DE60022663D1 - Verfahren zur herstellung von cox-2 inhibitoren - Google Patents
Verfahren zur herstellung von cox-2 inhibitorenInfo
- Publication number
- DE60022663D1 DE60022663D1 DE60022663T DE60022663T DE60022663D1 DE 60022663 D1 DE60022663 D1 DE 60022663D1 DE 60022663 T DE60022663 T DE 60022663T DE 60022663 T DE60022663 T DE 60022663T DE 60022663 D1 DE60022663 D1 DE 60022663D1
- Authority
- DE
- Germany
- Prior art keywords
- general formula
- compound
- reacting
- iii
- cox
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title abstract 2
- 229940111134 coxibs Drugs 0.000 title 1
- 239000003255 cyclooxygenase 2 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000000010 aprotic solvent Substances 0.000 abstract 1
- 150000001923 cyclic compounds Chemical class 0.000 abstract 1
- 230000018044 dehydration Effects 0.000 abstract 1
- 238000006297 dehydration reaction Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
- -1 tri-substituted phenyl Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/60—Two oxygen atoms, e.g. succinic anhydride
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C323/18—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C07C323/19—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton with singly-bound oxygen atoms bound to acyclic carbon atoms of the carbon skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Pain & Pain Management (AREA)
- Animal Behavior & Ethology (AREA)
- Rheumatology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Furan Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9912583A FR2799462B1 (fr) | 1999-10-08 | 1999-10-08 | Procede de preparation d'inhibiteurs cox-2 |
| FR9912583 | 1999-10-08 | ||
| PCT/FR2000/002770 WO2001027098A2 (fr) | 1999-10-08 | 2000-10-05 | Procede de preparation d'inhibiteurs cox-2 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60022663D1 true DE60022663D1 (de) | 2005-10-20 |
| DE60022663T2 DE60022663T2 (de) | 2006-06-22 |
Family
ID=9550723
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60022663T Expired - Lifetime DE60022663T2 (de) | 1999-10-08 | 2000-10-05 | Verfahren zur herstellung von cox-2 inhibitoren |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6541646B2 (de) |
| EP (1) | EP1218366B8 (de) |
| JP (1) | JP4933012B2 (de) |
| AT (1) | ATE304537T1 (de) |
| AU (1) | AU773221B2 (de) |
| CA (1) | CA2386807C (de) |
| DE (1) | DE60022663T2 (de) |
| DK (1) | DK1218366T3 (de) |
| ES (1) | ES2249299T3 (de) |
| FR (1) | FR2799462B1 (de) |
| WO (1) | WO2001027098A2 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7531002B2 (en) * | 2004-04-16 | 2009-05-12 | Depuy Spine, Inc. | Intervertebral disc with monitoring and adjusting capabilities |
| US8541362B2 (en) | 2005-08-19 | 2013-09-24 | Emisphere Technologies, Inc. | Cyclopropyl compounds and compositions for delivering active agents |
| EP2833390A1 (de) | 2013-08-02 | 2015-02-04 | Fei Company | Verwendung von elektrostatischen Objektivlinsen in einem Elektronenmikroskop |
| CN104803956A (zh) * | 2015-03-06 | 2015-07-29 | 江苏天和制药有限公司 | 非罗考昔的一种合成方法 |
| CN105859664A (zh) * | 2016-05-03 | 2016-08-17 | 中国药科大学 | 非罗考昔的一种制备方法 |
| CN107641108A (zh) * | 2017-11-12 | 2018-01-30 | 韦韬 | 一种非罗考昔的精制方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA57002C2 (uk) * | 1995-10-13 | 2003-06-16 | Мерк Фросст Кенада Енд Ко./Мерк Фросст Кенада Енд Сі. | Похідне (метилсульфоніл)феніл-2-(5н)-фуранону, фармацевтична композиція та спосіб лікування |
| HRP970289A2 (en) * | 1996-05-31 | 1998-04-30 | Merck & Co Inc | Process for preparing phenyl heterocycles useful as cox-2 inhibitors |
| ATE244232T1 (de) * | 1997-03-14 | 2003-07-15 | Merck Frosst Canada Inc | (methylsulfonyl)phenyl-2-(5h)-furanone mit sauerstoff-bindung als cox-2-hemmer |
| GB2330833A (en) * | 1997-10-29 | 1999-05-05 | Merck & Co Inc | PREPARATION OF 4-(4-Methylsulfonylphenyl)-2-furanones USEFUL AS COX-2 INHIBITORS |
-
1999
- 1999-10-08 FR FR9912583A patent/FR2799462B1/fr not_active Expired - Lifetime
-
2000
- 2000-10-05 AU AU77944/00A patent/AU773221B2/en not_active Expired
- 2000-10-05 DK DK00967956T patent/DK1218366T3/da active
- 2000-10-05 DE DE60022663T patent/DE60022663T2/de not_active Expired - Lifetime
- 2000-10-05 CA CA2386807A patent/CA2386807C/en not_active Expired - Lifetime
- 2000-10-05 WO PCT/FR2000/002770 patent/WO2001027098A2/fr not_active Ceased
- 2000-10-05 EP EP00967956A patent/EP1218366B8/de not_active Expired - Lifetime
- 2000-10-05 JP JP2001530317A patent/JP4933012B2/ja not_active Expired - Lifetime
- 2000-10-05 ES ES00967956T patent/ES2249299T3/es not_active Expired - Lifetime
- 2000-10-05 AT AT00967956T patent/ATE304537T1/de active
-
2002
- 2002-04-08 US US10/117,832 patent/US6541646B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US20030028036A1 (en) | 2003-02-06 |
| AU773221B2 (en) | 2004-05-20 |
| EP1218366A2 (de) | 2002-07-03 |
| EP1218366B1 (de) | 2005-09-14 |
| US6541646B2 (en) | 2003-04-01 |
| JP2003511444A (ja) | 2003-03-25 |
| JP4933012B2 (ja) | 2012-05-16 |
| CA2386807C (en) | 2010-03-30 |
| EP1218366B8 (de) | 2005-11-09 |
| DK1218366T3 (da) | 2006-01-23 |
| WO2001027098A3 (fr) | 2001-08-30 |
| CA2386807A1 (en) | 2001-04-19 |
| ATE304537T1 (de) | 2005-09-15 |
| ES2249299T3 (es) | 2006-04-01 |
| WO2001027098A2 (fr) | 2001-04-19 |
| FR2799462A1 (fr) | 2001-04-13 |
| AU7794400A (en) | 2001-04-23 |
| DE60022663T2 (de) | 2006-06-22 |
| FR2799462B1 (fr) | 2004-05-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |