[go: up one dir, main page]

DE60108754D1 - Substituierte bizyklische derivate für die behandlung von unnormalem zellwachstum - Google Patents

Substituierte bizyklische derivate für die behandlung von unnormalem zellwachstum

Info

Publication number
DE60108754D1
DE60108754D1 DE60108754T DE60108754T DE60108754D1 DE 60108754 D1 DE60108754 D1 DE 60108754D1 DE 60108754 T DE60108754 T DE 60108754T DE 60108754 T DE60108754 T DE 60108754T DE 60108754 D1 DE60108754 D1 DE 60108754D1
Authority
DE
Germany
Prior art keywords
unnormal
treatment
cell growth
substituted bicyclic
bicyclic derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60108754T
Other languages
English (en)
Other versions
DE60108754T2 (de
Inventor
John Charles Kath
Samit Kumar Bhattacharya
Joel Morris
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
OSI Pharmaceuticals LLC
Original Assignee
Pfizer Products Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc filed Critical Pfizer Products Inc
Application granted granted Critical
Publication of DE60108754D1 publication Critical patent/DE60108754D1/de
Publication of DE60108754T2 publication Critical patent/DE60108754T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
DE60108754T 2000-06-22 2001-06-14 Substituierte bizyklische derivate für die behandlung von unnormalem zellwachstum Expired - Lifetime DE60108754T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US21313600P 2000-06-22 2000-06-22
US213136P 2000-06-22
PCT/IB2001/001046 WO2001098277A2 (en) 2000-06-22 2001-06-14 Substituted bicyclic derivatives for the treatment of abnormal cell growth

Publications (2)

Publication Number Publication Date
DE60108754D1 true DE60108754D1 (de) 2005-03-10
DE60108754T2 DE60108754T2 (de) 2005-06-23

Family

ID=22793862

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60108754T Expired - Lifetime DE60108754T2 (de) 2000-06-22 2001-06-14 Substituierte bizyklische derivate für die behandlung von unnormalem zellwachstum

Country Status (42)

Country Link
US (2) US6890924B2 (de)
EP (1) EP1292591B1 (de)
JP (1) JP4044839B2 (de)
KR (1) KR100545537B1 (de)
CN (3) CN101348467A (de)
AP (1) AP2001002192A0 (de)
AR (1) AR032353A1 (de)
AT (1) ATE288431T1 (de)
AU (1) AU2001264159A1 (de)
BG (1) BG107269A (de)
BR (1) BR0111548A (de)
CA (1) CA2413424C (de)
CZ (1) CZ20023951A3 (de)
DE (1) DE60108754T2 (de)
DK (1) DK1292591T3 (de)
DZ (1) DZ3407A1 (de)
EA (1) EA005525B1 (de)
EC (1) ECSP024393A (de)
EE (1) EE200200710A (de)
ES (1) ES2236240T3 (de)
GE (1) GEP20063831B (de)
HR (1) HRP20021005A2 (de)
HU (1) HUP0301120A2 (de)
IL (1) IL152985A0 (de)
IS (1) IS6616A (de)
MA (1) MA26914A1 (de)
MX (1) MXPA02012870A (de)
MY (1) MY127181A (de)
NO (1) NO20026166D0 (de)
NZ (1) NZ522568A (de)
OA (1) OA12291A (de)
PA (1) PA8520301A1 (de)
PE (1) PE20020257A1 (de)
PL (1) PL359557A1 (de)
PT (1) PT1292591E (de)
SK (1) SK17102002A3 (de)
SV (1) SV2002000504A (de)
TN (1) TNSN01091A1 (de)
UA (1) UA73990C2 (de)
WO (1) WO2001098277A2 (de)
YU (1) YU95102A (de)
ZA (1) ZA200210231B (de)

Families Citing this family (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7772432B2 (en) * 1991-09-19 2010-08-10 Astrazeneca Ab Amidobenzamide derivatives which are useful as cytokine inhibitors
GB9800569D0 (en) * 1998-01-12 1998-03-11 Glaxo Group Ltd Heterocyclic compounds
DE69905264T2 (de) * 1998-10-01 2003-12-11 Astrazeneca Ab, Soedertaelje Chinolin- und chinazolin derivate und ihre verwendung als inhibitoren von krankheiten, bei denen cytokine beteiligt wird
WO2001098277A2 (en) * 2000-06-22 2001-12-27 Pfizer Products Inc. Substituted bicyclic derivatives for the treatment of abnormal cell growth
KR100861486B1 (ko) * 2001-02-21 2008-10-02 미쓰비시 타나베 파마 코퍼레이션 퀴나졸린 유도체
US20030144308A1 (en) * 2001-09-24 2003-07-31 Bauer Paul H. Fructose 1,6-bisphosphatase inhibitors
IL160971A0 (en) * 2001-11-30 2004-08-31 Pfizer Prod Inc Processes for the preparation of substituted bicyclic derivatives for the treatment of abnormal cell growth
EP1456199A1 (de) 2001-12-12 2004-09-15 Pfizer Products Inc. Salzformen von e-2-methoxy-n-(3-(4-(3-methyl-pyridin-3-yloxy)phenylamino)-chinazolin-6-yl)-allyl)-acetamid und herstellungs verfahren
JP4181502B2 (ja) * 2001-12-12 2008-11-19 ファイザー・プロダクツ・インク 異常な細胞増殖を治療するためのキナゾリン誘導体
US6924285B2 (en) 2002-03-30 2005-08-02 Boehringer Ingelheim Pharma Gmbh & Co. Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them
EP2280003B1 (de) 2002-07-15 2014-04-02 Symphony Evolution, Inc. Verfahren zur Herstellung von Rezeptorkinase-Modulatoren
US7488823B2 (en) * 2003-11-10 2009-02-10 Array Biopharma, Inc. Cyanoguanidines and cyanoamidines as ErbB2 and EGFR inhibitors
EP1567506A4 (de) 2002-11-20 2007-06-20 Array Biopharma Inc Cyanoguanidine und cyanoamidine als erbb2- und egfr-inhibitoren
KR20050085749A (ko) * 2002-12-18 2005-08-29 화이자 프로덕츠 인크. 비정상적 세포 성장의 치료를 위한 4-아닐리노 퀴나졸린유도체
JP2006512355A (ja) * 2002-12-19 2006-04-13 ファイザー・プロダクツ・インク Ｅ−２−メトキシ−ｎ−（３−｛４−［３−メチル−４−（６−メチルピリジン−３−イルオキシ）−フェニルアミノ］−キナゾリン−６−イル｝−アリル）−アセトアミドの複合体、それらの製造方法および使用
CA2521348A1 (en) * 2003-04-09 2004-10-21 Pfizer Products Inc. Processes for the preparation of n-((((pyridinyloxy)-phenylamino) quinazolinyl)-allyl) acetamide derivatives and related compounds as well as intermediates of such processes and processes for the preparation of such intermediates
EP1636195A1 (de) * 2003-05-27 2006-03-22 Pfizer Products Inc. Chinazoline und pyrido[3,4-d]pyrimidine als rezeptor tyrosin kinase inhibitoren
US8309562B2 (en) 2003-07-03 2012-11-13 Myrexis, Inc. Compounds and therapeutical use thereof
KR101218213B1 (ko) * 2003-07-03 2013-01-04 시토비아 인크. 카스파제의 활성인자 및 세포자멸사의 유도인자로서의4-아릴아미노-퀴나졸린
EP1644017A2 (de) * 2003-07-15 2006-04-12 National Research Council Of Canada Cyclische analoga des humanen parahormons zur behanldung von erkrankungen, die durch hyperproliferative hautzellen charakterisiert sind
US7501427B2 (en) 2003-08-14 2009-03-10 Array Biopharma, Inc. Quinazoline analogs as receptor tyrosine kinase inhibitors
NZ545459A (en) * 2003-08-14 2009-12-24 Array Biopharma Inc Quinazoline analogs as receptor tyrosine kinase inhibitors
MXPA06001989A (es) * 2003-08-18 2006-05-17 Pfizer Prod Inc Programa de dosificacion para un nuevo agente anticanceroso.
ATE395346T1 (de) 2003-09-16 2008-05-15 Astrazeneca Ab Chinazolinderivate als tyrosinkinaseinhibitoren
GB0322409D0 (en) 2003-09-25 2003-10-29 Astrazeneca Ab Quinazoline derivatives
PT2213661E (pt) 2003-09-26 2011-12-15 Exelixis Inc Moduladores de c-met e métodos de uso
MXPA06005024A (es) * 2003-11-06 2006-07-06 Pfizer Prod Inc Combinaciones de inhibidor de erbb2 selectivo/anticuerpos anti-erbb en el tratamiento del cancer.
GB0326459D0 (en) 2003-11-13 2003-12-17 Astrazeneca Ab Quinazoline derivatives
ES2315834T3 (es) 2004-02-03 2009-04-01 Astrazeneca Ab Derivados de quinazolina.
US20050192298A1 (en) * 2004-02-27 2005-09-01 Pfizer Inc Crystal forms of E-2-Methoxy-N-(3-{4-[3-methyl-4-(6-methyl-pyridin-3-yloxy)-phenylamino]-quinazolin-6-yl}-allyl)-acetamide
CN101014365B (zh) 2004-07-16 2011-04-13 辉瑞产品公司 使用抗-igf-1r抗体联合治疗非血液的恶性肿瘤
KR20070058529A (ko) * 2004-09-01 2007-06-08 미쯔비시 웰 파마 가부시키가이샤 분자 샤프론 기능 조절제
WO2006071079A1 (en) * 2004-12-29 2006-07-06 Hanmi Pharm. Co., Ltd. Quinazoline derivatives for inhibiting cancer cell growth and method for the preparation thereof
KR100735639B1 (ko) 2004-12-29 2007-07-04 한미약품 주식회사 암세포 성장 억제 효과를 갖는 퀴나졸린 유도체 및 이의제조방법
EP1833482A4 (de) 2005-01-03 2011-02-16 Myriad Genetics Inc Verbindungen und ihre therapeutische verwendung
US8258145B2 (en) 2005-01-03 2012-09-04 Myrexis, Inc. Method of treating brain cancer
KR100990027B1 (ko) 2005-04-26 2010-10-26 화이자 인코포레이티드 Ｐ-카드헤린 항체
CA2610491A1 (en) * 2005-06-03 2006-12-07 Pfizer Products Inc. Bicyclic derivatives for the treatment of abnormal cell growth
US20080194596A1 (en) * 2005-06-03 2008-08-14 Frizer Inc. Therapeutic Combination Including a Selective Erbb2 Inhibitor
DOP2006000195A (es) 2005-09-07 2017-08-15 Amgen Fremont Inc Anticuerpos monoclonales humanos para la quinasa-1 tipo receptor de activina
CN102887891B (zh) 2005-11-15 2016-03-09 阿雷生物药品公司 N4-苯基-喹唑啉-4-胺衍生物和相关化合物
GB0526552D0 (en) * 2005-12-29 2006-02-08 Morvus Technology Ltd New use
BRPI0711358A2 (pt) 2006-05-09 2011-09-27 Pfizer Prod Inc derivados do ácido cicloalquilamino e suas composições farmacêuticas
WO2008002039A1 (en) * 2006-06-28 2008-01-03 Hanmi Pharm. Co., Ltd. Quinazoline derivatives for inhibiting the growth of cancer cell
SG174772A1 (en) * 2006-09-11 2011-10-28 Curis Inc Multi-functional small molecules as anti-proliferative agents
US7547781B2 (en) 2006-09-11 2009-06-16 Curis, Inc. Quinazoline based EGFR inhibitors containing a zinc binding moiety
US8604044B2 (en) * 2006-09-11 2013-12-10 Curis, Inc. Quinazoline based EGFR inhibitors containing a zinc binding moiety
EP1921070A1 (de) 2006-11-10 2008-05-14 Boehringer Ingelheim Pharma GmbH & Co. KG Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstelllung
US20100004238A1 (en) 2006-12-12 2010-01-07 Takeda Pharmaceutical Company Limited Fused heterocyclic compound
BRPI0807234A2 (pt) 2007-02-06 2014-06-03 Boehringer Ingelheim Int Heterociclos bicíclicos, composições farmacêuticas que contêm estes compostos, o uso dos mesmos e processos para a preparação dos mesmos
AU2008239594B2 (en) 2007-04-13 2013-10-24 Beth Israel Deaconess Medical Center Methods for treating cancer resistant to ErbB therapeutics
KR20100111291A (ko) 2008-02-07 2010-10-14 베링거 인겔하임 인터내셔날 게엠베하 스피로사이클릭 헤테로사이클, 상기 화합물을 함유하는 약제, 이의 용도 및 이의 제조 방법
UY31704A (es) 2008-03-12 2009-11-10 Takeda Pharmaceutical Compuesto heterociclico fusionado
US8426430B2 (en) * 2008-06-30 2013-04-23 Hutchison Medipharma Enterprises Limited Quinazoline derivatives
CA2733153C (en) 2008-08-08 2016-11-08 Boehringer Ingelheim International Gmbh Cyclohexyloxy substituted heterocycles, pharmaceutical compositions containing these compounds and processes for preparing them
EP2387563B2 (de) 2009-01-16 2022-04-27 Exelixis, Inc. Malatsalz von n-(4-{[6,7-bis(methyloxy)chinolin-4-yl]-oxy}phenyl-n'-(4-fluorphenyl)cyclo-propan-1,1-dicarbonsäureamid und kristalline formen davon zur behandlung von krebs
UA108618C2 (uk) 2009-08-07 2015-05-25 Застосування c-met-модуляторів в комбінації з темозоломідом та/або променевою терапією для лікування раку
WO2011027249A2 (en) 2009-09-01 2011-03-10 Pfizer Inc. Benzimidazole derivatives
WO2011153050A1 (en) 2010-06-02 2011-12-08 The Trustees Of The University Of Pennsylvania Methods and use of compounds that bind to her2/neu receptor complex
WO2011153049A1 (en) 2010-06-02 2011-12-08 The Trustees Of The University Of Pennsylvania Methods and use of compounds that bind to her2/neu receptor complex
US9526648B2 (en) 2010-06-13 2016-12-27 Synerz Medical, Inc. Intragastric device for treating obesity
US10010439B2 (en) 2010-06-13 2018-07-03 Synerz Medical, Inc. Intragastric device for treating obesity
US8628554B2 (en) 2010-06-13 2014-01-14 Virender K. Sharma Intragastric device for treating obesity
US10420665B2 (en) 2010-06-13 2019-09-24 W. L. Gore & Associates, Inc. Intragastric device for treating obesity
US9056865B2 (en) 2010-10-20 2015-06-16 Pfizer Inc. Pyridine-2-derivatives as smoothened receptor modulators
JP5914667B2 (ja) 2011-09-22 2016-05-11 ファイザー・インク ピロロピリミジンおよびプリン誘導体
CN102872018B (zh) * 2012-10-23 2015-07-15 广州市恒诺康医药科技有限公司 酪氨酸激酶不可逆抑制剂及其制备方法和用途
US9468681B2 (en) 2013-03-01 2016-10-18 California Institute Of Technology Targeted nanoparticles
UA115388C2 (uk) 2013-11-21 2017-10-25 Пфайзер Інк. 2,6-заміщені пуринові похідні та їх застосування в лікуванні проліферативних захворювань
WO2015155624A1 (en) 2014-04-10 2015-10-15 Pfizer Inc. Dihydropyrrolopyrimidine derivatives
GEP20186879B (en) 2014-04-30 2018-07-10 Pfizer Cycloalkyl-linked diheterocycle derivatives
KR101589632B1 (ko) 2014-06-03 2016-02-01 한국과학기술연구원 항암활성을 가지는 6-벤질옥시퀴나졸린-7-일유레아 유도체
WO2016001789A1 (en) 2014-06-30 2016-01-07 Pfizer Inc. Pyrimidine derivatives as pi3k inhibitors for use in the treatment of cancer
EP3317323B1 (de) 2015-07-01 2021-05-26 California Institute of Technology Kationische schleimsäurepolymerbasierte abgabesysteme
WO2017009751A1 (en) 2015-07-15 2017-01-19 Pfizer Inc. Pyrimidine derivatives
CN107141293B (zh) * 2016-03-01 2022-09-23 上海医药集团股份有限公司 一种含氮杂环化合物、制备方法、中间体、组合物和应用
US10779980B2 (en) 2016-04-27 2020-09-22 Synerz Medical, Inc. Intragastric device for treating obesity
JP7483193B2 (ja) 2018-06-13 2024-05-15 カリフォルニア・インスティテュート・オブ・テクノロジー 血脳バリアを越えるためのナノ粒子とそれを用いた治療法
JP7546550B2 (ja) 2018-09-18 2024-09-06 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト 抗腫瘍剤としてのキナゾリン誘導体
CA3253847A1 (en) * 2022-03-28 2025-07-04 Shanghai Hengrui Pharmaceutical Co., Ltd. HETEROCYCLIC COMPOUND CONTAINING NITROGEN, ITS PREPARATION PROCESS AND PHARMACEUTICAL USE
WO2025067396A1 (zh) * 2023-09-27 2025-04-03 江苏恒瑞医药股份有限公司 一种喹唑啉衍生物的可药用盐、其结晶形式及用途

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW321649B (de) * 1994-11-12 1997-12-01 Zeneca Ltd
GB9424233D0 (en) * 1994-11-30 1995-01-18 Zeneca Ltd Quinazoline derivatives
GB9603095D0 (en) * 1996-02-14 1996-04-10 Zeneca Ltd Quinazoline derivatives
US6225318B1 (en) 1996-10-17 2001-05-01 Pfizer Inc 4-aminoquinazolone derivatives
ZA986732B (en) * 1997-07-29 1999-02-02 Warner Lambert Co Irreversible inhibitiors of tyrosine kinases
GB9800575D0 (en) 1998-01-12 1998-03-11 Glaxo Group Ltd Heterocyclic compounds
GB9800569D0 (en) 1998-01-12 1998-03-11 Glaxo Group Ltd Heterocyclic compounds
ES2241324T3 (es) 1998-10-08 2005-10-16 Astrazeneca Ab Derivados de quinazolina.
UA71945C2 (en) * 1999-01-27 2005-01-17 Pfizer Prod Inc Substituted bicyclic derivatives being used as anticancer agents
JP3270834B2 (ja) * 1999-01-27 2002-04-02 ファイザー・プロダクツ・インク 抗がん剤として有用なヘテロ芳香族二環式誘導体
WO2001098277A2 (en) * 2000-06-22 2001-12-27 Pfizer Products Inc. Substituted bicyclic derivatives for the treatment of abnormal cell growth

Also Published As

Publication number Publication date
UA73990C2 (en) 2005-10-17
NZ522568A (en) 2004-12-24
BR0111548A (pt) 2003-05-06
CA2413424A1 (en) 2001-12-27
CN1576275A (zh) 2005-02-09
DZ3407A1 (de) 2001-12-27
DK1292591T3 (da) 2005-05-30
OA12291A (en) 2004-03-18
PA8520301A1 (es) 2003-06-30
US20020169165A1 (en) 2002-11-14
WO2001098277A2 (en) 2001-12-27
TNSN01091A1 (fr) 2005-11-10
BG107269A (bg) 2003-06-30
CN101348467A (zh) 2009-01-21
EP1292591A2 (de) 2003-03-19
GEP20063831B (en) 2006-05-25
CN1330640C (zh) 2007-08-08
AP2001002192A0 (en) 2002-12-21
US6890924B2 (en) 2005-05-10
WO2001098277A3 (en) 2002-06-13
NO20026166L (no) 2002-12-20
KR100545537B1 (ko) 2006-01-25
US7332493B2 (en) 2008-02-19
DE60108754T2 (de) 2005-06-23
HRP20021005A2 (en) 2004-02-29
ECSP024393A (es) 2003-02-06
NO20026166D0 (no) 2002-12-20
ZA200210231B (en) 2004-02-12
HUP0301120A2 (hu) 2003-08-28
KR20030016303A (ko) 2003-02-26
EA005525B1 (ru) 2005-04-28
EE200200710A (et) 2004-06-15
JP2004501139A (ja) 2004-01-15
PL359557A1 (en) 2004-08-23
CZ20023951A3 (cs) 2004-01-14
SV2002000504A (es) 2002-10-24
ES2236240T3 (es) 2005-07-16
CA2413424C (en) 2007-10-02
ATE288431T1 (de) 2005-02-15
EA200201277A1 (ru) 2003-06-26
US20050159435A1 (en) 2005-07-21
MXPA02012870A (es) 2003-05-14
MA26914A1 (fr) 2004-12-20
IS6616A (is) 2002-11-14
PT1292591E (pt) 2005-06-30
YU95102A (sh) 2005-11-28
SK17102002A3 (sk) 2004-04-06
HK1069576A1 (en) 2005-05-27
IL152985A0 (en) 2003-06-24
CN1437594A (zh) 2003-08-20
MY127181A (en) 2006-11-30
PE20020257A1 (es) 2002-04-08
AU2001264159A1 (en) 2002-01-02
JP4044839B2 (ja) 2008-02-06
AR032353A1 (es) 2003-11-05
EP1292591B1 (de) 2005-02-02

Similar Documents

Publication Publication Date Title
DE60108754D1 (de) Substituierte bizyklische derivate für die behandlung von unnormalem zellwachstum
DE60019556D1 (de) 2-amino-benzoxazinonderivate zur behandlung von fettleibigkeit
DE60019555D1 (de) 2-oxy-benzoxazinonderivate zur behandlung von fettleibigkeit
DE60124302D1 (de) Thiazolderivate zur behandlung von ppar-lierte krankheiten
ATE275145T1 (de) Chinazolinderivate zur behandlung von tumoren
DE60028358D1 (de) Hmg1 antagonisten zur behandlung von entzündungen
ATE551340T1 (de) Azabicyclisch- substituierte annelierte heteroaryl-verbinungen für die behandlung von krankheiten
ATE374196T1 (de) Dihydrobenzodiazepin-2-on-derivative für die behandlung von neurologischen erkrankungen
ATE345331T1 (de) Verbindungen verwendbar für die behandlung von entzündungskrankheiten
DE60219292D1 (de) Pyrazolderivate zur behandlung von hiv
ATE441417T1 (de) Benzoädüazepinderivate für die behandlung von neurologischen krankheiten
ATE304358T1 (de) (s,s)-reboxetin zur behandlung von migränekopfschmerzen
DE69927823T2 (de) Hydrogel für die therapeutische behandlung von aneurysmas
ATE312117T1 (de) Verbindungen für die behandlung von ischämie
ATE455106T1 (de) Acyl derivate zur behandlung von krankheiten die in zusammenhang mit vla-4 stehen
ATE458731T1 (de) Pyrimidin-derivate zur behandlung von anormalem zellwachstum
DE60325498D1 (de) 1-acyl-pyrrolidin-derivate für die behandlung von viralen infektionen
DE60239558D1 (de) Kombinationen für die behandlung von immun-entzündlichen erkrankungen
ATE286895T1 (de) Sulfonyl-pyrrolidinderivate geeignet für die behandlung von neurologischen krankheiten
DE60204951D1 (de) Ccr5 antagonisten verwendbar für die behandlung von aids
DE60136477D1 (de) Retinoide zur behandlung von emphysem
ATE418552T1 (de) Substituierte amino-furan-2-yl-essigsaure- und amino-thien-2-yl-essigsaure-derivate und ihre verwendung zur behandlung von migraine bzw. schmerz
DE50105735D1 (de) Chlorzoxazon zur behandlung von psoriasis
DE60223279D1 (de) Verfahren für die herstellung substituierter bicyclischer derivate zur behandlung von anomalem zellwachstum
DE60120990D1 (de) Verwendung von 3-bezoylphenylessigsäure-derivaten zur behandlung von netzhauterkrankungen

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: OSI PHARMACEUTICALS, INC. (N.D.GES.D. STAATES , US

Owner name: PFIZER INC. (N.D.GES.D. STAATES DELAWARE), NEW, US