DE60112897D1 - Stabilisierung von implantierbarem bioprothesegewebe - Google Patents
Stabilisierung von implantierbarem bioprothesegewebeInfo
- Publication number
- DE60112897D1 DE60112897D1 DE60112897T DE60112897T DE60112897D1 DE 60112897 D1 DE60112897 D1 DE 60112897D1 DE 60112897 T DE60112897 T DE 60112897T DE 60112897 T DE60112897 T DE 60112897T DE 60112897 D1 DE60112897 D1 DE 60112897D1
- Authority
- DE
- Germany
- Prior art keywords
- implantable
- bioprothesee
- weave
- stabilization
- bioprosthesis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000006641 stabilisation Effects 0.000 title 1
- 238000011105 stabilization Methods 0.000 title 1
- -1 amine compound Chemical class 0.000 abstract 1
- 230000002308 calcification Effects 0.000 abstract 1
- 238000002513 implantation Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000000087 stabilizing effect Effects 0.000 abstract 1
- 229920002994 synthetic fiber Polymers 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
- A61L27/3687—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by the use of chemical agents in the treatment, e.g. specific enzymes, detergents, capping agents, crosslinkers, anticalcification agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/507—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials for artificial blood vessels
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Botany (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/501,331 US6391538B1 (en) | 2000-02-09 | 2000-02-09 | Stabilization of implantable bioprosthetic tissue |
| US501331 | 2000-02-09 | ||
| PCT/US2001/003509 WO2001058503A1 (en) | 2000-02-09 | 2001-02-02 | Stabilization of implantable bioprosthetic tissue |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60112897D1 true DE60112897D1 (de) | 2005-09-29 |
| DE60112897T2 DE60112897T2 (de) | 2006-06-08 |
Family
ID=23993090
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60112897T Expired - Lifetime DE60112897T2 (de) | 2000-02-09 | 2001-02-02 | Stabilisierung von implantierbaren bio-prothetischen Vorrichtungen und Geweben |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US6391538B1 (de) |
| EP (1) | EP1257305B1 (de) |
| JP (1) | JP4841097B2 (de) |
| AT (1) | ATE302622T1 (de) |
| CA (1) | CA2397263C (de) |
| DE (1) | DE60112897T2 (de) |
| WO (1) | WO2001058503A1 (de) |
Families Citing this family (72)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6254564B1 (en) | 1998-09-10 | 2001-07-03 | Percardia, Inc. | Left ventricular conduit with blood vessel graft |
| US6214054B1 (en) * | 1998-09-21 | 2001-04-10 | Edwards Lifesciences Corporation | Method for fixation of biological tissues having mitigated propensity for post-implantation calcification and thrombosis and bioprosthetic devices prepared thereby |
| DE10010074B4 (de) | 2000-02-28 | 2005-04-14 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Vorrichtung zur Befestigung und Verankerung von Herzklappenprothesen |
| DE10010073B4 (de) * | 2000-02-28 | 2005-12-22 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Verankerung für implantierbare Herzklappenprothesen |
| US6468660B2 (en) | 2000-12-29 | 2002-10-22 | St. Jude Medical, Inc. | Biocompatible adhesives |
| FR2828263B1 (fr) | 2001-08-03 | 2007-05-11 | Philipp Bonhoeffer | Dispositif d'implantation d'un implant et procede d'implantation du dispositif |
| US7147661B2 (en) * | 2001-12-20 | 2006-12-12 | Boston Scientific Santa Rosa Corp. | Radially expandable stent |
| US6878168B2 (en) | 2002-01-03 | 2005-04-12 | Edwards Lifesciences Corporation | Treatment of bioprosthetic tissues to mitigate post implantation calcification |
| AU2003201493A1 (en) | 2002-01-07 | 2003-07-24 | The Children's Hospital Of Philadelphia | Counteracting bioprosthetic calcification |
| AU2003291311A1 (en) * | 2002-11-07 | 2004-06-03 | Carbon Medical Technologies, Inc. | Biocompatible medical device coatings |
| US7189259B2 (en) * | 2002-11-26 | 2007-03-13 | Clemson University | Tissue material and process for bioprosthesis |
| US7632291B2 (en) * | 2003-06-13 | 2009-12-15 | Trivascular2, Inc. | Inflatable implant |
| US20050244460A1 (en) * | 2004-04-29 | 2005-11-03 | Ivan Alferiev | Biodegradable crosslinking strategies using triglycidyl amine (TGA) |
| DE102005003632A1 (de) | 2005-01-20 | 2006-08-17 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Katheter für die transvaskuläre Implantation von Herzklappenprothesen |
| CN1903143A (zh) * | 2005-07-29 | 2007-01-31 | 广东冠昊生物科技有限公司 | 生物型人工血管及其制备方法 |
| DE102005051849B4 (de) | 2005-10-28 | 2010-01-21 | JenaValve Technology Inc., Wilmington | Vorrichtung zur Implantation und Befestigung von Herzklappenprothesen |
| DE102005052628B4 (de) * | 2005-11-04 | 2014-06-05 | Jenavalve Technology Inc. | Selbstexpandierendes, flexibles Drahtgeflecht mit integrierter Klappenprothese für den transvaskulären Herzklappenersatz und ein System mit einer solchen Vorrichtung und einem Einführkatheter |
| US20070213813A1 (en) | 2005-12-22 | 2007-09-13 | Symetis Sa | Stent-valves for valve replacement and associated methods and systems for surgery |
| FI20060288A0 (fi) * | 2006-03-27 | 2006-03-27 | Abr Innova Oy | Pinnoitusmenetelmä |
| CN101626682B (zh) | 2006-10-27 | 2014-04-16 | 爱德华兹生命科学公司 | 用于外科植入的生物组织 |
| US8142805B1 (en) | 2006-11-06 | 2012-03-27 | Clemson University Research Foundation | Implantable devices including fixed tissues |
| CA2680812C (en) | 2007-03-15 | 2017-01-24 | Ortho-Space Ltd. | Prosthetic devices and methods for using same |
| US7896915B2 (en) * | 2007-04-13 | 2011-03-01 | Jenavalve Technology, Inc. | Medical device for treating a heart valve insufficiency |
| US9138315B2 (en) | 2007-04-13 | 2015-09-22 | Jenavalve Technology Gmbh | Medical device for treating a heart valve insufficiency or stenosis |
| CN101720211B (zh) | 2007-05-15 | 2013-06-05 | 耶拿阀门科技公司 | 用于操纵导管尖端的手柄、导管系统和用于插入自扩式心脏瓣膜支架的医疗插入系统 |
| US9101691B2 (en) * | 2007-06-11 | 2015-08-11 | Edwards Lifesciences Corporation | Methods for pre-stressing and capping bioprosthetic tissue |
| US8858490B2 (en) | 2007-07-18 | 2014-10-14 | Silk Road Medical, Inc. | Systems and methods for treating a carotid artery |
| US8357387B2 (en) | 2007-12-21 | 2013-01-22 | Edwards Lifesciences Corporation | Capping bioprosthetic tissue to reduce calcification |
| JP2011513220A (ja) * | 2008-02-21 | 2011-04-28 | ヴァトリックス・メディカル・インコーポレーテッド | デリバリービヒクルと組み合わせた結合組織安定剤の適用による動脈瘤の処置 |
| US8465540B2 (en) | 2008-02-26 | 2013-06-18 | Jenavalve Technology, Inc. | Stent for the positioning and anchoring of a valvular prosthesis |
| US9168130B2 (en) | 2008-02-26 | 2015-10-27 | Jenavalve Technology Gmbh | Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient |
| US8398704B2 (en) | 2008-02-26 | 2013-03-19 | Jenavalve Technology, Inc. | Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient |
| US9044318B2 (en) | 2008-02-26 | 2015-06-02 | Jenavalve Technology Gmbh | Stent for the positioning and anchoring of a valvular prosthesis |
| WO2011104269A1 (en) | 2008-02-26 | 2011-09-01 | Jenavalve Technology Inc. | Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient |
| US8317858B2 (en) | 2008-02-26 | 2012-11-27 | Jenavalve Technology, Inc. | Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient |
| US20100119605A1 (en) * | 2008-11-12 | 2010-05-13 | Isenburg Jason C | Compositions for tissue stabilization |
| US20100292779A1 (en) | 2009-05-15 | 2010-11-18 | Helmut Straubinger | Device for compressing a stent and a system as well as a method for loading a stent into a medical delivery system |
| US8496911B2 (en) * | 2009-07-29 | 2013-07-30 | Vatrix CHF, Inc. | Tissue stabilization for heart failure |
| EP2485687A1 (de) * | 2009-10-09 | 2012-08-15 | Vatrix Medical, Inc. | Chemische in-vivo-stabilisierung empfindlicher plaque |
| FR2951549B1 (fr) | 2009-10-15 | 2013-08-23 | Olivier Schussler | Procede d'obtention de bioprotheses medicales implantables |
| US8444624B2 (en) * | 2009-10-19 | 2013-05-21 | Vatrix Medical, Inc. | Vascular medical devices with sealing elements and procedures for the treatment of isolated vessel sections |
| EP2549957B1 (de) | 2010-03-23 | 2019-01-30 | Edwards Lifesciences Corporation | Verfahren zur bearbeitung eines scheibenförmigen bioprothese-gewebes |
| US11278406B2 (en) | 2010-05-20 | 2022-03-22 | Jenavalve Technology, Inc. | Catheter system for introducing an expandable heart valve stent into the body of a patient, insertion system with a catheter system and medical device for treatment of a heart valve defect |
| US10856978B2 (en) | 2010-05-20 | 2020-12-08 | Jenavalve Technology, Inc. | Catheter system |
| BR112012029896A2 (pt) | 2010-05-25 | 2017-06-20 | Jenavalve Tech Inc | válcula cardíaca protética para endoprótese e endoprótese |
| US8906601B2 (en) | 2010-06-17 | 2014-12-09 | Edwardss Lifesciences Corporation | Methods for stabilizing a bioprosthetic tissue by chemical modification of antigenic carbohydrates |
| EP2582411B1 (de) | 2010-06-17 | 2019-05-01 | Edwards Lifesciences Corporation | Verfahren zur stabilisierung eines bioprothesengewebes durch modifikation antigener kohlenhydrate |
| US9351829B2 (en) | 2010-11-17 | 2016-05-31 | Edwards Lifesciences Corporation | Double cross-linkage process to enhance post-implantation bioprosthetic tissue durability |
| WO2013057566A2 (en) | 2011-10-18 | 2013-04-25 | Ortho-Space Ltd. | Prosthetic devices and methods for using same |
| CA2852369A1 (en) | 2011-10-21 | 2013-04-25 | Jenavalve Technology Inc. | Catheter system for introducing an expandable heart valve stent into the body of a patient, insertion system with a catheter system and medical device for treatment of a heart valve defect |
| US9878127B2 (en) | 2012-05-16 | 2018-01-30 | Jenavalve Technology, Inc. | Catheter delivery system for heart valve prosthesis |
| US20140017263A1 (en) | 2012-06-28 | 2014-01-16 | Clemson University | Delivery Agents for Targeted Treatment of Elastin Degradation |
| US9283241B2 (en) * | 2012-07-10 | 2016-03-15 | Clemson University | Treatment to render implants resistant to diabetes |
| US10238771B2 (en) | 2012-11-08 | 2019-03-26 | Edwards Lifesciences Corporation | Methods for treating bioprosthetic tissue using a nucleophile/electrophile in a catalytic system |
| US9867694B2 (en) | 2013-08-30 | 2018-01-16 | Jenavalve Technology Inc. | Radially collapsible frame for a prosthetic valve and method for manufacturing such a frame |
| US9795573B2 (en) | 2013-09-24 | 2017-10-24 | Clemson University | Multi-step connective tissue stabilization method and stabilized tissue formed thereby |
| US9615922B2 (en) | 2013-09-30 | 2017-04-11 | Edwards Lifesciences Corporation | Method and apparatus for preparing a contoured biological tissue |
| US10959839B2 (en) | 2013-10-08 | 2021-03-30 | Edwards Lifesciences Corporation | Method for directing cellular migration patterns on a biological tissue |
| JP6829692B2 (ja) | 2015-03-20 | 2021-02-10 | イェーナヴァルヴ テクノロジー インコーポレイテッド | 心臓弁プロテーゼ送出システム及び導入体シースにより心臓弁プロテーゼを送出するための方法 |
| CA2980316A1 (en) | 2015-03-24 | 2016-09-29 | Osiris Therapeutics, Inc. | Compositions comprising meniscal tissues and uses thereof |
| JP6767388B2 (ja) | 2015-05-01 | 2020-10-14 | イェーナヴァルヴ テクノロジー インコーポレイテッド | 心臓弁置換におけるペースメーカー割合を低減させるデバイス及び方法 |
| US10959761B2 (en) | 2015-09-18 | 2021-03-30 | Ortho-Space Ltd. | Intramedullary fixated subacromial spacers |
| CN109475419B (zh) | 2016-05-13 | 2021-11-09 | 耶拿阀门科技股份有限公司 | 用于通过引导鞘和装载系统来递送心脏瓣膜假体的心脏瓣膜假体递送系统和方法 |
| WO2018138658A1 (en) | 2017-01-27 | 2018-08-02 | Jenavalve Technology, Inc. | Heart valve mimicry |
| US11045981B2 (en) | 2017-01-30 | 2021-06-29 | Ortho-Space Ltd. | Processing machine and methods for processing dip-molded articles |
| WO2018222434A1 (en) | 2017-05-31 | 2018-12-06 | Edwards Lifesciences Corporation | Collagen fibers and articles formed therefrom |
| AU2019212059A1 (en) | 2018-01-23 | 2020-05-21 | Edwards Lifesciences Corporation | Method for pre-stretching implantable biocompatible materials, and materials and devices produced thereby |
| KR102271744B1 (ko) | 2018-07-25 | 2021-07-01 | 가톨릭대학교 산학협력단 | 생체 모사형 인공방광 및 이의 제어방법 |
| WO2020092205A1 (en) | 2018-11-01 | 2020-05-07 | Edwards Lifesciences Corporation | Transcatheter pulmonic regenerative valve |
| KR20250130862A (ko) | 2019-01-22 | 2025-09-02 | 클렘손 유니버서티 리서치 화운데이션 | 항-엘라스틴 항체 및 사용 방법 |
| US20250205388A1 (en) * | 2022-06-08 | 2025-06-26 | Cortronik GmbH | Process for applying a polymer coating to a protein-containing biological material |
| US12171658B2 (en) | 2022-11-09 | 2024-12-24 | Jenavalve Technology, Inc. | Catheter system for sequential deployment of an expandable implant |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4394370A (en) * | 1981-09-21 | 1983-07-19 | Jefferies Steven R | Bone graft material for osseous defects and method of making same |
| US4753652A (en) | 1984-05-04 | 1988-06-28 | Children's Medical Center Corporation | Biomaterial implants which resist calcification |
| CA1264476A (en) * | 1985-05-30 | 1990-01-16 | William J. Schultz | Epoxy resin curing agent, process, and composition |
| JPH01500730A (ja) | 1986-08-20 | 1989-03-16 | ザ・チャイルドレンズ・メディカル・センター・コーポレーション | 生物学的材料移植片 |
| AT398373B (de) * | 1987-12-17 | 1994-11-25 | Immuno Ag | Biologisches resorbierbares implantationsmaterial sowie verfahren zur herstellung desselben |
| JP2592420B2 (ja) * | 1988-01-25 | 1997-03-19 | 日本合成化学工業株式会社 | ポリビニルアルコール系繊維の製造法 |
| JPH069920A (ja) * | 1992-06-24 | 1994-01-18 | Kansai Paint Co Ltd | 水性塗料用樹脂組成物 |
| US5436291A (en) | 1992-07-09 | 1995-07-25 | University Of Michigan, The Board Of . . . | Calcification-resistant synthetic biomaterials |
| JPH0680741A (ja) * | 1992-08-28 | 1994-03-22 | Seiren Co Ltd | 蛋白質含有合成高分子材料及びその調製方法 |
| JPH07184990A (ja) * | 1993-12-28 | 1995-07-25 | Kuraray Co Ltd | 医療用高分子材料および医療材料 |
| US5891196A (en) * | 1997-04-16 | 1999-04-06 | Baxter International Inc. | Method for actively binding heparin to crosslinked biological tissues |
| US6117979A (en) | 1997-08-18 | 2000-09-12 | Medtronic, Inc. | Process for making a bioprosthetic device and implants produced therefrom |
| US6008292A (en) * | 1997-12-02 | 1999-12-28 | Baxter International Inc. | Method for inhibiting calcification of aldehyde-fixed bioprosthetic materials |
| DE60036114T2 (de) * | 1999-06-25 | 2008-05-15 | Kaneka Corp. | Regenerierte kollagenfaser mit verringertem geruch und verbesserten fixierungseigenschaften; herstellungs- und fixierungsverfahren |
-
2000
- 2000-02-09 US US09/501,331 patent/US6391538B1/en not_active Expired - Fee Related
-
2001
- 2001-02-02 EP EP01908805A patent/EP1257305B1/de not_active Expired - Lifetime
- 2001-02-02 CA CA2397263A patent/CA2397263C/en not_active Expired - Fee Related
- 2001-02-02 AT AT01908805T patent/ATE302622T1/de not_active IP Right Cessation
- 2001-02-02 JP JP2001557611A patent/JP4841097B2/ja not_active Expired - Fee Related
- 2001-02-02 DE DE60112897T patent/DE60112897T2/de not_active Expired - Lifetime
- 2001-02-02 WO PCT/US2001/003509 patent/WO2001058503A1/en not_active Ceased
-
2002
- 2002-05-15 US US10/145,038 patent/US6824970B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP4841097B2 (ja) | 2011-12-21 |
| EP1257305A1 (de) | 2002-11-20 |
| DE60112897T2 (de) | 2006-06-08 |
| US20020172706A1 (en) | 2002-11-21 |
| EP1257305B1 (de) | 2005-08-24 |
| WO2001058503A1 (en) | 2001-08-16 |
| US6824970B2 (en) | 2004-11-30 |
| JP2003522001A (ja) | 2003-07-22 |
| CA2397263A1 (en) | 2001-08-16 |
| ATE302622T1 (de) | 2005-09-15 |
| US6391538B1 (en) | 2002-05-21 |
| CA2397263C (en) | 2011-01-25 |
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