DE60112966D1 - Trizyklische indolderivate mit antiangiogenischer wirkung - Google Patents

Trizyklische indolderivate mit antiangiogenischer wirkung

Info

Publication number: DE60112966D1
Authority: DE; Germany
Prior art keywords: tricyclic; indoor; derivatives; antiangiogenic effect; antiangiogenic
Prior art date: 2000-11-03
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

DE60112966T

Other languages

English (en)

Other versions

DE60112966T2 (de

Inventor

Giuseppe Giannini

Mauro Marzi

Maria Ornella Tinti

Claudio Pisano

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Sigma Tau Industrie Farmaceutiche Riunite SpA

Original Assignee

Sigma Tau Industrie Farmaceutiche Riunite SpA

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-11-03

Filing date

2001-10-16

Publication date

2005-09-29

2001-10-16 Application filed by Sigma Tau Industrie Farmaceutiche Riunite SpA filed Critical Sigma Tau Industrie Farmaceutiche Riunite SpA

2005-09-29 Publication of DE60112966D1 publication Critical patent/DE60112966D1/de

2006-05-24 Application granted granted Critical

2006-05-24 Publication of DE60112966T2 publication Critical patent/DE60112966T2/de

2021-10-17 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/86—Carbazoles; Hydrogenated carbazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Oncology (AREA)
Rheumatology (AREA)
Hematology (AREA)
Vascular Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Cardiology (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Obesity (AREA)
Pain & Pain Management (AREA)
Urology & Nephrology (AREA)
Immunology (AREA)
Heart & Thoracic Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Compositions Of Macromolecular Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

DE60112966T 2000-11-03 2001-10-16 Trizyklische indolderivate mit antiangiogenischer wirkung Expired - Fee Related DE60112966T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
IT2000RM000570A IT1317926B1 (it)	2000-11-03	2000-11-03	Derivati triciclici dell'indolo ad attivita' antiangiogenica.
ITRM20000570		2000-11-03
PCT/IT2001/000526 WO2002036597A1 (en)	2000-11-03	2001-10-16	Tricyclic derivatives of indole with antiangiogenic activity

Publications (2)

Publication Number	Publication Date
DE60112966D1 true DE60112966D1 (de)	2005-09-29
DE60112966T2 DE60112966T2 (de)	2006-05-24

Family

ID=11454976

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE60112966T Expired - Fee Related DE60112966T2 (de)	2000-11-03	2001-10-16	Trizyklische indolderivate mit antiangiogenischer wirkung

Country Status (19)

Country	Link
US (2)	US6887892B2 (de)
EP (1)	EP1343789B1 (de)
JP (1)	JP2004513130A (de)
KR (1)	KR20030042030A (de)
CN (1)	CN1247589C (de)
AT (1)	ATE302780T1 (de)
AU (1)	AU1518602A (de)
BR (1)	BR0115119A (de)
CA (1)	CA2427568A1 (de)
CZ (1)	CZ297299B6 (de)
DE (1)	DE60112966T2 (de)
DK (1)	DK1343789T3 (de)
ES (1)	ES2247182T3 (de)
HU (1)	HUP0400546A3 (de)
IT (1)	IT1317926B1 (de)
MX (1)	MXPA03003798A (de)
PL (1)	PL364908A1 (de)
SK (1)	SK5342003A3 (de)
WO (1)	WO2002036597A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6849656B1 (en)	1999-09-17	2005-02-01	Baylor University	Indole-containing and combretastatin-related anti-mitotic and anti-tubulin polymerization agents
US7528165B2 (en)	2001-12-13	2009-05-05	National Health Research Institutes	Indole compounds
US7632955B2 (en)	2001-12-13	2009-12-15	National Health Research Institutes	Indole compounds
US6800655B2 (en)	2002-08-20	2004-10-05	Sri International	Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents
US7456289B2 (en)	2004-12-31	2008-11-25	National Health Research Institutes	Anti-tumor compounds
JP2008530229A (ja) *	2005-02-17	2008-08-07	ワイス	シクロアルキル縮合インドール、ベンゾチオフェン、ベンゾフランおよびインデン誘導体
DE502007005017D1 (de) *	2006-04-25	2010-10-28	Merck Patent Gmbh	Hexahydro-dibenzofuranderivate
FR2928645A1 (fr)	2008-03-14	2009-09-18	Sanofi Aventis Sa	Nouveaux derives de carbazole inhibiteurs d'hsp90, compositions les contenant et utilisation
WO2014041125A1 (en) *	2012-09-13	2014-03-20	Baden-Württemberg Stiftung Gmbh	Specific inhibitors of protein p21 as therapeutic agents

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5100891A (en)	1991-01-18	1992-03-31	Hoechst-Roussel Pharmaceuticals Inc.	Substituted 1,2,3,4-tetrahydrocyclopent[b]indoles, 1,2,3,3a,4,8a-hexahydrocyclopent[B]indoles and related compounds
US5350762A (en) *	1993-03-08	1994-09-27	Hoechst-Roussel Pharmaceuticals Incorporated	Tetrahydrocyclopent[B]indole methanamines and related compounds

2000
- 2000-11-03 IT IT2000RM000570A patent/IT1317926B1/it active
2001
- 2001-10-16 US US10/415,896 patent/US6887892B2/en not_active Expired - Fee Related
- 2001-10-16 WO PCT/IT2001/000526 patent/WO2002036597A1/en not_active Ceased
- 2001-10-16 CA CA002427568A patent/CA2427568A1/en not_active Abandoned
- 2001-10-16 KR KR10-2003-7005651A patent/KR20030042030A/ko not_active Ceased
- 2001-10-16 EP EP01983768A patent/EP1343789B1/de not_active Expired - Lifetime
- 2001-10-16 MX MXPA03003798A patent/MXPA03003798A/es active IP Right Grant
- 2001-10-16 BR BR0115119-3A patent/BR0115119A/pt not_active IP Right Cessation
- 2001-10-16 JP JP2002539355A patent/JP2004513130A/ja active Pending
- 2001-10-16 CZ CZ20031042A patent/CZ297299B6/cs not_active IP Right Cessation
- 2001-10-16 SK SK534-2003A patent/SK5342003A3/sk not_active Application Discontinuation
- 2001-10-16 CN CNB018181996A patent/CN1247589C/zh not_active Expired - Fee Related
- 2001-10-16 ES ES01983768T patent/ES2247182T3/es not_active Expired - Lifetime
- 2001-10-16 DK DK01983768T patent/DK1343789T3/da active
- 2001-10-16 AT AT01983768T patent/ATE302780T1/de not_active IP Right Cessation
- 2001-10-16 HU HU0400546A patent/HUP0400546A3/hu unknown
- 2001-10-16 AU AU1518602A patent/AU1518602A/xx not_active Withdrawn
- 2001-10-16 PL PL01364908A patent/PL364908A1/xx unknown
- 2001-10-16 DE DE60112966T patent/DE60112966T2/de not_active Expired - Fee Related
2005
- 2005-01-11 US US11/032,068 patent/US20050124647A1/en not_active Abandoned

Also Published As

Publication number	Publication date
CN1471535A (zh)	2004-01-28
HUP0400546A2 (hu)	2004-06-28
EP1343789B1 (de)	2005-08-24
HK1061244A1 (en)	2004-09-10
HUP0400546A3 (en)	2007-08-28
US6887892B2 (en)	2005-05-03
JP2004513130A (ja)	2004-04-30
ITRM20000570A0 (it)	2000-11-03
US20050124647A1 (en)	2005-06-09
PL364908A1 (en)	2004-12-27
SK5342003A3 (en)	2003-10-07
US20040034052A1 (en)	2004-02-19
DE60112966T2 (de)	2006-05-24
AU1518602A (en)	2002-05-15
CN1247589C (zh)	2006-03-29
BR0115119A (pt)	2003-09-30
WO2002036597A1 (en)	2002-05-10
DK1343789T3 (da)	2005-12-27
ITRM20000570A1 (it)	2002-05-03
MXPA03003798A (es)	2004-04-20
CZ297299B6 (cs)	2006-11-15
ATE302780T1 (de)	2005-09-15
ES2247182T3 (es)	2006-03-01
CZ20031042A3 (cs)	2003-10-15
CA2427568A1 (en)	2002-05-10
IT1317926B1 (it)	2003-07-15
KR20030042030A (ko)	2003-05-27
EP1343789A1 (de)	2003-09-17

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Legal Events

Date	Code	Title	Description
2006-09-14	8364	No opposition during term of opposition
2008-08-14	8339	Ceased/non-payment of the annual fee