DE602004004143D1 - Imidazopyrimidine und triazolopyrimidine: benzodiazepinrezeptorliganden - Google Patents
Imidazopyrimidine und triazolopyrimidine: benzodiazepinrezeptorligandenInfo
- Publication number
- DE602004004143D1 DE602004004143D1 DE602004004143T DE602004004143T DE602004004143D1 DE 602004004143 D1 DE602004004143 D1 DE 602004004143D1 DE 602004004143 T DE602004004143 T DE 602004004143T DE 602004004143 T DE602004004143 T DE 602004004143T DE 602004004143 D1 DE602004004143 D1 DE 602004004143D1
- Authority
- DE
- Germany
- Prior art keywords
- imidazopyrimidine
- triazolopyrimidine
- receptor ligands
- benzodiazepine receptor
- benzodiazepine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 title 1
- 102000004300 GABA-A Receptors Human genes 0.000 title 1
- 108090000839 GABA-A Receptors Proteins 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
- YWBFPKPWMSWWEA-UHFFFAOYSA-O triazolopyrimidine Chemical compound BrC1=CC=CC(C=2N=C3N=CN[N+]3=C(NCC=3C=CN=CC=3)C=2)=C1 YWBFPKPWMSWWEA-UHFFFAOYSA-O 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49000603P | 2003-07-25 | 2003-07-25 | |
| US490006P | 2003-07-25 | ||
| US54308304P | 2004-02-09 | 2004-02-09 | |
| US543083P | 2004-02-09 | ||
| PCT/US2004/023794 WO2005012306A2 (en) | 2003-07-25 | 2004-07-23 | Imidazo-pyrimidines and triazolo-pyrimidines: benzodiazepine receptor ligands |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE602004004143D1 true DE602004004143D1 (de) | 2007-02-15 |
| DE602004004143T2 DE602004004143T2 (de) | 2007-10-11 |
Family
ID=34118813
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602004004143T Expired - Lifetime DE602004004143T2 (de) | 2003-07-25 | 2004-07-23 | Imidazopyrimidine und triazolopyrimidine: benzodiazepinrezeptorliganden |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US7271170B2 (de) |
| EP (1) | EP1648899B1 (de) |
| JP (1) | JP2007500130A (de) |
| KR (1) | KR20060098425A (de) |
| AR (1) | AR045117A1 (de) |
| AT (1) | ATE350382T1 (de) |
| AU (1) | AU2004261591A1 (de) |
| BR (1) | BRPI0412908A (de) |
| CA (1) | CA2537331A1 (de) |
| CY (1) | CY1107565T1 (de) |
| DE (1) | DE602004004143T2 (de) |
| DK (1) | DK1648899T3 (de) |
| ES (1) | ES2278345T3 (de) |
| IL (1) | IL173265A0 (de) |
| MX (1) | MXPA06000887A (de) |
| NZ (1) | NZ544262A (de) |
| PL (1) | PL1648899T3 (de) |
| PT (1) | PT1648899E (de) |
| TW (1) | TW200524937A (de) |
| WO (1) | WO2005012306A2 (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7482366B2 (en) * | 2001-12-21 | 2009-01-27 | X-Ceptor Therapeutics, Inc. | Modulators of LXR |
| EP1619948A4 (de) * | 2003-05-05 | 2007-02-14 | Neurogen Corp | Substituierte imidazolpyrazin- und triazolpyrazinderivate: gabaa-rezeptor-liganden |
| US20080167324A1 (en) * | 2005-03-02 | 2008-07-10 | Yuelian Xu | Thiazolymethyl and Oxazolylmethyl Heteroaryl Derivatives |
| TW200800213A (en) | 2005-09-02 | 2008-01-01 | Abbott Lab | Novel imidazo based heterocycles |
| WO2008128116A1 (en) * | 2007-04-11 | 2008-10-23 | Cypress Biosciences, Inc. | Treatment of down syndrome with benzodiazepine receptor antagonists |
| CN101687873A (zh) * | 2007-04-17 | 2010-03-31 | 百时美施贵宝公司 | 具有稠合杂环的11β-羟基类固醇Ⅰ型脱氢酶抑制剂 |
| GB0719803D0 (en) | 2007-10-10 | 2007-11-21 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
| US20090270373A1 (en) * | 2008-04-11 | 2009-10-29 | Cypress Biosciences, Inc. | Treatment of down syndrom with benzodiazepine receptor antagonists |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US544057A (en) * | 1895-08-06 | Bill and letter file | ||
| EP1165557B1 (de) * | 1999-04-02 | 2004-09-29 | Neurogen Corporation | Aryl- und heteroaryl-kondensierte aminoalkyl-imidazol-derivate: selektive modulatoren der gabaa-rezeptoren |
| US6737242B1 (en) * | 1999-05-07 | 2004-05-18 | Neurogen Corporation | Methods for screening GABA-modulatory compounds for specified pharmacological activities |
| GB9929687D0 (en) * | 1999-12-15 | 2000-02-09 | Merck Sharp & Dohme | Therapeutic agents |
| US6552037B2 (en) * | 2000-06-30 | 2003-04-22 | Neurogen Corporation | 2-Substituted imidazo[1,2-A]pyridine derivatives |
