DE60130813D1 - Verfahren zum herbeiführen eines eisprungs mittels eines nicht-polypeptid camp-level-modulators - Google Patents

Verfahren zum herbeiführen eines eisprungs mittels eines nicht-polypeptid camp-level-modulators

Info

Publication number: DE60130813D1
Authority: DE; Germany
Prior art keywords: causing; level modulator; camp level; host; polypeptide camp
Prior art date: 2001-12-14
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE60130813T

Other languages

English (en)

Other versions

DE60130813T2 (de

Inventor

Stephen Palmer

Mark Tepper

Sean Mckenna

Michael C Macnamee

Aliza Eshkol

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Merck Serono SA

Serono Laboratories UK Ltd

Original Assignee

Laboratoires Serono SA

Serono Laboratories UK Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-12-14

Filing date

2001-12-14

Publication date

2007-11-15

2001-12-14 Application filed by Laboratoires Serono SA, Serono Laboratories UK Ltd filed Critical Laboratoires Serono SA

2007-11-15 Application granted granted Critical

2007-11-15 Publication of DE60130813D1 publication Critical patent/DE60130813D1/de

2008-07-03 Publication of DE60130813T2 publication Critical patent/DE60130813T2/de

2021-12-15 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
- A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Epidemiology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Immunology (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Pregnancy & Childbirth (AREA)
Gynecology & Obstetrics (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Steroid Compounds (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Enzymes And Modification Thereof (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Peptides Or Proteins (AREA)

DE60130813T 2001-12-14 2001-12-14 Verfahren zum herbeiführen eines eisprungs mittels eines nicht-polypeptid camp-level-modulators Expired - Lifetime DE60130813T2 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/EP2001/014730 WO2003051344A1 (en)	2001-12-14	2001-12-14	Methods of inducing ovulation_using a non-polypeptide camp level modulator

Publications (2)

Publication Number	Publication Date
DE60130813D1 true DE60130813D1 (de)	2007-11-15
DE60130813T2 DE60130813T2 (de)	2008-07-03

Family

ID=8164724

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE60130813T Expired - Lifetime DE60130813T2 (de)	2001-12-14	2001-12-14	Verfahren zum herbeiführen eines eisprungs mittels eines nicht-polypeptid camp-level-modulators

Country Status (18)

Country	Link
US (1)	US7507707B2 (de)
EP (2)	EP1463493B1 (de)
JP (1)	JP4532115B2 (de)
KR (2)	KR101056916B1 (de)
CN (1)	CN1582146A (de)
AT (2)	ATE374606T1 (de)
AU (1)	AU2002217111B2 (de)
BR (2)	BRPI0117198B1 (de)
CA (1)	CA2469939C (de)
DE (1)	DE60130813T2 (de)
DK (2)	DK1463493T3 (de)
EA (1)	EA011213B1 (de)
ES (1)	ES2293965T3 (de)
IL (3)	IL162506A0 (de)
MX (1)	MXPA04005782A (de)
PT (2)	PT1463493E (de)
UA (1)	UA80418C2 (de)
WO (1)	WO2003051344A1 (de)

