DE2551991A1 - Medication metering distributor for hypodermic - has dosing unit on flexible wall transmitting power pulses - Google Patents

Abstract

The variable dose is dispensed by a plunger-and-barrel or bellows mechanism automatically actuated hydraulically, pneumatically or by solenoid - alternatively a rotary pump or an electronically-controlled restricted passage can be used. This is mounted near a reservoir containing more than the unit dose, and is fixed to a flexible wall through which the power pulses are transmitted. Means are included to prevent germ colonisation of the reservoir, typically in the form of a vessel subjected to the effect of sterilising material, and resealing of the outlet can likewise be effected hydraulically, pneumatically or electrically, or heat can be applied. A permanently mounted or detachable syringe nozzle can be included.

Description

Title: Dosing medicinal dispensers for peroral and injection treatment Introduction: The invention relates to the field of medical technology, especially drug administration.

Status of the pressure storage bottles in connection with fixed dosage and without technology: the separation of drugs and propellants become drug administration on the skin, mucous membranes and bronchi to an increasing extent in recent years applied in medicine. The freons cF C13 (Frigen 11, Hoechst) with boiling point 23.70, the CF Cl2 (S.p. -30 °) and for setting the boiling point added CF3. CFCl2 (b.p. + 3.55 ° C) used. Medicines intended for slagging are still dispensed in dropper bottles, liquids to be injected from Manufactured in ampoules or disposable syringes. Disposable syringes are included in the Trade, bel which a solvent only before the injection with a medicinal powder comes into contact and must be shaken to dissolve in this. Injection fluids are also packaged in small stopper bottles for multiple uses, under injection non-sterile air can be used before filling the syringe.

Task: The present invention is intended to be used for oral drug treatment are made easier by the fact that drops are no longer counted by the patient or carer and no additional rinsing vessel is required. Especially for the treatment of the mentally ill is still advantageous in that the amount of administered Afznei does not have to be made known to the godmother. On the injection area should the more cumbersome single-dose packaging and the conventional syringe can be saved at least for the subcutaneous area of application, but in any case the difficult to achieve solution: dosing function of the syringe. To these goals To achieve this, the technical effort for the metering devices had to be reduced; Primarily older were the functions of the influence of the medicinal product on the dosage rate to automate as far as possible until it flows under the skin.

To achieve these goals was a German Rgichspatent assumed the membrane separation of the Afznei in the bottle provided, then pressure storage bottles chosen with a separation of pressurized gas or propellant or forwarded liquid or Gas pressure from the drug through a membrane or advantageously with liquid separation by a piston compressed gas inclusion in a membrane behind it or a slightly sliding bellows. The drug movement in the dosing piston takes place first through the dosing piston under control of the drug outlet, then by lowering one Valve at the end of the filling tube located in the medicine through the bottle neck seal Rotation of the dosing piston with eccentric valve seat over its oval shape using a locking disk against valve closure before pressure compensation, finally from the drug outlet with the limitation of the piston path by an elastic Sheath lying string. The drug outflow from the dosing chamber is activated by pulling it is precisely this string that causes it, or via spring force or via the pressure in the medicine bottle under valve movement of the dosing cylinder as a whole. For practice and clinic use is counterbalanced by larger pressure storage cylinders, their medicine in syringes is filled that after actuation of the outlet valve with inserted syringe cone by lifting or lowering, over the filling of the syringe plunger up to a stop is lifted (if the plunger is stationary, there is also a movement of the syringe barrel against a Dosiernaciilag conceivable). The air seal of the drug outlet opening is made possible by various lid constructions that spring back into the closed position overcomes, also with the use of disinfecting pastes and pale or surfaces, by sucking off liquid or air by moving the tape from the drug outlet opening away (with or without a passage hole for the syringe cone) 'by gas or liquid flow, im stationary nu area also already in the area of the dosing chamber and the supply lines; + e by blowing drug residues out of the cannula, using heat or cold this becomes reusable. In the case of single use, a cannula appears to be attached with germ-hostile kit edge in the cone and leaving it under lock and key after use the cannula tip through a lid pad as a cheap means. The application in suction injection devices or the training of the Bosier dispenser itself as such (for Disposable articulated designed and grids and shape distinctions for the blind be also mentioned the single pressure storage ampoule for peroral ~. and injection.

Description of the first embodiment: Figure 1 shows a Two-chamber dosing device in connection with egg medicine bottle with membrane-bound Ventilation. The dosage is set by means of a spindle (1) with a right and left thread.

Uic air over the medicine into which the filling tube (S) is immersed bounded by the shell (6) and is via the opening (9) with the ventilation space in connection2 the medicine compartment via the filling pipe with the dosing chamber (1I) 2which closed by the check valve (10) and the valve sleeve (13) actuated by pressure from the syringe will.

The solution is a prerequisite for commissioning the facility the rigid connection between cylinder caps that can be moved via stationary pistons on the latch (2) and the actuation of the air cylinder cap (3) as a pump up to the opening of the preloaded valve (4) in the filling pipe. The cylinder cap movements are used for commissioning via the spindle again gekoppeEtX so that one of the withdrawn medicaments corresponds Amount of air in the medicine bottle into the elastic Iille of various wall thicknesses To favor the space filling from one end - is pumped in 'while the Check valve (7) prevents air from escaping through the ventilation pipe (8). The pump function of the air cylinder cap is made possible by the check valve (10), the drug is dispensed from the dosing chamber through the non-return valve (12) after opening the valve sleeve (15) by pressing the syringe case (14) while lowering the dosing cylinder cap (15) When the dosing chamber is emptied, the dosing chamber cylinder is held in place via the Zaiuiraster (16). The dosage can be read off on a scale (17).

Description of the second exemplary embodiment: FIG. 2 represents, for example a single-chamber dosing device prior to application already under gas pressure Medicine holder.

In Figure 2a, the gas pressure is generated by a wall surrounding the bottle Cover (6) with compressed gas between the cover and the bottle wall on the inside present drug effective. The gas envelope surrounds also the short ones Filling tube attachment (5). In FIG. 2b, gas pressure is used in the case of a cylindrical medicine container a piston (18) is propelled against the medicament in seal on the outflow tube.

I) he function of the metering device (Figure 2) sets a metering setting on the piston (19) by means of the knurled screw (20). is displaceable just above the filling pipe (5).

The upper edge of the knurled screw limits the movement of the dosing cylinder cap (15) nach oben'deren inner edge actuates a spring mechanism via a nose with a steep Waste in connection with a dosing scale, to the dosing setting also hearing and to make it foldable. The piston rotation when setting the dosage is controlled by a The groove (22) between the Eolben tube (23) and the filling tube is prevented. The liquid filling the dosing chamber can only be delivered if the dosing cylinder cap is in contact with the dosing piston rests and after through the closed non-return valve (25) and the stop (26) the resilient needle (27) protected by a sheath over the outflow opening of the Syringe cone has opened the slip valve (25) in the dosing plunger as a result of friction delay due to the guide ring (28) on the valve cone, the valve closes so late that even the largest filling volume can have flowed into the dosing chamber. An intermediate ring (24) secures the freedom of piston tube movement. The membrane (29) protects the dosing chamber Pollution. Fig.2a shows embran, Fig.2b piston (18) propulsion, in the example of Figure 2c is the structure by means of a suction cylinder (35) in connection with a water jet pump (36) pulled up.

The medicine bottle is in a sliding inner cylinder (37) sealed, which eüg grips with a groove in a spring snapper (38) before the injection. The suction makes the medicine bottle with the dosing device (39) and attached Cannula moved towards the skin. When the cannula is blocked by the stop (40), the last the dosing cylinder is lowered so that the medicine flows out.

Figure 2d shows a dosing device, r similar to that just shown. The inflow from the iEllrohr (5) through the piston (19) is via dus From t 11 (30) flurcll lowering of the slide sleeve (31) triggered, with the cylinder caps along with the filling pipe over the fastening solves, with the cylinder caps together with the filling pipe held on the medicine bottle via the Refestiglugsklanuner (32) will. The height of the piston is adjusted via the worm thread (21) on the cylinder cap (2O) when the axles are attached by cutting blades on the TRillrollr in the stopper and guide pin and guide channel between the worm thread and the calf tube (for I) ouierung).

In Figure 2e, the valve (30) for the flow of medicament into the metering chamber located inside the dosing piston. After setting the dosage (as above) by turning the oval dosing cylinder cap (15) and thus the dosing piston If the valve plate is fixed in the valve (3O), there is also an opening in the valve plate brought such in the valve seat to cover. According to the influence of the medicine, the The spring (33) returns the metering piston to its initial position.

Figure 2f shows a clip with the label 11Morgenfl on one End and "evening" on the other. This makes the difference between the two ends even more It is easier to determine that one end is round and the other has an angular shape. The Klanmer is used to hold two dosing devices or syringe cylinders This means that confusion is ruled out. There is also a resilient connection between the dosing devices and the sealing caps for the cannula connector.

Figure 2g shows a detail of a modification of Example 2e.

The valve seat of the valve (30) is centrally located on the surface of the Dosing piston (19) and is held by the tension spring (95). The eccentric to the dosing piston The lying disc (96) has a notch for the passage of the valve cone (valve plate). After setting the dosage, the screw (97) is turned and with it the washer against the spring (33) via an angular pin in the angular central bore of the disc. After the valve cone has entered the notch of the Disc has been lifted, its rotation is prevented until a pressure equalization between Pressure storage tank and metering chamber is made. (The valve cone will now retracted by the spring in the seat, and the disc locks after rotation the spring (33) the movement of the valve cone). The Dre- Spin through the spring (33) the movement of the valve cone). The rotation of the disc can also be about a serrated rim on the disc and a serrated rim inside the Dosing cylinder (15) (Figure 3). The dosing cylinder is translucent (from Materiol) Description of the third embodiment: Figure 3 shows a metering device as just described, devices for changing the dose not being shown. The dosing cylinder has a plate-like band (43) which protrudes against the The container wall is sealed. The latter shows a sealing edge (42) against the dosing cylinder The space between the two edges contains a bellows from which ventilation ducts leads to the space above the syringe connector (13) under an antibacterial tape (51). If the cover plate (46) is swiveled to one side against the spring (47), this has the effect Transport wheel (50) over the spring-loaded upper toothed strip (48) under the cover disc a movement of the band (51), which has holes for the syringe cone at regular intervals having. The syringe cone is inserted and the dosing cylinder against a spring lowered, the air escapes from the bellows next to the syringe cone up to The lid swivel arm engages in the catch (52). The dosing cylinder empties into the syringe. If this is removed, the cover disk swings back, the band is pushed through the action of the spring-loaded lower toothed strip (49) (and thus the hole), the latch released and the dosing cylinder lifted. The emerging Vacuum pulls the tape into the syringe funnel. The drug propulsion happens via the pressure bottle membrane.

Figure 3a shows the example of a fixed dosage. This takes place within a cylindrically-shaped accordion-like foldable plastic body (53), which is in a Corresponding cavity is inserted in the bottom of the bottle.Bci pressure on the filling tube (5) seals the lower edge of the plastic body and the contents are opened by opening the valve (12) emptied through the syringe nozzle with air entering through the air tube (8) in the space limited by the memhran (6). sealed against the bottle neck.

FIG. 3 b shows an example with fixed metering within the bottle holder. When the filling tube (5) is lowered, it is first sunk into the metering piston, see above that the inlet openings (56) are sealed with opening of the Rückschla: 'irntiles (3O). Further lowering of the lEllrollres causes a lowering of the metering piston, whereby the dosing chamber via the channels (57) within a pressure storage bottle £ üllt.Lasst now the pressure on the filling tube after the check valve is closed, the Inlet openings are exposed within the metering chamber and as a result of the pressure the liquid against the dosing piston, this is lifted and the dosing chamber emptied.

The filling tube is protected by a membrane with a spring (55) Entrance to the cannula connector through a strap (51). These are made from cassettes659) wound on rolls (6O). The coil movement elblg.t via the downward movement of the Lever (61) with toothed bar by sliding friction when blocking the opposite direction / before Introduction of the syringe cone. After removing it, the entrance slot becomes closed by spring clips.

FIG. 3c shows a closure by means of adhesion or an adhesive surface adherent stacked platelets with a strong affinity for the rim of the syringe funnel (13). Against the spring (58) the cover with the stacked plates in the guide slot (62) be lifted and tilted to the side with a plate attached to the edge of the cannula sticks. After removing the plate, the syringe cone can be inserted the platelets and the outer layer of the pads (63) - in detail A with air or liquid filled - made of silicone, for example, have a high content of metal powder (for example of aluminum). The necessary check valve is not shown.

Figure 3d shows a closure by means of a magnetic slide (55). The check valve (3O) is activated directly by the pressure of the syringe cone. Figure 3e shows a Solution with two fixed dosing devices on a polygonal medicine container is placed on different Linteji when required.

4th embodiment: + the dosing device ++ syringe in figure 4 the dosing piston is locked by a lock (64) on the piston rod during filling placed on the syringe funnel + detached, with the projection of the syringe barrel during the operation of the check valve of the pressure storage bottle of the syringe barrel 5 Sits (or is lowered below the same to the groove, with the syringe clamp holder is resiliently connected to the pressure storage cylinder, see Figure 4a). In Figure 4a is the locking rod is attached to the pressure storage bottle using the bracket (66) The piston lock can be pulled back with a spring and along a dosing scale (17). can be adjusted in height or can be inserted into corresponding holes. In FIG. 4b, the variation consists in a predetermined articulated connection with the Medicinal bottle, which allows the pivoting of at least two locking rods of different Height or dosage setting allowed. In Figure 4c, the syringe to be filled in a sleeve inserted inside which a threaded bolt (64) with a metering scale and Click (17), similar to that described for FIG. 2, allows an exact Y predosing. The application of the principle within an injection device is shown in FIG. 4d using the example of a device for single suction injection. The syringe barrel will pushed into the suction cylinder (35) up to the stop (67), the sealing piston mim The plunger (68) after the metering nut (69) has engaged in the grid (70) according to the scale and click (17) adjustable in height. After inserting the syringe cone into the dropping nozzle of a pressure storage bottle and actuation of the check valve, the syringe plunger rises in the set position Scope. Pulling the handle (71) triggers the stop (67) and grid (70) and the syringe can over the guide claw (72) on the plunger (68) until the The metering nut in the spring scimper (38). Connection of the device to a Effect the jet pump and sealing of the suction cylinder by placing it on the skin the injection under the unrestrained downward movement of the sealing plunger and syringe the raised skin.

FIG. 4e shows a dosage when the upward movement of the plunger is hindered by a snap lock on the syringe itself via a screw-in sleeve (23); the piston rod engages. FIG. 4g shows a locking pin on a retaining clip (removable) on the syringe which, fixed or adjustable, limits the movements of the syringe plunger relative to the syringe cylinder by means of detents. Figure shows the connection of several pressure storage bottles Kanitger form via tongue and groove on the corresponding wall position or by plastic rings to form a block.

Figure 4i brings the connection of a double bottle with a separate one Medicinal storage with common filler neck. The latter is + a above one Check valve, the functional sequence of which is determined by the length of the filler pipe that penetrates the syringe cone and rests on the syringe plunger During use, the filling tube is protected by a spring-loaded cover. Idt the filling pipe extended to the maximum length, its side opening becomes the inlet pipe (73) free. After the metering device of the second medicine bottle as in Figure 3b but was operated via the hand bar (7i), the second medicine can flow in. At figure 4j there is a metering niche embedded in the edge of a medicine pressure storage bottle. The Sprite is plugged into the filler neck after lifting the cap. Then the syringe and filler neck are pulled up with their protruding edge (13) and thereby the valve opened. After dosing by hitting the plunger of the syringe on the niche ceiling, the neck of the filler neck is pushed back by hand so that the Syringe can be removed 5. Ausfül1rungsbeispiel game Figure 5 relates on the dissolution of solids by a solvent that is passed through the filler neck is directed into a funnel by deflecting the beam and dissolving a powder and finally the filling of the syringe.

In Figure 5a is a neck with a filter-like acting fabric or several filter layers filled and the medicine bottle filled with solids bescl; ickt, which @win brought out the current between the filler neck and the syringe cone will.

6.4 Example: Figure G shows an electronic version the facility for example 4. The solenoid valve (76) is through Pressure switch (77) open when the syringe cone is inserted. Weun the end of the plunger the light barrier between the lamp (78) and the photocell (79) is interrupted, the Control element {80) the solenoid valve is closed.

Tn Figure 6a actuates the vibration in the liquid cushion of the Make sure to release the solenoid valve (76) as soon as the syringe plunger has a marking on the cylinder wall crossed.

7.Example: In Figure 7, the filler neck is for a cylinder extended'which is closed by a sealing lid'of a liquid can be flowed through and sealed towards the opening receives a syringe. While the liquid is sucked off, the syringe cone passes elastic cushions to the check valve or to the medicine bottle. In Figure 7a acts behind a for the syringe cone provides a continuous diaphragm over the sealing bag with suction.

8. Embodiment The example of Figure 8 relates to a Hose storage of a medicament between dividing insulating bodies (74). Will the When the hose is pressurized from one end, the insulated mutt gets on + r the other end over the seal (63) in the area of the cap and can after Interruption of the pressure supply can be lifted manually.

After introducing the syringe cone and increasing the pressure again, it flows the amount of medicine in the syringe which in the tube to the next insulating body is included.

9. Embodiment: In Figure 9 an example for a medicine bottle shown with dosing device for oral use. The retaining clip (32) has foot-like runners which are used for the devices with the dosing device turn down. The valve sleeve (13) continues in a bracket that extends can be operated by two fingers. The two-part closure (76) is thus i.e. because of the sylmlletIy of the construction in two stripes, like a bird's beak closed against the spring (25). The non-return valve and thus + the Dosierholben operated. + then.

FIG. 9a shows a metering medicament dispenser in which the medicament enters the dosing cylinder via the opening (82) and the dosing piston (19) with the aid of the spring (83) lowers to the piston stop (84). If the eccentric (85) operated with a dog lever, the l) osierzylinuer and the ring-shaped opening (82) are lifted comes into cover with the outlet opening (87). The dosage is done with the hand crank operated on the adjustment lock (86) with mechanical rotation prevention. The compressed gas is filled into the rolling diaphragms (9) via a filler neck with a check valve.

10. Embodiment: Figure 10 shows a single ampoule below Pressurized gas action that empties into a syringe after the stopper is removed from the The cannula is pierced (in front of the sliding mesh sleeve or by the cannula adapter 11. Embodiment: zen In Figure 11, a sleeve-like cannula attachment piece outside of use in the space between the non-return valve surrounded by water (25) and cushion-like seal (633 held by a spring mechanism (88). Small Vanes (89) encourage rotation in the flow of cleaning fluid. When lowering of the lid cylinder (90) with the cushion type seal opens the sleeve-like extension piece the check valve and forms a sealed connection with the filling pipe (5), { to fill the syringe. After use, the spring (91) guides the lid cylinder into the starting position back.

12. Embodiment: Figure 12 shows a metering piston (metering device), the connected to a medicine supply bottle via the valve support (tube) (92) @ itself can be fixed with a bar (93) next to other dosing heads The connection to a flushing system is established in a technically well-known manner via solenoid valves (76) is operated periodically with the timer (98). When filling the valve port the non-return valve (25) is inserted into the medicine bottle, which has previously been closed in a sterile the medicine supply bottle opened by a pin (99). The content the medicine bottle is under pressure or is, for example, via a flushing system put under pressure. In the mechanical solution of the control shown in FIG of the valve (30) positioned in the end positions within the metering piston (19) if the 2/2-way valve (100) is in position As so dtll3 the Arliznei can flow into the dosing cylinder (15) Xinsorern the solenoid valve (76) in position A stands. The metering piston is driven forward against the pressure of the spring (83) until the plunger of the valve (30) hits the outlet pipe slide (101) and so on is shifted that the valve (30) from the locked closed position in the Locked opening position device. Via the actuation of the outlet pipe slide (1O1) the 2/2-way slide valve (100) is brought to position B, so that the medicinal product is blocked. During the downward movement of the dosing piston by the action of the Spring (83), the drug flows through the valve (3O) through the dosing piston.

By stopping the valve tappet (30) on the inlet pipe slide (102) valve (30) is closed and the 2/2 slide valve is returned to position A. The solenoid valve (76) was meanwhile in its position B instead of the drug the flushing liquid supply is free, so that with the next dosing piston movement / through Influence of the same the medicine is emptied through the outlet pipe, etc. At the end of the cover (54), position B of the solenoid valve (76) is set via the control unit (80) maintained0 A contact switch (77) on the cover causes the Switching the solenoid valve to position A and unlocking the latch (103) below Opening of the cover after the outlet pipe slide has been actuated via the metering piston became.

In variation A (Figure 12a), the sealed piston plate (104) a dose-changing knob on the screw (105); the outlet nozzle lies in the middle of the piston plate. The mechanical slide valve (100) is through an electro-mechanical valve (106) replaced with electrical contacts (107).

13. Embodiment: In Figure 13 there is next to the medicine pressure bottle a pressure bottle with rinsing liquid or disinfectant gas Liquid or. Gas outlet into a common space through a sprung Lid is closed and can also include a cannula.

Dns valve (108) in lever connection with the cover causes dus Briefly with the pressurized flushing liquid container inside the cannula The 2/2 valve (109) is activated by suction (e.g. from a suction injection device) or moved from position B to position A against the spring (11O) by operating the island, see above that the inner cannula is connected to the drug supply. The widest lid opening in position III allows the Einrie to be placed while the lid is closed Spring (111) is brought into position II for a short time so that the valve (108) opens and then closes (back to position 1). The 2/2 valve was before has been returned to position B by the spring (110). + will.

In Figure 13a, the valve (108) is a pressure bottle with cleaning fluid or disinfectant gas for a predetermined period of time (as in the technique for spray bottles usual) open 'when the lid is just closed. The cleaning current is directed against the drug outlet.

In Figure 13b, the pressure bottle valve is reduced by lowering the + a nula adapter sleeve (112) actuated, which of cleaning liquid or disinfectant gas surrounded'wenn the cover (54) after actuation of the valve (108) by a spring closed is.

In Figure 13c, the lid has a central seal through which at Pressure on the lid of the cannula connector or the filling funnel pushed through are'until finally the valve to the pressure bottle is actuated.

The cleaning liquid or the disinfecting gas is located in FIG. 13d in an elastic tube, in FIG. 13e in an elastic balloon inside the medicine supply bottle.

14. Embodiment: In Figure 14 i> <tlur impacts the spring-loaded locking pin (113) in End position of the dosing piston (19) a brief opening of the valve (108), which sticks in connection with pressurized gas, so that the drug in the cannula connector or in the cannula is displaced by gas immediately after or during the injection. The cannula set connector is surrounded by a sealed, sliding cylinder (114) which is passed through an eccentric cover assembly is closed. Rotation of the cylinder during its Countersink on a screw spindle guide (116) caused by a knockout mandrel (115) the opening of the lid (54). The disinfectant liquid or mass around the cannula hub, which also touches the edge of the cannula connector and weights the lid into the space below the perforated guide disk (117, which is attached to the cannula hub, back. While the cylinder is being lowered, the perforated damping piston (119) the pressure switch (118) for the valve (108) actuates so that compressed gas via the outlet pipe (120) flows out with an annular groove on the dosing piston. After the injection, the valve (108) in lever connection with the cover that the cannula interior - as described above - briefly is connected to a pressurized flushing liquid container, The 2/2 valve (109) is counteracted by suction (e.g. a suction injection device) or by manual operation brought the spring (110) from position B to position A, so that the cannula inside with is connected to the drug supply. The widest lid opening in position III allows the To press the device against the skin. The problem of sealing the chewing attachment nozzle can be solved thereby that those flowing mass, which from 2 to 3 weight percent COK 84 Aerosil (Degusa) and 97 to 98 percent by weight Lysol mixed according to the "snowball principle" when the cylinder is rotated by reducing the size of the space the cannula connector shrinks while the lid is turned open. Even hydrophobized Aerosil 2 to 5 percent by weight R 972 with 97 to 98 percent by weight Oil, e.g. E "Helago" can be used mixed into a gel, or other compositions. The cannula connector can be made hydrophobic in a known manner he rinsed with a silicone oil solution and then left for G hours at 300 ° C Is left in the drying cabinet. "Manuseptgel" (Baeill @ lfabrik Dr. Bode & Co Hamburg) can used are 'for the production of solid surfaces "Impregnwa" (Espe' + c ScefeldaDberbayern) solved with 1 percent by weight formalsdehyde before the addition of hardener or silicone. The described Materialin has proven itself in the inhibition of coli bacteria (Prof. Grossgebauer F. U.

FIG. 14a shows the upper part of a metering device 2 as in FIG Examplenn 2 described, in which, however, the syringe funnel has an on the Valve sleeve centrally attached pin with additional valve plate to prevent air from entering is locked. If the syringe cone is inserted, it opens by pressing a cross-like echo on the valve plate the same and at the same time he thinks also the valve sleeve as Gzes, so that when the dosing cylinder is lowered the ARznei dodges into the syringe.

In Figure 14b, the cannula is connected to a dosing device * used several times. The cannula lies within a space (114) with disinfectant ointment which it passes through after opening the lid, taking the disinfectant ointment is slipped back through a seal and the vented bellows is compressed In FIG. 14c, the change in roughness for evasion of the ointment is shown by bruising of a cylinder (122) achieved by means of a drawer-like chamber extension with stationary and the bottom cylinder vented through the opening (123).

+ In the cannula attachment (Figure 14b) there is an elastic sealing surface, which can have germicidal properties' or a putty compound is provided which can also be germicidal.

15. Embodiment FIG. 15 shows a similar metering device as in Example 9a, but connected to a pressure storage cylinder without a rolling membrane can be. The passage (133) on the cylinder (15) for the cable (125) is through a Valve rubber tube sealed, the opening around the axis of the roller (128) by a disinfectant fifasse.The dosing piston is counteracted by opening the valve (30) the spring (121) pulled down by the cable over the roller, the Elemm bran (126) on the cylinder base prevents a pressure effect on the valve (127) and the The drug moves into the space in front of the cannula attachment. Actuation of the rope addition takes place via the role by means of the lever (129) 'with little play between two Lever cam between a spring-loaded feed stop, initially noticeable below it Snap into place in the Feststencllden ratchet wheel, with counter bearing of the gear wheel stop the lever cam does not allow the lever to be lowered. By pulling on the piston (13O) (for example by suction of a suction injection device with a cylinder-like outlet for receiving of the piston) the pressure-balanced valve (131) is opened @ and the metering piston moved by the drug entering the cylinder towards the cannula nozzle connector and emptied the medicine there. The cable pulls the gear lock (133 :) and the lever is lowered to the starting position. The dosage can be adjusted along a scale (17) for several fixed doses in the locker pins at various distances from the ilebel axis hit appropriately attached screws and block the lever movement. Sealing cap and cannula adapter or other plastic parts come with one provided germicidal coating. 16. Example: /Fig.15a shows Drug advance through bellows.

In Figure 16, a perforated disk (134) between plates (I35) mediates the Transport of a medicinal powder or tablets into the mixing cylinder (156), wherein The piston is lifted so far by turning the axis of the perforated disc by means of an inclined plane that it leaves room for movement and dry matter. The activity of The valve (108) causes the solvent to penetrate through the hose (137) Piston (19) lifted against spring (138). Spring-loaded plates (139) in the piston serve as a mixer, which is actuated by reciprocating movement of the piston rod (140) on the lever (141) while the solvent is admitted continuously or intermittently by actuating the valve (108) is at the end of the exhaust valve (25). The axis opening is through a disinfectant compound (gel) sealed or the lever covered by a thin membrane, which is also the axis opening covered.

17. Embodiment: In Figure 17 there is a heat-insulating cannula connector provided, onto which a cannula with a tlctall attachment can be attached.Eine I (contact spring (142) for The metal attachment of the cannula is connected to a casting current generator (143). When this is switched on, the knee is connected to the electric current with intense heating the same.

18. Embodiment: In Figure 18, a Peltier element (144) surrounds like a cylinder the cannula connector and the cannula for cooling and can after opening (Fig. 18a) be pushed back over the dosing cylinder.

19. Embodiment: In Figure 19, two liquids for oral use by actuating the valve (145) via a common outlet port emptied, with the amount of fluid being predetermined via a metering piston, while the amount of flushing liquid by the length of time the valve is operated can be changed.

20. Embodiment: Figure 20 shows a bellows instead of a cylinder and piston. FIG. 20 a: The container (145) is shaped in such a way that two medicinal pressure tabs can be accommodated in it, the one fixed to its dosing cylinder (15a) connected by the inlet pipe (146a), while the other first with its inlet pipe (146) with the dosing cylinder (15b) is connected by opening the check valve (25) removal of the cover cap (147). The medicinal product flows into the dosing cylinder After opening the valve (166) by the lever control (148) during the segment (167) movement of the valve ring (149), as for example during the lowering of the container accordingly the telescopic guide of a guide pin (152) in a guide channel of the wall sleeve (180) takes place, which both dosing cylinders surround the transfer of the drug from the inlet tube (146) into the dosing cylinder takes place via elongated troughs in the valve ring, which for both jorzneia outlet tubes provided at various distances from the center of movement are.

The dosing piston (19a, 19b) movement is determined by the length of the strings (125a, 125b), which is limited by a locking mechanism (154a, 154b) along a dosing scale (17) can be set. The string is protected from knots by an elastic wrapping secured, which when the tension is released into a series of symmetrical waves the satites can be arranged along the sleeve wall. The space between the strings on the dosing piston and the opening for the string w ith an elastic Cone (155) sealed, which is fitted into a central cavity of the metering piston when the dosing cylinder has been emptied. The course of the strings between the outlet opening from Cone (155a, 155b) and the tension rollers (156a, 156b) is characterized by a deep groove, see above that the string cannot be pulled along the valve ring when it is turned. A cover plate (160) with a compression spring (158) is fastened over the valve ring. the The metering piston moves backwards when the cylinder is pressurized the spring (124a, 124b) after opening the valve (3O) by pressure from the cannula or in variation A of detail A (Fig.2 (M) by suction of a suction injection device over the Piston ring (161) against the return spring (162). The conclusion of the two dosing cylinders common cannula connection piece takes place via a displaceable neck, whose Gap to the cannula connector is filled by a mass, during the Lid (54) connected to a movable neck by an elastic ring (163) is and only after Rückwei chen the disinfectant with the sleeve movement against the spring (164) pops open and the cannula connector ireigibt.Fdr the mass Mastic drops (lacrimae) in a disinfectant such as lyee Lysol or note up dissolved to the desired consistency; latex is also suitable for admixture. In Detail A, Variation B, the used cannula is not removed, but dipped in until the device is used again in a disinfectant liquid container (165) or in a disinfectant mass to seal the inside of the cannula.

In variation A of detail B (Fig. 20 @) the space between the drug inlet tube (146a, 146b) and Drug inlet opening in the dosing cylinder spanned by a membrane, which. in trough-like Holes of the valve ring is bulged by the drug pressure and the cylinder filling allows while the movable valve disc edge outside of the trough formations Rubber (silicone) membrane presses, read channel formations (170) in the immovable lid (I71) in the bridge disc (i69), which via spring-loaded pins (172) the rotation of the valve ring conveyed, this step back over the strings. In variation B of detail B. common valves gestured over the valve ring, while the valves (166a'166b) omitted.

FIG. 20 e transmits the sketch of a solution with three metering cylinders and three different medicine containers.

FIG. 20 f shows a solution with a medicine container and two metering cylinders.

Figure 20g shows a solution with two medicine containers, each of which two dosing cylinders are assigned to each.

21. Execution example: FIG. 21 shows a modification of the invention for oral use with a dippel flap (valve) function (145) similar to that in Figure 19th

Supplement to Figure 20a: A counting mechanism (168) is via a Pin (167) actuates and acts itself on a warning device according to the setting on a scale (173) on which the number of uses possible with the given dosage can be read, table: Reserved quantity: 50ml insulin (units = dosing units, Number number of possible uses) units number units number 4 500 48 41 8 250 52 38 i2 166 56 35 16 125 60 33 20 100 64 31 24 83 68 29 28 71 72 27 32 62 76 26 36 55 80 25 40 50 84 23 44 85 88 22 Supplement: Figure 4k shows a solution for which the syringe plunger attached to a retaining clip over a medicine pressure bottle is, but the syringe cylinder is actuated up to the adjustable dosing stop of the drug outlet valve is lowered. The resilient bellows lifts the filling nozzle and the filling tube after use.

Claims (110)

PATENT CLAIMS: 1. Facilities for the storage and dosing of medicines for the oral and injection brunch, characterized in that at least one device for variable pre-metering by means of pumps according to piston-cylinder type or bellows with at least partially automatic (through pre-stored or hydraulic or pneumatically or electrically generated (raft-induced) lifting or pushing movement or by means of rotary pumps or electronically controlled + e flow limitation in front of, behind or between at least one drug storage container which exceeds the content of the single dose with rigid or movable or partly rigid and partly movable walls exists in a permanent connection or in connection with it as intended is set, which can also be done with the help of hypodermic syringes or a cannula communicating cavities and by external movement or cavity limitation can be effected when the power source generating or transmitting the drive is disconnected by means of a membrane or devices according to piston or gear type (i.e. via the movement communication moving mechanical parts) or others determined to be used up soon after dosing ) LArznei, - if necessary for peroral use in fixed or detachable connection with a container or a supply line with rinsing liquid or for such namely in front of the drug outlet or in front of an outlet valve, wherein for the Injection use at least one that inhibits the colonization of germs in the arneivore and their biological fitness preserving devices may be available for Completion of the drug outlet opening outside of use by means of a seal including the use of germicidal or inhibiting materials or Additives or via a germicidal or germ-inhibiting substance placed container, sealed to the outside air, around the Arzueiaustrittsöfung or through Form designs in the area of the drug outlet opening that reduce the air ion rate up to and including the exhaust valve or devices for lowering in this area or to see mass displacement (including gas or liquid separation) in the poor range or to increase the adhesion + in this case also with a fixed dose determination of Closure or by devices that are automatic (by pre-stored or hydraulic or pneumatic or electrically generated force) a locking state restore or by thermal manipulation devices, all Also called seat devices, one that is permanently or detachably connected Can include cannula, or that a single dissolution is pre-stored in the container power generating force is present. 2. Devices according to claim 1, characterized in that as a power source at least one pressure storage cylinder is used, 3. Facilities according to claim 1 + 2, characterized in that the medicine container has only one opening or openings pointing to one side, 4. Devices according to claim 1 to 3, characterized in that that the pipe for the drug outlet is firmly connected to the container or a Is part of the container. 5. Devices according to claim 1 to 4, characterized in that The volume replacement for the administered drug takes place within an envelope causes a separation to the drug. 6. Devices according to claim 1 to 5 'characterized in that a pressurized membrane spreads from the bottom of the container. 7. devices according to claim 1 to 6, d @ characterized in that d <iß (the medication pass over I) in a liquid, or a gas or a mixture of liquid and gas a membrane or a body with a piston function is effected. 8. Devices according to claim 1 + 2 + 5, characterized gekennzeiclmet, duss the drive-transmitting power source from the inside or outside of a membrane acts' which spreads along the container wall. 9. Facilities according to Anprusch 1 + 2, characterized in that medicine and gas or liquid space for volume replacement of the used medicament by a Diaphragm or a piston or a structure with a piston function or through a diaphragm and a structure with a piston function is separated. 10. Devices according to claim 1 + 2, characterized in that the The power source generating the drive is a compressor. 11. Devices according to claim 1 + 2, characterized in that the Outlet valve is actuated through the drug outlet opening. 12. Devices according to claim 1 + 2, characterized in that the Connection piece to a syringe or cannula in the drug outlet opening for actuation the outlet valve is moved towards or away from it, 13. Devices according to claim 1 + 2, characterized in that the valve is in front the drug entry into the dosing chamber through the drug outlet opening is operated. 14. Devices according to claim 1 + 2, characterized in that the The valve is actuated by a rotary movement before the drug enters the dosing chamber will. 15. Devices according to claim 1 + 2, characterized in that the area around the drug outlet opening is designed so that a syringe can be used with it or a cannula can be connected directly or via an adapter piece. 16. Devices according to claim 1 + 2, characterized in that between Medicinal outlet opening and syringe or cannula switched on a connector that solid or liquid medicines or substances necessary for their effectiveness for dissolution by the outflowing liquid contains. in a predetermined amount. 17. Devices according to claim i + 2 + i6, characterized in that a fluid vortex over eccentric flow guide the solution solid or favor liquid substances. 18. Devices according to claim 1 + 2 + 16, characterized in that Filter devices favor the solution of solid or the distribution of liquid substances. 19. Devices according to claim 1 + 2, characterized in that durclischeinende Dosing tanks are used. 20. Einricllttrngen according to claim: 1 + 2, characterized in that HOhfi the drug movement for Dusierungtals also the one from dcltl @osier @@@ directly, or indirectly through mediation a spring, via fluid pressure is effected as a transmitting power source. + in the dosing room 21 .. Facilities according to claim 1 + 2, characterized in that the movement from the metering chamber takes place via the drug outlet opening by pre-stored force. 22. Devices according to claim 1 + 2, characterized in that a Dosing container is arranged movably in relation to the drug storage container. 23. Devices according to claim 1 + 2, characterized in that the Arzaeibewsung in the dosing chamber via a valve with an eccentrically arranged valve seat he follows. 24. Devices according to claim 1 + 2 + 23, characterized in that the valve moves the drug into the dosing chamber via a disk or a mechanical one Obstacle at all temporarily prevented, whereby the obstacle via rotation of the dosing container is temporarily influenced by pressure equalization between the drug supply and the dosing chamber overridden. 25th Devices according to claim 1 + 2, characterized in that + u that the Drug outlet opening through a sealing membraneX or a stopper or elastic Cushions (also filled with air or liquid, which can evade) calmed is. 26. Devices according to claim 1 + 2, characterized in that at least @ a safety device within the Medicine bottle neck or the medicine container is located. 27. Devices according to claim 1 + 2, characterized in that the Dosing takes place by means of a hollow body with elastic walls. 28. Devices according to claim 1 + 2, characterized in that the Limitation of the dosing space is set to a single + e size value. 29.Einrichtungen according to claim 1 + 2, characterized in that the Limitation of the dosing space is set to two predeterminable size values or to not predeterminable by the user. on or in a medicine container. 30. Devices according to claim 1 + 2, characterized in that the Has medicine container hexagonal shape. 31. Devices according to claim 1 + 2, characterized in that the Dosing takes place via the limitation of a + piston movement. outside the medication outlet opening. + Syringe 32. Devices according to claim 1 + 2 +31, characterized in that the Dosing via the limitation of a piston movement of a syringe on a fixed one or adjustable obstacle takes place, which verbun firmly with the medicine container or can be connected or through the shape of the medicine container (for example as wall niche) is given. 33. Devices according to claim 1 + 2 +31> characterized in that that the dosage takes place by means of the limitation of a syringe piston movement a device consisting of a clip for the syringe wld a locking bar for dvedas piston ends there is a final cover, fixed or machinable. 34. Devices according to claim 1 + 2 + 3 #, characterized in + 33 that the device for limiting the syringe plunger movement, for actuating the Drug outlet valve resiliently with the holding clamp, or non-resilient with the medicine container can be connected or is connected. 35. Devices according to claim 1 + 2 + 31 to 34, characterized in that that the device for limiting the movement of the syringe plunger is turned around an axis can be to save space or to make the drug outlet opening accessible at least around an axis. 36. Devices according to Claim 1 + 2 + 31 to 35, characterized that several devices for limiting the syringe plunger movement on a medicine container be attached. 37. Devices according to claim 1 + 2 + 31 to 36, characterized in that that the mechanical obstacles to the syringe plunger movement along a dosing scale can be moved or inserted or at least one obstacle. 38. Devices according to claim 1 + 2 +31 to 36, characterized in that that at least one sleeve, which surrounds the syringe barrel, with fixed or adjustable Obstacles to the syringe plunger movement is used. 39. Devices according to claim 1 + 2 + 31 to 38, characterized in that that the valve between the dosing chamber and the drug outlet opening with or without Spring back, actuated by pulling, 40. Devices according to claim 1 + 2 + 31, characterized characterized in that a syringe with a movement-limited plunger rod or with a Device for limiting movement adjustable or not adjustable in or is used on the syringe barrel. 41. Devices according to claim 1 + 2 + 31 + 40, characterized in that that the obstacle to the movement of the piston rod is set (solved) especially for drawing air into the vein. 42. Devices according to claim 1 + 2 + 31, characterized in that the limitation of movement for the syringe plunger within a suction injection device which by suction the iiaut against and through the cannula, d. H. moved along this is done. 43. Devices according to claim 1 + 2 + 3, characterized in that electromagnetic valves are used. 44.Einrichtungen according to claim 1 + 2 + 31, characterized in that the control of the valve in front of the drug outlet opening via a Leitsehranke below Use of electromagnetic or sound waves even in the imperceptible range, such as infrared or ultra-schi1 1 takes place. 45. Devices according to claim 1 + 2 + 31, characterized in that a switching mechanism that responds to vibrations when bumps are hit at a predetermined point between the syringe plunger and cylinder or the surrounding area Outlet valve for the medicament influenced (actuated). 46. Devices according to claim 1 + 2, characterized in that separating Body within a cavity connection (especially in Schlächen + u) the drug supply divide in the same or alternating or increasing or decreasing dosage or from another liquid or from a gas or gas mixture as the transferring Disconnect the power source. 47. Devices according to claim 1 + 2 +, characterized in +46 that there are devices which the drug separating bodies in front of or through remove the drug outlet. 48. Devices according to claim 1 + 2, characterized in that the Medicinal containers can be stored with the medicinal outlet opening facing down. 49. Devices according to claim 1 + 2, characterized in that a Liquid flow or gas flow from the Ärzneiaausstellsöffliung to the outside or is directed over the same. 50. Devices according to claim 1 + 2, characterized in that covers the drug outlet opening in plate or Becijeri'orm via rotation around a vertical or horizontal axis or table shift eliminated via pre-stored + and Force into the closed @@ de Luge @ above the drug outlet opening to be filled back. 51. Devices according to claim 1 + 2 + 5O, characterized in that adhesive or adhesive foils in stacked form in the lid device, the drug outlet opening close. 52.Einrichtungen according to claim 1 + 2 (+50) dadurchnet that the conclusion the drug outlet opening by suction from a special device is strengthened and the + e effect of the air entry into the second supply is reduced 53. Devices according to claim 1 + 2, characterized in that the conclusion of the The drug outlet opening is made by a belt2 that moves past this opening and has openings for the drug outlet or passage of the syringe cone. 54. Devices according to claim 1 + 2, characterized gekennzeicnet + h that at least one band connects in the direction past the drug outlet opening with a tape pressure device moved by mechanical means dirt deposits to remove. 55. Devices according to claim 1 + 2, characterized in that for the closure of the drug outlet opening materials with a metallized surface or metals are used with or without the application of magnetic force for the locking effect. 56. Binding according to claims 1 + 2, characterized in that the Valve to the drug outlet is actuated by a tube probe, which into the interior animal to be dosed syringe is inserted and its piston movement is limited. 57. Devices according to claim 1 + 2 + 12, characterized in that a device for local operation for the outlet valve near the drug iaustri opening is available. 58. Devices according to claim 1 + 2, characterized in that one tubular extension between the dosing chamber or outlet valve and the drug outlet opening is present in a straight or curved shape. 59. Devices according to claim 1 + 2, characterized in that devices are available to make the dosage tangible and audible via baster movements, and via special shape design, also that of an associated holding device a side distinction for at least two medicine containers (if the latter is used) to make it easier to avoid confusion, what by writing or color marking can be reinforced. 60. Einrichtuncen according to claim 1 + 2, characterized in that at least two different medicines from separate medicine containers via a common medicine outlet opening be emptied. 61. Devices according to claim 1 + 2, characterized in that angled + medicine containers can be used individually or via holding devices or special wall devices connected to a block. + angular angular 62. Facilities after Claim 1 + 2 + 49, characterized in that a liquid or gas stream already within the dosing space or in the pipelines connected to it is intended for cleaning. 63. Devices according to claim 1 + 2 + 49 + 62, characterized in that that metering space or with this in connection stchende ducts or he space before the exhaust valve oer all named cavities regularly or repeatedly and be automatically flowed through by liquid or gas via a timer. 64. Devices according to claim 1 + 2, characterized in that the dosing devices are interchangeable or the medicine containers. 65. Devices according to claim 1 + 2 + 62b1s64, characterized in that in which at least two dosing devices with a common cleaning device are connected, whereby these are also the transmitting power source for the drug movement can be. 66. Devices according to claim 1 + 2 + 62 to 64, characterized in that that the cleaning flow through an opening in the lid for the drug outlet opening is derived. 67. Devices according to claim 1 + 2, characterized in that the Design of the space in front of and around the drug outlet opening by closing between the use of a cannula left there, protection from dirt and damage where they are exposed to the action of a gel or a liquid can when sealing the cannula tip, which without any influence can be caused by G @ s oer liquid, but the latter also without sealing. 68. Eiiiriclitungen according to claim 1 + 2 + 62 to 65, characterized in that datt the gas or liquid wedge propulsion through a common drive @ riebserzeugenie Power source takes place. () 9. Devices according to claim 1 + 2, characterized in that a gas or spray or rinsing liquid container connected to a medicine container is or is connected as intended or in an elastic hose or otherwise under pressure shrinking container inside another container Medicinal or rinsing liquid is located either with a common opening with the Medicinal outlet opening or directed against it or an opening in the vicinity of the Medicinal or Rinsing liquid outlet opening or at least temporarily within one sealed common container around the outlet openings. or at least with a common direction of action. 70. Devices according to claim 1 + 2 + 49 + 62 to 65 + 68, characterized in that that a hissing piece to the syringe cone or cannula attachment piece outside the In use, withdrawn behind a seal on the drug outlet opening in the area of influence of a gas or liquid stream. 71. Einrichtuigen according to claim 1 + 2, characterized in that the Openings between the medicine container and the outside air through substances between solid and liquid nature but deformable closed, well germicidal or iienuncn (Ie% additions can occur 72. Facilities after Claim 1 + 2 +49, characterized in that the drug delivery with the outside air the area around the drug outlet opening that comes into contact, be it as a device designed to accommodate a syringe cone or a cannula attachment, outside the box of the use behind a seal under the at least temporary influence of one The purification stream lies, be it gas or liquid, even if the channels are attached remain. 73. Devices according to claim 1 + 2, characterized in that over a transport device can bring solid substances into a cavity, too in the form of tablets or pellets also of different sizes, whichever is intended filled with solvent and emptied by reducing the size of the cavity is provided after the impulse of a mechanical device for mixing can be. 74.Einrichtungen according to claim 1 + 2 +73, characterized in that for the transport of solid materials one + disc, also one with different ones Hole size, is used. + Hole 75. Devices according to claim 1 + 2 + 73, characterized in that that the reduction of the cavity by a piston, the + by the flow of the Solution liquid can be driven + also takes place. 76. Devices according to claim 1 + 2 +75, characterized in that the piston to reduce the cavity s is driven forward by a spring + h will. 77. Devices according to claim 1 + 2, characterized by that det the cannula or the Kaaii Icnorlsutzs Lu tzcn or the filling + a nozzle for the container surrounding the syringe cone, which also with liquid or deformable material with or without + e addition of disinfectants in chemical, physical or spatial connection or in their combination be filled kaml, and before or, in use, is moved in the direction of the medicine container while passing through the cannula or the cannula extension nozzle or the filling nozzle for the syringe collus by a; Seal or lid opening, which is also due to the movement of the container triggered or effected, 78. Devices according to claim 1 + 2 +77, thereby characterized in that at least one device is present around the cannula or the material surrounding the cannula connector or the filler neck, either in any aggregate state between gas and deformable strength, on the mixture to prevent with the drug to be administered, be it by mechanical seal @ode by a suction device (suction device) or by creating cavities in which the material can recede'or by a liquid or gas stream, that also in the space between the outlet valve and the medicament inlet opening can be effective 79. Devices according to claim 1 + 2 + 7 @ characterized in that that the liquid or gas flow to ensure the purity of the drug from one Container is removed, which is connected to the medicine container or as intended is connected. 80. Devices according to claim 1 + 2 +, characterized in that one Valve device immediately behind the valve outlet opening, if necessary There is still room for the introduction of the syringe cone. 81. Devices according to claim 1 + 2, characterized in that a germicidal or germicidal coating is used in the device 'especially in the vicinity of the drug outlet opening. 82. Devices according to claim 1 + 2, characterized in that the Outlet valve for the medicament by negative pressure in a cannula connection piece surrounding it Space or by overpressure from the drug is opened. 83. Devices according to claim 1 + 2 + 78, characterized in that the substances or substance mixtures around the cannula or the cannula connector or the filler neck for the syringe cone becomes more fluid under the influence of movement or pressure become (thixotropy). 84. Devices according to claim 1 + 2, characterized in that at least a container with solid substances or liquid with an ar container with solution or The rinsing liquid is firmly connected. 85. Devices according to claim 1 + 2, characterized in that the Dosing piston moved over a Zugcrorrichtungea, which can consist of a kind of string will. 86. Devices according to claim 1 + 2, characterized in that a Piston 'which can consist, for example, of glass or plastic' the Aznei of the Trees as a transmitting power source, which can also be a bellows. 87. Devices according to claim 1 + 2, characterized in that at least two dosing devices are connected to a common medicine container. 88. facilities according to claim 1 + 2 + 87, characterized in that Dosing devices are arranged in parallel in spatial nuts. 89. Devices according to claim 1 + 2 + 82, characterized in that the suction causing the opening of the outlet valve in the direction of the drug outlet opening is effective 90. Devices according to claim 1 + 2 + 82, characterized in that the suction in the direction of dloie Aj-Zneiaustrittöf, causing the outlet valve to open opening is counteracting. 91. Devices according to claim 1 + 2 + 85, characterized in that Flexible connections to the dosing piston or to delimiting the dosing space at all (for example when using bellows) through a predeterminable change in length of the Dosing + according to a locking device on the flexible connection insertable route or the amount of movement released for the container delimiting the dosing space (for example when using bellows) allow a dosage. cylinder 92. Devices according to claim 1 + 2 + 85 + 91 'characterized by that the flexible connectors on the dosing piston or Dosicrbchiil are attached to the front and in the direction of the nrzllcicrustri Ctsöffung are effective. 93. Devices according to claim 1 + 2 + 85 + 91 + 92, dadurcll gekemizeichnet, that the flexible connecting means on the route between the fasteners on Dosing piston or on the dosing tank and the stop limit of the dosing movement around the fastening edge to the outlet opening from the dosing cylinder or dosing container are covered by an elastic sheath preventing the entry of air or dirt prevented from entering the dosing room 0 94. Devices according to claim 1 + 2, marked thereby, that the drug influence in the dosing cylinder or dosing container from the side of the Medicinal outlet opening or at least in the space between this and the dosing piston or the moving delimitation of the dosing tank takes place. 95. Devices according to claim 1 + 2, characterized in that the Drug influence in the dosing cylinder or dosing container, at least in one, via a rotating device for valve control takes place with several metering cylinders or dosing containers each the different valves one after the other, each only one before use, actuating. 96. Devices according to claim 1 + 2 +95, characterized in that alternates the direction of rotation of the device acting on the valve control. 97. Devices according to claim 1 + 2 + 95 + 96, characterized in that that the valve control of the drug influence within a telescopic guide un an enveloping wall-mounted container. 98. Devices according to claim 1 + 2, + 60 + 84, characterized thereby, that at least one medicine container is exchangeable. 99. Devices according to claim 1 + 2, characterized in that one sealing compound, which can also contain germicidal or germicidal substances, inside of the cannula hub. 100. Devices according to claim 1 + 2 +99, characterized in that that the cannula between use or after use until a new cannula immediately before use + fe with the device as intended remains connected and thereby the tip by immersion in a container / or a Seal, which can also be attached to the lid, and germicidal or inhibitory May contain substances, is sealed as intended. + Cannula- 101. Facilities according to claim 1 + 2 + 99 + 100 ', characterized in that the device for leaving a sealed cannula is present in a device for suction injection. 102.Einrichtungen according to claim 1 + 2, characterized in that the number of possible uses of a supply can be read from a table can. 103. Devices according to claim 1 + 2 + 102, characterized in that that a warning waiver at or before the consumption of the drug supply in activity occurs. 104. Devices according to claim 1 + 2, characterized in that before the zneiaiistrittsöffung a supply line for water or solvent or detergent is available in Verbill (generally with an open or closed or at least partially flexible container for oral use. 105. Devices according to claim 1 + 2, characterized in that the Drug and solution or detergent escape through a common valve device is actuated behind the A1'zneia outlet opening. 106. Devices according to claim 1 + 2 + 105, characterized in that that the drug outlet is operated via a double valve. 107. Devices according to claim 1 + 2 +99, characterized in that that instead of one of the sealing putty in the cannula hub, a tiaterial is more elastic Texture with germicidal or germ-inhibiting properties is used, 108. Devices according to claim 1 + 2 in that the dosing is carried out similarly to claim 32 ff, characterized in that a syringe plunger is held at a fixed spatial distance from a medicine container via a holding device and the dosing is carried out in that the syringe cylinder is moved against a predetermined fixed or variable stop while the outlet valve is or is being opened for the supply of medicines. 109. Devices according to claim 1 + 2, characterized in that for Heat or cold generation at least temporarily in the area of the cannula or the drug outlet opening we are. + that devices 110. Devices according to claim 1 + 2, characterized characterized in that the metering feed is carried out by a bellows or a similar c Device takes place, which or which serve as a drive-transmitting power source. Blank page