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DE60033147D1 - Rekombinantes menschliches mannan-bindendes lektin - Google Patents

Rekombinantes menschliches mannan-bindendes lektin

Info

Publication number
DE60033147D1
DE60033147D1 DE60033147T DE60033147T DE60033147D1 DE 60033147 D1 DE60033147 D1 DE 60033147D1 DE 60033147 T DE60033147 T DE 60033147T DE 60033147 T DE60033147 T DE 60033147T DE 60033147 D1 DE60033147 D1 DE 60033147D1
Authority
DE
Germany
Prior art keywords
treatment
prophylaxis
mbl
infection
mannan
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60033147T
Other languages
English (en)
Other versions
DE60033147T2 (de
Inventor
Steffen Thiel
Jens Christian Jensenius
Thomas Vorup Jensen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of DE60033147D1 publication Critical patent/DE60033147D1/de
Application granted granted Critical
Publication of DE60033147T2 publication Critical patent/DE60033147T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4726—Lectins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Toxicology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Filtering Materials (AREA)
  • Wrappers (AREA)
  • Chemical And Physical Treatments For Wood And The Like (AREA)
  • Medicinal Preparation (AREA)
DE60033147T 1999-05-14 2000-05-10 Rekombinantes menschliches mannan-bindendes lektin Expired - Fee Related DE60033147T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DKPA199900668 1999-05-14
DK99668 1999-05-14
DKPA199901508 1999-10-20
DK991508 1999-10-20
PCT/DK2000/000246 WO2000070043A1 (en) 1999-05-14 2000-05-10 Recombinant human mannan-binding lectin

Publications (2)

Publication Number Publication Date
DE60033147D1 true DE60033147D1 (de) 2007-03-15
DE60033147T2 DE60033147T2 (de) 2007-12-13

Family

ID=26064419

Family Applications (3)

Application Number Title Priority Date Filing Date
DE60009896T Expired - Fee Related DE60009896T2 (de) 1999-05-14 2000-05-10 Neue indikationen für mannan-binding lectin (mbl) zur behandlung von immungeschwächten patienten
DE60033147T Expired - Fee Related DE60033147T2 (de) 1999-05-14 2000-05-10 Rekombinantes menschliches mannan-bindendes lektin
DE60030173T Expired - Fee Related DE60030173T2 (de) 1999-05-14 2000-05-10 Neue Indikationen für Mannan-binding Lectin (MBL) zur Behandlung von immungeschwächten Patienten

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE60009896T Expired - Fee Related DE60009896T2 (de) 1999-05-14 2000-05-10 Neue indikationen für mannan-binding lectin (mbl) zur behandlung von immungeschwächten patienten

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE60030173T Expired - Fee Related DE60030173T2 (de) 1999-05-14 2000-05-10 Neue Indikationen für Mannan-binding Lectin (MBL) zur Behandlung von immungeschwächten Patienten

Country Status (15)

Country Link
US (5) US6562784B1 (de)
EP (3) EP1181038B1 (de)
JP (2) JP2002543837A (de)
CN (2) CN1359420A (de)
AT (3) ATE352620T1 (de)
AU (2) AU779404B2 (de)
CA (2) CA2372128A1 (de)
DE (3) DE60009896T2 (de)
DK (3) DK1402897T3 (de)
ES (3) ES2219336T3 (de)
NO (2) NO20015481L (de)
NZ (2) NZ515718A (de)
PT (3) PT1181038E (de)
RU (2) RU2292217C2 (de)
WO (2) WO2000069894A2 (de)

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CN1359420A (zh) * 1999-05-14 2002-07-17 斯蒂芬·蒂尔 重组人甘露聚糖结合型凝集素
WO2002005833A1 (en) * 2000-07-13 2002-01-24 Natimmune A/S MANNAN-BINDING LECTIN (MBL) TREATMENT OF INFECTIONS IN INDIVIDUALS TREATED WITH TNF-αinhibitors
EP1186299A1 (de) * 2000-09-12 2002-03-13 Universitair Medisch Centrum Utrecht Diagnose, Verbeugung und/oder Behandlung von Atherosklerose, Infectionen und Störungen des Immunsystems
WO2002041913A1 (en) * 2000-11-27 2002-05-30 Jens Christian Jensenius Collectins as adjuvants
CN101011573A (zh) 2001-07-23 2007-08-08 纳蒂芒公司 高分子量凝集素的生产
JP4051030B2 (ja) * 2001-08-31 2008-02-20 扶桑薬品工業株式会社 ヒトマンノース結合レクチンの精製方法、ヒトマンノース結合レクチン組成物およびヒトマンノース結合レクチンの医薬用途
DE60207678T2 (de) * 2001-10-19 2006-08-24 Natimmune A/S Isolierung von lectinen
US7462596B2 (en) * 2002-03-15 2008-12-09 Natimmune A/S Pharmaceutical compositions comprising mannose binding lectin
US7211396B2 (en) * 2002-04-18 2007-05-01 Antibodyshop A/S Antibody pairs and kits for immunochemical determination of mannan-binding lectin
US20050037949A1 (en) * 2002-04-24 2005-02-17 O'brien Grace Mannose binding lectin and uses thereof
JPWO2004002511A1 (ja) * 2002-06-28 2005-10-27 扶桑薬品工業株式会社 抗ｈｉｖ剤
DK1539964T3 (da) * 2002-09-10 2007-05-07 Natimmune As Cellectin-komplementaktiverende proteinkimærer
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PL1625166T3 (pl) * 2003-05-12 2015-08-31 Helion Biotech Aps Przeciwciała przeciwko masp-2
US7135338B2 (en) * 2003-06-11 2006-11-14 Dobeel Corporation Methods for overexpression of high molecular weight form of mannose binding lectin (MBL) and a specific formulation for active treatment for systemic infection with microorganism
DE20317914U1 (de) 2003-11-19 2004-12-30 Weh, Erwin Betätigungsvorrichtung für eine Schnellanschlusskupplung
US7335633B2 (en) 2004-01-12 2008-02-26 Cornell Research Foundation, Inc. Detecting recurrent vulvovaginal candidiasis or vulvar vestibulitis syndrome and method for treating same
AU2005214091B2 (en) * 2004-02-24 2010-08-12 Abbvie B.V. Method for determining the risk of developing a neurological disease
WO2005087799A2 (en) * 2004-03-09 2005-09-22 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Mvl, an antiviral protein from a cyanobacterium
US7919094B2 (en) * 2004-06-10 2011-04-05 Omeros Corporation Methods for treating conditions associated with MASP-2 dependent complement activation
EP1618887A1 (de) * 2004-07-12 2006-01-25 UMC Utrecht Holding B.V. Beseitigung von Polyolen aus dem Körper
WO2006035024A1 (en) * 2004-09-29 2006-04-06 Mellitus, S.L. Method for detecting a predisposition to develop gestational diabetes mellitus and treatment for this disease
DE602005026705D1 (de) * 2004-12-23 2011-04-14 Council Scient Ind Res Pharmazeutische zusammensetzung zur behandlung von invasiver lungenaspergillose
EP1830810A4 (de) * 2004-12-30 2011-02-02 Dobeel Co Ltd Sprühgetrocknete zusammensetzung mit proteinen der collectin-familie oder varianten davon und herstellungsverfahren dafür
JP2008535872A (ja) * 2005-04-11 2008-09-04 ナットイムネ・アクティーゼルスカブ 免疫障害を持つ個体の処置におけるマンナン結合レクチン（ｍｂｌ）の新規癌適用
WO2007044642A2 (en) 2005-10-06 2007-04-19 President And Fellows Of Harvard College And Children's Medical Center Corporation Device and method for combined microfluidic-micromagnetic separation of material in continuous flow
WO2007073186A2 (en) 2005-12-21 2007-06-28 Pharming Intellectual Property Bv Use of c1 inhibitor for the prevention of ischemia-reperfusion injury
WO2007085057A1 (en) * 2006-01-25 2007-08-02 The Council Of The Queensland Institute Of Medical Research A medical protocol
US20070226567A1 (en) * 2006-03-23 2007-09-27 Gorman Kevin W High speed bist utilizing clock multiplication
US20110052428A1 (en) * 2008-01-16 2011-03-03 Superpar Otomotiv Sanayi Ve Ticaret Anonim Sirketi Electric fuel pump for heavy duty engine platforms
US20100331240A1 (en) * 2008-01-18 2010-12-30 The General Hospital Corporation Methods for prevention and treatment of infections with supraphysiological doses of mannan-binding lectin (mbl) and ficolin-mbl fusion proteins
US9156037B2 (en) 2009-01-15 2015-10-13 Children's Medical Center Corporation Microfluidic device and uses thereof
AU2011207626B2 (en) 2010-01-19 2015-06-18 President And Fellows Of Harvard College Engineered opsonin for pathogen detection and treatment
WO2011100528A2 (en) * 2010-02-12 2011-08-18 Emory University Compositions and uses of lectins
DE102011003478A1 (de) * 2011-02-01 2012-08-02 Cytavis Biopharma Gmbh Antivirales Mittel enthaltend rekombinante Mistellektine
US9593160B2 (en) 2011-07-18 2017-03-14 President And Fellows Of Harvard College Engineered microbe-targeting molecules and uses thereof
EP2820147B1 (de) 2012-02-29 2018-08-08 President and Fellows of Harvard College Schnelltests auf empfindlichkeit gegen antibiotika
EP3327090A1 (de) 2012-07-18 2018-05-30 President and Fellows of Harvard College Modifizierung von oberflächen zur gleichzeitigen abweisung und gezielten bindung gewünschter gruppen
WO2014144325A1 (en) 2013-03-15 2014-09-18 President And Fellows Of Harvard College Methods and compositions for improving detection and/or capture of a target entity
US9988617B2 (en) 2013-05-21 2018-06-05 President And Fellows Of Harvard College Engineered heme-binding compositions and uses thereof
WO2015095604A2 (en) 2013-12-18 2015-06-25 President And Fellows Of Harvard College Methods and assays relating to circulating tumor cells
WO2016077067A2 (en) 2014-10-27 2016-05-19 President And Fellows Of Harvard College Magnetic capture of a target from a fluid
EP3763378A1 (de) 2015-08-06 2021-01-13 President and Fellows of Harvard College Verbesserte mikrobenbindende moleküle und verwendungen davon
JP7163192B2 (ja) 2016-05-16 2022-10-31 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ Ｃｏ２プラズマ活性化表面にカップリングする水性生体分子
CN107050427A (zh) * 2017-02-27 2017-08-18 新乡医学院 MBL在制备预防或治疗以Tregs为靶点的疾病药物中的应用
CN107050436B (zh) * 2017-02-27 2020-03-17 新乡医学院 Mbl在制备预防或治疗效应t细胞引发疾病药物中的应用
WO2019110706A1 (en) * 2017-12-08 2019-06-13 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting the risk of developing a sepsis or a systemic inflammatory response syndrome (sirs)
RU2739113C1 (ru) * 2019-10-04 2020-12-21 Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр терапии и профилактической медицины" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ ТПМ" Минздрава России) Способ определения активности маннан-связывающих лектин-ассоциированных сериновых протеаз в тесте коагуляции фибриногена
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EP1084143B1 (de) 1998-06-10 2006-08-16 Statens Serum Institut Reinigungsverfahren zur herstellng von mannan bindendem lectin (mbl) und mbl enthaltende medizinische zubereitung
CN1359420A (zh) * 1999-05-14 2002-07-17 斯蒂芬·蒂尔 重组人甘露聚糖结合型凝集素

Also Published As

Publication number Publication date
DE60009896T2 (de) 2005-04-21
ES2281341T3 (es) 2007-10-01
DK1181363T3 (da) 2007-05-29
EP1402897B1 (de) 2006-08-16
NO20015506D0 (no) 2001-11-09
ES2219336T3 (es) 2004-12-01
EP1181363B1 (de) 2007-01-24
US6562784B1 (en) 2003-05-13
US6846649B1 (en) 2005-01-25
NZ515718A (en) 2004-03-26
RU2005125625A (ru) 2007-02-20
DK1402897T3 (da) 2006-12-27
EP1402897A3 (de) 2004-06-30
NZ515717A (en) 2004-01-30
PT1181038E (pt) 2004-08-31
EP1402897A2 (de) 2004-03-31
CN1359420A (zh) 2002-07-17
DE60030173D1 (de) 2006-09-28
US7439224B2 (en) 2008-10-21
DE60030173T2 (de) 2007-08-23
RU2292217C2 (ru) 2007-01-27
DE60009896D1 (de) 2004-05-19
EP1181363A1 (de) 2002-02-27
WO2000069894A3 (en) 2001-02-08
JP2002544286A (ja) 2002-12-24
NO20015481L (no) 2002-01-11
US20040229212A1 (en) 2004-11-18
EP1181038A2 (de) 2002-02-27
AU4393600A (en) 2000-12-05
ATE352620T1 (de) 2007-02-15
US20070197428A1 (en) 2007-08-23
AU781135B2 (en) 2005-05-05
US7202207B2 (en) 2007-04-10
ATE336260T1 (de) 2006-09-15
JP2002543837A (ja) 2002-12-24
AU779404B2 (en) 2005-01-20
EP1181038B1 (de) 2004-04-14
US20030191052A1 (en) 2003-10-09
WO2000070043A1 (en) 2000-11-23
WO2000069894A2 (en) 2000-11-23
DK1181038T3 (da) 2004-08-09
CA2372128A1 (en) 2000-11-23
AU4393500A (en) 2000-12-05
ES2271468T3 (es) 2007-04-16
CN1359298A (zh) 2002-07-17
PT1402897E (pt) 2007-01-31
NO20015481D0 (no) 2001-11-08
ATE264111T1 (de) 2004-04-15
CA2372435A1 (en) 2000-11-23
NO20015506L (no) 2002-01-09
DE60033147T2 (de) 2007-12-13
PT1181363E (pt) 2007-05-31

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