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DE102004002557A1 (de) *	2004-01-17	2005-08-04	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Verwendung von substituierten Pyrimido(5,4-d)pyrimidinen zur Behandlung von Atemwegserkrankungen
DE102004029784A1 (de) *	2004-06-21	2006-01-05	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Neue 2-Benzylaminodihydropteridinone, Verfahren zur deren Herstellung und deren Verwendung als Arzneimittel
DE102004033670A1 (de) *	2004-07-09	2006-02-02	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Neue Pyridodihydropyrazinone, Verfahren zu Ihrer Herstellung und Ihre Verwendung als Arzneimittel
US7759485B2 (en) *	2004-08-14	2010-07-20	Boehringer Ingelheim International Gmbh	Process for the manufacture of dihydropteridinones
US7728134B2 (en) *	2004-08-14	2010-06-01	Boehringer Ingelheim International Gmbh	Hydrates and polymorphs of 4[[(7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)-benzamide, process for their manufacture and their use as medicament
US20060035903A1 (en) *	2004-08-14	2006-02-16	Boehringer Ingelheim International Gmbh	Storage stable perfusion solution for dihydropteridinones
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EP1632493A1 (de) *	2004-08-25	2006-03-08	Boehringer Ingelheim Pharma GmbH & Co.KG	Dihydropteridinonderivative, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
EP1630163A1 (de) *	2004-08-25	2006-03-01	Boehringer Ingelheim Pharma GmbH & Co.KG	Dihydropteridinonderivative, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
DE102004058337A1 (de) *	2004-12-02	2006-06-14	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Verfahren zur Herstellung von annelierten Piperazin-2-on Derivaten
WO2007014838A1 (en) *	2005-08-03	2007-02-08	Boehringer Ingelheim International Gmbh	Dihydropteridinones in the treatment of respiratory diseases
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WO2009019205A1 (en) *	2007-08-03	2009-02-12	Boehringer Ingelheim International Gmbh	Crystalline form of a dihydropteridione derivative
US8546566B2 (en)	2010-10-12	2013-10-01	Boehringer Ingelheim International Gmbh	Process for manufacturing dihydropteridinones and intermediates thereof
US9358233B2 (en)	2010-11-29	2016-06-07	Boehringer Ingelheim International Gmbh	Method for treating acute myeloid leukemia
US9370535B2 (en)	2011-05-17	2016-06-21	Boehringer Ingelheim International Gmbh	Method for treatment of advanced solid tumors
CN103169699B (zh) *	2011-12-22	2014-11-12	中国农业大学	来曲唑在用于制备成年牛超数排卵药物中的应用
CN104968664A (zh) *	2012-12-12	2015-10-07	山东亨利医药科技有限责任公司	作为酪氨酸激酶抑制剂的并环化合物
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2001
- 2001-12-14 WO PCT/EP2001/014730 patent/WO2003051344A1/en not_active Ceased
- 2001-12-14 JP JP2003552277A patent/JP4532115B2/ja not_active Expired - Fee Related
- 2001-12-14 ES ES01274987T patent/ES2293965T3/es not_active Expired - Lifetime
- 2001-12-14 BR BRPI0117198-4A patent/BRPI0117198B1/pt unknown
- 2001-12-14 PT PT01274987T patent/PT1463493E/pt unknown
- 2001-12-14 BR BR0117198-4A patent/BR0117198A/pt not_active IP Right Cessation
- 2001-12-14 PT PT07018904T patent/PT1908463E/pt unknown
- 2001-12-14 IL IL16250601A patent/IL162506A0/xx unknown
- 2001-12-14 US US10/498,639 patent/US7507707B2/en not_active Expired - Fee Related
- 2001-12-14 MX MXPA04005782A patent/MXPA04005782A/es active IP Right Grant
- 2001-12-14 DK DK01274987T patent/DK1463493T3/da active
- 2001-12-14 EP EP01274987A patent/EP1463493B1/de not_active Expired - Lifetime
- 2001-12-14 AT AT01274987T patent/ATE374606T1/de active
- 2001-12-14 EP EP07018904A patent/EP1908463B1/de not_active Expired - Lifetime
- 2001-12-14 AU AU2002217111A patent/AU2002217111B2/en not_active Ceased
- 2001-12-14 KR KR1020097000508A patent/KR101056916B1/ko not_active Expired - Fee Related
- 2001-12-14 DE DE60130813T patent/DE60130813T2/de not_active Expired - Lifetime
- 2001-12-14 DK DK07018904.8T patent/DK1908463T3/da active
- 2001-12-14 EA EA200400808A patent/EA011213B1/ru not_active IP Right Cessation
- 2001-12-14 KR KR10-2004-7009259A patent/KR20040075004A/ko not_active Ceased
- 2001-12-14 UA UA20040705737A patent/UA80418C2/uk unknown
- 2001-12-14 AT AT07018904T patent/ATE526013T1/de active
- 2001-12-14 CA CA2469939A patent/CA2469939C/en not_active Expired - Fee Related
- 2001-12-14 CN CNA01823951XA patent/CN1582146A/zh active Pending
2004
- 2004-06-14 IL IL162506A patent/IL162506A/en not_active IP Right Cessation
2010
- 2010-04-15 IL IL205106A patent/IL205106A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
CN1582146A (zh)	2005-02-16
ES2293965T3 (es)	2008-04-01
IL162506A (en)	2012-03-29
ATE374606T1 (de)	2007-10-15
CA2469939C (en)	2012-06-19
EP1908463A3 (de)	2009-11-25
ATE526013T1 (de)	2011-10-15
EP1908463B1 (de)	2011-09-28
AU2002217111B8 (en)	2003-06-30
BRPI0117198B1 (pt)	2018-03-13
DK1908463T3 (da)	2011-11-28
JP2005516924A (ja)	2005-06-09
IL205106A (en)	2013-02-28
AU2002217111A1 (en)	2003-06-30
EP1463493A1 (de)	2004-10-06
UA80418C2 (en)	2007-09-25
MXPA04005782A (es)	2004-09-13
US7507707B2 (en)	2009-03-24
PT1463493E (pt)	2008-01-04
CA2469939A1 (en)	2003-06-26
KR101056916B1 (ko)	2011-08-12
KR20040075004A (ko)	2004-08-26
US20050148501A1 (en)	2005-07-07
DK1463493T3 (da)	2008-02-04
EA011213B1 (ru)	2009-02-27
DE60130813T2 (de)	2008-07-03
PT1908463E (pt)	2011-12-19
EP1463493B1 (de)	2007-10-03
AU2002217111B2 (en)	2007-05-31
EA200400808A1 (ru)	2004-12-30
JP4532115B2 (ja)	2010-08-25
IL162506A0 (en)	2005-11-20
WO2003051344A1 (en)	2003-06-26
KR20090009336A (ko)	2009-01-22
IL205106A0 (en)	2010-11-30
EP1908463A2 (de)	2008-04-09
BR0117198A (pt)	2004-10-26

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