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DE19951360A1 - Substituierte Indole - Google Patents

Substituierte Indole

Info

Publication number
DE19951360A1
DE19951360A1 DE19951360A DE19951360A DE19951360A1 DE 19951360 A1 DE19951360 A1 DE 19951360A1 DE 19951360 A DE19951360 A DE 19951360A DE 19951360 A DE19951360 A DE 19951360A DE 19951360 A1 DE19951360 A1 DE 19951360A1
Authority
DE
Germany
Prior art keywords
formula
unsubstituted
substituted
alkyl
ring members
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19951360A
Other languages
German (de)
English (en)
Inventor
Olaf Ritzeler
Hans Ulrich Stilz
Bernhard Neises
Gerhard Jaehne
Joerg Habermann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis Deutschland GmbH
Original Assignee
Aventis Pharma Deutschland GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Deutschland GmbH filed Critical Aventis Pharma Deutschland GmbH
Priority to DE19951360A priority Critical patent/DE19951360A1/de
Priority to PT00974405T priority patent/PT1261601E/pt
Priority to EEP200200217A priority patent/EE05036B1/et
Priority to DK00974405T priority patent/DK1261601T3/da
Priority to IL14927200A priority patent/IL149272A0/xx
Priority to KR1020027005395A priority patent/KR100795709B1/ko
Priority to ES00974405T priority patent/ES2329871T3/es
Priority to MEP-2008-655A priority patent/ME00434B/me
Priority to CNB008144729A priority patent/CN1172929C/zh
Priority to SI200031041T priority patent/SI1261601T1/sl
Priority to JP2001533128A priority patent/JP3843012B2/ja
Priority to HK03101851.3A priority patent/HK1049671B/xx
Priority to RU2002113651/04A priority patent/RU2255087C2/ru
Priority to AT00974405T priority patent/ATE437867T1/de
Priority to SK543-2002A priority patent/SK287116B6/sk
Priority to CA2389165A priority patent/CA2389165C/en
Priority to HR20020357A priority patent/HRP20020357B1/xx
Priority to AU12728/01A priority patent/AU781553B2/en
Priority to BRPI0015026-6A priority patent/BR0015026B1/pt
Priority to PL354528A priority patent/PL200115B1/pl
Priority to YUP-217/02A priority patent/RS50424B/sr
Priority to DE50015700T priority patent/DE50015700D1/de
Priority to EP00974405A priority patent/EP1261601B1/de
Priority to NZ518587A priority patent/NZ518587A/en
Priority to TR2002/01144T priority patent/TR200201144T2/xx
Priority to MXPA02003998A priority patent/MXPA02003998A/es
Priority to CZ2002-1413A priority patent/CZ304885B6/cs
Priority to PCT/EP2000/010210 priority patent/WO2001030774A1/de
Priority to HU0203228A priority patent/HU229215B1/hu
Publication of DE19951360A1 publication Critical patent/DE19951360A1/de
Priority to NO20021808A priority patent/NO323952B1/no
Priority to IL149272A priority patent/IL149272A/en
Priority to ZA200203204A priority patent/ZA200203204B/en
Priority to US10/263,691 priority patent/US20030119820A1/en
Priority to US10/842,427 priority patent/US20040209868A1/en
Priority to US11/187,396 priority patent/US7342029B2/en
Priority to CY20091101115T priority patent/CY1110521T1/el
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/08—Antibacterial agents for leprosy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • AIDS & HIV (AREA)
  • Biotechnology (AREA)
DE19951360A 1999-10-26 1999-10-26 Substituierte Indole Withdrawn DE19951360A1 (de)

Priority Applications (36)

Application Number Priority Date Filing Date Title
DE19951360A DE19951360A1 (de) 1999-10-26 1999-10-26 Substituierte Indole
AU12728/01A AU781553B2 (en) 1999-10-26 2000-10-17 Substituted indoles for modulating NFkB activity
PL354528A PL200115B1 (pl) 1999-10-26 2000-10-17 Nowe podstawione indole, lek zawierający nowe podstawione indole oraz zastosowanie nowych podstawionych indoli
DK00974405T DK1261601T3 (da) 1999-10-26 2000-10-17 Substituerede indoler til modulering af NFKB-aktivitet
IL14927200A IL149272A0 (en) 1999-10-26 2000-10-17 Substituted indoles for modulating nfkb activity
KR1020027005395A KR100795709B1 (ko) 1999-10-26 2000-10-17 치환된 인돌
DE50015700T DE50015700D1 (de) 1999-10-26 2000-10-17 Substituierte indole zur modulierung von nfkb-aktivität
MEP-2008-655A ME00434B (me) 1999-10-26 2000-10-17 Supstituisani indoli za moduliranje nfkb aktivnosti
CNB008144729A CN1172929C (zh) 1999-10-26 2000-10-17 取代的吲哚
SI200031041T SI1261601T1 (sl) 1999-10-26 2000-10-17 Substituirani indoli za moduliranje NFkB aktivnosti
JP2001533128A JP3843012B2 (ja) 1999-10-26 2000-10-17 ＮＦκＢ活性を調節するための置換インドール
HK03101851.3A HK1049671B (en) 1999-10-26 2000-10-17 Substituted indoles
RU2002113651/04A RU2255087C2 (ru) 1999-10-26 2000-10-17 Замещенные индолы
AT00974405T ATE437867T1 (de) 1999-10-26 2000-10-17 Substituierte indole zur modulierung von nfkb- aktivität
SK543-2002A SK287116B6 (sk) 1999-10-26 2000-10-17 Substituované indoly, spôsob ich prípravy, liečivo, ktoré ich obsahuje, a ich použitie
CA2389165A CA2389165C (en) 1999-10-26 2000-10-17 Substituted indoles for modulating nfkb activity
HR20020357A HRP20020357B1 (hr) 1999-10-26 2000-10-17 SUPSTITUIRANI INDOLI ZA MODULIRANJE AKTIVNOSTI NFkB
PT00974405T PT1261601E (pt) 1999-10-26 2000-10-17 Indoles substituídos para a modulação da actividade do nfκb
BRPI0015026-6A BR0015026B1 (pt) 1999-10-26 2000-10-17 indóis substituìdos para a modulação da atividade de nfkb.
YUP-217/02A RS50424B (sr) 1999-10-26 2000-10-17 Supstituisani indoli za moduliranje nfkb aktivnosti
EEP200200217A EE05036B1 (et) 1999-10-26 2000-10-17 Asendatud indoolid NFkB aktiivsuse moduleerimiseks, nende valmistamismeetod ja kasutamine ning ravim ja selle valmistamismeetod
ES00974405T ES2329871T3 (es) 1999-10-26 2000-10-17 Indoles sustituidos para la modulacion de la actividad de nfkb.
EP00974405A EP1261601B1 (de) 1999-10-26 2000-10-17 Substituierte indole zur modulierung von nfkb-aktivität
NZ518587A NZ518587A (en) 1999-10-26 2000-10-17 Substituted indoles for modulating NFKB activity
TR2002/01144T TR200201144T2 (tr) 1999-10-26 2000-10-17 NFKB aktivitesinin modülasyonu için ikame edilmiş indoller
MXPA02003998A MXPA02003998A (es) 1999-10-26 2000-10-17 Indoles substituidos.
CZ2002-1413A CZ304885B6 (cs) 1999-10-26 2000-10-17 Substituovaný indol, způsob jeho přípravy, farmaceutická kompozice tento indol obsahující, použití tohoto indolu pro přípravu léčiva a způsob výroby tohoto léčiva
PCT/EP2000/010210 WO2001030774A1 (de) 1999-10-26 2000-10-17 Substituierte indole zur modulierung von nfkb-aktivität
HU0203228A HU229215B1 (en) 1999-10-26 2000-10-17 Substituted indoles for modulating nfkb activity
NO20021808A NO323952B1 (no) 1999-10-26 2002-04-17 Substituerte indoler for modulering av NFκB-aktivitet, fremgangsmate for fremstilling, legemiddel omfattende disse, deres anvendelse og en fremgangsmate for fremstilling av et legemiddel.
IL149272A IL149272A (en) 1999-10-26 2002-04-22 Indoles are converted to regulate NFκB activity
ZA200203204A ZA200203204B (en) 1999-10-26 2002-04-23 Substituted indoles for modulating NFKB activity.
US10/263,691 US20030119820A1 (en) 1999-10-26 2002-10-04 Substituted indoles
US10/842,427 US20040209868A1 (en) 1999-10-26 2004-05-11 Substituted indoles
US11/187,396 US7342029B2 (en) 1999-10-26 2005-07-22 Substituted indoles
CY20091101115T CY1110521T1 (el) 1999-10-26 2009-10-26 Υποκατεστημενα ινδολια για τη διαμορφωση της nfkb-ενεργοτητας

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19951360A DE19951360A1 (de) 1999-10-26 1999-10-26 Substituierte Indole

Publications (1)

Publication Number Publication Date
DE19951360A1 true DE19951360A1 (de) 2001-05-03

Family

ID=7926798

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19951360A Withdrawn DE19951360A1 (de) 1999-10-26 1999-10-26 Substituierte Indole
DE50015700T Expired - Lifetime DE50015700D1 (de) 1999-10-26 2000-10-17 Substituierte indole zur modulierung von nfkb-aktivität

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE50015700T Expired - Lifetime DE50015700D1 (de) 1999-10-26 2000-10-17 Substituierte indole zur modulierung von nfkb-aktivität

Country Status (31)

Country Link
US (3) US20030119820A1 (et)
EP (1) EP1261601B1 (et)
JP (1) JP3843012B2 (et)
KR (1) KR100795709B1 (et)
CN (1) CN1172929C (et)
AT (1) ATE437867T1 (et)
AU (1) AU781553B2 (et)
BR (1) BR0015026B1 (et)
CA (1) CA2389165C (et)
CY (1) CY1110521T1 (et)
CZ (1) CZ304885B6 (et)
DE (2) DE19951360A1 (et)
DK (1) DK1261601T3 (et)
EE (1) EE05036B1 (et)
ES (1) ES2329871T3 (et)
HR (1) HRP20020357B1 (et)
HU (1) HU229215B1 (et)
IL (2) IL149272A0 (et)
ME (1) ME00434B (et)
MX (1) MXPA02003998A (et)
NO (1) NO323952B1 (et)
NZ (1) NZ518587A (et)
PL (1) PL200115B1 (et)
PT (1) PT1261601E (et)
RS (1) RS50424B (et)
RU (1) RU2255087C2 (et)
SI (1) SI1261601T1 (et)
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WO2004092167A1 (en) * 2003-04-09 2004-10-28 Millennium Pharmaceuticals, Inc. Beta-carbolines useful for treating inflammatory disease
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