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DE2812585A1 - Chinazolin-derivate - Google Patents

Chinazolin-derivate

Info

Publication number
DE2812585A1
DE2812585A1 DE19782812585 DE2812585A DE2812585A1 DE 2812585 A1 DE2812585 A1 DE 2812585A1 DE 19782812585 DE19782812585 DE 19782812585 DE 2812585 A DE2812585 A DE 2812585A DE 2812585 A1 DE2812585 A1 DE 2812585A1
Authority
DE
Germany
Prior art keywords
formula
compounds
hydrogen
alkylamino
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19782812585
Other languages
German (de)
English (en)
Inventor
Richard Wightman Kierstead
Jefferson Wright Tilley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of DE2812585A1 publication Critical patent/DE2812585A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/57—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C205/59—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE19782812585 1977-03-24 1978-03-22 Chinazolin-derivate Withdrawn DE2812585A1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78093977A 1977-03-24 1977-03-24
US87156478A 1978-01-23 1978-01-23

Publications (1)

Publication Number Publication Date
DE2812585A1 true DE2812585A1 (de) 1978-09-28

Family

ID=27119777

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19782812586 Withdrawn DE2812586A1 (de) 1977-03-24 1978-03-22 Chinazolin-derivate
DE19782812585 Withdrawn DE2812585A1 (de) 1977-03-24 1978-03-22 Chinazolin-derivate

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE19782812586 Withdrawn DE2812586A1 (de) 1977-03-24 1978-03-22 Chinazolin-derivate

Country Status (23)

Country Link
JP (2) JPS53119896A (el)
AR (3) AR218480A1 (el)
AT (2) AT367051B (el)
AU (2) AU521096B2 (el)
DE (2) DE2812586A1 (el)
DK (2) DK128878A (el)
ES (13) ES468127A1 (el)
FI (2) FI780918A7 (el)
FR (2) FR2384770A1 (el)
GB (2) GB1601371A (el)
GR (2) GR72948B (el)
HU (1) HU180782B (el)
IE (1) IE46505B1 (el)
IL (2) IL54328A (el)
IT (2) IT1093710B (el)
LU (2) LU79290A1 (el)
MC (2) MC1186A1 (el)
NL (2) NL7803122A (el)
NO (2) NO781051L (el)
NZ (2) NZ186760A (el)
PH (2) PH13915A (el)
PT (2) PT67820A (el)
SE (2) SE7803418L (el)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4332802A (en) * 1975-12-19 1982-06-01 Boehringer Ingelheim Kg 11-Oxo-11H-pyrido[2,1-b]quinazoline-2-carboxylic acid and salts thereof, antiallergic compositions containing it and methods of suppressing allergic reactions with it
US4457927A (en) * 1978-10-18 1984-07-03 Schering, Aktiengesellschaft Pyrido[2,1-b]quinazolinone derivatives and the preparation and use thereof

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4395549A (en) 1981-10-02 1983-07-26 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt. 6-Hydrazono-pyrido[2,1-b] quinazoline-11 ones
ES8306729A1 (es) * 1982-04-30 1983-06-01 Lafarquim "procedimiento de obtencion de 2-isopropil pirido (2-1-b) quinazolinas y sus sales no toxicas con actividad antianafilactica".
US4551460A (en) * 1982-05-10 1985-11-05 Hoffmann-La Roche Inc. Pyrido[2,1-b]quinazoline derivatives useful as agents for treatment of allergic conditions and vascular disorders involving thrombosis
DE3300477A1 (de) * 1983-01-08 1984-07-12 Boehringer Ingelheim KG, 6507 Ingelheim Neue heterocyclische verbindungen, ihre herstellung und verwendung
JPS62238264A (ja) * 1986-04-04 1987-10-19 Nippon Tokushu Noyaku Seizo Kk ２−ハロ−５−アセチルピリジン

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4012387A (en) * 1975-09-18 1977-03-15 Warner-Lambert Company Benzo-[g]pyrido[2,1-b]quinazolinones
US4033961A (en) * 1975-10-07 1977-07-05 Warner-Lambert Company Pyrido[2-1-b]quinazolin-ones and their methods of preparation

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4332802A (en) * 1975-12-19 1982-06-01 Boehringer Ingelheim Kg 11-Oxo-11H-pyrido[2,1-b]quinazoline-2-carboxylic acid and salts thereof, antiallergic compositions containing it and methods of suppressing allergic reactions with it
US4457927A (en) * 1978-10-18 1984-07-03 Schering, Aktiengesellschaft Pyrido[2,1-b]quinazolinone derivatives and the preparation and use thereof

Also Published As

Publication number Publication date
JPS53119897A (en) 1978-10-19
IT1095493B (it) 1985-08-10
PT67821A (en) 1978-04-01
IE46505B1 (en) 1983-06-29
AU3447478A (en) 1979-09-27
AR218480A1 (es) 1980-06-13
NL7803122A (nl) 1978-09-26
DK128878A (da) 1978-09-25
ES478325A1 (es) 1979-11-01
GB1601371A (en) 1981-10-28
IT7821578A0 (it) 1978-03-23
FI780918A7 (fi) 1978-09-25
FI780917A7 (fi) 1978-09-25
NO781051L (no) 1978-09-26
ES478327A1 (es) 1979-11-01
AT367051B (de) 1982-05-25
ATA210478A (de) 1981-10-15
ES478332A1 (es) 1979-11-16
IT7821655A0 (it) 1978-03-24
FR2384771B1 (el) 1980-04-04
ES468127A1 (es) 1979-09-16
FR2384771A1 (fr) 1978-10-20
ES478323A1 (es) 1979-11-01
FR2384770A1 (fr) 1978-10-20
AU521096B2 (en) 1982-03-18
ES478333A1 (es) 1979-11-16
AT367050B (de) 1982-05-25
PT67820A (en) 1978-04-01
ES478328A1 (es) 1979-11-01
IL54326A0 (en) 1978-06-15
IE780582L (en) 1978-09-24
NL7803112A (nl) 1978-09-26
AU521352B2 (en) 1982-04-01
ES478324A1 (es) 1979-11-01
GR73170B (el) 1983-02-14
GB1601991A (en) 1981-11-04
IL54326A (en) 1982-04-30
LU79290A1 (de) 1979-05-25
IL54328A0 (en) 1978-06-15
SE7803419L (sv) 1978-09-25
SE7803418L (sv) 1978-09-25
PH14130A (en) 1981-02-26
HU180782B (en) 1983-04-29
LU79293A1 (de) 1979-05-25
MC1185A1 (fr) 1978-12-22
ATA210278A (de) 1981-10-15
MC1186A1 (fr) 1978-12-22
PH13915A (en) 1980-11-04
NZ186759A (en) 1981-03-16
AR218060A1 (es) 1980-05-15
AU3447578A (en) 1979-09-27
IT1093710B (it) 1985-07-26
DK132778A (da) 1978-09-25
IL54328A (en) 1982-03-31
DE2812586A1 (de) 1978-09-28
ES478330A1 (es) 1979-11-01
ES478329A1 (es) 1979-11-01
FR2384770B1 (el) 1980-10-24
NZ186760A (en) 1981-03-16
JPS53119896A (en) 1978-10-19
ES478326A1 (es) 1979-11-01
NO781053L (no) 1978-09-26
PT67821B (en) 1980-03-04
ES478331A1 (es) 1979-11-16
ES468126A1 (es) 1979-09-01
AR225415A1 (es) 1982-03-31
GR72948B (el) 1984-01-17

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Legal Events

Date Code Title Description
OB Request for examination as to novelty
OC Search report available
8139 Disposal/non-payment of the annual fee