[go: up one dir, main page]

DE60102357D1 - Verfahren zur herstellung von quetiapin und intermediate dafür - Google Patents

Verfahren zur herstellung von quetiapin und intermediate dafür

Info

Publication number
DE60102357D1
DE60102357D1 DE60102357T DE60102357T DE60102357D1 DE 60102357 D1 DE60102357 D1 DE 60102357D1 DE 60102357 T DE60102357 T DE 60102357T DE 60102357 T DE60102357 T DE 60102357T DE 60102357 D1 DE60102357 D1 DE 60102357D1
Authority
DE
Germany
Prior art keywords
quetiapine
intermediates therefor
producing
formula
producing quetiapine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60102357T
Other languages
English (en)
Other versions
DE60102357T2 (de
Inventor
Daniel Bozsing
Lax Gyoergyi Kovanyine
Gyula Simig
Gyoergyne Rakoczy
Peter Toempe
Gyoergy Krasznai
Donath Gyoergyi Vereczkeyne
Kalman Nagy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Egyt Gyogyszervegyeszeti Gyar
Egis Pharmaceuticals PLC
Original Assignee
Egyt Gyogyszervegyeszeti Gyar
Egis Pharmaceuticals PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egyt Gyogyszervegyeszeti Gyar, Egis Pharmaceuticals PLC filed Critical Egyt Gyogyszervegyeszeti Gyar
Application granted granted Critical
Publication of DE60102357D1 publication Critical patent/DE60102357D1/de
Publication of DE60102357T2 publication Critical patent/DE60102357T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D281/16—[b, f]-condensed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Steroid Compounds (AREA)
DE2001602357 2000-01-25 2001-01-24 Verfahren zur herstellung von quetiapin und intermediate dafür Expired - Lifetime DE60102357T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
HU0000283 2000-01-25
HU0000283A HU227039B1 (en) 2000-01-25 2000-01-25 New process for the production of quetiapine and intermediates therefor
PCT/HU2001/000010 WO2001055125A1 (en) 2000-01-25 2001-01-24 A process for the preparation of quetiapine and intermediates therefor

Publications (2)

Publication Number Publication Date
DE60102357D1 true DE60102357D1 (de) 2004-04-22
DE60102357T2 DE60102357T2 (de) 2005-01-13

Family

ID=89978038

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2001602357 Expired - Lifetime DE60102357T2 (de) 2000-01-25 2001-01-24 Verfahren zur herstellung von quetiapin und intermediate dafür

Country Status (16)

Country Link
EP (1) EP1252151B1 (de)
CN (2) CN1239487C (de)
AT (1) ATE261949T1 (de)
AU (1) AU3214601A (de)
CZ (1) CZ301236B6 (de)
DE (1) DE60102357T2 (de)
DK (1) DK1252151T3 (de)
ES (1) ES2217115T3 (de)
HR (1) HRP20020579B1 (de)
HU (1) HU227039B1 (de)
PL (1) PL211338B1 (de)
RU (1) RU2258067C2 (de)
SI (1) SI1252151T1 (de)
SK (1) SK287171B6 (de)
UA (1) UA73547C2 (de)
WO (1) WO2001055125A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002539191A (ja) 1999-03-15 2002-11-19 アクシス・ファーマシューティカルズ・インコーポレイテッド プロテアーゼ阻害剤としての新規化合物及び組成物
MXPA03005601A (es) 2000-12-22 2004-12-02 Axys Pharm Inc Nuevos compuestos y composiciones como inhibidores de catepsina.
US7030116B2 (en) 2000-12-22 2006-04-18 Aventis Pharmaceuticals Inc. Compounds and compositions as cathepsin inhibitors
RS19504A (sr) 2001-09-14 2007-02-05 Aventis Pharmaceuticals Inc., Nova jedinjenja i kompozicije kao inhibitori katepsina
US6977256B2 (en) 2001-11-14 2005-12-20 Aventis Pharmaceuticals Inc. Compounds and compositions as cathepsin S inhibitors
CA2516646A1 (en) 2003-02-22 2004-09-10 Teva Pharmaceutical Industries Ltd. Synthesis of quetiapine and pharmaceutically acceptable salts thereof
EP1631590B1 (de) 2003-04-23 2011-07-27 Medarex, Inc. Humanisierte antikörper gegen interferon-alpha-rezeptor-1 (ifnar-1)
PL195728B1 (pl) * 2003-07-18 2007-10-31 Helm Ag Sposób wytwarzania 11-(1-piperazynylo)dibenzo[b,f][1,4]tiazepiny
ES2223294B2 (es) * 2003-08-08 2005-10-01 Vita Cientifica, S.L. Procedimiento de preparacion de un compuesto farmaceuticamente activo.
US7858777B2 (en) 2003-09-23 2010-12-28 Fermion Oy Preparation method for quetiapine
CA2538745A1 (en) * 2003-09-23 2005-03-31 Fermion Oy Preparation of quetiapine
KR101038389B1 (ko) * 2004-06-23 2011-06-01 에스케이바이오팜 주식회사 11-(4-[2-(2-히드록시에톡시)에틸]-1-피페라지닐)-디벤조[ｂ,ｆ][1,4]티아제핀의 제조방법
WO2006035293A1 (en) * 2004-09-27 2006-04-06 Ranbaxy Laboratories Limited Polymorphic forms of quetiapine hemifumarate
WO2006056772A2 (en) * 2004-11-23 2006-06-01 Pliva Hrvatska D.O.O. Salts of quetiapine
GB0425729D0 (en) * 2004-11-23 2004-12-22 Pliva Res & Dev Ltd Heterocyclic compounds
ES2234447B1 (es) * 2005-03-07 2006-03-01 Union Quimico-Farmaceutica S.A. Procedimiento para la obtencion de un derivado de 11-(4-sustituido-1-piperazinil)dibenzo(b,f)(1,4)tiazepina.
US7687622B2 (en) 2005-04-14 2010-03-30 Teva Pharmaceutical Industries, Ltd Process for preparing quetiapine fumarate
EP1928849A1 (de) 2005-09-30 2008-06-11 Fermion Oy Neues kristallisationsverfahren für quetiapin-hemifumarat
PL2262486T3 (pl) 2008-08-01 2013-06-28 Krka Tovarna Zdravil D D Novo Mesto Kompozycja kwetiapiny
CN101676275B (zh) * 2008-09-17 2014-05-07 北京德众万全药物技术开发有限公司 一种富马酸喹硫平的制备方法
US20120071649A1 (en) 2009-03-04 2012-03-22 Ranbaxy Laboratories Limited Process for the preparation of quetiapine fumarate

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2683147A (en) * 1949-12-07 1954-07-06 Geigy Ag J R Quaternary ammonium compounds of bis-tertiary aminoalkoxy alkanes
CH422793A (de) * 1961-07-20 1966-10-31 Wander Ag Dr A Verfahren zur Herstellung 11-basisch substituierter Dibenzo(b,f) (1,4)thiazepine
CH476753A (de) * 1962-06-08 1969-08-15 Wander Ag Dr A Verfahren zur Herstellung von 11-basisch substituierter Dibenzo(b,f)(1,4)thiazepine
US3539573A (en) * 1967-03-22 1970-11-10 Jean Schmutz 11-basic substituted dibenzodiazepines and dibenzothiazepines
US3560622A (en) * 1967-10-13 1971-02-02 American Cyanamid Co Trifluoromethyl oxazepines,thiazepines and diazepines as anti-inflammatory agents

Also Published As

Publication number Publication date
CN1396916A (zh) 2003-02-12
SK10602002A3 (sk) 2002-11-06
DE60102357T2 (de) 2005-01-13
HU227039B1 (en) 2010-05-28
CZ301236B6 (cs) 2009-12-16
ES2217115T3 (es) 2004-11-01
CZ20022463A3 (cs) 2002-10-16
EP1252151B1 (de) 2004-03-17
HRP20020579B1 (en) 2005-08-31
AU3214601A (en) 2001-08-07
CN1537847A (zh) 2004-10-20
HUP0000283A2 (hu) 2002-04-29
CN1177839C (zh) 2004-12-01
UA73547C2 (uk) 2005-08-15
PL211338B1 (pl) 2012-05-31
WO2001055125A1 (en) 2001-08-02
PL355726A1 (en) 2004-05-17
EP1252151A1 (de) 2002-10-30
RU2002122723A (ru) 2004-01-10
SK287171B6 (sk) 2010-02-08
RU2258067C2 (ru) 2005-08-10
HUP0000283A3 (en) 2002-11-28
CN1239487C (zh) 2006-02-01
ATE261949T1 (de) 2004-04-15
HU0000283D0 (en) 2000-03-28
SI1252151T1 (en) 2004-08-31
HRP20020579A2 (en) 2004-08-31
DK1252151T3 (da) 2004-07-12

Similar Documents

Publication Publication Date Title
DE60102357D1 (de) Verfahren zur herstellung von quetiapin und intermediate dafür
ATE452882T1 (de) Herstellung von quetiapin
BR0111472A (pt) Processo para a preparação de um composto, composto, e, forma polimórfica de um composto
ATE407127T1 (de) Verfahren zur herstellung von beraprost und dessen salzen
NO20075071L (no) Fremgangsmate for fremstilling av et 11-(4-substituert-1-piperazinyl) dibenzo [b,f] [1,4]thiazepin dericvat2005
ATE277915T1 (de) Verfahren sowie neue zwischenprodukte zur herstellung von isoxazolin-3-yl-acylbenzolen
ITTO20000593A0 (it) Metodo per la preparazione di mescole di gomma vulcanizzabile contenenti silice finalizzate alla produzione di fasce di battistrada.
ATE280167T1 (de) Zwischenprodukte und ein verfahren zur herstellung von beta3-adrenergischer rezeptor- agoniste
ATE367383T1 (de) Verfahren zur herstellung von 11-(4-(2-(2- hydroxyethoxy)ethyl)-1-piperazinyl)dibenzo(b,f) 1,4)thiazepin
ATE281434T1 (de) Verfahren zur herstellung von benzoperhydroisoindolen
ATE371654T1 (de) Verfahren zur herstellung von 11-(1- piperazinyl)dibenzo(b,f)(1,4)-thiazepin, ein zwischenprodukt in der synthese des antipsychotischen arzneimittels quetiapin
DE60116201D1 (de) Verfahren zur Herstellung von Cephalosporin-Verbindungen und Zwischenprodukte für die Synthese dieser Verbindungen
ATE496038T1 (de) Verfahren zur herstellung von quetiapin
ATE402136T1 (de) Verfahren zur herstellung von aminoalkoxybenzylaminen und aminoalkoxybenzonitrilen als zwischenprodukte
ATE223414T1 (de) Prozess zur herstellung von zwischebprodukten für imidazodeazepinen
DE60003169D1 (de) Verfahren zur herstellung von [s-(r*,s*)]-g(b)-[[1-[1-oxo-3-(4-piperidinyl)propyl]-3-piperidinyl]carbonyl] amino]-3-pyridinpropansäurederivate
DE60015177D1 (de) Verfahren zur herstellung von 2-[4-(alpha-phenyl-p-chlorobenzyl)piperazin-1-yl]ethoxyessigsäure und zwischenprodukte dafür
EP1781646A4 (de) Verfahren zur herstellung von 11-(4-[2-(2-hydroxyethoxy)ethyl]-1-piperazinyl)dibenzo[b,f][1,4]thiazepin
DE69812079D1 (de) Verfahren zur herstellung eines buthylthuio-isochinolinderivates und zwischenprodukte dafür
DE60009945D1 (de) Beta-d-thioxylos-derivate, verfahren zur herstellung und verwendung als arzneimittel
ATE311375T1 (de) Verfahren zur herstellung antiosteoporicagenz
PL356064A1 (en) Method for preparing 2-(2-arylmorpholin-2-yl)ethanol derivatives and intermediates
FR2854403A1 (fr) Nouveau procede et intermediaires de preparation de composes 19-nor-steroides 17-halogenes
WO2004089890A3 (en) Process and intermediates for preparing benzazepines
ZA200200158B (en) Process for producing dibenzothiazepine derivatives.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
R082 Change of representative

Ref document number: 1252151

Country of ref document: EP

Representative=s name: STOLMAR & PARTNER, DE