applied Nanosystems BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Nanosystems BV filed Critical Applied Nanosystems BV
Publication of DE602004031301D1 publication Critical patent/DE602004031301D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/29Chiral phases
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64Proteins; Peptides; Derivatives or degradation products thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/06Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/291Gel sorbents
    • CCHEMISTRY; METALLURGY
    • C04CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04BLIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B35/00Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
    • C04B35/622Forming processes; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
    • C04B35/626Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B
    • C04B35/63Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B using additives specially adapted for forming the products, e.g.. binder binders
    • C04B35/632Organic additives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00Carboxylic acid amides
    • C07C233/57Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C233/63Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38Nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/48Thickener, Thickening system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Analytical Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Manufacturing & Machinery (AREA)
  • Ceramic Engineering (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Materials Engineering (AREA)
  • Birds (AREA)
  • Structural Engineering (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dispersion Chemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Quinoline Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Fire-Extinguishing Compositions (AREA)
  • Materials For Medical Uses (AREA)
DE602004031301T 2003-11-12 2004-10-14 Nichtsymmetrisches geliermittel Expired - Lifetime DE602004031301D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03078599 2003-11-12
PCT/NL2004/000723 WO2005047231A1 (en) 2003-11-12 2004-10-14 Non-symmetrical gelling agent

Publications (1)

Publication Number Publication Date
DE602004031301D1 true DE602004031301D1 (de) 2011-03-17

Family

ID=34585883

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602004031301T Expired - Lifetime DE602004031301D1 (de) 2003-11-12 2004-10-14 Nichtsymmetrisches geliermittel

Country Status (9)

Country Link
US (1) US7534915B2 (de)
EP (1) EP1682491B1 (de)
JP (1) JP4741505B2 (de)
CN (1) CN100453528C (de)
AT (1) ATE497489T1 (de)
CA (1) CA2544814C (de)
DE (1) DE602004031301D1 (de)
DK (1) DK1682491T3 (de)
WO (1) WO2005047231A1 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE497489T1 (de) 2003-11-12 2011-02-15 Applied Nanosystems Bv Nichtsymmetrisches geliermittel
US7220300B2 (en) 2004-12-04 2007-05-22 Xerox Corporation Phase change inks containing bis(urea-urethane) compounds
US7314949B2 (en) 2004-12-04 2008-01-01 Xerox Corporation Trans-1,2-cyclohexane bis(urea-urethane) compounds
US7153349B2 (en) 2004-12-04 2006-12-26 Xerox Corporation Phase change inks containing curable trans-1,2-cyclohexane bis(urea-urethane) compounds
US7317122B2 (en) 2004-12-04 2008-01-08 Xerox Corporation Curable trans-1,2-cyclohexane bis(urea-urethane) compounds
US7144450B2 (en) * 2004-12-04 2006-12-05 Xerox Corporation Phase change inks containing trans-1,2-cyclohexane bis(urea-urethane) compounds
US7576235B2 (en) 2004-12-04 2009-08-18 Xerox Corporation Processes for preparing bis(urea-urethane) compounds
US7560587B2 (en) 2004-12-04 2009-07-14 Xerox Corporation Bis[urea-urethane] compounds
EP1800694A1 (de) * 2005-12-23 2007-06-27 Applied NanoSystems B.V. Gele mit kontrollierter Wirkstofffreisetzung
JP4871640B2 (ja) * 2006-05-17 2012-02-08 花王株式会社 環状イミド化合物
CN101743289B (zh) 2007-07-05 2014-03-26 日产化学工业株式会社 脂质三肽型水凝胶形成剂和水凝胶
KR101717145B1 (ko) 2008-05-20 2017-03-16 노이로제스엑스, 인코포레이티드 간보호제 아세트아미노펜 공통 프로드러그
US20110229565A1 (en) 2008-09-17 2011-09-22 Karp Jeffrey M Drug Delivery Composition Comprising a Self-Assembled Gelator
BR112012023014A2 (pt) * 2010-03-12 2016-05-31 Procter & Gamble composições fluidas detergentes que compreendem um gelificante de diamido e processos para produção das mesmas
CA2792759C (en) * 2010-03-12 2014-07-08 The Procter & Gamble Company Liquid detergent compositions comprising ph tuneable amido-gellants, and processes for making
WO2011150347A2 (en) * 2010-05-28 2011-12-01 Pharmatrophix Non-peptide bdnf neurotrophin mimetics
US20130280334A1 (en) 2010-09-24 2013-10-24 Massachusetts Institute Of Technology Nanostructured Gels Capable of Controlled Release of Encapsulated Agents
US10093674B2 (en) 2011-05-31 2018-10-09 Brandeis University Supramolecular nanofibers and hydrogels based on nucleic acids functionalized with nucleobases
WO2012166706A2 (en) * 2011-05-31 2012-12-06 Brandeis University Supramolecular nanofibers and hydrogels based on oligopeptides functionalized with nucleobases
US20130303427A1 (en) * 2011-09-13 2013-11-14 Susana Fernandez Prieto MICROCAPSULE COMPOSITIONS COMPRISING pH TUNEABLE DI-AMIDO GELLANTS
KR20150134368A (ko) 2013-03-15 2015-12-01 파마트로픽스 인코포레이티드 비펩타이드 bdnf 뉴로트로핀 모방체
KR20150134369A (ko) 2013-03-15 2015-12-01 파마트로픽스 인코포레이티드 비펩타이드 bdnf 뉴로트로핀 모방체
EP3078655B1 (de) * 2013-12-06 2019-07-31 Daicel Corporation Verdickungsmittel/stabilisator und verdickte/stabilisierte zusammensetzung damit
EP3286174A1 (de) * 2015-04-23 2018-02-28 VIIV Healthcare UK (No.5) Limited Inhibitoren der neubildung menschlicher immundefektviren
US9962339B2 (en) 2015-10-08 2018-05-08 The Brigham And Women's Hospital, Inc. Stabilized assembled nanostructures for delivery of encapsulated agents
EP3452094B1 (de) 2016-05-06 2021-11-17 The Brigham and Women's Hospital, Inc. Binäre selbstangeordnete gele zur kontrollierten abgabe von verkapselten wirkstoffen an knorpel
US11020410B2 (en) 2017-02-03 2021-06-01 The Brigham And Women's Hospital, Inc. Self-assembled gels formed with anti-retroviral drugs, prodrugs thereof, and pharmaceutical uses thereof
JP7211974B2 (ja) 2017-05-08 2023-01-24 アリヴィオ セラピューティクス, インコーポレイテッド 増大した薬剤負荷および接着のためのナノ構造化ゲルの製剤
WO2020125926A1 (en) * 2018-12-17 2020-06-25 Rudjer Boskovic Institute Composition comprising oxalamide gelators and vegetable oil
CN111729622A (zh) * 2020-04-22 2020-10-02 上海交通大学医学院附属第九人民医院 一种苯丙氨酸衍生的手性超分子水凝胶及其应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08231942A (ja) * 1995-02-24 1996-09-10 Nisshin Oil Mills Ltd:The 有機液体のゲル化または固化剤
JP3641143B2 (ja) * 1998-09-01 2005-04-20 日清オイリオグループ株式会社 ベンゼンカルボン酸アミド化合物、および有機液体のゲル化または固化剤
AU2844100A (en) * 1998-12-15 2000-07-03 Yale University Association of compounds in carbon dioxide and the gels and/or foams formed therefrom
FR2811552B1 (fr) * 2000-07-17 2002-12-27 Oreal Composition notamment cosmetique ou pharmaceutique se presentant sous forme solide
EP1490028A1 (de) * 2002-04-04 2004-12-29 Applied NanoSystems B.V. Abgabe einer substanz auf eine vorbestimmte stelle
EP1364941A1 (de) * 2002-05-22 2003-11-26 Applied NanoSystems B.V. Geliermittel
ATE497489T1 (de) 2003-11-12 2011-02-15 Applied Nanosystems Bv Nichtsymmetrisches geliermittel

Also Published As

Publication number Publication date
US7534915B2 (en) 2009-05-19
JP2007510791A (ja) 2007-04-26
CA2544814C (en) 2013-05-14
WO2005047231A1 (en) 2005-05-26
US20060276676A1 (en) 2006-12-07
EP1682491A1 (de) 2006-07-26
CA2544814A1 (en) 2005-05-26
JP4741505B2 (ja) 2011-08-03
CN100453528C (zh) 2009-01-21
EP1682491B1 (de) 2011-02-02
DK1682491T3 (da) 2011-05-09
ATE497489T1 (de) 2011-02-15
CN1902160A (zh) 2007-01-24

Similar Documents

Publication Publication Date Title
DE602004031301D1 (de) Nichtsymmetrisches geliermittel
ATE296094T1 (de) Stickstoffmonoxid bildende zusammensetzungen zur behandlung von nagelbettinfektionen
BRPI0510428A (pt) composições tópicas de metadona e processos para utilização das mesmas
ATE415817T1 (de) Agrochemische formulierungen
SE0100901D0 (sv) New composition
DK1797053T3 (da) Phenothiazinium-forbindelse til sårheling
BR0209777A (pt) Formulações lìquidas estáveis
ATE376434T1 (de) Injektionsgerät für mrna applikation
DK1264602T3 (da) Farmaceutiske præparater
DE602005023755D1 (de) Indolonderivate, verfahren zu deren herstellung und deren anwendungen
BRPI0416311A (pt) composição, uso de uma composição e processo para melhorar a penetração de um agente ativo farmacêutico
NO20042158L (no) Substituert 4-fenyl-tetrahydroisokinoliner, fremgangsmate for fremstilling derav, anvendelse derav som medikamenter, i tillegg til medikamenter inneholdende samme
DK1519944T3 (da) Fremgangsmåder til fremstilling af fibrinogen
DE50312948D1 (de) Alicyclische ester mit moschusgeruch
PL1962815T3 (pl) Zastosowanie błonotwórczych polimerów do pielęgnacji włosów z grupy poluretanów i zawierające te polimery preparaty i plastry farmaceutyczne
ATE316101T1 (de) Thrombinspaltbare faktor-x-analoga
ATE256392T1 (de) Verwendung von polyaminosäurederivate als konservierungsmittel
BRPI0510422A (pt) formulação cosmética transparente à base de microemulsões contendo um ácido alfa-hidroxicarboxìlico
EA200601288A1 (ru) Производные 1,3-дифенилпроп-2-ен-1-она, способ их получения и применение
ATE329910T1 (de) 5-trityloxymethyl-2-oxazolidinon und verfahren zu dessen herstellung
DK1139980T3 (da) Kosmetisk eller medicinsk praparat til topisk anvendelse
TW200719920A (en) Topical skin care composition
BR0016638B1 (pt) compostos anÁlogos de homopiperidilbenzimidazàis substituÍdos como relaxantes féndicos, processo para preparar os mesmos, composiÇço farmacÊutica e processo para preparÁ-la.
ATE548343T1 (de) Umsetzungsprodukte von 2-propylheptanol mit 1- halogen-2,3-epoxypropanen und 1-hydroxy-2,3- epoxypropan
DE50300126D1 (de) Coffein enthaltende Zusammensetzung als Hauptflegemittel