| GB0027561D0 (en) * | 2000-11-10 | 2000-12-27 | Merck Sharp & Dohme | Therapeutic agents |
| US6900215B2 (en) * | 2000-12-15 | 2005-05-31 | Merck Sharp & Dohme Ltd. | Imidazo-pyrimidine derivatives as ligands for gaba receptors |
| PA8535601A1 (es) * | 2000-12-21 | 2002-11-28 | Pfizer | Derivados benzimidazol y piridilimidazol como ligandos para gabaa |
| TWI248936B (en) * | 2001-03-21 | 2006-02-11 | Merck Sharp & Dohme | Imidazo-pyrimidine derivatives as ligands for GABA receptors |
| US7030128B2 (en) * | 2001-03-23 | 2006-04-18 | Merck Sharp & Dohme Ltd. | Imidazo-pyrimidine derivatives as ligands for GABA receptors |
| IL159811A0 (en) * | 2001-07-13 | 2004-06-20 | Neurogen Corp | Heteroaryl substituted fused bicyclic heteroaryl compounds as gabaa receptor ligands |
| GB0128499D0 (en) * | 2001-11-28 | 2002-01-23 | Merck Sharp & Dohme | Therapeutic agents |
| AU2003245259A1 (en) * | 2002-05-02 | 2003-11-17 | Neurogen Corporation | Substituted imidazole derivatives: gabaa receptor ligands |
| EP1501825A2 (de) * | 2002-05-08 | 2005-02-02 | Neurogen Corporation | Substituierte imidazolylmethylpyridin- und pyrazinderivate: gabaa-rezeptorliganden |
| WO2003097643A1 (en) * | 2002-05-17 | 2003-11-27 | Neurogen Corporation | Substituted ring-fused imidazole derivates: gabaa receptor ligands |
| CN100579579C (zh) * | 2002-10-01 | 2010-01-13 | 诺华疫苗和诊断公司 | 抗癌及抗感染性疾病组合物及其使用方法 |
| JP2006508102A (ja) | 2002-11-08 | 2006-03-09 | ニューロジェン・コーポレイション | Ｇａｂａａ受容体のリガンドとしての４−イミダゾール−１−イルメチル−ピリミジン誘導体 |
| EP1619948A4 (de) | 2003-05-05 | 2007-02-14 | Neurogen Corp | Substituierte imidazolpyrazin- und triazolpyrazinderivate: gabaa-rezeptor-liganden |
-
2004
- 2004-07-23 DE DE602004004143T patent/DE602004004143T2/de not_active Expired - Lifetime
- 2004-07-23 WO PCT/US2004/023794 patent/WO2005012306A2/en not_active Ceased
- 2004-07-23 EP EP04779031A patent/EP1648899B1/de not_active Expired - Lifetime
- 2004-07-23 DK DK04779031T patent/DK1648899T3/da active
- 2004-07-23 MX MXPA06000887A patent/MXPA06000887A/es active IP Right Grant
- 2004-07-23 PL PL04779031T patent/PL1648899T3/pl unknown
- 2004-07-23 AU AU2004261591A patent/AU2004261591A1/en not_active Abandoned
- 2004-07-23 CA CA002537331A patent/CA2537331A1/en not_active Abandoned
- 2004-07-23 KR KR1020067001782A patent/KR20060098425A/ko not_active Ceased
- 2004-07-23 JP JP2006521278A patent/JP2007500130A/ja active Pending
- 2004-07-23 US US10/898,690 patent/US7271170B2/en not_active Expired - Lifetime
- 2004-07-23 AT AT04779031T patent/ATE350382T1/de not_active IP Right Cessation
- 2004-07-23 BR BRPI0412908-3A patent/BRPI0412908A/pt not_active IP Right Cessation
- 2004-07-23 PT PT04779031T patent/PT1648899E/pt unknown
- 2004-07-23 ES ES04779031T patent/ES2278345T3/es not_active Expired - Lifetime
- 2004-07-23 NZ NZ544262A patent/NZ544262A/xx unknown
- 2004-07-26 AR ARP040102649A patent/AR045117A1/es unknown
- 2004-07-26 TW TW093122247A patent/TW200524937A/zh unknown
-
2006
- 2006-01-19 IL IL173265A patent/IL173265A0/en unknown
-
2007
- 2007-02-26 CY CY20071100262T patent/CY1107565T1/el unknown
- 2007-09-14 US US11/855,386 patent/US20080139580A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| PT1648899E (pt) | 2007-03-30 |
| AU2004261591A1 (en) | 2005-02-10 |
| US7271170B2 (en) | 2007-09-18 |
| EP1648899B1 (de) | 2007-01-03 |
| ES2278345T3 (es) | 2007-08-01 |
| US20050038043A1 (en) | 2005-02-17 |
| JP2007500130A (ja) | 2007-01-11 |
| CY1107565T1 (el) | 2013-03-13 |
| EP1648899A2 (de) | 2006-04-26 |
| AR045117A1 (es) | 2005-10-19 |
| NZ544262A (en) | 2009-06-26 |
| KR20060098425A (ko) | 2006-09-18 |
| MXPA06000887A (es) | 2006-04-19 |
| CA2537331A1 (en) | 2005-02-10 |
| DE602004004143T2 (de) | 2007-10-11 |
| DK1648899T3 (da) | 2007-04-02 |
| US20080139580A1 (en) | 2008-06-12 |
| ATE350382T1 (de) | 2007-01-15 |
| PL1648899T3 (pl) | 2007-06-29 |
| TW200524937A (en) | 2005-08-01 |
| IL173265A0 (en) | 2006-06-11 |
| HK1089446A1 (en) | 2006-12-01 |
| WO2005012306A2 (en) | 2005-02-10 |
| BRPI0412908A (pt) | 2006-09-26 |
| WO2005012306A3 (en) | 2005-04-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |