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DE20018005U1 - Sandwich PCR DNA microarray - Google Patents

Sandwich PCR DNA microarray

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Publication number
DE20018005U1
DE20018005U1 DE20018005U DE20018005U DE20018005U1 DE 20018005 U1 DE20018005 U1 DE 20018005U1 DE 20018005 U DE20018005 U DE 20018005U DE 20018005 U DE20018005 U DE 20018005U DE 20018005 U1 DE20018005 U1 DE 20018005U1
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Prior art keywords
dna microarray
pcr dna
plates
additionally characterized
microarray according
Prior art date
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Expired - Lifetime
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DE20018005U
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German (de)
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Priority to DE20018005U priority Critical patent/DE20018005U1/en
Publication of DE20018005U1 publication Critical patent/DE20018005U1/en
Priority to PCT/DE2001/001025 priority patent/WO2001081619A2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • B01L3/50851—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates specially adapted for heating or cooling samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/02—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance
    • G01N27/04—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance
    • G01N27/06—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance of a liquid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00436—Maskless processes
    • B01J2219/00441—Maskless processes using lasers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00527—Sheets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00527—Sheets
    • B01J2219/00529—DNA chips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00585—Parallel processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00675—In-situ synthesis on the substrate
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00722—Nucleotides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/143—Quality control, feedback systems
    • B01L2200/147—Employing temperature sensors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0645—Electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0663—Whole sensors
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/14—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Nanotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Composite Materials (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Materials Engineering (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biochemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Electrochemistry (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Description

ABS.: ING BUERO DR A ARNETH; 06172 304900; 22-OKT-OO 16:00; SEITE 15/15ABS.: ING OFFICE DR A ARNETH; 06172 304900; 22-OCT-OO 16:00; PAGE 15/15

Beschreibung:Description: Sandwich-PC R-DNA-Microarrav ;Sandwich PC R-DNA Microarrav ;

In Zukunft wird die Frage nach der Anwesenheit bestimmter Gene bzw. Gensequenzen in weiter Bereichen der Medizin und molekularbiotogischen Wissenschaft eine wichtige Rolle spielen.In the future, the question of the presence of certain genes or gene sequences will play an important role in many areas of medicine and molecular biology.

Zu diesem Zweck wurden vom Anmelder PCR-DNA-Mikroarrays entwickelt, die die schnelle und einfache Bestimmung von Gensequenzen erlauben.For this purpose, the applicant has developed PCR DNA microarrays that allow the rapid and easy determination of gene sequences.

Dieser Erfindung liegt eine mögliche apperative Anordnung zur Herstellung von derartigen DNA-PCR-Mikroarrays zugrunde.This invention is based on a possible apparatus arrangement for the production of such DNA PCR microarrays.

Die Schwierigkeit besteht dabei darin die beiden Primer in exakt dem richtigen Abstand von ca. 500 - 2000 basenpaaren auf der Festphase zu synthetisieren.The difficulty lies in synthesizing the two primers on the solid phase at exactly the right distance of approx. 500 - 2000 base pairs.

Dieser Apparat nutzt die Möglichkeit jeweils nur einen Oligonucleotid-Primer auf jeweils eine Platte zu synthetisieren und die beiden Platten anschließend in den richtigen geometrischen Abstand zueinander zu bringen.This device uses the possibility of synthesizing only one oligonucleotide primer on each plate and then placing the two plates at the correct geometric distance from each other.

So wird die Synthese derartiger PCR-DNA-Microarrays deutlich vereinfacht.This significantly simplifies the synthesis of such PCR DNA microarrays.

Schwierig bleibt die Notwendigkeit beide Platten anschließend in den richtigen Abstand zueinander zu bringen.What remains difficult is the need to then place the two plates at the correct distance from each other.

Dies wird möglich, wenn bereits vor der Synthese entspechend viel Material mittels eines Laserstrahls von der Oberfläche einer oder beider Platten verdampft wird.This becomes possible if a sufficient amount of material is evaporated from the surface of one or both plates using a laser beam before synthesis.

Besonders eignet sich diese Technik in Kombination mit dem Messen der elektrischen Leitfähigkeit zum Verfolgen der Reaktion.This technique is particularly suitable for monitoring the reaction in combination with measuring electrical conductivity.

Auf diese Weise wird es möglich Chips zu entwerfen, die sich für die gleichzeitigeIn this way it will be possible to design chips that are suitable for the simultaneous

molekuarbiologtsche Analyse vieler Gensequenzen eignen. Diese Chips zeichnen sich aus durch eine Architektur bestehend aus den mittels des Laserstrahls definierten Kammern, kleinen Kapillaren zum Befüllen der Kammern sowie aus Mikroelektroden und Leiterbahnen zur Messung der elektrischen Leitfähigkeit in jeder Kammermolecular biological analysis of many gene sequences. These chips are characterized by an architecture consisting of chambers defined by the laser beam, small capillaries for filling the chambers as well as microelectrodes and conductor tracks for measuring the electrical conductivity in each chamber

Datum 22.10.00 15:41 FAXG3 Nr: 32Q62<Uon &Ngr;^&Mgr;^&Igr;&Ogr;-&aacgr;&ogr;&idiagr;«*) föM]6 vo> 15j JDate 10/22/00 3:41 p.m. FAXG3 No.: 32Q62<Uon &Ngr;^&Mgr;^&Igr;&Ogr;-&aacgr;&ogr;&idiagr;«*) föM]6 vo> 1 5 j J

Claims (6)

1. Ein PCR-DNA-Microarray dadurch gekennzeichnet, daß die beiden Oligonucleotid-Primer tragenden Platten einander gegenüberliegend angeordnet sind. 1. A PCR DNA microarray characterized in that the two plates carrying oligonucleotide primers are arranged opposite each other. 2. Ein PCR-DNA-Microarray entspechend Schutzanspruch 1, zusätzlich dadurch gekennzeichnet, daß jede der beiden einander gegenüberliegenden Platten genau einen Oligonucleotid-Primer trägt. 2. A PCR DNA microarray according to claim 1, additionally characterized in that each of the two opposing plates carries exactly one oligonucleotide primer. 3. Ein PCR-DNA-Microarray entsprechend Schutzanspruch 1 oder 2, zusätzlich dadurch gekennzeichnet, daß der Abstand der beiden Oligonucleotid-Primer tragenden Platten genau der Länge des zu bildenden Amplifikats entspricht. 3. A PCR DNA microarray according to claim 1 or 2, additionally characterized in that the distance between the two plates carrying oligonucleotide primers corresponds exactly to the length of the amplificate to be formed. 4. Ein PCR-DNA-Microarrsy entsprechend Schutzanspruch 1, 2 oder 3, zusätzlich dadurch gekennzeichnet, daß der Abstand der beiden oligonucleotidtragenden Platten vor Synthese der Oligonucleotide durch Verdampfung der Oberfläche einer oder beider Platten mittels eines Laserstrahls definiert wird. 4. A PCR DNA microarray according to claim 1, 2 or 3, additionally characterized in that the distance between the two oligonucleotide-bearing plates is defined before synthesis of the oligonucleotides by evaporation of the surface of one or both plates by means of a laser beam. 5. Ein PCR-DNA-Microarray entsprechend Schutzanspruch 1, 2, 3 oder 4, zusätzlich dadurch gekennzeichnet, daß zwischen den beiden Platten die elektrische Leitfähigkeit gemessen wird. 5. A PCR DNA microarray according to claim 1, 2, 3 or 4, additionally characterized in that the electrical conductivity is measured between the two plates. 6. Ein PCR-DNA-Microarray entsprechend Schutzanspruch 1, 2, 3, 4 oder 5, zusätzlich dadurch gekennzeichnet, daß der entstehende Chip eine "Architektur" aus nach Schutzanspruch 4 definierten Kammern, kleinen Kapillaren zum Befüllen der Kammern sowie aus Mikroelektroden und Leiterbahnen zur Messung der elektrischen Leitfähigkeit in jeder Kammer besitzt. 6. A PCR DNA microarray according to claim 1, 2, 3, 4 or 5, additionally characterized in that the resulting chip has an "architecture" of chambers defined according to claim 4, small capillaries for filling the chambers and microelectrodes and conductor tracks for measuring the electrical conductivity in each chamber.
DE20018005U 2000-04-22 2000-10-22 Sandwich PCR DNA microarray Expired - Lifetime DE20018005U1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
DE20018005U DE20018005U1 (en) 2000-10-22 2000-10-22 Sandwich PCR DNA microarray
PCT/DE2001/001025 WO2001081619A2 (en) 2000-04-22 2001-03-17 Conductivity pcr

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE20018005U DE20018005U1 (en) 2000-10-22 2000-10-22 Sandwich PCR DNA microarray

Publications (1)

Publication Number Publication Date
DE20018005U1 true DE20018005U1 (en) 2001-02-22

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DE20018005U Expired - Lifetime DE20018005U1 (en) 2000-04-22 2000-10-22 Sandwich PCR DNA microarray

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004087323A1 (en) * 2003-03-28 2004-10-14 Mergen Ltd. Multi-array systems and methods of use thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004087323A1 (en) * 2003-03-28 2004-10-14 Mergen Ltd. Multi-array systems and methods of use thereof

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