DE60029084D1 - Neue depsipeptid-verbindung - Google Patents

Neue depsipeptid-verbindung

Info

Publication number: DE60029084D1
Authority: DE; Germany
Prior art keywords: depsipeptid; new; connection; activity; tgf
Prior art date: 1999-01-13
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE60029084T

Other languages

English (en)

Other versions

DE60029084T2 (de

Inventor

Koji Nagai

Nakako Arao

Kinya Sohda

Kazuma Kamigiri

Masamichi Mori

Nobuaki Shindo

Haruo Seto

Kazuo Shin-Ya

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Astellas Pharma Inc

Original Assignee

Astellas Pharma Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-01-13

Filing date

2000-01-12

Publication date

2006-08-10

2000-01-12 Application filed by Astellas Pharma Inc filed Critical Astellas Pharma Inc

2006-08-10 Publication of DE60029084D1 publication Critical patent/DE60029084D1/de

2007-02-01 Application granted granted Critical

2007-02-01 Publication of DE60029084T2 publication Critical patent/DE60029084T2/de

2020-01-13 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

206010028980 Neoplasm Diseases 0.000 abstract 1
239000002246 antineoplastic agent Substances 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000001472 cytotoxic effect Effects 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Crystallography & Structural Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

DE60029084T 1999-01-13 2000-01-12 Neue depsipeptid-verbindung Expired - Lifetime DE60029084T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
JP704099		1999-01-13
JP704099		1999-01-13
PCT/JP2000/000110 WO2000042062A1 (en)	1999-01-13	2000-01-12	Novel depsipeptide compound

Publications (2)

Publication Number	Publication Date
DE60029084D1 true DE60029084D1 (de)	2006-08-10
DE60029084T2 DE60029084T2 (de)	2007-02-01

Family

ID=11654946

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE60029084T Expired - Lifetime DE60029084T2 (de)	1999-01-13	2000-01-12	Neue depsipeptid-verbindung

Country Status (13)

Country	Link
US (2)	US6670326B1 (de)
EP (1)	EP1142905B1 (de)
JP (1)	JP3554707B2 (de)
KR (1)	KR100611265B1 (de)
CN (1)	CN1173990C (de)
AT (1)	ATE331730T1 (de)
AU (1)	AU2002700A (de)
CA (1)	CA2356845C (de)
DE (1)	DE60029084T2 (de)
DK (1)	DK1142905T3 (de)
ES (1)	ES2265906T3 (de)
PT (1)	PT1142905E (de)
WO (1)	WO2000042062A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE353663T1 (de) *	1999-12-08	2007-03-15	Cyclacel Pharmaceuticals Inc	Verwendung von depsipeptide und deren analoge als immunosuppressiva zur behandlung von infektionskrankheiten, autoimmunerkrankungen, allergien und hyperproliferativer hautkrankheiten
AU2003261801A1 (en) *	2002-08-30	2004-03-19	Yamanouchi Pharmaceutical Co., Ltd.	Novel depsipeptide compound
WO2007020871A1 (ja) *	2005-08-12	2007-02-22	Astellas Pharma Inc.	デプシペプチド含有注射液
US7943568B2 (en) *	2005-09-30	2011-05-17	The Ohio State University Research Foundation	Antitumor agents
US8865655B2 (en) *	2006-11-22	2014-10-21	Karus Therapeutics Limited	Depsipeptides and their therapeutic use
GB0623357D0 (en) *	2006-11-22	2007-01-03	Karus Therapeutics Ltd	Chemical compounds
GB0623388D0 (en) *	2006-11-23	2007-01-03	Univ Southampton	Chemical compounds
GB0715750D0 (en) *	2007-08-13	2007-09-19	Karus Therapeutics Ltd	Chemical compounds
JPWO2014115859A1 (ja)	2013-01-25	2017-01-26	酒井　敏行	分子標的併用腫瘍治療・予防薬
EP3824906A1 (de)	2016-12-21	2021-05-26	Amgen Inc.	Anti-tnf alpha antikörperformulierungen

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS61101501A (ja) *	1984-10-24	1986-05-20	Yamanouchi Pharmaceut Co Ltd	制癌作用を有する多糖及びその製法
GB8817743D0 (en) *	1988-07-26	1988-09-01	Fujisawa Pharmaceutical Co	Fr901228 substance & preparation thereof
US5681813A (en) *	1994-04-06	1997-10-28	Pharma Mar, S.A.	Thiodepsipeptide isolated from a marine actinomycete

2000
- 2000-01-12 CN CNB00802510XA patent/CN1173990C/zh not_active Expired - Lifetime
- 2000-01-12 DK DK00900351T patent/DK1142905T3/da active
- 2000-01-12 WO PCT/JP2000/000110 patent/WO2000042062A1/ja not_active Ceased
- 2000-01-12 CA CA2356845A patent/CA2356845C/en not_active Expired - Lifetime
- 2000-01-12 KR KR1020017008693A patent/KR100611265B1/ko not_active Expired - Lifetime
- 2000-01-12 AT AT00900351T patent/ATE331730T1/de active
- 2000-01-12 AU AU20027/00A patent/AU2002700A/en not_active Abandoned
- 2000-01-12 DE DE60029084T patent/DE60029084T2/de not_active Expired - Lifetime
- 2000-01-12 EP EP00900351A patent/EP1142905B1/de not_active Expired - Lifetime
- 2000-01-12 PT PT00900351T patent/PT1142905E/pt unknown
- 2000-01-12 US US09/889,303 patent/US6670326B1/en not_active Expired - Lifetime
- 2000-01-12 ES ES00900351T patent/ES2265906T3/es not_active Expired - Lifetime
- 2000-01-12 JP JP2000593629A patent/JP3554707B2/ja not_active Expired - Lifetime
2003
- 2003-10-15 US US10/684,656 patent/US7098024B2/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EP1142905B1 (de)	2006-06-28
JP3554707B2 (ja)	2004-08-18
WO2000042062A1 (en)	2000-07-20
EP1142905A1 (de)	2001-10-10
CN1335852A (zh)	2002-02-13
DK1142905T3 (da)	2006-09-18
ES2265906T3 (es)	2007-03-01
KR100611265B1 (ko)	2006-08-10
CN1173990C (zh)	2004-11-03
CA2356845C (en)	2010-10-19
US20040082054A1 (en)	2004-04-29
US7098024B2 (en)	2006-08-29
PT1142905E (pt)	2006-10-31
US6670326B1 (en)	2003-12-30
EP1142905A4 (de)	2004-05-19
CA2356845A1 (en)	2000-07-20
DE60029084T2 (de)	2007-02-01
KR20010101443A (ko)	2001-11-14
AU2002700A (en)	2000-08-01
ATE331730T1 (de)	2006-07-15

Publication	Publication Date	Title
PT960107E (pt)	2003-02-28	Compostos de paclitaxel 6-tio-substituidos
PT717041E (pt)	2002-11-29	Hidratos de paclitaxel cristalinos
ATE339406T1 (de)	2006-10-15	Chinazoline verbindungen als heilmittel
DK1413582T3 (da)	2006-07-17	Dimere pyrrolobenzodiazepiner
DE69931925D1 (de)	2006-07-27	2-chinolonen enthaltende arzneimittel
PT1200412E (pt)	2004-04-30	Agentes anti-proliferativos de imidazole
IL160051A0 (en)	2004-06-20	Ecteinascidin derivatives and pharmaceutical compositions containing the same
EP1142573A4 (de)	2002-07-24	Antibakterielle medizinische zusammenstellung
EE200200281A (et)	2003-06-16	Pikornaviirusevastased ühendid ja kompositsioonid, nende farmatseutilised kasutusalad ning ained nende sünteesiks
BR0208017A (pt)	2004-12-07	Combinação compreendendo combretastatina e agentes anticâncer
TR200101978T2 (tr)	2001-12-21	3,3-Biarilpiperidin ve 2,2-biarilmorfolin türevleri.
DE60029084D1 (de)	2006-08-10	Neue depsipeptid-verbindung
ATE297904T1 (de)	2005-07-15	Halo-alkoxycarbonylverbindungen
SE9801494D0 (sv)	1998-04-28	Novel use
GB9907571D0 (en)	1999-05-26	Compounds
DK1011329T3 (da)	2003-12-22	7-Methylthiooxomethyl- og 7-methylthiodioxomethyl-paclitaxeler
HUP0203558A3 (en)	2004-01-28	Substituted pyrroles as antiproliferative compounds for the treatment of cancer and pharmaceutical compositions containing them
ATE249207T1 (de)	2003-09-15	Grf-haltige lyophilisierte arzneizusammensetzungen
DE60023307D1 (de)	2006-03-02	Phenanthrolin-7-onderivate und ihre therapeutische verwendung
BR9915898A (pt)	2001-08-21	Compostos, composição farmacêutica, e, utilização de um composto
IT1273460B (it)	1997-07-08	Formulazioni farmaceutiche ad azione antivirale per uso topico
TWI231815B (en)	2005-05-01	Glycopeptide derivatives and pharmaceutical compositions containing the same for use as antibacterial agents
IT1312375B1 (it)	2002-04-15	Composizione topica per l'eliminazione di tatuaggi.

Legal Events

Date	Code	Title	Description
2007-07-19	8364	No opposition during term of opposition