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DE60118914D1 - Pharmazeutische zusammensetzungen die acryloyl-substituierte distamycin-derivate und topoisomerase i und ii inhibitoren enthalten - Google Patents

Pharmazeutische zusammensetzungen die acryloyl-substituierte distamycin-derivate und topoisomerase i und ii inhibitoren enthalten

Info

Publication number
DE60118914D1
DE60118914D1 DE60118914T DE60118914T DE60118914D1 DE 60118914 D1 DE60118914 D1 DE 60118914D1 DE 60118914 T DE60118914 T DE 60118914T DE 60118914 T DE60118914 T DE 60118914T DE 60118914 D1 DE60118914 D1 DE 60118914D1
Authority
DE
Germany
Prior art keywords
topoisomerase
inhibitors
pharmaceutical compositions
distamycin derivatives
compositions containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60118914T
Other languages
English (en)
Other versions
DE60118914T2 (de
Inventor
Cristina Geroni
Paolo Cozzi
Italo Beria
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nerviano Medical Sciences SRL
Original Assignee
Nerviano Medical Sciences SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nerviano Medical Sciences SRL filed Critical Nerviano Medical Sciences SRL
Publication of DE60118914D1 publication Critical patent/DE60118914D1/de
Application granted granted Critical
Publication of DE60118914T2 publication Critical patent/DE60118914T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE60118914T 2000-06-23 2001-06-20 Pharmazeutische zusammensetzungen die acryloyl-substituierte distamycin-derivate und topoisomerase i und ii inhibitoren enthalten Expired - Lifetime DE60118914T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0015444 2000-06-23
GBGB0015444.3A GB0015444D0 (en) 2000-06-23 2000-06-23 Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and topoisomerase I and II inhibitors
PCT/EP2001/007059 WO2001097789A2 (en) 2000-06-23 2001-06-20 Pharmaceutical compositions comprising acryloyl distamycin derivatives and topoisomerase i and ii inhibitors

Publications (2)

Publication Number Publication Date
DE60118914D1 true DE60118914D1 (de) 2006-05-24
DE60118914T2 DE60118914T2 (de) 2006-12-21

Family

ID=9894285

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60118914T Expired - Lifetime DE60118914T2 (de) 2000-06-23 2001-06-20 Pharmazeutische zusammensetzungen die acryloyl-substituierte distamycin-derivate und topoisomerase i und ii inhibitoren enthalten

Country Status (27)

Country Link
US (1) US20030162722A1 (de)
EP (1) EP1292290B1 (de)
JP (1) JP2003535890A (de)
KR (1) KR100853955B1 (de)
CN (1) CN1241573C (de)
AT (1) ATE323483T1 (de)
AU (2) AU2001278463B2 (de)
BR (1) BR0111813A (de)
CA (1) CA2411172C (de)
CZ (1) CZ20024155A3 (de)
DE (1) DE60118914T2 (de)
DK (1) DK1292290T3 (de)
EA (1) EA006684B1 (de)
EE (1) EE05319B1 (de)
ES (1) ES2261448T3 (de)
GB (1) GB0015444D0 (de)
HK (1) HK1054334B (de)
HU (1) HUP0301257A2 (de)
IL (1) IL153177A0 (de)
MX (1) MXPA02012163A (de)
NO (1) NO329783B1 (de)
NZ (1) NZ523000A (de)
PL (1) PL200503B1 (de)
PT (1) PT1292290E (de)
SK (1) SK287549B6 (de)
WO (1) WO2001097789A2 (de)
ZA (1) ZA200209834B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0015444D0 (en) * 2000-06-23 2000-08-16 Pharmacia & Upjohn Spa Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and topoisomerase I and II inhibitors
GB0015447D0 (en) * 2000-06-23 2000-08-16 Pharmacia & Upjohn Spa Combined therapy against tumors comprising substituted acryloyl derivates and alkylating agents
BR0215454A (pt) * 2002-01-02 2004-11-23 Pharmacia Italia Spa Terapia combinada contra tumores, comprendendo derivados de acriloil-distamicina substituìdos e inibidores de proteìna cinase (serina/treonina cinase)
CN100438913C (zh) * 2004-11-22 2008-12-03 山东蓝金生物工程有限公司 一种抗癌药物组合物
MD36Z (ro) * 2008-12-02 2010-01-31 Василе ЖОВМИР Metodă de tratament diferenţiat al carcinomului ductal in situ neinvaziv al glandei mamare
MD23Z (ro) * 2008-12-02 2010-01-31 Василе ЖОВМИР Metodă de tratament diferenţiat al carcinomului lobular in situ neinvaziv al glandei mamare
MD35Z (ro) * 2008-12-02 2010-01-31 Василе ЖОВМИР Metodă de apreciere a riscului dezvoltării carcinomului neinvaziv in situ al glandei mamare
MD24Z (ro) * 2008-12-02 2010-01-31 Василе ЖОВМИР Metodă de tratament diferenţiat al carcinomului neinvaziv al glandei mamare
BR112012033295A2 (pt) 2010-07-02 2016-10-11 Angiochem Inc polipeptídeos curtos e contendo d-aminoácido para conjugados terapêuticos e seu uso
CN109718228A (zh) * 2017-10-30 2019-05-07 沈阳药科大学 米托蒽醌的抗肿瘤淋巴转移作用及其药物制剂

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9615692D0 (en) * 1996-07-25 1996-09-04 Pharmacia Spa Acryloyl substituted distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents
GB9623522D0 (en) * 1996-11-11 1997-01-08 Pharmacia & Upjohn Spa Benzoheterocycle distamycin derivatives process for preparing them and their use as antitumour and antiviral agents
GB9727524D0 (en) * 1997-12-31 1998-02-25 Pharmacia & Upjohn Spa Synergistic antitumor composition containing a biologically active ureido compound
GB9806692D0 (en) * 1998-03-27 1998-05-27 Pharmacia & Upjohn Spa Benzoheterocyclic distamycin derivatives, process for preparing them and their use as antitumour agents
GB0015444D0 (en) * 2000-06-23 2000-08-16 Pharmacia & Upjohn Spa Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and topoisomerase I and II inhibitors

Also Published As

Publication number Publication date
WO2001097789A2 (en) 2001-12-27
CN1241573C (zh) 2006-02-15
EA006684B1 (ru) 2006-02-24
MXPA02012163A (es) 2003-04-25
DK1292290T3 (da) 2006-07-10
EE200200681A (et) 2004-06-15
PL200503B1 (pl) 2009-01-30
WO2001097789A3 (en) 2002-05-16
EP1292290A2 (de) 2003-03-19
US20030162722A1 (en) 2003-08-28
GB0015444D0 (en) 2000-08-16
EP1292290B1 (de) 2006-04-19
KR20030019448A (ko) 2003-03-06
EE05319B1 (et) 2010-08-16
AU2001278463B2 (en) 2006-02-23
CZ20024155A3 (cs) 2003-04-16
HK1054334B (zh) 2006-09-22
CA2411172A1 (en) 2001-12-27
AU7846301A (en) 2002-01-02
JP2003535890A (ja) 2003-12-02
DE60118914T2 (de) 2006-12-21
CN1437474A (zh) 2003-08-20
HUP0301257A2 (hu) 2003-08-28
PT1292290E (pt) 2006-08-31
PL360297A1 (en) 2004-09-06
SK287549B6 (sk) 2011-01-04
KR100853955B1 (ko) 2008-08-25
BR0111813A (pt) 2003-05-20
HK1054334A1 (en) 2003-11-28
EA200300060A1 (ru) 2003-04-24
NO329783B1 (no) 2010-12-13
NZ523000A (en) 2005-12-23
CA2411172C (en) 2009-11-17
IL153177A0 (en) 2003-06-24
ATE323483T1 (de) 2006-05-15
NO20026078D0 (no) 2002-12-18
ES2261448T3 (es) 2006-11-16
NO20026078L (no) 2002-12-18
ZA200209834B (en) 2003-12-04
SK18332002A3 (sk) 2003-07-01

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Legal Events

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