DE60110932D1 - Kontinuierliches verfahren zur herstellung von l-ascorbinsäure - Google Patents
Kontinuierliches verfahren zur herstellung von l-ascorbinsäureInfo
- Publication number
- DE60110932D1 DE60110932D1 DE60110932T DE60110932T DE60110932D1 DE 60110932 D1 DE60110932 D1 DE 60110932D1 DE 60110932 T DE60110932 T DE 60110932T DE 60110932 T DE60110932 T DE 60110932T DE 60110932 D1 DE60110932 D1 DE 60110932D1
- Authority
- DE
- Germany
- Prior art keywords
- ascorbic acid
- separation process
- klg
- acid
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 title abstract 12
- 239000002211 L-ascorbic acid Substances 0.000 title abstract 6
- 235000000069 L-ascorbic acid Nutrition 0.000 title abstract 6
- 229960005070 ascorbic acid Drugs 0.000 title abstract 6
- 238000011437 continuous method Methods 0.000 title 1
- 238000006243 chemical reaction Methods 0.000 abstract 3
- 238000000926 separation method Methods 0.000 abstract 3
- VBUYCZFBVCCYFD-NUNKFHFFSA-N 2-dehydro-L-idonic acid Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)C(=O)C(O)=O VBUYCZFBVCCYFD-NUNKFHFFSA-N 0.000 abstract 1
- VBUYCZFBVCCYFD-UHFFFAOYSA-N D-arabino-2-Hexulosonic acid Natural products OCC(O)C(O)C(O)C(=O)C(O)=O VBUYCZFBVCCYFD-UHFFFAOYSA-N 0.000 abstract 1
- 239000003377 acid catalyst Substances 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000000354 decomposition reaction Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000011084 recovery Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/62—Three oxygen atoms, e.g. ascorbic acid
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Furan Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25799100P | 2000-12-22 | 2000-12-22 | |
| US257991P | 2000-12-22 | ||
| PCT/US2001/049609 WO2002051826A1 (en) | 2000-12-22 | 2001-12-21 | Continuous process for producing l-ascorbic acid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60110932D1 true DE60110932D1 (de) | 2005-06-23 |
| DE60110932T2 DE60110932T2 (de) | 2006-01-19 |
Family
ID=22978632
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60110932T Expired - Fee Related DE60110932T2 (de) | 2000-12-22 | 2001-12-21 | Kontinuierliches verfahren zur herstellung von l-ascorbinsäure |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6610863B2 (de) |
| EP (1) | EP1351949B1 (de) |
| JP (1) | JP2004516318A (de) |
| CN (1) | CN1507440A (de) |
| AT (1) | ATE295843T1 (de) |
| BR (1) | BR0116451A (de) |
| CA (1) | CA2432173A1 (de) |
| DE (1) | DE60110932T2 (de) |
| MX (1) | MXPA03005640A (de) |
| WO (1) | WO2002051826A1 (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10231890B4 (de) * | 2002-07-12 | 2004-07-01 | Basf Ag | Verfahren zur Abtrennung von Ascorbinsäure aus einem polaren, Ascorbinsäure und 2-Keto-L-gulonsäure enthaltenden Lösungsmittel |
| US6872314B2 (en) | 2003-08-29 | 2005-03-29 | Eastman Chemical Company | Dewatering process |
| US9070850B2 (en) | 2007-10-31 | 2015-06-30 | Cree, Inc. | Light emitting diode package and method for fabricating same |
| US8866169B2 (en) * | 2007-10-31 | 2014-10-21 | Cree, Inc. | LED package with increased feature sizes |
| CN101397286B (zh) * | 2008-11-18 | 2011-12-21 | 江苏江山制药有限公司 | 一种维生素c连续结晶的方法 |
| CN110452934A (zh) * | 2012-05-23 | 2019-11-15 | 朗泽科技新西兰有限公司 | 发酵和模拟移动床过程 |
| EP2682168A1 (de) | 2012-07-02 | 2014-01-08 | Millipore Corporation | Reinigung biologischer Moleküle |
| CN103254159A (zh) * | 2013-01-29 | 2013-08-21 | 南京凯通粮食生化研究设计有限公司 | 一种维生素c生产工艺的改进方法 |
| CN104693160B (zh) * | 2015-02-16 | 2016-10-05 | 安徽泰格生物技术股份有限公司 | 一种维生素c的制备方法 |
| CN110407782A (zh) * | 2019-08-08 | 2019-11-05 | 安徽丰原发酵技术工程研究有限公司 | 一种以古龙酸为原料转化提取维生素c的色谱方法 |
| CN110372648A (zh) * | 2019-08-08 | 2019-10-25 | 安徽丰原发酵技术工程研究有限公司 | 一种以古龙酸盐为原料转化提取维生素c的色谱方法 |
| CN111087373A (zh) * | 2019-12-29 | 2020-05-01 | 安徽丰原发酵技术工程研究有限公司 | 一种酸法制备维生素c的方法 |
| CN113788752A (zh) * | 2021-10-20 | 2021-12-14 | 浙江圣达生物研究院有限公司 | 用模拟移动床色谱分离发酵液中2-酮基-d-葡萄糖酸的方法 |
| CN114369075B (zh) * | 2022-02-14 | 2023-09-29 | 河北乐开节能科技股份有限公司 | 利用2-酮基-l-古龙酸的水溶液一步制备vc结晶的方法 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2265121A (en) | 1933-10-25 | 1941-12-02 | Hoffmann La Roche | Process for the manufacture of levoascorbic acid |
| GB428815A (en) | 1933-12-09 | 1935-05-20 | Tadeus Reichstein | Process for the manufacture of laevo-ascorbic acid (vitamin-c) |
| US2491065A (en) | 1941-12-01 | 1949-12-13 | Tno | Process for producing ascorbic acid from 2-keto-levo-gulonic acid or its derivatives |
| US2462251A (en) | 1945-05-16 | 1949-02-22 | Merck & Co Inc | Process for preparing ascorbic acids |
| CH490368A (fr) * | 1968-02-01 | 1970-05-15 | Politechnika Slaska Im Wincent | Procédé de production de vitamine C |
| JPS4815931B1 (de) | 1970-10-05 | 1973-05-18 | ||
| US4111958A (en) | 1977-06-03 | 1978-09-05 | Pfizer Inc. | Ascorbic acid synthesis |
| DD141832A1 (de) * | 1978-10-31 | 1980-05-21 | Joachim Schmidt | Verfahren und vorrichtung zur herstellung von l-ascorbinsaeure |
| DE3621781A1 (de) | 1985-07-05 | 1987-01-15 | Takeda Chemical Industries Ltd | Verfahren zur reinigung von l-ascorbinsaeure |
| CN86105960A (zh) | 1985-08-09 | 1987-05-13 | 鲁布里佐尔公司 | 在基本无水条件下从2-酮-l-古洛糖酸制备l-抗坏血酸 |
| DE3843389A1 (de) | 1988-12-23 | 1990-06-28 | Basf Ag | Verfahren zur herstellung von ascorbinsaeure |
| FR2648136B1 (fr) | 1989-06-12 | 1994-06-17 | Rhone Poulenc Sante | Procede de preparation de l'acide ascorbique |
| CH678057A5 (de) | 1989-06-26 | 1991-07-31 | Enco Eng Ag | Verfahren zur herstellung von natrium- oder kalium-l-ascorbat. |
| JP3134236B2 (ja) | 1992-01-30 | 2001-02-13 | 株式会社林原生物化学研究所 | α−グリコシル−Ｌ−アスコルビン酸高含有物の製造方法とその製造のための分離システム |
| JPH08188578A (ja) * | 1994-11-11 | 1996-07-23 | Takeda Chem Ind Ltd | Ｌ−アスコルビン酸の製造方法 |
| JPH08176133A (ja) * | 1994-12-26 | 1996-07-09 | Takeda Chem Ind Ltd | Ｌ−アスコルビン酸の精製法 |
| IL115564A (en) | 1995-10-11 | 1999-06-20 | Yissum Res Dev Co | Process for the recovery of ascorbic acid from an aqueous feed solution |
| DE19547073C1 (de) | 1995-12-16 | 1996-11-14 | Merck Patent Gmbh | Verfahren zur Herstellung von Ascorbinsäure |
| BR9810227A (pt) | 1997-06-30 | 2000-08-08 | Electrosynthesis Co Inc | Processos para a produção de ácido ascórbico, de um co-produto base e de um co-produto de sal de metóxido |
| DE19734086C1 (de) | 1997-08-07 | 1998-08-13 | Merck Patent Gmbh | Verfahren zur Herstellung von L-Ascorbinsäure |
| DE19904821C1 (de) * | 1999-02-05 | 2000-07-06 | Merck Patent Gmbh | Verfahren zur Herstellung von L-Ascobinsäure |
| US5998634A (en) | 1999-03-15 | 1999-12-07 | The United States Of America As Represented By The Secretary Of The Interior | One-step synthesis of vitamin-C (L-ascorbic acid) |
| DE19919203A1 (de) | 1999-04-28 | 2000-11-02 | Basf Ag | Verfahren zur Herstellung von L-Ascorbinsäure |
-
2001
- 2001-12-21 EP EP01991443A patent/EP1351949B1/de not_active Expired - Lifetime
- 2001-12-21 MX MXPA03005640A patent/MXPA03005640A/es active IP Right Grant
- 2001-12-21 BR BR0116451-1A patent/BR0116451A/pt not_active IP Right Cessation
- 2001-12-21 US US10/037,126 patent/US6610863B2/en not_active Expired - Fee Related
- 2001-12-21 WO PCT/US2001/049609 patent/WO2002051826A1/en not_active Ceased
- 2001-12-21 JP JP2002552921A patent/JP2004516318A/ja active Pending
- 2001-12-21 AT AT01991443T patent/ATE295843T1/de not_active IP Right Cessation
- 2001-12-21 CN CNA018228046A patent/CN1507440A/zh active Pending
- 2001-12-21 DE DE60110932T patent/DE60110932T2/de not_active Expired - Fee Related
- 2001-12-21 CA CA002432173A patent/CA2432173A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| DE60110932T2 (de) | 2006-01-19 |
| CN1507440A (zh) | 2004-06-23 |
| US20020151726A1 (en) | 2002-10-17 |
| CA2432173A1 (en) | 2002-07-04 |
| BR0116451A (pt) | 2003-09-30 |
| WO2002051826A1 (en) | 2002-07-04 |
| EP1351949A1 (de) | 2003-10-15 |
| ATE295843T1 (de) | 2005-06-15 |
| JP2004516318A (ja) | 2004-06-03 |
| US6610863B2 (en) | 2003-08-26 |
| EP1351949B1 (de) | 2005-05-18 |
| MXPA03005640A (es) | 2003-10-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |