DE60022960D1 - Verfahren zur Reinigung von S-Adenosyl-L-Methionin und zur Herstellung von pharmazeutisch verträglichen Salzen davon - Google Patents
Verfahren zur Reinigung von S-Adenosyl-L-Methionin und zur Herstellung von pharmazeutisch verträglichen Salzen davonInfo
- Publication number
- DE60022960D1 DE60022960D1 DE60022960T DE60022960T DE60022960D1 DE 60022960 D1 DE60022960 D1 DE 60022960D1 DE 60022960 T DE60022960 T DE 60022960T DE 60022960 T DE60022960 T DE 60022960T DE 60022960 D1 DE60022960 D1 DE 60022960D1
- Authority
- DE
- Germany
- Prior art keywords
- adenosyl
- methionine
- purification
- preparation
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- MEFKEPWMEQBLKI-AIRLBKTGSA-N S-adenosyl-L-methioninate Chemical compound O[C@@H]1[C@H](O)[C@@H](C[S+](CC[C@H](N)C([O-])=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 MEFKEPWMEQBLKI-AIRLBKTGSA-N 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 238000000746 purification Methods 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 title abstract 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/38—Nucleosides
- C12P19/40—Nucleosides having a condensed ring system containing a six-membered ring having two nitrogen atoms in the same ring, e.g. purine nucleosides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI992070 | 1999-10-05 | ||
| IT1999MI002070A IT1315236B1 (it) | 1999-10-05 | 1999-10-05 | Processo per la purificazione di s-adenosil-l-metionina e per lapreparazione dei suoi sali farmaceuticamente accettabili. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60022960D1 true DE60022960D1 (de) | 2006-02-16 |
| DE60022960T2 DE60022960T2 (de) | 2006-06-29 |
Family
ID=11383720
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60022960T Expired - Lifetime DE60022960T2 (de) | 1999-10-05 | 2000-09-20 | Verfahren für die Aufreinigung von S-Adenosyl-L-methionin und für die Herstellung von pharmazeutisch annehmbaren Salzen davon |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1091001B1 (de) |
| AT (1) | ATE305978T1 (de) |
| CA (1) | CA2322231C (de) |
| DE (1) | DE60022960T2 (de) |
| DK (1) | DK1091001T3 (de) |
| ES (1) | ES2249221T3 (de) |
| IT (1) | IT1315236B1 (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102005009751A1 (de) | 2005-03-03 | 2006-09-07 | Consortium für elektrochemische Industrie GmbH | Verfahren zur fermentativen Herstellung von S-Adenosyl-Methionin |
| WO2007083631A1 (ja) | 2006-01-17 | 2007-07-26 | Mitsubishi Gas Chemical Company, Inc. | Ｓ－アデノシル－ｌ－メチオニンの安定化法及び安定化された組成物 |
| JP5136409B2 (ja) | 2006-05-16 | 2013-02-06 | 三菱瓦斯化学株式会社 | 保存安定性に優れたｓ−アデノシル−ｌ−メチオニン含有乾燥酵母の製造方法、その製造物及び経口摂取用組成物 |
| PT2116593T (pt) | 2007-01-25 | 2018-03-12 | Mitsubishi Gas Chemical Co | Método de produção de levedura seca contendo s-adenosil-l-metionina e com estabilidade de armanezamento excelente, produto produzido pelo método e composição moldada da levedura seca |
| CN102321136B (zh) * | 2011-09-19 | 2014-10-22 | 北京化工大学 | S-腺苷-l-甲硫氨酸对甲苯磺酸硫酸双盐的制备方法 |
| CN104211744A (zh) * | 2013-05-30 | 2014-12-17 | 北京东方瑞德生物技术有限公司 | 一种s-腺苷蛋氨酸对甲苯磺酸硫酸盐的制备方法 |
| CN109456377A (zh) * | 2018-12-17 | 2019-03-12 | 山东金城生物药业有限公司 | 一种腺苷蛋氨酸盐的制备方法 |
| CN110396120B (zh) * | 2019-02-13 | 2020-05-12 | 山东惠仕莱生物科技有限公司 | 一种从s-腺苷蛋氨酸发酵液中提取分离s-腺苷蛋氨酸的方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1803978C2 (de) * | 1968-10-18 | 1985-05-02 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren zur Gewinnung von S-Adenosyl-l-methionin und S-Adenosyl-l-ethionin |
| US3962034A (en) * | 1973-02-01 | 1976-06-08 | Ajinomoto Co., Inc. | Method for producing s-adenosylmethionine or methylthioadenosine by yeast |
| US4028183A (en) * | 1973-06-27 | 1977-06-07 | Bioresearch Limited | Process of preparing double salts of S-adenosyl-L-methionine |
| GB2116172B (en) * | 1982-02-25 | 1986-07-09 | Nippon Zeon Co | Microbial cells containing s-adenosyl methionine in high concentrations and process for production of s adenosyl methionine |
| IT1169773B (it) * | 1983-08-24 | 1987-06-03 | Bioresearch Spa | Processo per la produzione di sali stabili della solfo-adenosil-l-metionina |
-
1999
- 1999-10-05 IT IT1999MI002070A patent/IT1315236B1/it active
-
2000
- 2000-09-20 ES ES00120521T patent/ES2249221T3/es not_active Expired - Lifetime
- 2000-09-20 EP EP00120521A patent/EP1091001B1/de not_active Expired - Lifetime
- 2000-09-20 AT AT00120521T patent/ATE305978T1/de active
- 2000-09-20 DE DE60022960T patent/DE60022960T2/de not_active Expired - Lifetime
- 2000-09-20 DK DK00120521T patent/DK1091001T3/da active
- 2000-10-04 CA CA002322231A patent/CA2322231C/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ITMI992070A1 (it) | 2001-04-05 |
| EP1091001B1 (de) | 2005-10-05 |
| ES2249221T3 (es) | 2006-04-01 |
| CA2322231C (en) | 2009-03-17 |
| IT1315236B1 (it) | 2003-02-03 |
| DK1091001T3 (da) | 2005-11-14 |
| ATE305978T1 (de) | 2005-10-15 |
| EP1091001A1 (de) | 2001-04-11 |
| CA2322231A1 (en) | 2001-04-05 |
| ITMI992070A0 (it) | 1999-10-05 |
| DE60022960T2 (de) | 2006-06-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |