DE60000661D1 - Eine methode zur herstellung eines polymorphes von einem doxazosin-mesylat - Google Patents
Eine methode zur herstellung eines polymorphes von einem doxazosin-mesylatInfo
- Publication number
- DE60000661D1 DE60000661D1 DE60000661T DE60000661T DE60000661D1 DE 60000661 D1 DE60000661 D1 DE 60000661D1 DE 60000661 T DE60000661 T DE 60000661T DE 60000661 T DE60000661 T DE 60000661T DE 60000661 D1 DE60000661 D1 DE 60000661D1
- Authority
- DE
- Germany
- Prior art keywords
- polymorphes
- producing
- alcohol
- mesylate
- solvent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 title abstract 3
- 229960001389 doxazosin Drugs 0.000 title abstract 2
- RUZYUOTYCVRMRZ-UHFFFAOYSA-N doxazosin Chemical compound C1OC2=CC=CC=C2OC1C(=O)N(CC1)CCN1C1=NC(N)=C(C=C(C(OC)=C2)OC)C2=N1 RUZYUOTYCVRMRZ-UHFFFAOYSA-N 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000002904 solvent Substances 0.000 abstract 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- 238000004821 distillation Methods 0.000 abstract 1
- 229960000220 doxazosin mesylate Drugs 0.000 abstract 1
- VJECBOKJABCYMF-UHFFFAOYSA-N doxazosin mesylate Chemical compound [H+].CS([O-])(=O)=O.C1OC2=CC=CC=C2OC1C(=O)N(CC1)CCN1C1=NC(N)=C(C=C(C(OC)=C2)OC)C2=N1 VJECBOKJABCYMF-UHFFFAOYSA-N 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 229940098779 methanesulfonic acid Drugs 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000001376 precipitating effect Effects 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 238000010992 reflux Methods 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES009900535A ES2164520B1 (es) | 1999-03-16 | 1999-03-16 | "procedimiento de obtencion del polimorfo a del mesilato de doxazosina" |
| PCT/ES2000/000086 WO2000055157A1 (es) | 1999-03-16 | 2000-03-13 | Procedimiento de obtencion del polimorfo a del mesilato de doxazosina |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60000661D1 true DE60000661D1 (de) | 2002-11-28 |
| DE60000661T2 DE60000661T2 (de) | 2003-06-26 |
Family
ID=8307680
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60000661T Expired - Lifetime DE60000661T2 (de) | 1999-03-16 | 2000-03-13 | Eine methode zur herstellung eines polymorphes von einem doxazosin-mesylat |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6525195B1 (de) |
| EP (1) | EP1162202B1 (de) |
| AT (1) | ATE226580T1 (de) |
| AU (1) | AU3167500A (de) |
| CA (1) | CA2367671C (de) |
| DE (1) | DE60000661T2 (de) |
| DK (1) | DK1162202T3 (de) |
| ES (2) | ES2164520B1 (de) |
| PT (1) | PT1162202E (de) |
| WO (1) | WO2000055157A1 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19912573A1 (de) * | 1999-03-19 | 2000-09-21 | Knoll Ag | Arzneimittel, enthaltend Doxazosin-Mesylat der Kristallmodifikaton D |
| WO2002096859A1 (en) | 2001-05-31 | 2002-12-05 | Orion Corporation Fermion | Process for preparing sertraline hydrochloride polymorphic form ii |
| CN1304374C (zh) | 2002-04-30 | 2007-03-14 | 永进药品工业株式会社 | 可用做caspase－3抑制剂的喹啉衍生物及其制备方法和药用组合物 |
| AU2008339652B2 (en) * | 2007-12-24 | 2013-07-04 | Cipla Limited | Crystalline polymorph of doxazosin mesylate (form IV) and process for preparation thereof |
| WO2016151466A1 (en) * | 2015-03-26 | 2016-09-29 | Unichem Laboratories Limited | Process of preparing potassium salt of azilsartan medoxomil |
| CN111303130B (zh) * | 2018-12-11 | 2021-09-14 | 合肥立方制药股份有限公司 | 一种多沙唑嗪甲磺酸盐晶型、其制备方法及用途 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4188390A (en) | 1977-11-05 | 1980-02-12 | Pfizer Inc. | Antihypertensive 4-amino-2-[4-(1,4-benzodioxan-2-carbonyl) piperazin-1-yl or homopiperazin-1-yl]quinazolines |
| DE69503066T2 (de) * | 1995-06-06 | 1998-10-15 | Pfizer Inc., New York, N.Y. | KRISTALLFORM VON WASSERFREIEN 7-((1a,5a,6a)-6-AMINO-3-AZABICYCLO (3.1.0.) HEX-3-YL)-6-FLUORO-1-(2,4-DIFLUOROPHENYL)-1,4-DIHYDRO-4-OXO-1,8-NAPHTHYRIDIN-CARBONSÄURE METHANESULFONSÄURE SALZ |
| IT1287588B1 (it) * | 1996-12-13 | 1998-08-06 | Alfa Chem Ital | Forma cristallina del doxazosin mesilato e processo per la sua produzione |
| EP0849265A1 (de) | 1996-12-20 | 1998-06-24 | HEUMANN PHARMA GmbH | Neue polymorphe Form von Doxazosin-Mesylat (Form II) |
| PT849266E (pt) | 1996-12-20 | 2007-03-30 | Heumann Pcs Gmbh | Nova forma polimorfa de mesilato de doxazosina (forma iii) |
| EP0849264A1 (de) | 1996-12-20 | 1998-06-24 | HEUMANN PHARMA GmbH | Neue polymorphe Form von doxazosinmesylat (Form I) |
| DE19800214A1 (de) * | 1998-01-06 | 1999-07-15 | Knoll Ag | Verfahren zur Herstellung von Doxazosin-Mcsylat in einer als Form A bezeichneten Kristallmodifikation und ein Zwischenprodukt dafür |
-
1999
- 1999-03-16 ES ES009900535A patent/ES2164520B1/es not_active Expired - Lifetime
-
2000
- 2000-03-13 AT AT00909370T patent/ATE226580T1/de not_active IP Right Cessation
- 2000-03-13 AU AU31675/00A patent/AU3167500A/en not_active Abandoned
- 2000-03-13 DK DK00909370T patent/DK1162202T3/da active
- 2000-03-13 DE DE60000661T patent/DE60000661T2/de not_active Expired - Lifetime
- 2000-03-13 WO PCT/ES2000/000086 patent/WO2000055157A1/es not_active Ceased
- 2000-03-13 EP EP00909370A patent/EP1162202B1/de not_active Expired - Lifetime
- 2000-03-13 US US09/913,778 patent/US6525195B1/en not_active Expired - Fee Related
- 2000-03-13 ES ES00909370T patent/ES2184698T3/es not_active Expired - Lifetime
- 2000-03-13 PT PT00909370T patent/PT1162202E/pt unknown
- 2000-03-13 CA CA2367671A patent/CA2367671C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1162202A1 (de) | 2001-12-12 |
| ES2164520B1 (es) | 2003-04-01 |
| ES2164520A1 (es) | 2002-02-16 |
| EP1162202B1 (de) | 2002-10-23 |
| WO2000055157A1 (es) | 2000-09-21 |
| ATE226580T1 (de) | 2002-11-15 |
| AU3167500A (en) | 2000-10-04 |
| ES2184698T3 (es) | 2003-04-16 |
| DE60000661T2 (de) | 2003-06-26 |
| PT1162202E (pt) | 2003-02-28 |
| US6525195B1 (en) | 2003-02-25 |
| CA2367671A1 (en) | 2000-09-21 |
| DK1162202T3 (da) | 2003-02-24 |
| CA2367671C (en) | 2010-06-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |