DE60043400D1 - Interleukin-1 und Tumornekrosefaktor-alpha Modulatoren,Synthese dieser Modulatoren und Methoden zur Anwendung dieser Modulatoren - Google Patents

Interleukin-1 und Tumornekrosefaktor-alpha Modulatoren,Synthese dieser Modulatoren und Methoden zur Anwendung dieser Modulatoren

Info

Publication number: DE60043400D1
Authority: DE; Germany
Prior art keywords: modulators; interleukin; necrosis factor; tumor necrosis; synthesis
Prior art date: 1999-05-14
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE60043400T

Other languages

English (en)

Inventor

Michael Palladino

Emmanuel A Theodorakis

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Nereus Pharmaceuticals Inc

University of California Berkeley

University of California San Diego UCSD

Original Assignee

Nereus Pharmaceuticals Inc

University of California Berkeley

University of California San Diego UCSD

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-05-14

Filing date

2000-05-12

Publication date

2010-01-07

2000-05-12 Application filed by Nereus Pharmaceuticals Inc, University of California Berkeley, University of California San Diego UCSD filed Critical Nereus Pharmaceuticals Inc

2010-01-07 Application granted granted Critical

2010-01-07 Publication of DE60043400D1 publication Critical patent/DE60043400D1/de

2020-05-13 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C62/30—Unsaturated compounds
- C07C62/32—Unsaturated compounds containing hydroxy or O-metal groups
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C61/16—Unsaturated compounds
- C07C61/28—Unsaturated compounds polycyclic
- C07C61/29—Unsaturated compounds polycyclic having a carboxyl group bound to a condensed ring system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C61/16—Unsaturated compounds
- C07C61/35—Unsaturated compounds having unsaturation outside the rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
- C07C69/753—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring of polycyclic acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/22—Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
- C07C2603/26—Phenanthrenes; Hydrogenated phenanthrenes

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Emergency Medicine (AREA)
Diabetes (AREA)
Immunology (AREA)
Pulmonology (AREA)
Heart & Thoracic Surgery (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Cardiology (AREA)
Endocrinology (AREA)
Dermatology (AREA)
Obesity (AREA)
Transplantation (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Otolaryngology (AREA)
Virology (AREA)
Hematology (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Hydrogenated Pyridines (AREA)

DE60043400T 1999-05-14 2000-05-12 Interleukin-1 und Tumornekrosefaktor-alpha Modulatoren,Synthese dieser Modulatoren und Methoden zur Anwendung dieser Modulatoren Expired - Lifetime DE60043400D1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US13429599P	1999-05-14	1999-05-14
US18685300P	2000-03-03	2000-03-03

Publications (1)

Publication Number	Publication Date
DE60043400D1 true DE60043400D1 (de)	2010-01-07

Family

ID=26832188

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DE60036101T Expired - Lifetime DE60036101T2 (de)	1999-05-14	2000-05-12	Interleukin-1 und tumornekrosefaktor-alpha modulatoren,synthese dieser modulatoren und methoden zur anwendung dieser modulatoren
DE60043400T Expired - Lifetime DE60043400D1 (de)	1999-05-14	2000-05-12	Interleukin-1 und Tumornekrosefaktor-alpha Modulatoren,Synthese dieser Modulatoren und Methoden zur Anwendung dieser Modulatoren

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DE60036101T Expired - Lifetime DE60036101T2 (de)	1999-05-14	2000-05-12	Interleukin-1 und tumornekrosefaktor-alpha modulatoren,synthese dieser modulatoren und methoden zur anwendung dieser modulatoren

Country Status (17)

Country	Link
US (3)	US6365768B1 (de)
EP (2)	EP1178952B1 (de)
JP (2)	JP5059996B2 (de)
KR (3)	KR20060110013A (de)
CN (1)	CN1361760A (de)
AT (2)	ATE370928T1 (de)
AU (2)	AU783372B2 (de)
BR (1)	BR0011522A (de)
CA (1)	CA2372962C (de)
DE (2)	DE60036101T2 (de)
DK (1)	DK1178952T5 (de)
ES (2)	ES2337264T3 (de)
IL (3)	IL146221A0 (de)
MX (1)	MXPA01011613A (de)
NZ (3)	NZ540001A (de)
PT (2)	PT1178952E (de)
WO (1)	WO2000073253A1 (de)

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CN104739841B (zh)	2008-01-11	2018-06-01	里亚塔医药公司	合成三萜类化合物及用以治病之方法
WO2009146216A2 (en)	2008-04-18	2009-12-03	Reata Pharmaceuticals. Inc.	Antioxidant inflammation modulators: novel derivatives of oleanolic acid
US8124799B2 (en)	2008-04-18	2012-02-28	Reata Pharmaceuticals, Inc.	Antioxidant inflammation modulators: oleanolic acid derivatives with amino and other modifications at C-17
BRPI0911105B1 (pt)	2008-04-18	2022-11-08	Reata Pharmaceuticals, Inc	Compostos contendo um farmacóforo anti-inflamatório, composição farmacêutica, bem como seus usos
TWI442925B (zh)	2008-04-18	2014-07-01	Reata Pharmaceuticals Inc	抗氧化性發炎調節劑：ｃ－環飽和之齊墩果酸衍生物
CA2721666C (en)	2008-04-18	2017-05-23	Reata Pharmaceuticals, Inc.	Antioxidant inflammation modulators: c-17 homologated oleanolic acid derivatives
CA2731650A1 (en)	2008-07-22	2010-01-28	Tadashi Honda	Monocyclic cyanoenones and methods of use thereof
US20110293653A1 (en) *	2010-03-11	2011-12-01	University Of Massachusetts	Antagonists of mir-155 for the treatment of inflammatory liver disease
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MX2013004234A (es) *	2010-10-27	2013-08-21	Sigma Tau Ind Farmaceuti	Derivados de diterpenoide dotados de propiedades biologicas.
US8785502B2 (en)	2010-12-06	2014-07-22	The Penn State Research Foundation	Compositions and methods relating to proliferative diseases
ME02973B (me)	2010-12-17	2018-07-20	Reata Pharmaceuticals Inc	Pirazolil i pirimidinil triciklični enoni kao antioksidantni modulatori inflamacije
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PT3444261T (pt)	2012-04-27	2021-03-12	Reata Pharmaceuticals Inc	Derivados de 2,2-difluoropropionamida de metil bardoxolona, formas polimorfas e métodos de uso dos mesmos
US8921419B2 (en)	2012-05-08	2014-12-30	Trustees Of Dartmouth College	Triterpenoids and compositions containing the same
US9556222B2 (en)	2012-06-15	2017-01-31	Reata Pharmaceuticals, Inc.	A-ring epoxidized triterpenoid-based anti-inflammation modulators and methods of use thereof
TWI630212B (zh)	2012-09-10	2018-07-21	瑞塔醫藥有限責任公司	丁香油素（ｏｌｅａｎｏｌｉｃａｃｉｄ）之ｃ１７－烷二基與烯二基衍生物及其使用方法
US9512094B2 (en)	2012-09-10	2016-12-06	Reata Pharmaceuticals, Inc.	C17-heteroaryl derivatives of oleanolic acid and methods of use thereof
US9278912B2 (en)	2012-09-10	2016-03-08	Reata Pharmaceuticals, Inc.	C13-hydroxy derivatives of oleanolic acid and methods of use thereof
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2000
- 2000-05-12 AU AU50133/00A patent/AU783372B2/en not_active Ceased
- 2000-05-12 PT PT00932408T patent/PT1178952E/pt unknown
- 2000-05-12 NZ NZ540001A patent/NZ540001A/en not_active IP Right Cessation
- 2000-05-12 DK DK00932408T patent/DK1178952T5/da active
- 2000-05-12 KR KR1020067020613A patent/KR20060110013A/ko not_active Withdrawn
- 2000-05-12 NZ NZ529505A patent/NZ529505A/en not_active IP Right Cessation
- 2000-05-12 JP JP2000621320A patent/JP5059996B2/ja not_active Expired - Lifetime
- 2000-05-12 NZ NZ515675A patent/NZ515675A/en not_active IP Right Cessation
- 2000-05-12 DE DE60036101T patent/DE60036101T2/de not_active Expired - Lifetime
- 2000-05-12 WO PCT/US2000/013202 patent/WO2000073253A1/en not_active Ceased
- 2000-05-12 CA CA002372962A patent/CA2372962C/en not_active Expired - Fee Related
- 2000-05-12 AT AT00932408T patent/ATE370928T1/de active
- 2000-05-12 ES ES05076500T patent/ES2337264T3/es not_active Expired - Lifetime
- 2000-05-12 IL IL14622100A patent/IL146221A0/xx active IP Right Grant
- 2000-05-12 KR KR1020017014545A patent/KR100856353B1/ko not_active Expired - Fee Related
- 2000-05-12 KR KR1020067025785A patent/KR100840925B1/ko not_active Expired - Fee Related
- 2000-05-12 EP EP00932408A patent/EP1178952B1/de not_active Expired - Lifetime
- 2000-05-12 US US09/570,202 patent/US6365768B1/en not_active Expired - Fee Related
- 2000-05-12 CN CN00810323A patent/CN1361760A/zh active Pending
- 2000-05-12 EP EP05076500A patent/EP1591437B1/de not_active Expired - Lifetime
- 2000-05-12 PT PT05076500T patent/PT1591437E/pt unknown
- 2000-05-12 ES ES00932408T patent/ES2295031T3/es not_active Expired - Lifetime
- 2000-05-12 DE DE60043400T patent/DE60043400D1/de not_active Expired - Lifetime
- 2000-05-12 AT AT05076500T patent/ATE449754T1/de active
- 2000-05-12 BR BR0011522-3A patent/BR0011522A/pt not_active Application Discontinuation
- 2000-05-12 MX MXPA01011613A patent/MXPA01011613A/es active IP Right Grant
2001
- 2001-10-29 IL IL146221A patent/IL146221A/en not_active IP Right Cessation
2002
- 2002-02-04 US US10/068,333 patent/US6881857B2/en not_active Expired - Lifetime
2005
- 2005-04-19 US US11/108,941 patent/US7342125B2/en not_active Expired - Lifetime
2006
- 2006-01-19 AU AU2006200240A patent/AU2006200240B2/en not_active Ceased
2007
- 2007-03-28 IL IL182272A patent/IL182272A/en not_active IP Right Cessation
2012
- 2012-06-19 JP JP2012137825A patent/JP2012211162A/ja not_active Withdrawn

Also Published As

Publication number	Publication date
US20030040640A1 (en)	2003-02-27
KR100856353B1 (ko)	2008-09-04
DE60036101T2 (de)	2008-05-15
EP1178952A1 (de)	2002-02-13
DK1178952T5 (da)	2008-03-17
WO2000073253A1 (en)	2000-12-07
KR20060110013A (ko)	2006-10-23
DK1178952T3 (da)	2008-01-28
US6881857B2 (en)	2005-04-19
PT1591437E (pt)	2010-03-04
IL182272A (en)	2010-05-31
ATE449754T1 (de)	2009-12-15
MXPA01011613A (es)	2003-10-14
ATE370928T1 (de)	2007-09-15
BR0011522A (pt)	2002-06-04
AU2006200240B2 (en)	2009-05-28
CN1361760A (zh)	2002-07-31
JP2003500464A (ja)	2003-01-07
JP2012211162A (ja)	2012-11-01
ES2295031T3 (es)	2008-04-16
IL182272A0 (en)	2007-07-24
IL146221A (en)	2007-07-04
US6365768B1 (en)	2002-04-02
HK1084657A1 (en)	2006-08-04
EP1591437A2 (de)	2005-11-02
JP5059996B2 (ja)	2012-10-31
AU783372B2 (en)	2005-10-20
AU5013300A (en)	2000-12-18
US7342125B2 (en)	2008-03-11
EP1591437A3 (de)	2006-03-08
KR100840925B1 (ko)	2008-06-24
NZ540001A (en)	2007-06-29
NZ529505A (en)	2005-09-30
EP1178952B1 (de)	2007-08-22
PT1178952E (pt)	2007-12-04
US20050209325A1 (en)	2005-09-22
CA2372962A1 (en)	2000-12-07
IL146221A0 (en)	2002-07-25
NZ515675A (en)	2004-06-25
KR20020028878A (ko)	2002-04-17
CA2372962C (en)	2008-04-08
DE60036101D1 (de)	2007-10-04
ES2337264T3 (es)	2010-04-22
AU2006200240A1 (en)	2006-02-16
EP1591437B1 (de)	2009-11-25
KR20060135080A (ko)	2006-12-28

Publication	Publication Date	Title
ATE449754T1 (de)	2009-12-15	Interleukin-1 und tumornekrosefaktor-alpha modulatoren,synthese dieser modulatoren und methoden zur anwendung dieser modulatoren
DE69407304D1 (de)	1998-01-22	Schleifmittel, verfahren zum herstellen und zur anwendung derselben.
WO2003006570A3 (en)	2003-09-25	Novel mesogens and methods for their synthesis and use
AU2001215528A1 (en)	2002-01-14	Base materials for tissue regeneration, transplant materials and process for producing the same
DE60011746D1 (de)	2004-07-29	Befestigungselement, antriebsvorrichtung zur ausführung des befestigungselements und bohrmeisel zum herstellen von bohrlöchern mit hinterschneidung
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SE0102858D0 (sv)	2001-08-27	N-type calcium channel antagonists for the treatment of pain
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EP2311795A3 (de)	2011-12-28	Interleukin-1- und Tumornekrosefaktor-Alpha-Modulatoren, Synthese solcher Modulatoren und Verfahren unter Anwendung solcher Modulatoren
AU2003233579A1 (en)	2003-12-12	Synthesis of inorganic structures using templation and catalysis by self assembled repeat protein polymers
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AU2001230628A1 (en)	2001-08-14	Method for producing somatic embryos of pine tress (genus pinus)
WO2005004606A3 (en)	2005-04-21	Pyridinylanilides
SE0004056D0 (sv)	2000-11-06	N-type calcium channel antagonists for the treatment of pain
AU2001260616A1 (en)	2001-12-03	Compounds generating amine by irradiation with light, photo-setting compositions and photoreactive adhesive compositions
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AU2003249999A1 (en)	2004-02-02	1,4,7,10-tetraazacyclododecanes as modulators of the guanine-binding protein for treating tumours
AU2002243647A1 (en)	2002-08-06	Novel mesogens
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ATE465989T1 (de)	2010-05-15	13-substituierte methacyclinverbindungen
ATE288687T1 (de)	2005-02-15	Kugelförmige sterinzubereitungen, deren herstellung und verwendung

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