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DE60126923T2 - Therapeutische zusammensetzungen bestehend aus antihypotensiva und antiangiogenika - Google Patents

Therapeutische zusammensetzungen bestehend aus antihypotensiva und antiangiogenika Download PDF

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Publication number
DE60126923T2
DE60126923T2 DE60126923T DE60126923T DE60126923T2 DE 60126923 T2 DE60126923 T2 DE 60126923T2 DE 60126923 T DE60126923 T DE 60126923T DE 60126923 T DE60126923 T DE 60126923T DE 60126923 T2 DE60126923 T2 DE 60126923T2
Authority
DE
Germany
Prior art keywords
alkyl
methoxy
quinazoline
yloxy
oder
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60126923T
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German (de)
English (en)
Other versions
DE60126923D1 (de
Inventor
Jon Owen Macclesfield CURWEN
Donald James Macclesfield OGILVIE
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AstraZeneca AB
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AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
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Publication of DE60126923D1 publication Critical patent/DE60126923D1/de
Publication of DE60126923T2 publication Critical patent/DE60126923T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55Protease inhibitors
    • A61K38/556Angiotensin converting enzyme inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/48Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE60126923T 2000-04-05 2001-04-02 Therapeutische zusammensetzungen bestehend aus antihypotensiva und antiangiogenika Expired - Lifetime DE60126923T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0008269.3A GB0008269D0 (en) 2000-04-05 2000-04-05 Combination chemotherapy
GB0008269 2000-04-05
PCT/GB2001/001522 WO2001074360A1 (en) 2000-04-05 2001-04-02 Therapeutic combinations of antihypertensive and antiangiogenic agents

Publications (2)

Publication Number Publication Date
DE60126923D1 DE60126923D1 (de) 2007-04-12
DE60126923T2 true DE60126923T2 (de) 2007-10-31

Family

ID=9889176

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60126923T Expired - Lifetime DE60126923T2 (de) 2000-04-05 2001-04-02 Therapeutische zusammensetzungen bestehend aus antihypotensiva und antiangiogenika

Country Status (29)

Country Link
US (1) US7829573B2 (et)
EP (3) EP1790340A3 (et)
JP (1) JP2003528917A (et)
KR (2) KR100849149B1 (et)
CN (1) CN1431902A (et)
AT (1) ATE355065T1 (et)
AU (2) AU4438601A (et)
BR (1) BR0109729A (et)
CA (1) CA2401854A1 (et)
CY (1) CY1107615T1 (et)
CZ (1) CZ299410B6 (et)
DE (1) DE60126923T2 (et)
DK (1) DK1272186T3 (et)
EE (1) EE200200578A (et)
ES (1) ES2280349T3 (et)
GB (1) GB0008269D0 (et)
HU (1) HUP0300426A2 (et)
IL (1) IL151503A0 (et)
IS (2) IS2455B (et)
MX (1) MXPA02009743A (et)
NO (2) NO323467B1 (et)
NZ (2) NZ534455A (et)
PL (1) PL357605A1 (et)
PT (1) PT1272186E (et)
RU (1) RU2002129353A (et)
SI (1) SI1272186T1 (et)
SK (1) SK14302002A3 (et)
WO (1) WO2001074360A1 (et)
ZA (1) ZA200206959B (et)

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US20060167027A1 (en) 2003-07-10 2006-07-27 Wedge Stephen R Use of the quinazoline derivative zd6474 combined with platinum compounds and optionally ionising radiation in the treatment of diseases associated with angiogenesis and/or increased vascular permeability
GB0316127D0 (en) 2003-07-10 2003-08-13 Astrazeneca Ab Combination therapy
GB0316123D0 (en) 2003-07-10 2003-08-13 Astrazeneca Ab Combination therapy
GB0406446D0 (en) 2004-03-23 2004-04-28 Astrazeneca Ab Combination therapy
GB0406445D0 (en) 2004-03-23 2004-04-28 Astrazeneca Ab Combination therapy
KR20060130764A (ko) 2004-03-23 2006-12-19 아스트라제네카 아베 병용 요법
JP2008514577A (ja) 2004-09-27 2008-05-08 アストラゼネカ アクチボラグ Zd6474及びイマチニブを含んでなる組合せ
KR20070073813A (ko) 2004-09-27 2007-07-10 아스트라제네카 아베 Azd2171 및 이마티닙을 포함하는 암의 병합 요법
GB0424339D0 (en) 2004-11-03 2004-12-08 Astrazeneca Ab Combination therapy
AU2006264620B2 (en) 2005-07-06 2009-10-22 Astrazeneca Ab Combination therapy of cancer with AZD2171 and gemcitabine
US20090123474A1 (en) 2005-12-15 2009-05-14 Astrazeneca Ab Combination of angiopoietin-2 antagonist and of vegf-a, kdr and/or fltl antagonist for treating cancer
PL1965801T3 (pl) 2005-12-22 2011-07-29 Astrazeneca Ab Połączenie AZD2171 i premetreksedu
PL1971338T3 (pl) 2005-12-22 2011-07-29 Astrazeneca Ab Połączenie ZD6474 i premetreksedu
EP2066353B1 (en) 2006-09-29 2013-01-02 AstraZeneca AB Combination of zd6474 and bevacizumab for cancer therapy
US20100130519A1 (en) 2007-04-13 2010-05-27 Stephen Robert Wedge Combination therapy comprising azd2171 and azd6244 or mek-inhibitor ii

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ATE355065T1 (de) 2006-03-15
PL357605A1 (en) 2004-07-26
CY1107615T1 (el) 2013-03-13
CN1431902A (zh) 2003-07-23
ES2280349T3 (es) 2007-09-16
JP2003528917A (ja) 2003-09-30
US7829573B2 (en) 2010-11-09
GB0008269D0 (en) 2000-05-24
HUP0300426A2 (hu) 2003-06-28
EP1790340A2 (en) 2007-05-30
BR0109729A (pt) 2003-02-04
NO323467B1 (no) 2007-05-21
DE60126923D1 (de) 2007-04-12
CZ299410B6 (cs) 2008-07-16
ZA200206959B (en) 2003-12-01
CA2401854A1 (en) 2001-10-11
EE200200578A (et) 2004-06-15
RU2002129353A (ru) 2004-03-20
SK14302002A3 (sk) 2003-05-02
KR100849149B1 (ko) 2008-07-31
PT1272186E (pt) 2007-04-30
NZ534455A (en) 2007-01-26
EP1272186A1 (en) 2003-01-08
MXPA02009743A (es) 2003-03-27
US20030144298A1 (en) 2003-07-31
IL151503A0 (en) 2003-04-10
NO20062050L (no) 2001-10-08
NZ520938A (en) 2005-08-26
IS2455B (is) 2008-11-15
IS6557A (is) 2002-09-20
IS8726A (is) 2008-04-16
EP1658849A3 (en) 2009-02-18
AU4438601A (en) 2001-10-15
AU2001244386B2 (en) 2005-01-27
NO20024814L (no) 2002-11-12
EP1272186B1 (en) 2007-02-28
EP1658849A2 (en) 2006-05-24
EP1790340A3 (en) 2009-03-18
KR20030007491A (ko) 2003-01-23
WO2001074360A1 (en) 2001-10-11
DK1272186T3 (da) 2007-05-21
KR20080034523A (ko) 2008-04-21
NO20024814D0 (no) 2002-10-04
NO326277B1 (no) 2008-10-27

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