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DE60023870T2 - Verfahren zur herstellung von 3-aryloxy-3-arylpropylamine und deren zwischenprodukte - Google Patents

Verfahren zur herstellung von 3-aryloxy-3-arylpropylamine und deren zwischenprodukte Download PDF

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Publication number
DE60023870T2
DE60023870T2 DE60023870T DE60023870T DE60023870T2 DE 60023870 T2 DE60023870 T2 DE 60023870T2 DE 60023870 T DE60023870 T DE 60023870T DE 60023870 T DE60023870 T DE 60023870T DE 60023870 T2 DE60023870 T2 DE 60023870T2
Authority
DE
Germany
Prior art keywords
aryloxy
preparation
arylpropylamine
intermediate products
arylpropylamines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60023870T
Other languages
English (en)
Other versions
DE60023870D1 (de
Inventor
Patton Kjell
Thomas Lorenz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of DE60023870D1 publication Critical patent/DE60023870D1/de
Publication of DE60023870T2 publication Critical patent/DE60023870T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/06—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton from hydroxy amines by reactions involving the etherification or esterification of hydroxy groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Luminescent Compositions (AREA)
DE60023870T 1999-04-09 2000-03-22 Verfahren zur herstellung von 3-aryloxy-3-arylpropylamine und deren zwischenprodukte Expired - Lifetime DE60023870T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12848099P 1999-04-09 1999-04-09
PCT/US2000/006423 WO2000061540A1 (en) 1999-04-09 2000-03-22 Methods for preparing 3-aryloxy-3-arylpropylamines and intermediates thereof

Publications (2)

Publication Number Publication Date
DE60023870D1 DE60023870D1 (de) 2005-12-15
DE60023870T2 true DE60023870T2 (de) 2006-06-14

Family

ID=22435565

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60023870T Expired - Lifetime DE60023870T2 (de) 1999-04-09 2000-03-22 Verfahren zur herstellung von 3-aryloxy-3-arylpropylamine und deren zwischenprodukte

Country Status (10)

Country Link
US (1) US6541668B1 (de)
EP (1) EP1171417B1 (de)
JP (1) JP2002541235A (de)
AT (1) ATE309196T1 (de)
AU (1) AU3877500A (de)
CA (1) CA2362185C (de)
DE (1) DE60023870T2 (de)
DK (1) DK1171417T3 (de)
ES (1) ES2249256T3 (de)
WO (1) WO2000061540A1 (de)

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KR20030092012A (ko) 2001-03-06 2003-12-03 일라이 릴리 앤드 캄파니 모노아민 흡수 억제제
US20040249170A1 (en) * 2002-01-24 2004-12-09 Alfio Borghese Process for preparing an intermediate useful for the asymmetric synthesis of duloxetine
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US20060100290A1 (en) * 2003-07-28 2006-05-11 Dunaway Leslie J Treatment of allergic rhinitis and asthma
US20050197503A1 (en) * 2004-03-05 2005-09-08 Boehringer Ingelheim International Gmbh Process for the preparation of N-alkyl-N-methyl-3-hydroxy-3-(2-thienyl)-propylamines
US7439399B2 (en) * 2004-06-28 2008-10-21 Teva Pharmaceutical Fine Chemicals Processes for the preparation of atomoxetine hydrochloride
CA2561386A1 (en) * 2004-06-28 2006-01-12 Teva Pharmaceutical Fine Chemicals S.R.L. Enantiomerically pure atomoxetine and tomoxetine mandelate
CA2568629A1 (en) * 2004-07-22 2006-02-23 Teva Pharmaceutical Fine Chemicals S.R.L. Polymorphs of atomoxetine hydrochloride
WO2006027798A2 (en) * 2004-08-05 2006-03-16 Sun Pharmaceutical Industries Limited A process for preparation of an antidepressant compound
WO2006037055A1 (en) * 2004-09-27 2006-04-06 Dr. Reddy's Laboratories Ltd. Synthesis of atomoxetine hydrochloride
US20060194869A1 (en) * 2004-12-23 2006-08-31 Santiago Ini Process for preparing pharmaceutically acceptable salts of duloxetine and intermediates thereof
US7399871B2 (en) * 2005-03-08 2008-07-15 Teva Pharmaceutical Industries Ltd. Crystal forms of (S)-(+)-N,N-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine oxalate and the preparation thereof
CA2599475A1 (en) * 2005-03-14 2006-09-21 Teva Pharmaceutical Industries Ltd. Pure duloxetine hydrochloride
JP2008501721A (ja) * 2005-04-05 2008-01-24 テバ ファーマシューティカル ファイン ケミカルズ ソチエタ レスポンサビリタ リミテ 安定性アトモキセチン塩酸塩、その調製方法及びその安定性の分析的調節
EP1889828A1 (de) * 2005-04-05 2008-02-20 Teva Pharmaceutical Fine Chemicals S.R.L. Stabiles Atomoxetinhydrochlorid, Herstellungsverfahren und analytische Steuerung seiner Stabilität
US7485754B2 (en) * 2005-07-08 2009-02-03 Apotex Pharmachem Inc. Efficient method for preparing 3-aryloxy-3-arylpropylamines and their optical stereoisomers
CZ296345B6 (cs) * 2005-07-21 2006-02-15 Zentiva, A. S Zpusob výroby hydrochloridu (R)-N-methyl-3-(2-methylfenoxy)-3-fenylpropylaminu (atomoxetinu)
EP1838692A2 (de) * 2005-09-22 2007-10-03 Teva Pharmaceutical Industries Ltd Dnt-maleat und herstellungsverfahren dafür
US20080207923A1 (en) * 2005-09-22 2008-08-28 Santiago Ini Pure DNT-maleate and methods of preparation thereof
EP1863782A1 (de) * 2005-12-05 2007-12-12 Teva Pharmaceutical Industries Ltd. 2-(n-methyl-propanamin)-3-(2-naphthol) thiophen, eine verunreinigung von duloxetin hydrochlorid
US20090093645A1 (en) 2005-12-12 2009-04-09 Medichem S.A. Synthesis and preparations of duloxetine salts
EP1798215A1 (de) * 2005-12-14 2007-06-20 SOLMAG S.p.A. Polymorph von Atomoxetin-hydrochloride in kristalliner Form
US7538232B2 (en) 2006-01-19 2009-05-26 Eli Lilly And Company Process for the asymmetric synthesis of duloxetine
WO2007086948A1 (en) * 2006-01-23 2007-08-02 Teva Pharmaceutical Industries Ltd. Dnt-fumarate and methods of preparation thereof
WO2007084193A1 (en) * 2006-01-23 2007-07-26 Teva Pharmaceutical Industries Ltd. Dnt-succinate and methods of preparation thereof
US20070238883A1 (en) * 2006-02-13 2007-10-11 Santiago Ini Process for the preparation of(s)-(+)-N,N-dimethyl-3-(1-Naphthalenyloxy)-3-(2-Thienyl)propanamine, A duloxetine intermediate
WO2007098250A2 (en) * 2006-02-21 2007-08-30 Teva Pharmaceutical Industries Ltd. Process for the preparation of (s)-(-)-n,n-dimethyl-3-(2-thienyl)-3-hydroxypropanamine, a duloxetine intermediate
US20080146675A1 (en) * 2006-04-05 2008-06-19 Eugenio Castelli Stable Atomoxetine Hydrochloride, a process for the preparation thereof, and an analytical control of its stability
US20080027128A1 (en) * 2006-05-23 2008-01-31 Santiago Ini Duloxetine HCL polymorphs
CN101454306A (zh) * 2006-05-31 2009-06-10 特瓦制药工业有限公司 制备度洛西汀和它的中间体的方法
CN100430370C (zh) * 2006-11-03 2008-11-05 华东理工大学 一种丙胺衍生物及其在制备托莫西汀中的应用
US20080145318A1 (en) * 2006-12-13 2008-06-19 Midha Kamal K Atomoxetine formulations and associated methods
WO2008077645A1 (en) 2006-12-22 2008-07-03 Synthon B.V. Process for making duloxetine and related compounds
EP2132192B1 (de) * 2007-03-05 2013-04-24 Lupin Limited Neues verfahren zur herstellung von duloxetinhydrochlorid
WO2009019719A2 (en) * 2007-08-09 2009-02-12 Ind-Swift Laboratories Limited Process for the preparation of 3-aryloxy-3-arylpropanamines
EP2060559A1 (de) 2007-11-19 2009-05-20 Cadila Pharmaceuticals Limited Herstellungsverfahren für enantiomerenreine 3-Hydroxy-3-Arylpropylamine und ihrer optischen Stereoisomere
US20100267968A1 (en) * 2007-12-26 2010-10-21 Orchid Chemicals & Pharmaceuticals Limited Method for the preparation of duloxetine hydrochloride
CA2712282A1 (en) * 2008-01-25 2009-07-30 Alphapharm Pty Ltd Delayed release pharmaceutical composition of duloxetine
WO2009141833A2 (en) * 2008-04-17 2009-11-26 Ind-Swift Laboratories Limited An improved process for synthesizing highly pure atomoxetine
US8288141B2 (en) 2008-08-27 2012-10-16 Codexis, Inc. Ketoreductase polypeptides for the production of 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine
EP2329013B1 (de) 2008-08-27 2015-10-28 Codexis, Inc. Ketoreduktasepolypeptide zur herstellung von einem 3-aryl-3-hydroxypropanamin aus einem 3-aryl-3-ketopropanamin
EP2558455B1 (de) 2010-04-13 2017-08-09 KRKA, D.D., Novo Mesto Synthese von duloxetin- und/oder pharmazeutisch akzeptablen salzen daraus
CN102863344B (zh) * 2012-07-20 2015-06-03 葫芦岛国帝药业有限责任公司 一种托莫西汀药物制备方法
CN106916074A (zh) * 2017-02-14 2017-07-04 万特制药(海南)有限公司 盐酸托莫西汀的制备
CN108929236A (zh) * 2017-05-26 2018-12-04 万特制药(海南)有限公司 盐酸托莫西汀的制备
CN110294680A (zh) * 2018-03-22 2019-10-01 北京深蓝海生物医药科技有限公司 一种盐酸阿托莫西汀的制备方法
CN111302958B (zh) * 2020-03-24 2023-05-02 合肥医工医药股份有限公司 一种光学纯的（r）-n-甲基-3-苯基-3-（邻-甲苯氧基）-丙胺盐酸盐制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR75395B (de) 1980-11-14 1984-07-13 Lilly Co Eli
JPS6023656A (ja) 1983-07-20 1985-02-06 Nissan Motor Co Ltd 自動変速機の遊星歯車列
US4868344A (en) 1988-03-30 1989-09-19 Aldrich-Boranes, Inc. Novel process of producing phenyl or substituted phenylalkylamine pharmaceutical agents and novel chiral intermediates of high enantiomeric purity useful therein
FI81083C (fi) * 1989-03-03 1990-09-10 Orion Yhtymae Oy Ett foerbaettrat foerfarande foer framstaellning av n-metyl-3-(p-trifluormetylfenoxi)-3-fenylpropylamin hydroklorid.
US5166437A (en) * 1989-03-03 1992-11-24 Orion-Yhtyma Oy Process for the preparation of fluoxetine
US5104899A (en) 1990-08-13 1992-04-14 Sepracor, Inc. Methods and compositions for treating depression using optically pure fluoxetine
US5362886A (en) 1993-10-12 1994-11-08 Eli Lilly And Company Asymmetric synthesis
ES2120368B1 (es) * 1996-06-14 1999-07-01 Almirall Prodesfarma Sa Procedimiento de obtencion de n-metil-3-(p-trifluorometilfenoxi)-3-fenilpropilamina y sus sales farmaceuticamente aceptables.
IT1283141B1 (it) * 1996-07-11 1998-04-07 Laporte Organics Francis S P A Procedimento per la preparazione di n-metil-3-(p-trifluorometilfenossi)-3-fenilpropilamina e dei suoi
TW514634B (en) 1997-10-14 2002-12-21 Lilly Co Eli Process to make chiral compounds

Also Published As

Publication number Publication date
JP2002541235A (ja) 2002-12-03
WO2000061540A1 (en) 2000-10-19
EP1171417A1 (de) 2002-01-16
ES2249256T3 (es) 2006-04-01
ATE309196T1 (de) 2005-11-15
EP1171417B1 (de) 2005-11-09
CA2362185A1 (en) 2000-10-19
CA2362185C (en) 2009-06-02
AU3877500A (en) 2000-11-14
DE60023870D1 (de) 2005-12-15
US6541668B1 (en) 2003-04-01
DK1171417T3 (da) 2006-02-20

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: KROHER, STROBEL RECHTS- UND PATENTANWAELTE, 80336

8328 Change in the person/name/address of the agent

Representative=s name: DR. SCHOEN & PARTNER, 80336 MUENCHEN