DE602004011578D1 - Tetrahydroisochinolin- und tetrahydrobenzazepin derivative als igf-1r inhibitoren - Google Patents

Tetrahydroisochinolin- und tetrahydrobenzazepin derivative als igf-1r inhibitoren

Info

Publication number: DE602004011578D1
Authority: DE; Germany
Prior art keywords: tetrahydroisochinoline; tetrahydrobenzazepine; igf; inhibitors; derivative
Prior art date: 2004-03-12
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE602004011578T

Other languages

English (en)

Other versions

DE602004011578T2 (de

Inventor

Jan Gunzinger

Kurt Leander

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Analytecon SA

Original Assignee

Analytecon SA

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-03-12

Filing date

2004-03-12

Publication date

2008-03-13

2004-03-12 Application filed by Analytecon SA filed Critical Analytecon SA

2008-03-13 Publication of DE602004011578D1 publication Critical patent/DE602004011578D1/de

2009-02-19 Application granted granted Critical

2009-02-19 Publication of DE602004011578T2 publication Critical patent/DE602004011578T2/de

2024-03-13 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
- C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Rheumatology (AREA)
Transplantation (AREA)
Physical Education & Sports Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pain & Pain Management (AREA)
Urology & Nephrology (AREA)
Orthopedic Medicine & Surgery (AREA)
Vascular Medicine (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DE602004011578T 2004-03-12 2004-03-12 Tetrahydroisochinolin- und tetrahydrobenzazepin derivative als igf-1r inhibitoren Expired - Lifetime DE602004011578T2 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/CH2004/000147 WO2005087743A1 (en)	2004-03-12	2004-03-12	Tetrahydroisoquinoline-and tetrahydrobenzazepine derivatives as igf-1r inhibitors

Publications (2)

Publication Number	Publication Date
DE602004011578D1 true DE602004011578D1 (de)	2008-03-13
DE602004011578T2 DE602004011578T2 (de)	2009-02-19

Family

ID=34957074

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE602004011578T Expired - Lifetime DE602004011578T2 (de)	2004-03-12	2004-03-12	Tetrahydroisochinolin- und tetrahydrobenzazepin derivative als igf-1r inhibitoren

Country Status (21)

Country	Link
US (1)	US7875631B2 (de)
EP (1)	EP1732898B1 (de)
JP (1)	JP2007528877A (de)
CN (1)	CN100590118C (de)
AR (1)	AR049323A1 (de)
AT (1)	ATE384700T1 (de)
AU (1)	AU2004317166B2 (de)
BR (1)	BRPI0418462A (de)
CA (1)	CA2555745C (de)
DE (1)	DE602004011578T2 (de)
DK (1)	DK1732898T3 (de)
EA (1)	EA200601687A1 (de)
ES (1)	ES2299825T3 (de)
IL (1)	IL177307A (de)
NO (1)	NO20063794L (de)
PL (1)	PL1732898T3 (de)
PT (1)	PT1732898E (de)
SI (1)	SI1732898T1 (de)
TW (1)	TW200530213A (de)
WO (1)	WO2005087743A1 (de)
ZA (1)	ZA200607198B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1940796A1 (de) *	2005-09-09	2008-07-09	Analytecon S.A.	Isochinolinderivate als igf-1r-inhibitoren
EP1931636B1 (de) *	2005-09-09	2011-04-13	Analytecon S.A.	Isochinoline als igf-1r-inhibitoren
US8476297B2 (en)	2007-12-04	2013-07-02	Amgen Inc.	TRP-M8 receptor ligands and their use in treatments
WO2011112666A1 (en)	2010-03-09	2011-09-15	OSI Pharmaceuticals, LLC	Combination anti-cancer therapy
AU2011275417A1 (en)	2010-07-05	2013-02-21	Actelion Pharmaceuticals Ltd	1-phenyl-substituted heterocyclyl derivatives and their use as prostaglandin D2 receptor modulators
JP2014510265A (ja)	2011-02-02	2014-04-24	アムジェンインコーポレイテッド	Ｉｇｆ−１ｒの阻害に関する方法および組成物
US9700619B2 (en)	2011-11-11	2017-07-11	Duke University	Combination drug therapy for the treatment of solid tumors
TW201331179A (zh)	2011-12-21	2013-08-01	Actelion Pharmaceuticals Ltd	雜環衍生物及其作為前列腺素ｄ２受體調節劑之用途
CA2876808A1 (en)	2012-07-05	2014-01-09	Actelion Pharmaceuticals Ltd	1-phenyl-substituted heterocyclyl derivatives and their use as prostaglandin d2 receptor modulators
US8980259B2 (en)	2012-07-20	2015-03-17	Novartis Ag	Combination therapy
CN104672136B (zh) *	2013-11-30	2017-01-25	沈阳药科大学	1‑取代菲基‑n‑烷基(酰基)‑6,7‑二甲氧基‑1,2,3,4‑四氢异喹啉衍生物及其制备方法和用途
WO2017129763A1 (en)	2016-01-28	2017-08-03	INSERM (Institut National de la Santé et de la Recherche Médicale)	Methods and pharmaceutical compositions for the treatment of signet ring cell gastric cancer
CN112500345B (zh) *	2020-12-18	2022-06-21	西安石油大学	α-氰基季碳取代四氢异喹啉化合物的合成方法
WO2024067463A1 (zh) *	2022-09-27	2024-04-04	苏州阿尔脉生物科技有限公司	苯并[7]环烯类衍生物、包含其的药物组合物及其医药用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4349472A (en)	1979-04-27	1982-09-14	Schering Corporation	(S)-8(1-Adamantanecarbonyloxy)-7-chloro-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine
CA1330560C (en) *	1986-05-21	1994-07-05	Maurits E. A. Vandewalle	Di- and tetrahydroisoquinoline derivatives
WO1990002119A1 (fr) *	1988-08-18	1990-03-08	Banyu Pharmaceutical Co., Ltd.	Derives de 1,2,3,4-tetrahydro-isoquinoline
WO2000035455A1 (en)	1998-12-15	2000-06-22	Telik, Inc.	Heteroaryl-aryl ureas as igf-1 receptor antagonists
EP1113007A1 (de) *	1999-12-24	2001-07-04	Pfizer Inc.	Tetrahydroisochinolin-Verbindungen zur Verwendung als Östrogen-Agonisten/-Antagonisten
WO2002046164A1 (en) *	2000-12-07	2002-06-13	Astrazeneca Ab	Therapeutic compounds
SE0102168D0 (sv)	2001-06-19	2001-06-19	Karolinska Innovations Ab	New use and new compounds
SE0104140D0 (sv) *	2001-12-07	2001-12-07	Astrazeneca Ab	Novel Compounds
GB0212303D0 (en)	2002-05-28	2002-07-10	Isis Innovation	Molecular targetting of IGF-1 receptor

2004
- 2004-03-12 BR BRPI0418462-9A patent/BRPI0418462A/pt not_active IP Right Cessation
- 2004-03-12 DK DK04719900T patent/DK1732898T3/da active
- 2004-03-12 JP JP2007502162A patent/JP2007528877A/ja active Pending
- 2004-03-12 EP EP04719900A patent/EP1732898B1/de not_active Expired - Lifetime
- 2004-03-12 CA CA2555745A patent/CA2555745C/en not_active Expired - Fee Related
- 2004-03-12 PL PL04719900T patent/PL1732898T3/pl unknown
- 2004-03-12 ES ES04719900T patent/ES2299825T3/es not_active Expired - Lifetime
- 2004-03-12 US US10/591,174 patent/US7875631B2/en not_active Expired - Fee Related
- 2004-03-12 EA EA200601687A patent/EA200601687A1/ru unknown
- 2004-03-12 PT PT04719900T patent/PT1732898E/pt unknown
- 2004-03-12 SI SI200430684T patent/SI1732898T1/sl unknown
- 2004-03-12 DE DE602004011578T patent/DE602004011578T2/de not_active Expired - Lifetime
- 2004-03-12 AU AU2004317166A patent/AU2004317166B2/en not_active Ceased
- 2004-03-12 WO PCT/CH2004/000147 patent/WO2005087743A1/en not_active Ceased
- 2004-03-12 AT AT04719900T patent/ATE384700T1/de active
- 2004-03-12 CN CN200480042030A patent/CN100590118C/zh not_active Expired - Fee Related
2005
- 2005-02-25 TW TW094105813A patent/TW200530213A/zh unknown
- 2005-03-10 AR ARP050100920A patent/AR049323A1/es not_active Application Discontinuation
2006
- 2006-08-06 IL IL177307A patent/IL177307A/en not_active IP Right Cessation
- 2006-08-24 NO NO20063794A patent/NO20063794L/no not_active Application Discontinuation
- 2006-08-29 ZA ZA2006/07198A patent/ZA200607198B/en unknown

Also Published As

Publication number	Publication date
CN1922147A (zh)	2007-02-28
US7875631B2 (en)	2011-01-25
EP1732898A1 (de)	2006-12-20
IL177307A (en)	2011-09-27
NO20063794L (no)	2006-12-12
DK1732898T3 (da)	2008-05-13
CA2555745A1 (en)	2005-09-22
ATE384700T1 (de)	2008-02-15
AR049323A1 (es)	2006-07-19
SI1732898T1 (sl)	2008-06-30
WO2005087743A1 (en)	2005-09-22
IL177307A0 (en)	2006-12-10
ZA200607198B (en)	2008-04-30
TW200530213A (en)	2005-09-16
PT1732898E (pt)	2008-04-07
AU2004317166A1 (en)	2005-09-22
CA2555745C (en)	2011-05-31
EA200601687A1 (ru)	2007-04-27
DE602004011578T2 (de)	2009-02-19
BRPI0418462A (pt)	2007-06-05
US20070129399A1 (en)	2007-06-07
EP1732898B1 (de)	2008-01-23
AU2004317166B2 (en)	2010-11-11
CN100590118C (zh)	2010-02-17
PL1732898T3 (pl)	2008-06-30
ES2299825T3 (es)	2008-06-01
JP2007528877A (ja)	2007-10-18

Publication	Publication Date	Title
CY2022001I1 (el)	2022-03-24	Παραγωγα του uk-2a
ATE423121T1 (de)	2009-03-15	Diphenylimidazopyrimidin- und -imidazolamine als b-sekretase-inhibitoren
ATE400271T1 (de)	2008-07-15	Aryl-pyridinderivate als 11-beta-hsd1-hemmer
ATE540936T1 (de)	2012-01-15	Substituierte 2-alkyl-chinazolinonderivate als parp-hemmer
ATE420076T1 (de)	2009-01-15	Indozolonderivate als 11b-hsd1-inhibitoren
ATE520671T1 (de)	2011-09-15	Pyrimidin-harnstoff-derivate als kinase-hemmer
DE602005017215D1 (de)	2009-12-03	Thiadiazolidinone als GSK3-Inhibitoren
ATE452631T1 (de)	2010-01-15	N-2-adamantanyl-2-phenoxy-acetamid-derivate als 11-betahydroxysteroid-dehydrogenase-hemmer
PT1586571E (pt)	2008-09-08	Inibidores da dipeptidil-peptidase
ATE527240T1 (de)	2011-10-15	Polyzyklische indazol-derivate als erk-hemmer
ATE437876T1 (de)	2009-08-15	Hexahydropyridoisochinoline als dpp-iv- inhibitoren
DE602006011363D1 (de)	2010-02-04	Heteroaryl-substituierte piperidin-derivate als l-cpt1-hemmer
ATE485268T1 (de)	2010-11-15	Pyrrolidin-derivate als erk-hemmer
DK2253614T3 (da)	2013-01-07	IAP-inhibitorer
DK1778718T3 (da)	2014-11-10	Iap-inhibitorer
DE602007008837D1 (de)	2010-10-14	Als protein-kinase-inhibitoren nutzbare dyhydrodiazepine
ATE531705T1 (de)	2011-11-15	Substituierte 2-chinolyloxazole geeignet als pde4 inhibitoren
ZA200610771B (en)	2008-08-27	Quinazolinedolone derivatives as PARP inhibitors
ATE501138T1 (de)	2011-03-15	Thiophenderivate als chk-1-inhibitoren
ATE478868T1 (de)	2010-09-15	Pyrrolodihydroisochinoline als pde10- inhibitoren
ATE553079T1 (de)	2012-04-15	Heteroarylphenylharnstoffderivat
ATE509011T1 (de)	2011-05-15	Pyrimidinderivate als 11beta-hsd1-inhibitoren
ATE462692T1 (de)	2010-04-15	3-amino-1-arylpropyl-indole als monoamin- wiederaufnahmehemmer
DE602004011578D1 (de)	2008-03-13	Tetrahydroisochinolin- und tetrahydrobenzazepin derivative als igf-1r inhibitoren
ATE433449T1 (de)	2009-06-15	Kinaseinhibitoren

Legal Events

Date	Code	Title	Description
2009-02-12	8364	No opposition during term of opposition