PT960107E - Compostos de paclitaxel 6-tio-substituidos - Google Patents
Compostos de paclitaxel 6-tio-substituidosInfo
- Publication number
- PT960107E PT960107E PT97954044T PT97954044T PT960107E PT 960107 E PT960107 E PT 960107E PT 97954044 T PT97954044 T PT 97954044T PT 97954044 T PT97954044 T PT 97954044T PT 960107 E PT960107 E PT 960107E
- Authority
- PT
- Portugal
- Prior art keywords
- tio
- substituted paclitaxel
- paclitaxel compounds
- compounds
- substituted
- Prior art date
Links
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical class O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 title 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000004579 taxol derivatives Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/6551—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a four-membered ring
- C07F9/65512—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a four-membered ring condensed with carbocyclic rings or carbocyclic ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epoxy Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Cephalosporin Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3341996P | 1996-12-24 | 1996-12-24 | |
| US3635197P | 1997-01-23 | 1997-01-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT960107E true PT960107E (pt) | 2003-02-28 |
Family
ID=26709670
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT97954044T PT960107E (pt) | 1996-12-24 | 1997-12-05 | Compostos de paclitaxel 6-tio-substituidos |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5977386A (pt) |
| EP (1) | EP0960107B1 (pt) |
| JP (1) | JP2001507029A (pt) |
| AT (1) | ATE225341T1 (pt) |
| AU (1) | AU722684B2 (pt) |
| CA (1) | CA2268774A1 (pt) |
| DE (1) | DE69716135T2 (pt) |
| DK (1) | DK0960107T3 (pt) |
| ES (1) | ES2184149T3 (pt) |
| PT (1) | PT960107E (pt) |
| WO (1) | WO1998028288A1 (pt) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001024763A2 (en) | 1999-10-01 | 2001-04-12 | Immunogen, Inc. | Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents |
| US6362217B2 (en) | 2000-03-17 | 2002-03-26 | Bristol-Myers Squibb Company | Taxane anticancer agents |
| AU7007001A (en) | 2000-06-22 | 2002-01-02 | Nitromed Inc | Nitrosated and nitrosylated taxanes, compositions and methods of use |
| US7351542B2 (en) | 2002-05-20 | 2008-04-01 | The Regents Of The University Of California | Methods of modulating tubulin deacetylase activity |
| EP2108362B1 (en) | 2002-06-26 | 2013-05-29 | MediGene AG | A cationic liposomal preparation comprising a taxane |
| EP1633317A4 (en) | 2003-05-16 | 2008-08-20 | Intermune Inc | Synthetic chemokine receptor ligands and methods of use therefor |
| US7597884B2 (en) | 2004-08-09 | 2009-10-06 | Alios Biopharma, Inc. | Hyperglycosylated polypeptide variants and methods of use |
| US8691780B2 (en) | 2005-02-17 | 2014-04-08 | The Board Of Trustees Of The Leland Stanford Junior University | Txr1 and enhanced taxane sensitivity based on the modulation of a pathway mediated thereby |
| ES2609388T3 (es) | 2006-03-22 | 2017-04-20 | Syncore Biotechnology Co., Ltd | Tratamiento del cáncer de mama triple negativo a receptores |
| PL217731B1 (pl) | 2006-06-01 | 2014-08-29 | Tomasz Byrski | Sposób wykrywania genetycznie uwarunkowanej obniżonej odpowiedzi na chemioterapię cytostatykiem taksanowym, zastosowanie mutacji założycielskiej oraz zestawu do wykrywania takiej odpowiedzi |
| WO2009143454A2 (en) | 2008-05-22 | 2009-11-26 | Kereos, Inc. | Combination antitumor therapy |
| EP2310507A4 (en) | 2008-07-08 | 2013-03-20 | David Gladstone Inst | METHOD AND COMPOSITIONS FOR ANGIOGENIC MODULATION |
| CN102040570B (zh) * | 2009-10-14 | 2014-07-30 | 江苏先声药物研究有限公司 | 硫代紫杉烷类衍生物及其制备方法和用途 |
| EP3539563A1 (en) | 2012-07-19 | 2019-09-18 | Redwood Bioscience, Inc. | Antibody specific for cd22 and methods of use thereof |
| WO2014074218A1 (en) | 2012-11-12 | 2014-05-15 | Redwood Bioscience, Inc. | Compounds and methods for producing a conjugate |
| ES2653487T3 (es) | 2013-02-15 | 2018-02-07 | The Regents Of The University Of California | Receptor de antígeno quimérico y métodos de uso del mismo |
| US9670162B2 (en) | 2013-03-14 | 2017-06-06 | The Board Of Trustees Of The Leland Stanford Junio | Mitochondrial aldehyde dehyrogenase-2 modulators and methods of use thereof |
| AU2014354643B2 (en) | 2013-11-27 | 2020-03-05 | Redwood Bioscience, Inc. | Hydrazinyl-pyrrolo compounds and methods for producing a conjugate |
| WO2015127137A1 (en) | 2014-02-19 | 2015-08-27 | Aldea Pharmaceuticals, Inc. | Mitochondrial aldehyde dehydrogenase 2 (aldh2) binding polycyclic amides and their use for the treatment of cancer |
| SG11201607746QA (en) | 2014-03-21 | 2016-10-28 | Abbvie Inc | Anti-egfr antibodies and antibody drug conjugates |
| EP3373977A4 (en) | 2015-11-12 | 2019-07-17 | The Board of Trustees of the Leland Stanford Junior University | CELL-PENETRATING, GUANIDINIUM-LICH OLIGOPHOSPHOTRIESTER FOR ACTIVE AND SPILL-RELIEF |
| WO2017087723A1 (en) | 2015-11-19 | 2017-05-26 | The Regents Of The University Of California | Conditionally repressible immune cell receptors and methods of use thereof |
| TWI760319B (zh) | 2015-12-30 | 2022-04-11 | 杏國新藥股份有限公司 | 乳癌治療 |
| EP3231421A1 (en) | 2016-04-11 | 2017-10-18 | Greenaltech, S.L. | Uses of a carotenoid in the treatment or prevention of stress induced conditions |
| CN109071634A (zh) | 2016-04-26 | 2018-12-21 | R.P.谢勒技术有限责任公司 | 抗体偶联物及其制备和使用方法 |
| JP7109427B2 (ja) | 2016-06-01 | 2022-07-29 | セルヴィエ アイピー ユーケー リミテッド | ポリアルキレンオキシド－アスパラギナーゼの製剤ならびにその製造法および使用法 |
| CN109562168A (zh) | 2016-06-08 | 2019-04-02 | 艾伯维公司 | 抗cd98抗体及抗体药物偶联物 |
| CA3027044A1 (en) | 2016-06-08 | 2017-12-14 | Abbvie Inc. | Anti-b7-h3 antibodies and antibody drug conjugates |
| BR112018075630A2 (pt) | 2016-06-08 | 2019-03-19 | Abbvie Inc. | anticorpos anti-cd98 e conjugados de fármaco de anticorpo |
| ES2861499T3 (es) | 2016-06-08 | 2021-10-06 | Abbvie Inc | Anticuerpos anti-B7-H3 y conjugados anticuerpo-fármaco |
| MX2018015285A (es) | 2016-06-08 | 2019-09-18 | Abbvie Inc | Anticuerpos anti-b7-h3 y conjugados de anticuerpo y farmaco. |
| TWI852903B (zh) | 2017-01-05 | 2024-08-21 | 杏國新藥股份有限公司 | 胰臟癌治療 |
| US12187801B2 (en) | 2017-01-18 | 2025-01-07 | Exuma Biotech Corp. | Chimeric antigen receptors against AXL or ROR2 and methods of use thereof |
| EP3388082A1 (en) | 2017-04-13 | 2018-10-17 | Galera Labs, LLC | Combination cancer immunotherapy with pentaaza macrocyclic ring complex |
| EP3630189A4 (en) | 2017-05-24 | 2021-06-23 | The Board of Regents of The University of Texas System | LINKER FOR ANTIBODY MEDICINAL CONJUGATES |
| CN110003142A (zh) * | 2018-01-04 | 2019-07-12 | 深圳福山生物科技有限公司 | 一种硒氰化合物及其用途 |
| EP3746085A4 (en) | 2018-01-31 | 2022-03-09 | Galera Labs, LLC | COMBINATION OF CANCER THERAPY USING A PENTAAZA MACROCYCLIC RING COMPLEX AND A PLATINUM-BASED ANTI-CANCER AGENT |
| EP3773632A4 (en) | 2018-04-06 | 2022-05-18 | The Regents of The University of California | Methods of treating egfrviii expressing glioblastomas |
| EP3773633A4 (en) | 2018-04-06 | 2022-01-26 | The Regents of The University of California | METHODS OF TREATMENT OF GLIOBLASTOMA |
| AU2019252676A1 (en) | 2018-04-11 | 2020-11-26 | Ohio State Innovation Foundation | Methods and compositions for sustained release microparticles for ocular drug delivery |
| US11897928B2 (en) | 2018-07-18 | 2024-02-13 | Manzanita Pharmaceuticals, Inc. | Conjugates for delivering an anti-cancer agent to nerve cells, methods of use and methods of making thereof |
| BR112021019701A2 (pt) | 2019-04-02 | 2021-12-14 | Kenjockety Biotechnology Inc | Anticorpos multiespecíficos para antígeno de câncer de bomba de efluxo e composições, reagentes, kits e métodos relacionados aos mesmos |
| EP4097134A1 (en) | 2020-01-29 | 2022-12-07 | Kenjockety Biotechnology, Inc. | Anti-mdr1 antibodies and uses thereof |
| AU2021283080A1 (en) | 2020-06-04 | 2022-12-15 | William Robert ARATHOON | ABCG2 efflux pump-cancer antigen multi-specific antibodies and compositions, reagents, kits and methods related thereto |
| AU2021284240A1 (en) | 2020-06-04 | 2022-12-08 | William Robert ARATHOON | Anti-ABCG2 antibodies and uses thereof |
| AU2021338286A1 (en) | 2020-09-02 | 2023-03-23 | William Robert ARATHOON | Anti-ABCC1 antibodies and uses thereof |
| EP4244257A1 (en) | 2020-11-13 | 2023-09-20 | Kenjockety Biotechnology, Inc. | Anti-mrp4 (encoded by abcc4 gene) antibodies and uses thereof |
| MX2023005979A (es) | 2020-11-20 | 2023-08-11 | Scherer Technologies Llc R P | Enlazadores de escisión doble de glicósido para conjugados de anticuerpo y fármaco. |
| AR124681A1 (es) | 2021-01-20 | 2023-04-26 | Abbvie Inc | Conjugados anticuerpo-fármaco anti-egfr |
| WO2023114658A1 (en) | 2021-12-13 | 2023-06-22 | Kenjockety Biotechnology, Inc. | Anti-abcb1 antibodies |
| WO2023159220A1 (en) | 2022-02-18 | 2023-08-24 | Kenjockety Biotechnology, Inc. | Anti-cd47 antibodies |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2601675B1 (fr) * | 1986-07-17 | 1988-09-23 | Rhone Poulenc Sante | Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent |
| US4876399A (en) * | 1987-11-02 | 1989-10-24 | Research Corporation Technologies, Inc. | Taxols, their preparation and intermediates thereof |
| US4960790A (en) * | 1989-03-09 | 1990-10-02 | University Of Kansas | Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof |
| US5714512A (en) * | 1991-07-08 | 1998-02-03 | Rhone-Poulenc Rorer, S.A. | Compositions containing taxane derivatives |
| EP0642503B1 (en) * | 1991-09-23 | 1999-12-01 | Florida State University | 10-desacetoxytaxol derivatives |
| US5272171A (en) * | 1992-02-13 | 1993-12-21 | Bristol-Myers Squibb Company | Phosphonooxy and carbonate derivatives of taxol |
| DE69325454T2 (de) * | 1992-04-17 | 2000-01-20 | Abbott Laboratories, Abbott Park | Taxol-derivate |
| US5254580A (en) * | 1993-01-19 | 1993-10-19 | Bristol-Myers Squibb Company | 7,8-cyclopropataxanes |
| US5294637A (en) * | 1992-07-01 | 1994-03-15 | Bristol-Myers Squibb Company | Fluoro taxols |
| FR2697019B1 (fr) * | 1992-10-15 | 1994-11-25 | Rhone Poulenc Rorer Sa | Nouveaux dérivés du taxane, leur préparation et les compositions pharmaceutiques qui les contiennent. |
| CA2109861C (en) * | 1992-12-04 | 1999-03-16 | Shu-Hui Chen | 6,7-modified paclitaxels |
| AU679206B2 (en) * | 1992-12-23 | 1997-06-26 | Bristol-Myers Squibb Company | Novel sidechain-bearing taxanes and intermediates thereof |
| CA2111527C (en) * | 1992-12-24 | 2000-07-18 | Jerzy Golik | Phosphonooxymethyl ethers of taxane derivatives |
| EP0687260B1 (en) * | 1993-03-05 | 2003-02-19 | Florida State University | Process for the preparation of 9-desoxotaxanes |
| US5703247A (en) * | 1993-03-11 | 1997-12-30 | Virginia Tech Intellectual Properties, Inc. | 2-Debenzoyl-2-acyl taxol derivatives and methods for making same |
| PT982301E (pt) * | 1993-06-11 | 2004-02-27 | Upjohn Co | Utilizacao antineoplasica de delta-6,7-taxois e composicoes farmaceuticas que oscontem |
| CA2192373A1 (en) * | 1994-06-09 | 1995-12-14 | Hirofumi Terasawa | Deacetoxytaxol derivative |
| WO1996000724A1 (en) * | 1994-06-28 | 1996-01-11 | Pharmacia & Upjohn Company | 7-ether-taxol analogs, antineoplastic use and pharmaceutical compositions containing them |
| CN1073105C (zh) * | 1994-07-26 | 2001-10-17 | 因迪纳有限公司 | 具有抗肿瘤活性的半合成紫杉烷 |
-
1997
- 1997-11-26 US US08/979,139 patent/US5977386A/en not_active Expired - Fee Related
- 1997-12-05 ES ES97954044T patent/ES2184149T3/es not_active Expired - Lifetime
- 1997-12-05 PT PT97954044T patent/PT960107E/pt unknown
- 1997-12-05 DE DE69716135T patent/DE69716135T2/de not_active Expired - Fee Related
- 1997-12-05 AT AT97954044T patent/ATE225341T1/de not_active IP Right Cessation
- 1997-12-05 EP EP97954044A patent/EP0960107B1/en not_active Expired - Lifetime
- 1997-12-05 WO PCT/US1997/022152 patent/WO1998028288A1/en not_active Ceased
- 1997-12-05 JP JP52877098A patent/JP2001507029A/ja not_active Abandoned
- 1997-12-05 CA CA002268774A patent/CA2268774A1/en not_active Abandoned
- 1997-12-05 DK DK97954044T patent/DK0960107T3/da active
- 1997-12-05 AU AU57922/98A patent/AU722684B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| CA2268774A1 (en) | 1998-07-02 |
| EP0960107A4 (pt) | 1999-12-01 |
| ES2184149T3 (es) | 2003-04-01 |
| EP0960107A1 (en) | 1999-12-01 |
| ATE225341T1 (de) | 2002-10-15 |
| DK0960107T3 (da) | 2003-02-10 |
| US5977386A (en) | 1999-11-02 |
| DE69716135T2 (de) | 2003-06-05 |
| AU722684B2 (en) | 2000-08-10 |
| WO1998028288A1 (en) | 1998-07-02 |
| DE69716135D1 (en) | 2002-11-07 |
| EP0960107B1 (en) | 2002-10-02 |
| JP2001507029A (ja) | 2001-05-29 |
| AU5792298A (en) | 1998-07-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PT960107E (pt) | Compostos de paclitaxel 6-tio-substituidos | |
| FI943749A0 (fi) | Taksaanijohdannaisten fosfono-oksimetyylieetterit | |
| PT971717E (pt) | Amino-acucar citotoxico e derivados de acucar afins de indolopirrolocarbazois | |
| ATE231872T1 (de) | Thiazolopyrimidinderivate | |
| ES2181744T3 (es) | Hidratos de paclitaxel cristalinos. | |
| ID23374A (id) | Halogenopirimidin | |
| CY1108610T1 (el) | Πεπτιδια της il-2 και παραγωγα αυτων και χρηση αυτων ως θεραπευτικοι παραγοντες | |
| TR199800436A3 (tr) | Primidin türevlerinin kanserin önlenmesi için kullanilmasi. | |
| MX9601994A (es) | Profarmacos de derivados de paclitaxel. | |
| CA2152771A1 (en) | 7-o-ethers of taxane derivatives | |
| SE9802937D0 (sv) | Novel compounds | |
| DK1073447T3 (da) | N1-modificerede glycopeptider | |
| PT1011329E (pt) | Paclitaxeis de 7-metiltio-oxometilo e 7-metiltiodioxometilo | |
| AU4558201A (en) | Taxane anticancer agents | |
| DE50004023D1 (de) | 1,4-dioxacycloalkan-2-one und 1,4-dioxacycloalken-2-one | |
| TWI231815B (en) | Glycopeptide derivatives and pharmaceutical compositions containing the same for use as antibacterial agents |