DE60115900D1 - Nukleotidsequenzen kodierend für das mdha gen aus corynebakterium glutamicum - Google Patents
Nukleotidsequenzen kodierend für das mdha gen aus corynebakterium glutamicumInfo
- Publication number
- DE60115900D1 DE60115900D1 DE60115900T DE60115900T DE60115900D1 DE 60115900 D1 DE60115900 D1 DE 60115900D1 DE 60115900 T DE60115900 T DE 60115900T DE 60115900 T DE60115900 T DE 60115900T DE 60115900 D1 DE60115900 D1 DE 60115900D1
- Authority
- DE
- Germany
- Prior art keywords
- polynucleotide
- sequence
- malate dehydrogenase
- gene
- thr
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 241000186226 Corynebacterium glutamicum Species 0.000 title 1
- 101100344726 Homo sapiens MDH1 gene Proteins 0.000 title 1
- 108091028043 Nucleic acid sequence Proteins 0.000 title 1
- 102000040430 polynucleotide Human genes 0.000 abstract 9
- 108091033319 polynucleotide Proteins 0.000 abstract 9
- 239000002157 polynucleotide Substances 0.000 abstract 9
- 108010026217 Malate Dehydrogenase Proteins 0.000 abstract 4
- 150000008575 L-amino acids Chemical class 0.000 abstract 3
- 102000013460 Malate Dehydrogenase Human genes 0.000 abstract 3
- 101150062452 mdhA gene Proteins 0.000 abstract 3
- 229920001184 polypeptide Polymers 0.000 abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 3
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 abstract 2
- 230000002238 attenuated effect Effects 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 241000894006 Bacteria Species 0.000 abstract 1
- 241000186031 Corynebacteriaceae Species 0.000 abstract 1
- 235000019766 L-Lysine Nutrition 0.000 abstract 1
- 239000004472 Lysine Substances 0.000 abstract 1
- 125000001429 N-terminal alpha-amino-acid group Chemical group 0.000 abstract 1
- 235000001014 amino acid Nutrition 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 239000002299 complementary DNA Substances 0.000 abstract 1
- 241000186254 coryneform bacterium Species 0.000 abstract 1
- 238000009396 hybridization Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 239000000523 sample Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE60115900T DE60115900T2 (de) | 2000-07-04 | 2001-06-20 | Nukleotidsequenzen kodierend für das mdha gen aus corynebakterium glutamicum |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10032350A DE10032350A1 (de) | 2000-07-04 | 2000-07-04 | Neue für das mdhA-Gen kodierende Nukleotidsequenzen |
| DE10032350 | 2000-07-04 | ||
| DE60115900T DE60115900T2 (de) | 2000-07-04 | 2001-06-20 | Nukleotidsequenzen kodierend für das mdha gen aus corynebakterium glutamicum |
| PCT/EP2001/006928 WO2002002778A1 (en) | 2000-07-04 | 2001-06-20 | Nucleotide sequences which code for the mdha gene from corynebacterium glutamicum |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60115900D1 true DE60115900D1 (de) | 2006-01-19 |
| DE60115900T2 DE60115900T2 (de) | 2006-08-03 |
Family
ID=7647660
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE10032350A Withdrawn DE10032350A1 (de) | 2000-07-04 | 2000-07-04 | Neue für das mdhA-Gen kodierende Nukleotidsequenzen |
| DE60115900T Expired - Lifetime DE60115900T2 (de) | 2000-07-04 | 2001-06-20 | Nukleotidsequenzen kodierend für das mdha gen aus corynebakterium glutamicum |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE10032350A Withdrawn DE10032350A1 (de) | 2000-07-04 | 2000-07-04 | Neue für das mdhA-Gen kodierende Nukleotidsequenzen |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US6995002B2 (de) |
| EP (1) | EP1297148B1 (de) |
| KR (1) | KR100904744B1 (de) |
| CN (1) | CN1440458A (de) |
| AT (1) | ATE312929T1 (de) |
| AU (1) | AU2001279674A1 (de) |
| DE (2) | DE10032350A1 (de) |
| ES (1) | ES2254459T3 (de) |
| WO (1) | WO2002002778A1 (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100506990C (zh) * | 2004-02-24 | 2009-07-01 | 中国科学院植物研究所 | 小麦高光效和抗逆相关的苹果酸脱氢酶、其编码基因及培育抗逆植物的方法 |
| KR100789270B1 (ko) | 2005-11-30 | 2008-01-02 | 씨제이 주식회사 | L-라이신 생산능이 향상된 코리네박테리움 속 미생물 및그를 이용하여 l-라이신을 생산하는 방법 |
| DE102006032634A1 (de) | 2006-07-13 | 2008-01-17 | Evonik Degussa Gmbh | Verfahren zur Herstellung von L-Aminosäuren |
| KR100822041B1 (ko) | 2006-12-21 | 2008-04-15 | 씨제이제일제당 (주) | 몰리브덴 보조인자 생합성 효소 에이 코딩 유전자의 발현이강화된 코리네박테리움 속 미생물 및 이를 이용한엘-라이신 생산방법 |
| US8647642B2 (en) | 2008-09-18 | 2014-02-11 | Aviex Technologies, Llc | Live bacterial vaccines resistant to carbon dioxide (CO2), acidic PH and/or osmolarity for viral infection prophylaxis or treatment |
| KR101072708B1 (ko) * | 2008-12-17 | 2011-10-11 | 씨제이제일제당 (주) | 5'-크산틸산 생산능이 향상된 미생물 및 이를 이용한 5'-크산틸산의 생산방법 |
| DE102013204728A1 (de) * | 2013-03-18 | 2014-09-18 | Wacker Chemie Ag | Mikroorganismenstamm und Verfahren zur fermentativen Herstellung von C4-Verbindungen aus C5-Zuckern |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| KR101947945B1 (ko) * | 2018-01-25 | 2019-02-13 | 씨제이제일제당 (주) | L-아미노산을 생산하는 코리네박테리움 속 미생물 및 이를 이용한 l-아미노산의 생산방법 |
| EP3594355A1 (de) | 2018-07-12 | 2020-01-15 | Evonik Operations GmbH | Verfahren zur fermentativen herstellung von l-lysin |
| CN109161555A (zh) * | 2018-09-07 | 2019-01-08 | 大连大学 | 一种海洋低温苹果酸脱氢酶基因及其重组表达载体 |
| KR102129379B1 (ko) * | 2018-10-10 | 2020-07-02 | 한국과학기술원 | 고활성의 말산 탈수소효소가 도입된 숙신산 생성용 변이 미생물 및 이를 이용한 숙신산 제조방법 |
| CN110129342B (zh) * | 2019-05-17 | 2021-11-23 | 河南农业大学 | 玉米高赖氨酸基因ZmcytMdh4的分子标记及其应用 |
| KR102258159B1 (ko) * | 2021-01-29 | 2021-05-27 | 씨제이제일제당 (주) | 신규한 말레이트 디하이드로게나제 변이체 및 이를 이용한 l-라이신 생산 방법 |
| CN115449518B (zh) * | 2021-06-08 | 2024-01-26 | 中国科学院天津工业生物技术研究所 | 基于mdh基因的具有启动子活性的多核苷酸及其用途 |
| WO2023038066A1 (ja) * | 2021-09-07 | 2023-03-16 | 花王株式会社 | 芳香族化合物の製造方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1323171C (zh) * | 1997-10-04 | 2007-06-27 | 德古萨股份公司 | 天冬氨酸和/或谷氨酸系氨基酸的生物制备方法和该方法用的添加剂 |
| AU783703B2 (en) * | 1999-06-25 | 2005-11-24 | Paik Kwang Industrial Co., Ltd. | Corynebacterium glutamicum genes encoding stress, resistance and tolerance proteins |
| ES2178979T1 (es) * | 1999-06-25 | 2003-01-16 | Basf Ag | Genes de corynebacterium glutamicum que codifican proteinas implicadas en el metabolismo del carbono y la produccion de energia. |
| DE19929365A1 (de) | 1999-06-25 | 2000-12-28 | Basf Lynx Bioscience Ag | Teilsequenzen der Gene des Primär- und Sekundärmetabolismus aus Corynebacterium glutamicum und ihr Einsatz zur mikrobiellen Herstellung von Primär- und Sekundärmetaboliten |
| JP2003144161A (ja) * | 1999-07-02 | 2003-05-20 | Ajinomoto Co Inc | L−アミノ酸の製造法 |
| JP4623825B2 (ja) * | 1999-12-16 | 2011-02-02 | 協和発酵バイオ株式会社 | 新規ポリヌクレオチド |
-
2000
- 2000-07-04 DE DE10032350A patent/DE10032350A1/de not_active Withdrawn
-
2001
- 2001-06-20 AU AU2001279674A patent/AU2001279674A1/en not_active Abandoned
- 2001-06-20 KR KR1020037000075A patent/KR100904744B1/ko not_active Expired - Fee Related
- 2001-06-20 CN CN01812254A patent/CN1440458A/zh active Pending
- 2001-06-20 ES ES01957867T patent/ES2254459T3/es not_active Expired - Lifetime
- 2001-06-20 AT AT01957867T patent/ATE312929T1/de not_active IP Right Cessation
- 2001-06-20 WO PCT/EP2001/006928 patent/WO2002002778A1/en not_active Ceased
- 2001-06-20 EP EP01957867A patent/EP1297148B1/de not_active Expired - Lifetime
- 2001-06-20 DE DE60115900T patent/DE60115900T2/de not_active Expired - Lifetime
- 2001-06-28 US US09/892,867 patent/US6995002B2/en not_active Expired - Fee Related
-
2003
- 2003-12-05 US US10/727,516 patent/US7067288B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US7067288B2 (en) | 2006-06-27 |
| EP1297148A1 (de) | 2003-04-02 |
| KR20030013521A (ko) | 2003-02-14 |
| CN1440458A (zh) | 2003-09-03 |
| EP1297148B1 (de) | 2005-12-14 |
| ATE312929T1 (de) | 2005-12-15 |
| DE10032350A1 (de) | 2002-01-24 |
| US20040142454A1 (en) | 2004-07-22 |
| WO2002002778A1 (en) | 2002-01-10 |
| US20020037568A1 (en) | 2002-03-28 |
| ES2254459T3 (es) | 2006-06-16 |
| DE60115900T2 (de) | 2006-08-03 |
| KR100904744B1 (ko) | 2009-06-29 |
| WO2002002778A8 (en) | 2002-02-07 |
| US6995002B2 (en) | 2006-02-07 |
| AU2001279674A1 (en) | 2002-01-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8363 | Opposition against the patent | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: DEGUSSA GMBH, 40474 DUESSELDORF, DE |
|
| 8327 | Change in the person/name/address of the patent owner |
Owner name: EVONIK DEGUSSA GMBH, 40474 DUESSELDORF, DE |
|
| 8365 | Fully valid after opposition proceedings |