DE60132337D1 - Nicht-sedierende barbituratverbindungen als neuroprotektive wirkstoffe - Google Patents
Nicht-sedierende barbituratverbindungen als neuroprotektive wirkstoffeInfo
- Publication number
- DE60132337D1 DE60132337D1 DE60132337T DE60132337T DE60132337D1 DE 60132337 D1 DE60132337 D1 DE 60132337D1 DE 60132337 T DE60132337 T DE 60132337T DE 60132337 T DE60132337 T DE 60132337T DE 60132337 D1 DE60132337 D1 DE 60132337D1
- Authority
- DE
- Germany
- Prior art keywords
- seding
- active substances
- barbiturate
- sedative
- barbiturate compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- HNYOPLTXPVRDBG-UHFFFAOYSA-N barbituric acid Chemical class O=C1CC(=O)NC(=O)N1 HNYOPLTXPVRDBG-UHFFFAOYSA-N 0.000 title abstract 2
- 230000000324 neuroprotective effect Effects 0.000 title abstract 2
- 239000013543 active substance Substances 0.000 title 1
- 239000000932 sedative agent Substances 0.000 abstract 3
- 230000001624 sedative effect Effects 0.000 abstract 3
- 229940125717 barbiturate Drugs 0.000 abstract 2
- 230000004112 neuroprotection Effects 0.000 abstract 2
- IKVPZYAOGOJTLK-UHFFFAOYSA-N 5,5-diphenyl-1,3-diazinane-2,4,6-trione Chemical compound O=C1NC(=O)NC(=O)C1(C=1C=CC=CC=1)C1=CC=CC=C1 IKVPZYAOGOJTLK-UHFFFAOYSA-N 0.000 abstract 1
- 206010002091 Anaesthesia Diseases 0.000 abstract 1
- 230000037005 anaesthesia Effects 0.000 abstract 1
- -1 barbiturate compound Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
- A61K31/515—Barbituric acids; Derivatives thereof, e.g. sodium pentobarbital
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22167200P | 2000-07-26 | 2000-07-26 | |
| US221672P | 2000-07-26 | ||
| PCT/US2001/023420 WO2002007729A1 (en) | 2000-07-26 | 2001-07-26 | Non-sedating barbiturate compounds as neuroprotective agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60132337D1 true DE60132337D1 (de) | 2008-02-21 |
| DE60132337T2 DE60132337T2 (de) | 2009-02-12 |
Family
ID=22828824
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60132337T Expired - Lifetime DE60132337T2 (de) | 2000-07-26 | 2001-07-26 | Nicht-sedierende barbituratverbindungen als neuroprotektive wirkstoffe |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP1311270B1 (de) |
| JP (1) | JP5047442B2 (de) |
| CN (2) | CN1329032C (de) |
| AT (1) | ATE383159T1 (de) |
| AU (2) | AU8077801A (de) |
| BR (1) | BR0112775A (de) |
| CA (1) | CA2416535C (de) |
| DE (1) | DE60132337T2 (de) |
| ES (1) | ES2300349T3 (de) |
| IL (3) | IL154060A0 (de) |
| MX (1) | MXPA03000824A (de) |
| PT (1) | PT1311270E (de) |
| WO (1) | WO2002007729A1 (de) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6093820A (en) | 1997-10-02 | 2000-07-25 | Taro Pharmaceutical Industries Ltd. | Method and reagents for N-alkylating ureides |
| US6939873B2 (en) | 2000-07-26 | 2005-09-06 | Taro Pharmaceuticals Industries Limited | Non-sedating barbituric acid derivatives |
| US7683071B2 (en) | 2000-07-26 | 2010-03-23 | Taro Pharmaceuticals Industries Ltd. | Composition and method for improved bioavailability and enhanced brain delivery of 5,5-diphenyl barbituric acid |
| US6756379B2 (en) | 2001-07-26 | 2004-06-29 | Taro Pharmaceutical Industries Ltd. | Non-sedating barbiturate compounds as neuroprotective agents |
| CN1329032C (zh) * | 2000-07-26 | 2007-08-01 | 塔罗制药工业有限公司 | 非镇静巴比土酸盐化合物用作神经保护剂 |
| EP1485101A4 (de) * | 2002-01-30 | 2006-04-12 | Taro Pharma Ind | Nichtsedierende barbitursäure-derivate |
| HK1079703A1 (zh) | 2002-10-11 | 2006-04-13 | 巴克斯特国际公司 | 通过静脉施用卤化挥发性麻醉药保护心脏和保护神经的方法 |
| CN101569626B (zh) * | 2002-12-11 | 2012-02-08 | 塔罗制药工业有限公司 | 使用巴比土酸衍生物治疗运动障碍的方法 |
| EP1625848A1 (de) * | 2004-08-10 | 2006-02-15 | Taro Pharmaceuticals North America, Inc. | Zusammensetzung und Verfahren zur verbesserten Abgabe von 5,5-Diphenylbarbitursäure |
| RU2370266C2 (ru) * | 2007-12-21 | 2009-10-20 | Федеральное государственное учреждение "Межотраслевой научно-технический комплекс "Микрохирургия глаза" имени академика С.Н. Федорова Федерального агентства по высокотехнологичной медицинской помощи" | Способ общего обезболивания |
| WO2013038427A1 (en) * | 2011-09-12 | 2013-03-21 | Council Of Scientific & Industrial Research | ARYLATED β-DICARBOIMYL COMPOUNDS AND PROCESS FOR THE PREPARATION THEREOF |
| CN102863579B (zh) * | 2012-09-14 | 2014-02-05 | 东南大学 | 一种巴比妥酸螯合树脂及其制备方法和应用 |
| US11016084B2 (en) | 2015-10-05 | 2021-05-25 | The University Of North Carolina At Chapel Hill | Decoding methods for multiplexing assays and associated fluidic devices, kits, and solid supports |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL69722A (en) * | 1983-09-14 | 1986-09-30 | Taro Pharma Ind | Oxopyrimidine derivatives and pharmaceutical compositions containing them |
| US4833148A (en) * | 1987-04-09 | 1989-05-23 | Washington University | Method of using alkenyl- or alkynyl-substituted thiobarbiturates to reduce neurotoxic injury |
| US5474990A (en) * | 1989-10-20 | 1995-12-12 | Olney; John W. | Barbiturates as safening agents in conjunction with NMDA antagonists |
| CN1329032C (zh) * | 2000-07-26 | 2007-08-01 | 塔罗制药工业有限公司 | 非镇静巴比土酸盐化合物用作神经保护剂 |
-
2001
- 2001-07-26 CN CNB018151426A patent/CN1329032C/zh not_active Expired - Fee Related
- 2001-07-26 AT AT01959195T patent/ATE383159T1/de not_active IP Right Cessation
- 2001-07-26 PT PT01959195T patent/PT1311270E/pt unknown
- 2001-07-26 WO PCT/US2001/023420 patent/WO2002007729A1/en not_active Ceased
- 2001-07-26 ES ES01959195T patent/ES2300349T3/es not_active Expired - Lifetime
- 2001-07-26 AU AU8077801A patent/AU8077801A/xx active Pending
- 2001-07-26 CA CA2416535A patent/CA2416535C/en not_active Expired - Fee Related
- 2001-07-26 IL IL15406001A patent/IL154060A0/xx unknown
- 2001-07-26 MX MXPA03000824A patent/MXPA03000824A/es active IP Right Grant
- 2001-07-26 EP EP01959195A patent/EP1311270B1/de not_active Expired - Lifetime
- 2001-07-26 AU AU2001280778A patent/AU2001280778B2/en not_active Ceased
- 2001-07-26 CN CNB2006100813267A patent/CN100522172C/zh not_active Expired - Fee Related
- 2001-07-26 JP JP2002513464A patent/JP5047442B2/ja not_active Expired - Fee Related
- 2001-07-26 BR BR0112775-6A patent/BR0112775A/pt not_active Application Discontinuation
- 2001-07-26 DE DE60132337T patent/DE60132337T2/de not_active Expired - Lifetime
-
2003
- 2003-01-20 IL IL154060A patent/IL154060A/en not_active IP Right Cessation
-
2004
- 2004-11-03 IL IL16501704A patent/IL165017A0/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2001280778B2 (en) | 2004-09-02 |
| PT1311270E (pt) | 2008-04-15 |
| CN100522172C (zh) | 2009-08-05 |
| BR0112775A (pt) | 2003-12-30 |
| IL165017A0 (en) | 2005-12-18 |
| WO2002007729A9 (en) | 2002-08-08 |
| CN1461219A (zh) | 2003-12-10 |
| DE60132337T2 (de) | 2009-02-12 |
| EP1311270A1 (de) | 2003-05-21 |
| IL154060A (en) | 2013-05-30 |
| AU8077801A (en) | 2002-02-05 |
| CA2416535C (en) | 2010-11-16 |
| MXPA03000824A (es) | 2004-11-01 |
| JP2004517808A (ja) | 2004-06-17 |
| EP1311270B1 (de) | 2008-01-09 |
| ATE383159T1 (de) | 2008-01-15 |
| WO2002007729A1 (en) | 2002-01-31 |
| CA2416535A1 (en) | 2002-01-31 |
| ES2300349T3 (es) | 2008-06-16 |
| HK1100814A1 (en) | 2007-09-28 |
| CN1329032C (zh) | 2007-08-01 |
| EP1311270A4 (de) | 2006-04-12 |
| CN1872067A (zh) | 2006-12-06 |
| JP5047442B2 (ja) | 2012-10-10 |
| IL154060A0 (en) | 2003-07-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |