DE60140941D1 - Hyaluronsäure oligosaccharid fraktionen und medikamente, die diese enthalten - Google Patents
Hyaluronsäure oligosaccharid fraktionen und medikamente, die diese enthaltenInfo
- Publication number
- DE60140941D1 DE60140941D1 DE60140941T DE60140941T DE60140941D1 DE 60140941 D1 DE60140941 D1 DE 60140941D1 DE 60140941 T DE60140941 T DE 60140941T DE 60140941 T DE60140941 T DE 60140941T DE 60140941 D1 DE60140941 D1 DE 60140941D1
- Authority
- DE
- Germany
- Prior art keywords
- hyaluronic acid
- agent
- acid oligosaccharides
- inhibitor
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- -1 HYALURONIC ACID OLIGOSACCHARIDE Chemical class 0.000 title abstract 4
- 229920002674 hyaluronan Polymers 0.000 title abstract 4
- 229960003160 hyaluronic acid Drugs 0.000 title abstract 4
- 229920001542 oligosaccharide Polymers 0.000 title abstract 4
- 239000003814 drug Substances 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 abstract 3
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 102000002812 Heat-Shock Proteins Human genes 0.000 abstract 1
- 108010004889 Heat-Shock Proteins Proteins 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000003699 antiulcer agent Substances 0.000 abstract 1
- 150000001720 carbohydrates Chemical class 0.000 abstract 1
- 230000005779 cell damage Effects 0.000 abstract 1
- 230000030833 cell death Effects 0.000 abstract 1
- 208000037887 cell injury Diseases 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 230000031261 interleukin-10 production Effects 0.000 abstract 1
- 230000021995 interleukin-8 production Effects 0.000 abstract 1
- 239000000082 organ preservation Substances 0.000 abstract 1
- 230000004526 pharmaceutical effect Effects 0.000 abstract 1
- 239000003223 protective agent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
- C07H7/02—Acyclic radicals
- C07H7/033—Uronic acids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Polymers & Plastics (AREA)
- Dermatology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Materials Engineering (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2000206404 | 2000-07-07 | ||
| JP2000247840 | 2000-08-17 | ||
| PCT/JP2001/005918 WO2002004471A1 (fr) | 2000-07-07 | 2001-07-06 | Fractions oligosaccharidiques d'acide hyaluronique et medicament les contenant |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60140941D1 true DE60140941D1 (de) | 2010-02-11 |
Family
ID=26595584
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60140941T Expired - Lifetime DE60140941D1 (de) | 2000-07-07 | 2001-07-06 | Hyaluronsäure oligosaccharid fraktionen und medikamente, die diese enthalten |
Country Status (9)
| Country | Link |
|---|---|
| US (5) | US7507723B2 (de) |
| EP (1) | EP1300412B1 (de) |
| JP (1) | JP4861596B2 (de) |
| CN (1) | CN100369925C (de) |
| AT (1) | ATE453655T1 (de) |
| AU (3) | AU6947801A (de) |
| CA (2) | CA2698561C (de) |
| DE (1) | DE60140941D1 (de) |
| WO (1) | WO2002004471A1 (de) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7511026B2 (en) | 2003-03-25 | 2009-03-31 | Seikagaku Corporation | Therapeutic agent for nerve damage |
| JP4576583B2 (ja) * | 2005-03-22 | 2010-11-10 | キユーピー株式会社 | ヒアルロン酸またはその塩、およびその製造方法、ならびにこれを含有する化粧料および食品組成物 |
| JP2007084509A (ja) * | 2005-09-26 | 2007-04-05 | Toshitsu Kagaku Kenkyusho:Kk | 細胞賦活剤 |
| US20070099867A1 (en) * | 2005-05-24 | 2007-05-03 | Glycoscience Laboratories, Inc. | Pharmaceutical agent containing hyaluronan as an active ingredient |
| JP2007153761A (ja) * | 2005-12-01 | 2007-06-21 | Toshitsu Kagaku Kenkyusho:Kk | シナプス伝達促進剤及びシナプス保護剤 |
| NO20064337L (no) * | 2005-09-26 | 2007-03-27 | Glycoscience Lab Inc | Farmasoytisk middel inneholdende hyaluronan som en aktiv ingrediens |
| JP2009091248A (ja) * | 2006-01-17 | 2009-04-30 | Toshitsu Kagaku Kenkyusho:Kk | 外傷性神経障害および／または運動機能障害の治療薬 |
| EP1992645A4 (de) * | 2006-02-24 | 2011-03-09 | Q P Corp | Neue niedermolekulare hyaluronsäure und/oder salz davon und kosmetische zubereitung, pharmazeutische zusammenstezung und lebensmittelzusammensetzung damit |
| JP5457675B2 (ja) * | 2006-10-17 | 2014-04-02 | 株式会社ヒアルロン酸研究所 | アトピー性皮膚炎の治療薬又は予防薬 |
| RU2385157C1 (ru) * | 2006-12-05 | 2010-03-27 | Гликосайенс Лабораториз, Инк. | Лечение остеоартрита |
| CA2641571C (en) | 2006-12-05 | 2010-01-19 | Glycoscience Laboratories, Inc. | Treatment of osteoarthritis |
| WO2009046530A1 (en) * | 2007-10-12 | 2009-04-16 | London Health Sciences Centre Research Inc. | Compositions affecting hyaluronic acid mediated activity |
| CN101326963B (zh) * | 2008-03-03 | 2011-06-22 | 北京神州圣业科技有限公司 | 一种碱性阳离子饲料免疫增强剂溶液、生产方法及其用途 |
| JPWO2009113512A1 (ja) * | 2008-03-11 | 2011-07-21 | キユーピー株式会社 | Ｓｏｃｓ３発現促進剤、これを含有する医薬品および食品、ならびにｓｏｃｓ３の発現を促進する方法 |
| TW201031749A (en) | 2009-02-10 | 2010-09-01 | Otsuka Chemical Co Ltd | IgG-Fc fragment and method for manufacturing the same |
| JP5587637B2 (ja) * | 2009-04-10 | 2014-09-10 | 生化学工業株式会社 | マトリックスメタロプロテアーゼ阻害剤及びその用途 |
| SG11201404959TA (en) | 2012-02-22 | 2014-11-27 | Hyaluronan Res Inst Inc | Sirtuin inducer, tissue repairing agent, hepatocyte growth factor inducer, tissue homeostasis maintenance agent, and tlr4 agonist, having hyaluronic acid fragment as active agent |
| EP2698636A1 (de) * | 2012-08-13 | 2014-02-19 | Fundació Institut d'Investigació Biomèdica de Bellvitge | Verfahren und Reagenzien zur Vorbeugung und/oder Behandlung von Transplantatabstoßung |
| US10723812B2 (en) * | 2014-02-06 | 2020-07-28 | New York University | Method for separating hyaluronan and quantifying its molecular mass distribution in biological samples |
| KR20180028787A (ko) * | 2016-09-09 | 2018-03-19 | 삼성전자주식회사 | 디펙 검사 시스템과 방법, 및 그 검사 방법을 이용한 반도체 소자 제조방법 |
| JP7330893B2 (ja) | 2017-03-10 | 2023-08-22 | ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル | 短時間作用型ヘパリンベースの抗凝集剤化合物及び方法 |
| JP7285048B2 (ja) * | 2017-03-31 | 2023-06-01 | ロート製薬株式会社 | ヒアルロン酸オリゴ糖含有組成物の製造方法 |
| WO2019010216A1 (en) | 2017-07-03 | 2019-01-10 | The University Of North Carolina At Chapel Hill | ENZYMATIC SYNTHESIS OF HOMOGENEOUS CHONDROITIN SULFATE OLIGOSACCHARIDES |
| US11865137B2 (en) | 2017-11-03 | 2024-01-09 | The University Of North Carolina At Chapel Hill | Sulfated oligosaccharides having anti-inflammatory activity |
| CN112437667B (zh) | 2018-06-20 | 2024-05-28 | 北卡罗来纳大学查珀尔希尔分校 | 细胞保护方法和组合物 |
| CN109517012B (zh) * | 2018-11-13 | 2020-05-22 | 华熙生物科技股份有限公司 | 一种透明质酸寡糖的制备方法 |
| CN109528753B (zh) * | 2018-12-20 | 2021-01-22 | 四川大学华西医院 | 寡聚透明质酸或其盐在制备治疗心肌梗死的药物中的用途 |
| CN113876623B (zh) * | 2021-09-24 | 2024-06-14 | 华熙生物科技股份有限公司 | 一种透明质酸寡糖组合物在抗皮肤衰老、促进胶原蛋白生成中的用途 |
| CN115774066B (zh) * | 2022-11-16 | 2024-08-27 | 南京乐韬生物科技有限公司 | 一种分析超低分子量透明质酸组分比例的方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4141973A (en) * | 1975-10-17 | 1979-02-27 | Biotrics, Inc. | Ultrapure hyaluronic acid and the use thereof |
| JPH06107538A (ja) * | 1992-03-31 | 1994-04-19 | Shiseido Co Ltd | 角膜移植用眼球保存液 |
| US5902795A (en) * | 1992-06-16 | 1999-05-11 | Trustees Of Tufts College | Oligosaccharides reactive with hyaluronan-binding protein and their methods of use |
| US5616568A (en) * | 1993-11-30 | 1997-04-01 | The Research Foundation Of State University Of New York | Functionalized derivatives of hyaluronic acid |
| JP4195107B2 (ja) * | 1996-02-16 | 2008-12-10 | 生化学工業株式会社 | ストレス蛋白質発現増強剤 |
| IT1287227B1 (it) | 1996-04-04 | 1998-08-04 | Fidia Spa In Amministrazione S | Acido ialuronico quale componente del liquido di conservazione della cornea |
| JPH11246301A (ja) | 1998-02-27 | 1999-09-14 | Denki Kagaku Kogyo Kk | 臓器保存溶液 |
| JP4301602B2 (ja) | 1998-09-28 | 2009-07-22 | 株式会社マルハニチロ水産 | 血管内皮細胞増殖促進剤 |
| RU2218922C2 (ru) * | 1998-04-30 | 2003-12-20 | Маруха Корпорейшн | Соединения, имеющие в своей структуре фрагмент производного глюкуроновой кислоты и фрагмент производного глюкозамина, способы получения этих соединений и применение этих соединений |
| JP4301591B2 (ja) | 1998-04-30 | 2009-07-22 | 株式会社マルハニチロ水産 | 新規な血小板粘着凝集抑制物質、その製造法およびその用途 |
| US7511026B2 (en) * | 2003-03-25 | 2009-03-31 | Seikagaku Corporation | Therapeutic agent for nerve damage |
-
2001
- 2001-07-06 JP JP2002509334A patent/JP4861596B2/ja not_active Expired - Fee Related
- 2001-07-06 AU AU6947801A patent/AU6947801A/xx active Pending
- 2001-07-06 DE DE60140941T patent/DE60140941D1/de not_active Expired - Lifetime
- 2001-07-06 WO PCT/JP2001/005918 patent/WO2002004471A1/ja not_active Ceased
- 2001-07-06 EP EP01947909A patent/EP1300412B1/de not_active Expired - Lifetime
- 2001-07-06 AT AT01947909T patent/ATE453655T1/de not_active IP Right Cessation
- 2001-07-06 AU AU2001269478A patent/AU2001269478B2/en not_active Ceased
- 2001-07-06 CA CA2698561A patent/CA2698561C/en not_active Expired - Fee Related
- 2001-07-06 CN CNB018124321A patent/CN100369925C/zh not_active Expired - Fee Related
- 2001-07-06 CA CA2414211A patent/CA2414211C/en not_active Expired - Fee Related
- 2001-07-06 US US10/312,879 patent/US7507723B2/en not_active Expired - Fee Related
-
2006
- 2006-12-21 AU AU2006252178A patent/AU2006252178B2/en not_active Ceased
-
2007
- 2007-01-12 US US11/622,673 patent/US7601488B2/en not_active Expired - Fee Related
- 2007-10-30 US US11/928,833 patent/US20080182983A1/en not_active Abandoned
-
2009
- 2009-05-27 US US12/472,479 patent/US20090291914A1/en not_active Abandoned
-
2011
- 2011-05-25 US US13/115,435 patent/US8314079B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JPWO2002004471A1 (ja) | 2004-01-15 |
| JP4861596B2 (ja) | 2012-01-25 |
| CA2414211C (en) | 2011-08-02 |
| AU2006252178B2 (en) | 2010-05-27 |
| US20050090661A1 (en) | 2005-04-28 |
| EP1300412B1 (de) | 2009-12-30 |
| US20110224169A1 (en) | 2011-09-15 |
| US8314079B2 (en) | 2012-11-20 |
| US20090291914A1 (en) | 2009-11-26 |
| CA2698561A1 (en) | 2002-01-17 |
| CA2414211A1 (en) | 2003-01-06 |
| CN1440418A (zh) | 2003-09-03 |
| AU2001269478B2 (en) | 2006-09-21 |
| CA2698561C (en) | 2012-07-10 |
| EP1300412A4 (de) | 2004-08-18 |
| US20070134646A1 (en) | 2007-06-14 |
| ATE453655T1 (de) | 2010-01-15 |
| US20080182983A1 (en) | 2008-07-31 |
| AU2006252178A1 (en) | 2007-01-18 |
| AU6947801A (en) | 2002-01-21 |
| CN100369925C (zh) | 2008-02-20 |
| EP1300412A1 (de) | 2003-04-09 |
| US7601488B2 (en) | 2009-10-13 |
| WO2002004471A1 (fr) | 2002-01-17 |
| US7507723B2 (en) | 2009-03-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |