DE3942643B4 - Mundpflegemittel - Google Patents

Mundpflegemittel Download PDF

Info

Publication number: DE3942643B4
Authority: DE; Germany
Prior art keywords: oral care; product according; care product; weight; bactericide
Prior art date: 1988-12-29
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE3942643A

Other languages

German (de)

English (en)

Other versions

DE3942643A1 (de

Inventor

Nuran Nabi

Abdul Gaffar

John Afflitto

Orum Stringer

Michael Prencipe

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Colgate Palmolive Co

Original Assignee

Colgate Palmolive Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-12-29

Filing date

1989-12-22

Publication date

2008-03-27

1988-12-29 Priority claimed from US07/291,712 external-priority patent/US4894220A/en

1989-08-25 Priority claimed from US07/398,566 external-priority patent/US5032386A/en

1989-08-25 Priority claimed from US07/398,592 external-priority patent/US5188821A/en

1989-12-22 Application filed by Colgate Palmolive Co filed Critical Colgate Palmolive Co

1990-07-05 Publication of DE3942643A1 publication Critical patent/DE3942643A1/de

2008-03-27 Application granted granted Critical

2008-03-27 Publication of DE3942643B4 publication Critical patent/DE3942643B4/de

2009-12-23 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

230000000844 anti-bacterial effect Effects 0.000 claims abstract description 114
239000003899 bactericide agent Substances 0.000 claims abstract description 85
239000012190 activator Substances 0.000 claims abstract description 67
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 42
230000014759 maintenance of location Effects 0.000 claims abstract description 39
239000003795 chemical substances by application Substances 0.000 claims abstract description 28
210000003296 saliva Anatomy 0.000 claims abstract description 27
125000002091 cationic group Chemical group 0.000 claims abstract description 23
150000001875 compounds Chemical class 0.000 claims abstract description 14
239000002553 antibacterial enhancer Substances 0.000 claims abstract description 12
150000003839 salts Chemical class 0.000 claims abstract description 11
229920000388 Polyphosphate Polymers 0.000 claims abstract description 9
239000001205 polyphosphate Substances 0.000 claims abstract description 9
235000011176 polyphosphates Nutrition 0.000 claims abstract description 9
ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical compound OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 claims abstract description 8
208000006558 Dental Calculus Diseases 0.000 claims abstract description 5
230000002378 acidificating effect Effects 0.000 claims abstract description 3
ACVYVLVWPXVTIT-UHFFFAOYSA-N phosphinic acid Chemical compound O[PH2]=O ACVYVLVWPXVTIT-UHFFFAOYSA-N 0.000 claims abstract description 3
150000001732 carboxylic acid derivatives Chemical class 0.000 claims abstract 2
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 73
239000000551 dentifrice Substances 0.000 claims description 47
239000000203 mixture Substances 0.000 claims description 37
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 32
229920001577 copolymer Polymers 0.000 claims description 26
230000001965 increasing effect Effects 0.000 claims description 24
239000002904 solvent Substances 0.000 claims description 20
238000005498 polishing Methods 0.000 claims description 18
239000004094 surface-active agent Substances 0.000 claims description 18
125000000129 anionic group Chemical group 0.000 claims description 17
239000000243 solution Substances 0.000 claims description 16
229910004298 SiO 2 Inorganic materials 0.000 claims description 15
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 15
239000000178 monomer Substances 0.000 claims description 15
239000007788 liquid Substances 0.000 claims description 13
PGKQTZHDCHKDQK-UHFFFAOYSA-N 2-phenylethenylphosphonic acid Chemical compound OP(O)(=O)C=CC1=CC=CC=C1 PGKQTZHDCHKDQK-UHFFFAOYSA-N 0.000 claims description 12
125000004432 carbon atom Chemical group C* 0.000 claims description 12
PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 claims description 11
239000002562 thickening agent Substances 0.000 claims description 10
XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 9
229910052799 carbon Inorganic materials 0.000 claims description 9
RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 9
239000002253 acid Substances 0.000 claims description 8
239000010692 aromatic oil Substances 0.000 claims description 7
239000001506 calcium phosphate Substances 0.000 claims description 7
239000002324 mouth wash Substances 0.000 claims description 7
239000003921 oil Substances 0.000 claims description 7
235000019198 oils Nutrition 0.000 claims description 7
229920001282 polysaccharide Polymers 0.000 claims description 7
SVTBMSDMJJWYQN-UHFFFAOYSA-N 2-methylpentane-2,4-diol Chemical compound CC(O)CC(C)(C)O SVTBMSDMJJWYQN-UHFFFAOYSA-N 0.000 claims description 6
VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 6
SESFRYSPDFLNCH-UHFFFAOYSA-N benzyl benzoate Chemical compound C=1C=CC=CC=1C(=O)OCC1=CC=CC=C1 SESFRYSPDFLNCH-UHFFFAOYSA-N 0.000 claims description 6
RBLGLDWTCZMLRW-UHFFFAOYSA-K dicalcium;phosphate;dihydrate Chemical compound O.O.[Ca+2].[Ca+2].[O-]P([O-])([O-])=O RBLGLDWTCZMLRW-UHFFFAOYSA-K 0.000 claims description 6
GSSDUXHQPXODCN-UHFFFAOYSA-N 1-phenylethenylphosphonic acid Chemical compound OP(O)(=O)C(=C)C1=CC=CC=C1 GSSDUXHQPXODCN-UHFFFAOYSA-N 0.000 claims description 5
239000003513 alkali Substances 0.000 claims description 5
150000003863 ammonium salts Chemical class 0.000 claims description 5
USIUVYZYUHIAEV-UHFFFAOYSA-N diphenyl ether Chemical class C=1C=CC=CC=1OC1=CC=CC=C1 USIUVYZYUHIAEV-UHFFFAOYSA-N 0.000 claims description 5
150000004676 glycans Chemical class 0.000 claims description 5
229940051866 mouthwash Drugs 0.000 claims description 5
150000002989 phenols Chemical class 0.000 claims description 5
239000005017 polysaccharide Substances 0.000 claims description 5
239000000377 silicon dioxide Substances 0.000 claims description 5
ZNQVEEAIQZEUHB-UHFFFAOYSA-N 2-ethoxyethanol Chemical compound CCOCCO ZNQVEEAIQZEUHB-UHFFFAOYSA-N 0.000 claims description 4
235000019739 Dicalciumphosphate Nutrition 0.000 claims description 4
125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims description 4
150000008064 anhydrides Chemical class 0.000 claims description 4
NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 claims description 4
229910000390 dicalcium phosphate Inorganic materials 0.000 claims description 4
229940038472 dicalcium phosphate Drugs 0.000 claims description 4
230000002209 hydrophobic effect Effects 0.000 claims description 4
DCXXMTOCNZCJGO-UHFFFAOYSA-N tristearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCCCC DCXXMTOCNZCJGO-UHFFFAOYSA-N 0.000 claims description 4
XNWFRZJHXBZDAG-UHFFFAOYSA-N 2-METHOXYETHANOL Chemical compound COCCO XNWFRZJHXBZDAG-UHFFFAOYSA-N 0.000 claims description 3
WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 claims description 3
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 3
OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims description 3
150000007513 acids Chemical class 0.000 claims description 3
150000001447 alkali salts Chemical class 0.000 claims description 3
125000000217 alkyl group Chemical group 0.000 claims description 3
229940072049 amyl acetate Drugs 0.000 claims description 3
PGMYKACGEOXYJE-UHFFFAOYSA-N anhydrous amyl acetate Natural products CCCCCOC(C)=O PGMYKACGEOXYJE-UHFFFAOYSA-N 0.000 claims description 3
229920006318 anionic polymer Polymers 0.000 claims description 3
125000003118 aryl group Chemical group 0.000 claims description 3
125000004429 atom Chemical group 0.000 claims description 3
229960002903 benzyl benzoate Drugs 0.000 claims description 3
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 3
229910000019 calcium carbonate Inorganic materials 0.000 claims description 3
SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 claims description 3
239000008103 glucose Substances 0.000 claims description 3
MNWFXJYAOYHMED-UHFFFAOYSA-M heptanoate Chemical compound CCCCCCC([O-])=O MNWFXJYAOYHMED-UHFFFAOYSA-M 0.000 claims description 3
229940051250 hexylene glycol Drugs 0.000 claims description 3
VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims description 3
239000011976 maleic acid Substances 0.000 claims description 3
XJRBAMWJDBPFIM-UHFFFAOYSA-N methyl vinyl ether Chemical group COC=C XJRBAMWJDBPFIM-UHFFFAOYSA-N 0.000 claims description 3
231100000252 nontoxic Toxicity 0.000 claims description 3
230000003000 nontoxic effect Effects 0.000 claims description 3
229910052760 oxygen Inorganic materials 0.000 claims description 3
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 3
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 3
YKTSYUJCYHOUJP-UHFFFAOYSA-N [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] Chemical compound [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] YKTSYUJCYHOUJP-UHFFFAOYSA-N 0.000 claims description 2
125000002252 acyl group Chemical group 0.000 claims description 2
125000003342 alkenyl group Chemical group 0.000 claims description 2
125000002877 alkyl aryl group Chemical group 0.000 claims description 2
239000008365 aqueous carrier Substances 0.000 claims description 2
125000003710 aryl alkyl group Chemical group 0.000 claims description 2
239000000440 bentonite Substances 0.000 claims description 2
229910000278 bentonite Inorganic materials 0.000 claims description 2
SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 claims description 2
WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid group Chemical group C(C1=CC=CC=C1)(=O)O WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 2
JUNWLZAGQLJVLR-UHFFFAOYSA-J calcium diphosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O JUNWLZAGQLJVLR-UHFFFAOYSA-J 0.000 claims description 2
229940043256 calcium pyrophosphate Drugs 0.000 claims description 2
235000019821 dicalcium diphosphate Nutrition 0.000 claims description 2
229910052757 nitrogen Inorganic materials 0.000 claims description 2
229910052698 phosphorus Inorganic materials 0.000 claims description 2
229910052717 sulfur Inorganic materials 0.000 claims description 2
239000000375 suspending agent Substances 0.000 claims description 2
229940078499 tricalcium phosphate Drugs 0.000 claims description 2
229910000391 tricalcium phosphate Inorganic materials 0.000 claims description 2
235000019731 tricalcium phosphate Nutrition 0.000 claims description 2
235000015112 vegetable and seed oil Nutrition 0.000 claims description 2
239000008158 vegetable oil Substances 0.000 claims description 2
GVALZJMUIHGIMD-UHFFFAOYSA-H magnesium phosphate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O GVALZJMUIHGIMD-UHFFFAOYSA-H 0.000 claims 2
MOMKYJPSVWEWPM-UHFFFAOYSA-N 4-(chloromethyl)-2-(4-methylphenyl)-1,3-thiazole Chemical compound C1=CC(C)=CC=C1C1=NC(CCl)=CS1 MOMKYJPSVWEWPM-UHFFFAOYSA-N 0.000 claims 1
MXRIRQGCELJRSN-UHFFFAOYSA-N O.O.O.[Al] Chemical compound O.O.O.[Al] MXRIRQGCELJRSN-UHFFFAOYSA-N 0.000 claims 1
BPQQTUXANYXVAA-UHFFFAOYSA-N Orthosilicate Chemical compound [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 claims 1
150000004683 dihydrates Chemical class 0.000 claims 1
229910000400 magnesium phosphate tribasic Inorganic materials 0.000 claims 1
ORTFAQDWJHRMNX-UHFFFAOYSA-M oxidooxomethyl Chemical compound [O-][C]=O ORTFAQDWJHRMNX-UHFFFAOYSA-M 0.000 claims 1
239000012188 paraffin wax Substances 0.000 claims 1
UVGZJJKEELPWRH-JSCKKFHOSA-M potassium (2S,3S,4S,5R)-2,3,4,5-tetrahydroxy-6-oxohexanoate Chemical compound [K+].O=C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C([O-])=O UVGZJJKEELPWRH-JSCKKFHOSA-M 0.000 claims 1
235000019983 sodium metaphosphate Nutrition 0.000 claims 1
230000003381 solubilizing effect Effects 0.000 claims 1
BDHFUVZGWQCTTF-UHFFFAOYSA-N sulfonic acid Chemical group OS(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-N 0.000 abstract 1
229960003500 triclosan Drugs 0.000 description 84
XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 description 83
-1 2 ' Chemical class 0.000 description 53
229920005646 polycarboxylate Polymers 0.000 description 47
239000000047 product Substances 0.000 description 40
239000000606 toothpaste Substances 0.000 description 33
PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol group Chemical group OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 32
229910052588 hydroxylapatite Inorganic materials 0.000 description 24
XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 24
229940034610 toothpaste Drugs 0.000 description 23
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 19
UPBDXRPQPOWRKR-UHFFFAOYSA-N furan-2,5-dione;methoxyethene Chemical compound COC=C.O=C1OC(=O)C=C1 UPBDXRPQPOWRKR-UHFFFAOYSA-N 0.000 description 19
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 18
229920000642 polymer Polymers 0.000 description 18
239000000600 sorbitol Substances 0.000 description 18
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 17
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 15
235000019441 ethanol Nutrition 0.000 description 15
239000004615 ingredient Substances 0.000 description 15
229910052708 sodium Inorganic materials 0.000 description 15
239000011734 sodium Substances 0.000 description 15
ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 14
235000011187 glycerol Nutrition 0.000 description 14
PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 14
235000019333 sodium laurylsulphate Nutrition 0.000 description 14
DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 13
150000003254 radicals Chemical class 0.000 description 13
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 12
210000002919 epithelial cell Anatomy 0.000 description 11
239000000499 gel Substances 0.000 description 11
RRAFCDWBNXTKKO-UHFFFAOYSA-N eugenol Chemical compound COC1=CC(CC=C)=CC=C1O RRAFCDWBNXTKKO-UHFFFAOYSA-N 0.000 description 10
GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 9
239000003906 humectant Substances 0.000 description 9
MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 description 8
208000002064 Dental Plaque Diseases 0.000 description 7
229920002125 Sokalan® Polymers 0.000 description 7
230000002272 anti-calculus Effects 0.000 description 7
230000002882 anti-plaque Effects 0.000 description 7
229960003742 phenol Drugs 0.000 description 7
239000011775 sodium fluoride Substances 0.000 description 7
235000013024 sodium fluoride Nutrition 0.000 description 7
229960000414 sodium fluoride Drugs 0.000 description 7
TYBHZVUFOINFDV-UHFFFAOYSA-N 2-bromo-6-[(3-bromo-5-chloro-2-hydroxyphenyl)methyl]-4-chlorophenol Chemical compound OC1=C(Br)C=C(Cl)C=C1CC1=CC(Cl)=CC(Br)=C1O TYBHZVUFOINFDV-UHFFFAOYSA-N 0.000 description 6
XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 description 6
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 6
238000009472 formulation Methods 0.000 description 6
229960004711 sodium monofluorophosphate Drugs 0.000 description 6
NPBVQXIMTZKSBA-UHFFFAOYSA-N Chavibetol Natural products COC1=CC=C(CC=C)C=C1O NPBVQXIMTZKSBA-UHFFFAOYSA-N 0.000 description 5
239000005770 Eugenol Substances 0.000 description 5
239000002202 Polyethylene glycol Substances 0.000 description 5
UVMRYBDEERADNV-UHFFFAOYSA-N Pseudoeugenol Natural products COC1=CC(C(C)=C)=CC=C1O UVMRYBDEERADNV-UHFFFAOYSA-N 0.000 description 5
239000000679 carrageenan Substances 0.000 description 5
229920001525 carrageenan Polymers 0.000 description 5
229940113118 carrageenan Drugs 0.000 description 5
230000000694 effects Effects 0.000 description 5
229960002217 eugenol Drugs 0.000 description 5
239000003349 gelling agent Substances 0.000 description 5
239000007791 liquid phase Substances 0.000 description 5
239000000463 material Substances 0.000 description 5
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 5
210000004400 mucous membrane Anatomy 0.000 description 5
125000001280 n-hexyl group Chemical group C(CCCCC)* 0.000 description 5
239000002245 particle Substances 0.000 description 5
229920001223 polyethylene glycol Polymers 0.000 description 5
239000002002 slurry Substances 0.000 description 5
AQMNWCRSESPIJM-UHFFFAOYSA-M sodium metaphosphate Chemical compound [Na+].[O-]P(=O)=O AQMNWCRSESPIJM-UHFFFAOYSA-M 0.000 description 5
ZTWTYVWXUKTLCP-UHFFFAOYSA-N vinylphosphonic acid Chemical compound OP(O)(=O)C=C ZTWTYVWXUKTLCP-UHFFFAOYSA-N 0.000 description 5
241000894006 Bacteria Species 0.000 description 4
239000005844 Thymol Substances 0.000 description 4
229910052783 alkali metal Inorganic materials 0.000 description 4
230000008901 benefit Effects 0.000 description 4
IISBACLAFKSPIT-UHFFFAOYSA-N bisphenol A Chemical class C=1C=C(O)C=CC=1C(C)(C)C1=CC=C(O)C=C1 IISBACLAFKSPIT-UHFFFAOYSA-N 0.000 description 4
235000014113 dietary fatty acids Nutrition 0.000 description 4
230000002708 enhancing effect Effects 0.000 description 4
239000000194 fatty acid Substances 0.000 description 4
229930195729 fatty acid Natural products 0.000 description 4
238000011534 incubation Methods 0.000 description 4
FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 description 4
210000004877 mucosa Anatomy 0.000 description 4
125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 4
125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 4
239000012071 phase Substances 0.000 description 4
230000002265 prevention Effects 0.000 description 4
GHMLBKRAJCXXBS-UHFFFAOYSA-N resorcinol Chemical compound OC1=CC=CC(O)=C1 GHMLBKRAJCXXBS-UHFFFAOYSA-N 0.000 description 4
229960000790 thymol Drugs 0.000 description 4
239000004408 titanium dioxide Substances 0.000 description 4
CPLXHLVBOLITMK-UHFFFAOYSA-N Magnesium oxide Chemical compound [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 description 3
229910019142 PO4 Inorganic materials 0.000 description 3
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
238000007792 addition Methods 0.000 description 3
239000000654 additive Substances 0.000 description 3
239000008346 aqueous phase Substances 0.000 description 3
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 3
230000015572 biosynthetic process Effects 0.000 description 3
239000007853 buffer solution Substances 0.000 description 3
150000007942 carboxylates Chemical class 0.000 description 3
210000004027 cell Anatomy 0.000 description 3
238000005119 centrifugation Methods 0.000 description 3
239000007859 condensation product Substances 0.000 description 3
229920006037 cross link polymer Polymers 0.000 description 3
229940091249 fluoride supplement Drugs 0.000 description 3
150000002222 fluorine compounds Chemical class 0.000 description 3
208000007565 gingivitis Diseases 0.000 description 3
229920000554 ionomer Polymers 0.000 description 3
210000003254 palate Anatomy 0.000 description 3
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 3
235000021317 phosphate Nutrition 0.000 description 3
229940068196 placebo Drugs 0.000 description 3
239000000902 placebo Substances 0.000 description 3
229920000867 polyelectrolyte Polymers 0.000 description 3
229920000098 polyolefin Polymers 0.000 description 3
235000010234 sodium benzoate Nutrition 0.000 description 3
239000004299 sodium benzoate Substances 0.000 description 3
125000001424 substituent group Chemical group 0.000 description 3
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HFIGWKOFZLNOQK-UHFFFAOYSA-K [O-]P([O-])(=O)OP(=O)([O-])O.[Ca+2].[Na+] Chemical compound [O-]P([O-])(=O)OP(=O)([O-])O.[Ca+2].[Na+] HFIGWKOFZLNOQK-UHFFFAOYSA-K 0.000 description 1
230000035508 accumulation Effects 0.000 description 1
238000009825 accumulation Methods 0.000 description 1
DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
GZCGUPFRVQAUEE-SLPGGIOYSA-N aldehydo-D-glucose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O GZCGUPFRVQAUEE-SLPGGIOYSA-N 0.000 description 1
125000001931 aliphatic group Chemical group 0.000 description 1
229910001515 alkali metal fluoride Inorganic materials 0.000 description 1
229910052910 alkali metal silicate Inorganic materials 0.000 description 1
150000008055 alkyl aryl sulfonates Chemical class 0.000 description 1
150000008051 alkyl sulfates Chemical class 0.000 description 1
150000001413 amino acids Chemical class 0.000 description 1
229910021529 ammonia Inorganic materials 0.000 description 1
CKGWFZQGEQJZIL-UHFFFAOYSA-N amylmetacresol Chemical compound CCCCCC1=CC=C(C)C=C1O CKGWFZQGEQJZIL-UHFFFAOYSA-N 0.000 description 1
UIERETOOQGIECD-ARJAWSKDSA-N angelic acid group Chemical group C(\C(\C)=C/C)(=O)O UIERETOOQGIECD-ARJAWSKDSA-N 0.000 description 1
239000003242 anti bacterial agent Substances 0.000 description 1
239000004599 antimicrobial Substances 0.000 description 1
229940027983 antiseptic and disinfectant quaternary ammonium compound Drugs 0.000 description 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
230000001580 bacterial effect Effects 0.000 description 1
230000003385 bacteriostatic effect Effects 0.000 description 1
OYLGJCQECKOTOL-UHFFFAOYSA-L barium fluoride Chemical class [F-].[F-].[Ba+2] OYLGJCQECKOTOL-UHFFFAOYSA-L 0.000 description 1
OGBUMNBNEWYMNJ-UHFFFAOYSA-N batilol Chemical class CCCCCCCCCCCCCCCCCCOCC(O)CO OGBUMNBNEWYMNJ-UHFFFAOYSA-N 0.000 description 1
229960001950 benzethonium chloride Drugs 0.000 description 1
UREZNYTWGJKWBI-UHFFFAOYSA-M benzethonium chloride Chemical compound [Cl-].C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 UREZNYTWGJKWBI-UHFFFAOYSA-M 0.000 description 1
125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 description 1
239000011230 binding agent Substances 0.000 description 1
FQUNFJULCYSSOP-UHFFFAOYSA-N bisoctrizole Chemical compound N1=C2C=CC=CC2=NN1C1=CC(C(C)(C)CC(C)(C)C)=CC(CC=2C(=C(C=C(C=2)C(C)(C)CC(C)(C)C)N2N=C3C=CC=CC3=N2)O)=C1O FQUNFJULCYSSOP-UHFFFAOYSA-N 0.000 description 1
239000007844 bleaching agent Substances 0.000 description 1
229920001400 block copolymer Polymers 0.000 description 1
239000000872 buffer Substances 0.000 description 1
125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
125000004063 butyryl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
229910052791 calcium Inorganic materials 0.000 description 1
239000011575 calcium Substances 0.000 description 1
229910000389 calcium phosphate Inorganic materials 0.000 description 1
235000011010 calcium phosphates Nutrition 0.000 description 1
239000004202 carbamide Substances 0.000 description 1
150000001721 carbon Chemical group 0.000 description 1
239000011203 carbon fibre reinforced carbon Substances 0.000 description 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
150000001734 carboxylic acid salts Chemical group 0.000 description 1
239000008112 carboxymethyl-cellulose Substances 0.000 description 1
235000010418 carrageenan Nutrition 0.000 description 1
239000012876 carrier material Substances 0.000 description 1
229960001777 castor oil Drugs 0.000 description 1
210000000170 cell membrane Anatomy 0.000 description 1
239000006285 cell suspension Substances 0.000 description 1
229960001927 cetylpyridinium chloride Drugs 0.000 description 1
YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 description 1
229940112822 chewing gum Drugs 0.000 description 1
235000015218 chewing gum Nutrition 0.000 description 1
229960003260 chlorhexidine Drugs 0.000 description 1
125000000068 chlorophenyl group Chemical group 0.000 description 1
ATNHDLDRLWWWCB-AENOIHSZSA-M chlorophyll a Chemical class C1([C@@H](C(=O)OC)C(=O)C2=C3C)=C2N2C3=CC(C(CC)=C3C)=[N+]4C3=CC3=C(C=C)C(C)=C5N3[Mg-2]42[N+]2=C1[C@@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H](C)C2=C5 ATNHDLDRLWWWCB-AENOIHSZSA-M 0.000 description 1
238000004587 chromatography analysis Methods 0.000 description 1
229930016911 cinnamic acid Natural products 0.000 description 1
235000013985 cinnamic acid Nutrition 0.000 description 1
229920001436 collagen Polymers 0.000 description 1
210000002808 connective tissue Anatomy 0.000 description 1
229910052802 copper Inorganic materials 0.000 description 1
239000010949 copper Substances 0.000 description 1
150000001880 copper compounds Chemical class 0.000 description 1
239000002537 cosmetic Substances 0.000 description 1
229910002026 crystalline silica Inorganic materials 0.000 description 1
208000002925 dental caries Diseases 0.000 description 1
210000001315 dental pellicle Anatomy 0.000 description 1
230000008021 deposition Effects 0.000 description 1
MNNHAPBLZZVQHP-UHFFFAOYSA-N diammonium hydrogen phosphate Chemical compound [NH4+].[NH4+].OP([O-])([O-])=O MNNHAPBLZZVQHP-UHFFFAOYSA-N 0.000 description 1
229910000388 diammonium phosphate Inorganic materials 0.000 description 1
235000019838 diammonium phosphate Nutrition 0.000 description 1
DGTVXEHQMSJRPE-UHFFFAOYSA-M difluorophosphinate Chemical compound [O-]P(F)(F)=O DGTVXEHQMSJRPE-UHFFFAOYSA-M 0.000 description 1
238000010790 dilution Methods 0.000 description 1
239000012895 dilution Substances 0.000 description 1
LDCRTTXIJACKKU-ARJAWSKDSA-N dimethyl maleate Chemical compound COC(=O)\C=C/C(=O)OC LDCRTTXIJACKKU-ARJAWSKDSA-N 0.000 description 1
LRCFXGAMWKDGLA-UHFFFAOYSA-N dioxosilane;hydrate Chemical compound O.O=[Si]=O LRCFXGAMWKDGLA-UHFFFAOYSA-N 0.000 description 1
XQRLCLUYWUNEEH-UHFFFAOYSA-L diphosphonate(2-) Chemical group [O-]P(=O)OP([O-])=O XQRLCLUYWUNEEH-UHFFFAOYSA-L 0.000 description 1
239000006185 dispersion Substances 0.000 description 1
239000012153 distilled water Substances 0.000 description 1
238000009826 distribution Methods 0.000 description 1
POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical class CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 1
239000003651 drinking water Substances 0.000 description 1
235000020188 drinking water Nutrition 0.000 description 1
150000002169 ethanolamines Chemical class 0.000 description 1
FJKIXWOMBXYWOQ-UHFFFAOYSA-N ethenoxyethane Chemical class CCOC=C FJKIXWOMBXYWOQ-UHFFFAOYSA-N 0.000 description 1
150000002170 ethers Chemical class 0.000 description 1
150000002191 fatty alcohols Chemical class 0.000 description 1
150000002193 fatty amides Chemical class 0.000 description 1
239000000796 flavoring agent Substances 0.000 description 1
229910052731 fluorine Inorganic materials 0.000 description 1
229950004696 flusalan Drugs 0.000 description 1
238000005187 foaming Methods 0.000 description 1
235000013355 food flavoring agent Nutrition 0.000 description 1
125000000524 functional group Chemical group 0.000 description 1
125000002541 furyl group Chemical group 0.000 description 1
230000002070 germicidal effect Effects 0.000 description 1
229920000578 graft copolymer Polymers 0.000 description 1
230000005484 gravity Effects 0.000 description 1
150000002357 guanidines Chemical class 0.000 description 1
229910052736 halogen Inorganic materials 0.000 description 1
150000002367 halogens Chemical class 0.000 description 1
ACGUYXCXAPNIKK-UHFFFAOYSA-N hexachlorophene Chemical compound OC1=C(Cl)C=C(Cl)C(Cl)=C1CC1=C(O)C(Cl)=CC(Cl)=C1Cl ACGUYXCXAPNIKK-UHFFFAOYSA-N 0.000 description 1
229960004068 hexachlorophene Drugs 0.000 description 1
229960003258 hexylresorcinol Drugs 0.000 description 1
229920001519 homopolymer Polymers 0.000 description 1
229930195733 hydrocarbon Natural products 0.000 description 1
150000002430 hydrocarbons Chemical class 0.000 description 1
239000000017 hydrogel Substances 0.000 description 1
125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
125000001165 hydrophobic group Chemical group 0.000 description 1
125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
238000010348 incorporation Methods 0.000 description 1
239000003112 inhibitor Substances 0.000 description 1
229910001506 inorganic fluoride Inorganic materials 0.000 description 1
230000010354 integration Effects 0.000 description 1
229910052740 iodine Inorganic materials 0.000 description 1
239000002563 ionic surfactant Substances 0.000 description 1
150000002500 ions Chemical class 0.000 description 1
125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
BJHIKXHVCXFQLS-OTWZMJIISA-N keto-L-sorbose Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)C(=O)CO BJHIKXHVCXFQLS-OTWZMJIISA-N 0.000 description 1
239000004973 liquid crystal related substance Substances 0.000 description 1
239000007937 lozenge Substances 0.000 description 1
ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
239000001095 magnesium carbonate Substances 0.000 description 1
229910000021 magnesium carbonate Inorganic materials 0.000 description 1
AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 description 1
125000000311 mannosyl group Chemical group C1([C@@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
JDSHMPZPIAZGSV-UHFFFAOYSA-N melamine Chemical compound NC1=NC(N)=NC(N)=N1 JDSHMPZPIAZGSV-UHFFFAOYSA-N 0.000 description 1
229910052751 metal Inorganic materials 0.000 description 1
239000002184 metal Substances 0.000 description 1
150000002739 metals Chemical class 0.000 description 1
125000005395 methacrylic acid group Chemical group 0.000 description 1
238000000034 method Methods 0.000 description 1
125000006178 methyl benzyl group Chemical group 0.000 description 1
WBYWAXJHAXSJNI-UHFFFAOYSA-N methyl p-hydroxycinnamate Natural products OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 description 1
239000000693 micelle Substances 0.000 description 1
239000004570 mortar (masonry) Substances 0.000 description 1
210000000214 mouth Anatomy 0.000 description 1
230000007935 neutral effect Effects 0.000 description 1
239000001301 oxygen Substances 0.000 description 1
NRZWYNLTFLDQQX-UHFFFAOYSA-N p-tert-Amylphenol Chemical group CCC(C)(C)C1=CC=C(O)C=C1 NRZWYNLTFLDQQX-UHFFFAOYSA-N 0.000 description 1
WXZMFSXDPGVJKK-UHFFFAOYSA-N pentaerythritol Chemical compound OCC(CO)(CO)CO WXZMFSXDPGVJKK-UHFFFAOYSA-N 0.000 description 1
229920001568 phenolic resin Polymers 0.000 description 1
125000000286 phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 description 1
125000004344 phenylpropyl group Chemical group 0.000 description 1
125000003170 phenylsulfonyl group Chemical group C1(=CC=CC=C1)S(=O)(=O)* 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
239000011295 pitch Substances 0.000 description 1
239000004014 plasticizer Substances 0.000 description 1
238000007747 plating Methods 0.000 description 1
229920000744 poly(arginines) Polymers 0.000 description 1
239000004584 polyacrylic acid Substances 0.000 description 1
229920002647 polyamide Polymers 0.000 description 1
229920000647 polyepoxide Polymers 0.000 description 1
229920000573 polyethylene Polymers 0.000 description 1
229940057847 polyethylene glycol 600 Drugs 0.000 description 1
229920000193 polymethacrylate Polymers 0.000 description 1
229920005862 polyol Polymers 0.000 description 1
150000003077 polyols Chemical class 0.000 description 1
229920002635 polyurethane Polymers 0.000 description 1
239000004814 polyurethane Substances 0.000 description 1
229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
239000001267 polyvinylpyrrolidone Substances 0.000 description 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
239000004224 potassium gluconate Substances 0.000 description 1
235000013926 potassium gluconate Nutrition 0.000 description 1
229960003189 potassium gluconate Drugs 0.000 description 1
229910001414 potassium ion Inorganic materials 0.000 description 1
OQZCJRJRGMMSGK-UHFFFAOYSA-M potassium metaphosphate Chemical compound [K+].[O-]P(=O)=O OQZCJRJRGMMSGK-UHFFFAOYSA-M 0.000 description 1
229940099402 potassium metaphosphate Drugs 0.000 description 1
239000002244 precipitate Substances 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
230000003449 preventive effect Effects 0.000 description 1
230000001737 promoting effect Effects 0.000 description 1
XWCIXXXLOAAWPU-UHFFFAOYSA-N prop-1-enylphosphonic acid Chemical compound CC=CP(O)(O)=O XWCIXXXLOAAWPU-UHFFFAOYSA-N 0.000 description 1
230000000069 prophylactic effect Effects 0.000 description 1
102000004169 proteins and genes Human genes 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
125000004076 pyridyl group Chemical group 0.000 description 1
150000003856 quaternary ammonium compounds Chemical class 0.000 description 1
230000008929 regeneration Effects 0.000 description 1
238000011069 regeneration method Methods 0.000 description 1
230000003252 repetitive effect Effects 0.000 description 1
229920005989 resin Polymers 0.000 description 1
239000011347 resin Substances 0.000 description 1
230000000284 resting effect Effects 0.000 description 1
230000000717 retained effect Effects 0.000 description 1
CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
229940081974 saccharin Drugs 0.000 description 1
235000019204 saccharin Nutrition 0.000 description 1
239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
108700004121 sarkosyl Proteins 0.000 description 1
229920006395 saturated elastomer Polymers 0.000 description 1
238000000926 separation method Methods 0.000 description 1
238000005029 sieve analysis Methods 0.000 description 1
229910002027 silica gel Inorganic materials 0.000 description 1
239000000741 silica gel Substances 0.000 description 1
150000004760 silicates Chemical class 0.000 description 1
229960004029 silicic acid Drugs 0.000 description 1
229960001866 silicon dioxide Drugs 0.000 description 1
235000012239 silicon dioxide Nutrition 0.000 description 1
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
159000000000 sodium salts Chemical class 0.000 description 1
UGTZMIPZNRIWHX-UHFFFAOYSA-K sodium trimetaphosphate Chemical compound [Na+].[Na+].[Na+].[O-]P1(=O)OP([O-])(=O)OP([O-])(=O)O1 UGTZMIPZNRIWHX-UHFFFAOYSA-K 0.000 description 1
239000001587 sorbitan monostearate Substances 0.000 description 1
235000011076 sorbitan monostearate Nutrition 0.000 description 1
229940035048 sorbitan monostearate Drugs 0.000 description 1
ANOBYBYXJXCGBS-UHFFFAOYSA-L stannous fluoride Chemical compound F[Sn]F ANOBYBYXJXCGBS-UHFFFAOYSA-L 0.000 description 1
229960002799 stannous fluoride Drugs 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
238000003756 stirring Methods 0.000 description 1
238000003860 storage Methods 0.000 description 1
238000006467 substitution reaction Methods 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
150000005846 sugar alcohols Polymers 0.000 description 1
125000000446 sulfanediyl group Chemical group *S* 0.000 description 1
125000001273 sulfonato group Chemical class [O-]S(*)(=O)=O 0.000 description 1
125000000542 sulfonic acid group Chemical group 0.000 description 1
150000003460 sulfonic acids Chemical class 0.000 description 1
239000006228 supernatant Substances 0.000 description 1
239000013589 supplement Substances 0.000 description 1
239000003826 tablet Substances 0.000 description 1
238000010998 test method Methods 0.000 description 1
125000001544 thienyl group Chemical group 0.000 description 1
125000004862 thiobutyl group Chemical group 0.000 description 1
210000001519 tissue Anatomy 0.000 description 1
OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
ICUTUKXCWQYESQ-UHFFFAOYSA-N triclocarban Chemical compound C1=CC(Cl)=CC=C1NC(=O)NC1=CC=C(Cl)C(Cl)=C1 ICUTUKXCWQYESQ-UHFFFAOYSA-N 0.000 description 1
125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
238000009281 ultraviolet germicidal irradiation Methods 0.000 description 1
238000003828 vacuum filtration Methods 0.000 description 1
125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
229920003169 water-soluble polymer Polymers 0.000 description 1
125000005023 xylyl group Chemical group 0.000 description 1
150000003751 zinc Chemical class 0.000 description 1
150000003752 zinc compounds Chemical class 0.000 description 1
UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
GFQYVLUOOAAOGM-UHFFFAOYSA-N zirconium(iv) silicate Chemical compound [Zr+4].[O-][Si]([O-])([O-])[O-] GFQYVLUOOAAOGM-UHFFFAOYSA-N 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8164—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical, and containing at least one other carboxyl radical in the molecule, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers, e.g. poly (methyl vinyl ether-co-maleic anhydride)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/87—Application Devices; Containers; Packaging

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Birds (AREA)
Epidemiology (AREA)
Emergency Medicine (AREA)
Oral & Maxillofacial Surgery (AREA)
Cosmetics (AREA)
Medicinal Preparation (AREA)

DE3942643A 1988-12-29 1989-12-22 Mundpflegemittel Expired - Lifetime DE3942643B4 (de)

Applications Claiming Priority (14)

Application Number	Priority Date	Filing Date	Title
US07/291,712 US4894220A (en)	1987-01-30	1988-12-29	Antibacterial antiplaque oral composition
US291,712		1988-12-29
US39860589A	1989-08-25	1989-08-25
US39860689A	1989-08-25	1989-08-25
US39966989A	1989-08-25	1989-08-25
US07/398,566 US5032386A (en)	1988-12-29	1989-08-25	Antiplaque antibacterial oral composition
US398,566		1989-08-25
US398,592		1989-08-25
US398,606		1989-08-25
US398,605		1989-08-25
US399,669		1989-08-25
US07/398,592 US5188821A (en)	1987-01-30	1989-08-25	Antibacterial antiplaque oral composition mouthwash or liquid dentifrice
US41068289A	1989-09-21	1989-09-21
US410,682		1989-09-21

Publications (2)

Publication Number	Publication Date
DE3942643A1 DE3942643A1 (de)	1990-07-05
DE3942643B4 true DE3942643B4 (de)	2008-03-27

Family

ID=27569612

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE3942643A Expired - Lifetime DE3942643B4 (de)	1988-12-29	1989-12-22	Mundpflegemittel

Country Status (30)

Country	Link
JP (1)	JP2708134B2 (fr)
CN (1)	CN1048867C (fr)
AT (1)	AT397765B (fr)
AU (1)	AU625379B2 (fr)
BR (1)	BR8906866A (fr)
CH (1)	CH679639A5 (fr)
DE (1)	DE3942643B4 (fr)
DK (1)	DK175071B1 (fr)
DZ (2)	DZ1382A1 (fr)
FI (1)	FI100691B (fr)
FR (2)	FR2641186B1 (fr)
GB (3)	GB2227660B (fr)
GR (1)	GR1004463B (fr)
HK (3)	HK154996A (fr)
HU (1)	HU212183B (fr)
IE (1)	IE65326B1 (fr)
IL (1)	IL92692A0 (fr)
LU (1)	LU87650A1 (fr)
MA (1)	MA21712A1 (fr)
MX (1)	MX173741B (fr)
MY (1)	MY105879A (fr)
NL (1)	NL194716C (fr)
NO (1)	NO179503C (fr)
NZ (1)	NZ231813A (fr)
OA (1)	OA09253A (fr)
PL (1)	PL165470B1 (fr)
PT (1)	PT92734B (fr)
SE (2)	SE507731C2 (fr)
SK (1)	SK280567B6 (fr)
ZW (1)	ZW17289A1 (fr)

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Publication number	Priority date	Publication date	Assignee	Title
US9180318B2 (en)	2010-03-09	2015-11-10	Conopco, Inc.	Stable oral care compositions

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US5256401A (en) *	1987-01-30	1993-10-26	Colgate-Palmolive Company	Antibacterial antiplaque mouthwash composition
US5334375A (en) *	1988-12-29	1994-08-02	Colgate Palmolive Company	Antibacterial antiplaque oral composition
IL92693A0 (en) *	1989-08-25	1990-09-17	Colgate Palmolive Co	Antibacterial antiplaque composition containing novel styrene-phosphonic acid copolymer
SE512333C2 (sv) *	1989-08-25	2000-02-28	Colgate Palmolive Co	Antibakteriell oral komposition med plack- och tandstensbegränsande verkan
WO1992010992A1 (fr) *	1990-12-19	1992-07-09	The Procter & Gamble Company	Compositions orales efficaces contre la plaque dentaire et la gingivite
US5094844A (en) *	1990-12-20	1992-03-10	Colgate-Palmolive Company	Anticalculus oral composition
US5385729A (en) *	1991-08-01	1995-01-31	Colgate Palmolive Company	Viscoelastic personal care composition
US5252313A (en) *	1991-12-20	1993-10-12	Colgate-Palmolive Company	Visually clear gel dentifrice
US5192533A (en) *	1992-03-25	1993-03-09	Chesebrough-Pond's Usa Co., Division Of Conopco, Inc.	Nonirritating antitartar and antiplaque oral compositions
NZ247712A (en) *	1992-06-19	1995-04-27	Colgate Palmolive Co	Oral composition comprising an anti-bacterial compound, a water-insoluble biodegradable polymer, and an organic solvent
JPH09507231A (ja) *	1993-12-29	1997-07-22	ザ、プロクター、エンド、ギャンブル、カンパニー	チモールを含有したタタール抑制歯磨組成物
US5462728A (en) *	1994-04-05	1995-10-31	Blank; Izhak	Pharmaceutical compositions
JP3494739B2 (ja) *	1995-02-13	2004-02-09	株式会社ジーシー	歯科用グラスアイオノマーセメント用歯面処理剤
HUP0100090A3 (en) *	1997-12-18	2002-11-28	Unilever Nv	Oral care composition
KR100384103B1 (ko) *	1998-04-02	2003-10-08	주식회사 태평양	트리클로산을함유한구강용조성물
US6241972B1 (en)	1999-02-19	2001-06-05	Block Drug Company, Inc.	Oral care formulation for the treatment of sensitivity teeth
RU2145209C1 (ru) *	1999-06-24	2000-02-10	Открытое акционерное общество косметическое объединение "Свобода"	Лечебно-профилактическая зубная паста
RU2180222C2 (ru) *	2000-02-29	2002-03-10	Чухаджян Ара Гарникович	Антимикробное средство
DE10051955A1 (de) *	2000-10-20	2002-05-02	Wella Ag	Haarbehandlungsmittel in Form eines festen und formstabilen Gels
BR0116674A (pt)	2000-12-15	2003-11-04	Unilever Nv	Composição oral para limpeza de dentes, uso de composição oral para limpeza de dentes e embalagem comercial
DE60109207T8 (de)	2001-01-16	2006-08-24	Unilever N.V.	Orale zusammensetzung
WO2003006519A1 (fr) *	2001-07-13	2003-01-23	Kao Corporation	Polymeres a usage oral et compositions a usage oral
RU2205625C1 (ru) *	2002-07-12	2003-06-10	Открытое акционерное общество "Косметическое объединение "Свобода"	Лечебно-профилактическая композиция для обработки зубов
US6912826B2 (en)	2002-10-07	2005-07-05	Zoran Momich	Carrier loading cartoner
US7846422B2 (en)	2003-08-04	2010-12-07	Kao Corporation	Method for prevention or treatment of periodontal diseases and composition for an oral cavity
US20060024245A1 (en) *	2004-07-29	2006-02-02	Cadbury Adams, Llc.	Tooth whitening compositions and delivery systems therefor
US8974772B2 (en) *	2004-12-28	2015-03-10	Colgate-Palmolive Company	Two phase toothpaste composition
EP3100716B1 (fr) *	2008-02-08	2018-09-26	Colgate-Palmolive Company	Nouveaux sels et leurs utilisations
AU2009343761B2 (en) *	2009-04-02	2013-05-09	Colgate-Palmolive Company	Dentifrice composition
EP2467121B1 (fr)	2009-08-19	2016-08-31	Unilever PLC	Système de livraison
RU2533220C2 (ru) *	2010-07-29	2014-11-20	Колгейт-Палмолив Компани	Не содержащие фосфатов композиции для ухода за полостью рта на основе антибактериального агента из магнолии
CN103079526A (zh)	2010-09-10	2013-05-01	荷兰联合利华有限公司	有益于牙齿的口腔护理组合物
US20130164359A1 (en)	2010-09-10	2013-06-27	Yan Deng	Composite particle active and method for making the same
EP2699217B1 (fr)	2011-04-18	2018-01-24	Unilever N.V.	Compositions de soins bucco-dentaires permettant la reminéralisation des dents
CN107743387A (zh)	2015-06-05	2018-02-27	荷兰联合利华有限公司	口腔护理装置
EP3302349B1 (fr)	2015-06-05	2019-11-20	Unilever PLC	Dispositif de soin buccodentaire
EA035881B1 (ru)	2015-06-05	2020-08-26	Юнилевер Н.В.	Способ косметического отбеливания зубов
EP3222326A1 (fr)	2016-03-23	2017-09-27	Unilever PLC	Composition de dentifrice
EP3295921A1 (fr)	2016-09-14	2018-03-21	Unilever PLC	Utilisation de composition de protection orale
GB201811065D0 (en) *	2018-07-05	2018-08-22	GlaxoSmithKline Consumer Healthcare UK IP Ltd	Novel composition
CN112689499A (zh)	2018-09-12	2021-04-20	联合利华知识产权控股有限公司	口腔护理组合物
WO2020212159A1 (fr)	2019-04-17	2020-10-22	Unilever Plc	Produit de soin buccal
EP3888620A1 (fr)	2020-04-02	2021-10-06	Unilever Global IP Ltd	Système de soins buccaux
EP3888621A1 (fr)	2020-04-02	2021-10-06	Unilever Global IP Ltd	Dispositif de soins buccaux
EP3888619A1 (fr)	2020-04-02	2021-10-06	Unilever Global IP Ltd	Dispositif de soins buccaux
EP3888623A1 (fr)	2020-04-02	2021-10-06	Unilever Global IP Ltd	Système de soins buccaux
EP3888622A1 (fr)	2020-04-02	2021-10-06	Unilever Global IP Ltd	Système de soins buccaux

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US3429963A (en) *	1964-06-09	1969-02-25	Colgate Palmolive Co	Dental preparation containing polymeric polyelectrolyte
DE3445695A1 (de) *	1983-12-28	1985-07-11	Colgate-Palmolive Co., New York, N.Y.	Mittel zur oral-dentalen anwendung gegen plaque und gingivitis
EP0220890A2 (fr) *	1985-10-22	1987-05-06	Beecham Group Plc	Composition d'hygiène orale
DE3802168A1 (de) *	1987-01-30	1988-08-11	Colgate Palmolive Co	Antibakterielles, zahnbelag und zahnstein verhinderndes mundpflegemittel

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1989
- 1989-12-12 SE SE8904180A patent/SE507731C2/sv unknown
- 1989-12-13 IL IL92692A patent/IL92692A0/xx not_active IP Right Cessation
- 1989-12-13 AU AU46769/89A patent/AU625379B2/en not_active Expired
- 1989-12-15 NZ NZ231813A patent/NZ231813A/en unknown
- 1989-12-20 MX MX018805A patent/MX173741B/es unknown
- 1989-12-21 GR GR890100853A patent/GR1004463B/el not_active IP Right Cessation
- 1989-12-21 ZW ZW172/89A patent/ZW17289A1/xx unknown
- 1989-12-21 GB GB8928878A patent/GB2227660B/en not_active Expired - Lifetime
- 1989-12-22 DE DE3942643A patent/DE3942643B4/de not_active Expired - Lifetime
- 1989-12-25 DZ DZ890197A patent/DZ1382A1/fr active
- 1989-12-26 MA MA21974A patent/MA21712A1/fr unknown
- 1989-12-27 MY MYPI89001861A patent/MY105879A/en unknown
- 1989-12-27 CH CH4685/89A patent/CH679639A5/de not_active IP Right Cessation
- 1989-12-27 PT PT92734A patent/PT92734B/pt not_active IP Right Cessation
- 1989-12-28 HU HU896808A patent/HU212183B/hu unknown
- 1989-12-28 NO NO895310A patent/NO179503C/no not_active IP Right Cessation
- 1989-12-28 FR FR8917373A patent/FR2641186B1/fr not_active Expired - Lifetime
- 1989-12-28 FI FI896316A patent/FI100691B/fi active IP Right Grant
- 1989-12-28 SK SK7512-89A patent/SK280567B6/sk not_active IP Right Cessation
- 1989-12-28 IE IE419589A patent/IE65326B1/en not_active IP Right Cessation
- 1989-12-28 CN CN89109648A patent/CN1048867C/zh not_active Expired - Fee Related
- 1989-12-28 DK DK198906709A patent/DK175071B1/da not_active IP Right Cessation
- 1989-12-29 AT AT0296889A patent/AT397765B/de not_active IP Right Cessation
- 1989-12-29 BR BR898906866A patent/BR8906866A/pt not_active Application Discontinuation
- 1989-12-29 PL PL89283117A patent/PL165470B1/pl unknown
- 1989-12-29 OA OA59716A patent/OA09253A/fr unknown
- 1989-12-29 LU LU87650A patent/LU87650A1/fr unknown
- 1989-12-29 NL NL8903187A patent/NL194716C/nl not_active IP Right Cessation
1990
- 1990-01-04 JP JP2000211A patent/JP2708134B2/ja not_active Expired - Lifetime
1992
- 1992-08-07 GB GB9216778A patent/GB2257362B/en not_active Expired - Lifetime
- 1992-10-13 FR FR9212240A patent/FR2681529B1/fr not_active Expired - Lifetime
- 1992-12-03 GB GB9225278A patent/GB2259856B/en not_active Expired - Lifetime
1993
- 1993-06-23 DZ DZ930077A patent/DZ1699A1/fr active
1996
- 1996-08-15 HK HK154996A patent/HK154996A/xx not_active IP Right Cessation
- 1996-08-15 HK HK154796A patent/HK154796A/xx not_active IP Right Cessation
- 1996-08-15 HK HK154896A patent/HK154896A/xx not_active IP Right Cessation
1997
- 1997-10-09 SE SE9703681A patent/SE510832C2/sv unknown

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3429963A (en) *	1964-06-09	1969-02-25	Colgate Palmolive Co	Dental preparation containing polymeric polyelectrolyte
DE3445695A1 (de) *	1983-12-28	1985-07-11	Colgate-Palmolive Co., New York, N.Y.	Mittel zur oral-dentalen anwendung gegen plaque und gingivitis
EP0220890A2 (fr) *	1985-10-22	1987-05-06	Beecham Group Plc	Composition d'hygiène orale
DE3802168A1 (de) *	1987-01-30	1988-08-11	Colgate Palmolive Co	Antibakterielles, zahnbelag und zahnstein verhinderndes mundpflegemittel

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US9180318B2 (en)	2010-03-09	2015-11-10	Conopco, Inc.	Stable oral care compositions

Also Published As

Publication number	Publication date
GB8928878D0 (en)	1990-02-28
SK751289A3 (en)	2000-03-13
GB2259856A (en)	1993-03-31
AT397765B (de)	1994-06-27
MA21712A1 (fr)	1990-07-01
AU625379B2 (en)	1992-07-09
PT92734B (pt)	1996-06-28
DE3942643A1 (de)	1990-07-05
ATA296889A (de)	1993-11-15
NL194716C (nl)	2003-01-07
FR2681529A1 (fr)	1993-03-26
SE9703681L (sv)	1997-10-09
GR1004463B (el)	2004-02-27
GB2227660A (en)	1990-08-08
GR890100853A (el)	1991-03-15
JP2708134B2 (ja)	1998-02-04
NL194716B (nl)	2002-09-02
SE8904180L (sv)	1990-06-30
DZ1382A1 (fr)	2004-09-13
HK154796A (en)	1996-08-23
FR2641186A1 (fr)	1990-07-06
JPH02288819A (ja)	1990-11-28
SK280567B6 (sk)	2000-03-13
IE65326B1 (en)	1995-10-18
HU896808D0 (en)	1990-03-28
MX173741B (es)	1994-03-25
AU4676989A (en)	1990-07-05
HK154996A (en)	1996-08-23
ZW17289A1 (en)	1992-01-01
IL92692A0 (en)	1990-09-17
PL165470B1 (pl)	1994-12-30
PL283117A1 (en)	1991-02-11
CH679639A5 (fr)	1992-03-31
LU87650A1 (fr)	1990-07-10
OA09253A (fr)	1992-06-30
NL8903187A (nl)	1990-07-16
DK670989A (da)	1990-06-30
DK670989D0 (da)	1989-12-28
FR2641186B1 (fr)	1994-12-23
GB2257362A (en)	1993-01-13
IE894195L (en)	1990-06-29
SE9703681D0 (sv)	1997-10-09
NO895310L (no)	1990-07-02
SE507731C2 (sv)	1998-07-06
MY105879A (en)	1995-02-28
PT92734A (pt)	1990-06-29
BR8906866A (pt)	1990-10-09
GB2259856B (en)	1993-09-01
DZ1699A1 (fr)	2002-02-17
NZ231813A (en)	1992-05-26
CN1048867C (zh)	2000-02-02
NO179503C (no)	1996-10-23
FR2681529B1 (fr)	1994-07-22
NO179503B (no)	1996-07-15
FI896316A0 (fi)	1989-12-28
SE8904180D0 (sv)	1989-12-12
GB2227660B (en)	1993-09-01
NO895310D0 (no)	1989-12-28
HK154896A (en)	1996-08-23
SE510832C2 (sv)	1999-06-28
DK175071B1 (da)	2004-05-24
CN1044047A (zh)	1990-07-25
GB9216778D0 (en)	1992-09-23
FI100691B (fi)	1998-02-13
HU212183B (en)	1996-03-28
GB9225278D0 (en)	1993-01-27
GB2257362B (en)	1993-09-01

Publication	Publication Date	Title
DE3942643B4 (de)	2008-03-27	Mundpflegemittel
DE3942644B4 (de)	2007-09-06	Antibakteriell zahnbelagverhinderndes und zahnsteinverhinderndes Mundpflegemittel
DD291246A5 (de)	1991-06-27	Mundpflegemittel
US5344641A (en)	1994-09-06	Antibacterial antiplaque oral composition
DE69625122T2 (de)	2003-09-11	Orale antibakterielle Zusammensetzung zum Aufbringen auf Zahnimplantatoberflächen
AT395109B (de)	1992-09-25	Mundpflegemittel
US5296214A (en)	1994-03-22	Anticalculus composition
DE69328903T2 (de)	2000-12-07	Gegen zahnbelag, gingivitis und karies wirkende orale zusammensetzung
US5192530A (en)	1993-03-09	Antibacterial antiplaque oral composition
DE69415515T2 (de)	1999-07-29	Orale präparate zur behandlung von plaque und gingivitis, die einen nicht-kationischen antibakteriellen wirkstoff und ein bikarbonatsalz enthalten
US4559223A (en)	1985-12-17	Silver sulfadiazine and/or zinc sulfadiazine-containing toothpaste or oral medicament
CH661440A5 (de)	1987-07-31	Mittel zur oral-dentalen anwendung gegen plaque und gingivitis.
DE3942641A1 (de)	1991-02-28	Styrol-phosphonsaeure-copolymere, verfahren zu deren herstellung sowie deren verwendung in zahnbelagverhindernden mitteln
CA2006703C (fr)	1997-02-04	Compose oral antibacterien anti-plaque
CZ283325B6 (cs)	1998-02-18	Prostředek proti tvorbě zubních povlaků pro orální aplikaci
IE65678B1 (en)	1995-11-15	Antiplaque antibacterial oral composition

Legal Events

Date	Code	Title	Description
1992-06-17	8128	New person/name/address of the agent	Representative=s name: STOLBERG-WERNIGERODE, GRAF ZU, U., DIPL.-CHEM. DR.
1997-02-20	8110	Request for examination paragraph 44
2008-09-25	8364	No opposition during term of opposition

DE3942643B4 - Mundpflegemittel - Google Patents

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Families Citing this family (47)

Citations (4)

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Patent Citations (4)

Cited By (1)

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