DE4011956A1 - Verfahren und vorrichtung zur darstellung von sterilen einspritzbaren antibiotikapulvern - Google Patents
Verfahren und vorrichtung zur darstellung von sterilen einspritzbaren antibiotikapulvernInfo
- Publication number
- DE4011956A1 DE4011956A1 DE4011956A DE4011956A DE4011956A1 DE 4011956 A1 DE4011956 A1 DE 4011956A1 DE 4011956 A DE4011956 A DE 4011956A DE 4011956 A DE4011956 A DE 4011956A DE 4011956 A1 DE4011956 A1 DE 4011956A1
- Authority
- DE
- Germany
- Prior art keywords
- solution
- active component
- reactor
- sodium
- inert gas
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 238000000034 method Methods 0.000 title claims description 61
- 239000006067 antibiotic powder Substances 0.000 title claims description 9
- 239000000843 powder Substances 0.000 claims abstract description 22
- 239000011261 inert gas Substances 0.000 claims abstract description 20
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims abstract description 18
- 239000003242 anti bacterial agent Substances 0.000 claims abstract description 13
- 229940088710 antibiotic agent Drugs 0.000 claims abstract description 13
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract description 9
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 33
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 31
- 239000007921 spray Substances 0.000 claims description 26
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 20
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 19
- 239000002904 solvent Substances 0.000 claims description 19
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 16
- 239000000203 mixture Substances 0.000 claims description 16
- 229910052708 sodium Inorganic materials 0.000 claims description 16
- 239000011734 sodium Substances 0.000 claims description 16
- 159000000000 sodium salts Chemical class 0.000 claims description 15
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 14
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 12
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 10
- 150000001875 compounds Chemical class 0.000 claims description 9
- 229960001139 cefazolin Drugs 0.000 claims description 8
- 229960001668 cefuroxime Drugs 0.000 claims description 8
- 229960000723 ampicillin Drugs 0.000 claims description 7
- 238000007872 degassing Methods 0.000 claims description 7
- 238000002360 preparation method Methods 0.000 claims description 7
- 229960004682 cefoperazone Drugs 0.000 claims description 6
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 5
- 235000017557 sodium bicarbonate Nutrition 0.000 claims description 5
- 238000011282 treatment Methods 0.000 claims description 5
- 238000002604 ultrasonography Methods 0.000 claims description 4
- 239000003782 beta lactam antibiotic agent Substances 0.000 claims description 3
- 239000007789 gas Substances 0.000 claims description 3
- 239000007787 solid Substances 0.000 claims description 3
- 239000002132 β-lactam antibiotic Substances 0.000 claims description 3
- 229940124586 β-lactam antibiotics Drugs 0.000 claims description 3
- 239000003990 capacitor Substances 0.000 claims 1
- 238000010438 heat treatment Methods 0.000 claims 1
- 238000000926 separation method Methods 0.000 claims 1
- 239000000243 solution Substances 0.000 abstract description 98
- 239000003795 chemical substances by application Substances 0.000 abstract description 9
- 230000003115 biocidal effect Effects 0.000 abstract description 6
- 238000002347 injection Methods 0.000 abstract description 2
- 239000007924 injection Substances 0.000 abstract description 2
- 229930186147 Cephalosporin Natural products 0.000 abstract 1
- 229930182555 Penicillin Natural products 0.000 abstract 1
- 229940124587 cephalosporin Drugs 0.000 abstract 1
- 150000001780 cephalosporins Chemical class 0.000 abstract 1
- 150000002960 penicillins Chemical class 0.000 abstract 1
- 238000001694 spray drying Methods 0.000 abstract 1
- 239000000047 product Substances 0.000 description 23
- 239000002253 acid Substances 0.000 description 15
- 235000019441 ethanol Nutrition 0.000 description 10
- 238000000889 atomisation Methods 0.000 description 8
- MLYYVTUWGNIJIB-BXKDBHETSA-N cefazolin Chemical compound S1C(C)=NN=C1SCC1=C(C(O)=O)N2C(=O)[C@@H](NC(=O)CN3N=NN=C3)[C@H]2SC1 MLYYVTUWGNIJIB-BXKDBHETSA-N 0.000 description 6
- JFPVXVDWJQMJEE-IZRZKJBUSA-N cefuroxime Chemical compound N([C@@H]1C(N2C(=C(COC(N)=O)CS[C@@H]21)C(O)=O)=O)C(=O)\C(=N/OC)C1=CC=CO1 JFPVXVDWJQMJEE-IZRZKJBUSA-N 0.000 description 6
- 238000002425 crystallisation Methods 0.000 description 6
- 230000008025 crystallization Effects 0.000 description 6
- 238000004090 dissolution Methods 0.000 description 6
- 238000001914 filtration Methods 0.000 description 6
- OVARTBFNCCXQKS-UHFFFAOYSA-N propan-2-one;hydrate Chemical compound O.CC(C)=O OVARTBFNCCXQKS-UHFFFAOYSA-N 0.000 description 6
- AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical class C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 description 5
- GCFBRXLSHGKWDP-XCGNWRKASA-N cefoperazone Chemical compound O=C1C(=O)N(CC)CCN1C(=O)N[C@H](C=1C=CC(O)=CC=1)C(=O)N[C@@H]1C(=O)N2C(C(O)=O)=C(CSC=3N(N=NN=3)C)CS[C@@H]21 GCFBRXLSHGKWDP-XCGNWRKASA-N 0.000 description 5
- 238000006243 chemical reaction Methods 0.000 description 5
- 239000007857 degradation product Substances 0.000 description 5
- 239000000539 dimer Substances 0.000 description 5
- 239000003814 drug Substances 0.000 description 5
- 239000013618 particulate matter Substances 0.000 description 5
- 229920000642 polymer Polymers 0.000 description 5
- 239000004480 active ingredient Substances 0.000 description 4
- 238000004108 freeze drying Methods 0.000 description 4
- 150000003839 salts Chemical class 0.000 description 4
- NCFTXMQPRQZFMZ-WERGMSTESA-M Cefoperazone sodium Chemical compound [Na+].O=C1C(=O)N(CC)CCN1C(=O)N[C@H](C=1C=CC(O)=CC=1)C(=O)N[C@@H]1C(=O)N2C(C([O-])=O)=C(CSC=3N(N=NN=3)C)CS[C@@H]21 NCFTXMQPRQZFMZ-WERGMSTESA-M 0.000 description 3
- URDOHUPGIOGTKV-JTBFTWTJSA-M Cefuroxime sodium Chemical compound [Na+].N([C@@H]1C(N2C(=C(COC(N)=O)CS[C@@H]21)C([O-])=O)=O)C(=O)\C(=N/OC)C1=CC=CO1 URDOHUPGIOGTKV-JTBFTWTJSA-M 0.000 description 3
- KLOHDWPABZXLGI-YWUHCJSESA-M ampicillin sodium Chemical compound [Na+].C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C([O-])=O)(C)C)=CC=CC=C1 KLOHDWPABZXLGI-YWUHCJSESA-M 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- FLKYBGKDCCEQQM-WYUVZMMLSA-M cefazolin sodium Chemical compound [Na+].S1C(C)=NN=C1SCC1=C(C([O-])=O)N2C(=O)[C@@H](NC(=O)CN3N=NN=C3)[C@H]2SC1 FLKYBGKDCCEQQM-WYUVZMMLSA-M 0.000 description 3
- 239000012467 final product Substances 0.000 description 3
- 238000012792 lyophilization process Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- 238000010923 batch production Methods 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 230000006866 deterioration Effects 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 239000000428 dust Substances 0.000 description 2
- 231100000572 poisoning Toxicity 0.000 description 2
- 230000000607 poisoning effect Effects 0.000 description 2
- 239000013543 active substance Substances 0.000 description 1
- 229960003311 ampicillin trihydrate Drugs 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000010924 continuous production Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 125000005909 ethyl alcohol group Chemical group 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 230000036512 infertility Effects 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 150000003385 sodium Chemical class 0.000 description 1
- 239000008247 solid mixture Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000000859 sublimation Methods 0.000 description 1
- 230000008022 sublimation Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D1/00—Evaporating
- B01D1/16—Evaporating by spraying
- B01D1/18—Evaporating by spraying to obtain dry solids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Inorganic Chemistry (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT8920292A IT1230095B (it) | 1989-04-27 | 1989-04-27 | Procedimento per la preparazione di forme sterili di polveri iniettabili di antibiotici. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE4011956A1 true DE4011956A1 (de) | 1990-10-31 |
Family
ID=11165487
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE4011956A Ceased DE4011956A1 (de) | 1989-04-27 | 1990-04-12 | Verfahren und vorrichtung zur darstellung von sterilen einspritzbaren antibiotikapulvern |
Country Status (6)
| Country | Link |
|---|---|
| JP (1) | JPH02295926A (it) |
| CA (1) | CA2012727A1 (it) |
| DE (1) | DE4011956A1 (it) |
| ES (1) | ES2019560A6 (it) |
| GB (1) | GB2231266A (it) |
| IT (1) | IT1230095B (it) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2857881A1 (fr) * | 2003-07-25 | 2005-01-28 | Ultrasound Brewery | Separateur de solution a ultrasons |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2278659C9 (ru) | 2002-02-01 | 2007-02-20 | Пфайзер Продактс Инк. | Способ получения гомогенных, высушенных распылением твердых аморфных дисперсий лекарственного средства с использованием модифицированной установки сушки распылением |
| CL2004001884A1 (es) * | 2003-08-04 | 2005-06-03 | Pfizer Prod Inc | Procedimiento de secado por pulverizacion para la formacion de dispersiones solidas amorfas de un farmaco y polimeros. |
| SI1959933T1 (sl) * | 2005-12-05 | 2011-02-28 | Sandoz Ag | Postopek za pripravo liofiliziranega natrijevega piperacilina v kombinaciji z natrijevim tazobaktamom z izboljšano stabilnostjo po rekonstituciji |
| WO2009081751A1 (ja) * | 2007-12-21 | 2009-07-02 | Nipro Corporation | 抗生物質製剤の新規製造法 |
| CN102372728B (zh) * | 2011-11-28 | 2013-12-11 | 齐鲁安替制药有限公司 | 一种头孢菌素类化合物的合成方法 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1403584A (en) * | 1972-05-19 | 1975-08-28 | Beecham Group Ltd | Control medicaments |
| DE2509572A1 (de) * | 1974-03-08 | 1975-09-11 | Beecham Group Ltd | Trockenpraeparat und feine partikel |
| DE2608079A1 (de) * | 1975-03-07 | 1976-09-16 | Beecham Group Ltd | Arzneipraeparat in form eines trockenpraeparats zur herstellung von injektionen |
| DE3327449A1 (de) * | 1982-07-30 | 1984-02-02 | Glaxo Group Ltd., London | Eine neue form von cefuroximester, verfahren zu dessen herstellung und diesen enthaltende zusammensetzung |
-
1989
- 1989-04-27 IT IT8920292A patent/IT1230095B/it active
-
1990
- 1990-03-21 CA CA002012727A patent/CA2012727A1/en not_active Abandoned
- 1990-04-12 DE DE4011956A patent/DE4011956A1/de not_active Ceased
- 1990-04-19 GB GB9008756A patent/GB2231266A/en not_active Withdrawn
- 1990-04-24 ES ES9001152A patent/ES2019560A6/es not_active Expired - Fee Related
- 1990-04-26 JP JP2108954A patent/JPH02295926A/ja active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1403584A (en) * | 1972-05-19 | 1975-08-28 | Beecham Group Ltd | Control medicaments |
| DE2509572A1 (de) * | 1974-03-08 | 1975-09-11 | Beecham Group Ltd | Trockenpraeparat und feine partikel |
| DE2608079A1 (de) * | 1975-03-07 | 1976-09-16 | Beecham Group Ltd | Arzneipraeparat in form eines trockenpraeparats zur herstellung von injektionen |
| DE3327449A1 (de) * | 1982-07-30 | 1984-02-02 | Glaxo Group Ltd., London | Eine neue form von cefuroximester, verfahren zu dessen herstellung und diesen enthaltende zusammensetzung |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2857881A1 (fr) * | 2003-07-25 | 2005-01-28 | Ultrasound Brewery | Separateur de solution a ultrasons |
| US7347889B2 (en) | 2003-07-25 | 2008-03-25 | Ultrasound Brewery | Ultrasonic solution separator |
Also Published As
| Publication number | Publication date |
|---|---|
| GB9008756D0 (en) | 1990-06-13 |
| IT8920292A0 (it) | 1989-04-27 |
| CA2012727A1 (en) | 1990-10-27 |
| ES2019560A6 (es) | 1991-06-16 |
| GB2231266A (en) | 1990-11-14 |
| IT1230095B (it) | 1991-10-05 |
| JPH02295926A (ja) | 1990-12-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8110 | Request for examination paragraph 44 | ||
| 8125 | Change of the main classification |
Ipc: A61K 45/08 |
|
| 8131 | Rejection |