DE19929410A1 - Inhibitoren des Integrins avß6 - Google Patents

Inhibitoren des Integrins avß6

Info

Publication number: DE19929410A1
Authority: DE; Germany
Prior art keywords: asp; leu; arg; ser; thr
Prior art date: 1999-06-26
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

DE19929410A

Other languages

German (de)

English (en)

Inventor

Alfred Jonczyk

Beate Diefenbach

Ulrich Groth

Gunther Zischinsky

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Merck Patent GmbH

Original Assignee

Merck Patent GmbH

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-06-26

Filing date

1999-06-26

Publication date

2000-12-28

1999-06-26 Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH

1999-06-26 Priority to DE19929410A priority Critical patent/DE19929410A1/de

2000-06-13 Priority to CA002377224A priority patent/CA2377224A1/en

2000-06-13 Priority to AU62630/00A priority patent/AU771099B2/en

2000-06-13 Priority to BR0011954-7A priority patent/BR0011954A/pt

2000-06-13 Priority to CZ20014484A priority patent/CZ20014484A3/cs

2000-06-13 Priority to EP00949177A priority patent/EP1189930A1/de

2000-06-13 Priority to MXPA01013247A priority patent/MXPA01013247A/es

2000-06-13 Priority to JP2001507066A priority patent/JP2003503422A/ja

2000-06-13 Priority to KR1020017016580A priority patent/KR20020015704A/ko

2000-06-13 Priority to HU0201729A priority patent/HUP0201729A3/hu

2000-06-13 Priority to CN00809493A priority patent/CN1358195A/zh

2000-06-13 Priority to SK1872-2001A priority patent/SK18722001A3/sk

2000-06-13 Priority to PCT/EP2000/005404 priority patent/WO2001000660A1/de

2000-06-13 Priority to PL00352374A priority patent/PL352374A1/xx

2000-06-23 Priority to ARP000103177A priority patent/AR024472A1/es

2000-12-28 Publication of DE19929410A1 publication Critical patent/DE19929410A1/de

2001-12-21 Priority to NO20016341A priority patent/NO20016341L/no

2002-01-24 Priority to ZA200200673A priority patent/ZA200200673B/en

Status Withdrawn legal-status Critical Current

Links

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239000011976 maleic acid Substances 0.000 description 1
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150000007524 organic acids Chemical class 0.000 description 1
235000005985 organic acids Nutrition 0.000 description 1
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230000003204 osmotic effect Effects 0.000 description 1
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239000002245 particle Substances 0.000 description 1
230000001717 pathogenic effect Effects 0.000 description 1
230000009054 pathological process Effects 0.000 description 1
125000001151 peptidyl group Chemical class 0.000 description 1
COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
COLNVLDHVKWLRT-QMMMGPOBSA-N phenylalanine group Chemical group N[C@@H](CC1=CC=CC=C1)C(=O)O COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 1
UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 description 1
150000008104 phosphatidylethanolamines Chemical class 0.000 description 1
150000003016 phosphoric acids Chemical class 0.000 description 1
230000035790 physiological processes and functions Effects 0.000 description 1
OXNIZHLAWKMVMX-UHFFFAOYSA-N picric acid Chemical class OC1=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C1[N+]([O-])=O OXNIZHLAWKMVMX-UHFFFAOYSA-N 0.000 description 1
239000006187 pill Substances 0.000 description 1
IUGYQRQAERSCNH-UHFFFAOYSA-N pivalic acid Chemical compound CC(C)(C)C(O)=O IUGYQRQAERSCNH-UHFFFAOYSA-N 0.000 description 1
239000013612 plasmid Substances 0.000 description 1
229920002401 polyacrylamide Polymers 0.000 description 1
229920002223 polystyrene Polymers 0.000 description 1
239000011591 potassium Substances 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
230000003389 potentiating effect Effects 0.000 description 1
239000002243 precursor Substances 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
238000007639 printing Methods 0.000 description 1
238000011321 prophylaxis Methods 0.000 description 1
235000019260 propionic acid Nutrition 0.000 description 1
125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 description 1
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
239000012460 protein solution Substances 0.000 description 1
238000004080 punching Methods 0.000 description 1
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
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208000023504 respiratory system disease Diseases 0.000 description 1
208000037803 restenosis Diseases 0.000 description 1
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238000007363 ring formation reaction Methods 0.000 description 1
CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical group C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
238000000926 separation method Methods 0.000 description 1
125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
238000010532 solid phase synthesis reaction Methods 0.000 description 1
239000008347 soybean phospholipid Substances 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
238000010561 standard procedure Methods 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
239000011550 stock solution Substances 0.000 description 1
238000006467 substitution reaction Methods 0.000 description 1
239000000758 substrate Substances 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
IIACRCGMVDHOTQ-UHFFFAOYSA-N sulfamic acid Chemical compound NS(O)(=O)=O IIACRCGMVDHOTQ-UHFFFAOYSA-N 0.000 description 1
125000000542 sulfonic acid group Chemical group 0.000 description 1
150000003460 sulfonic acids Chemical class 0.000 description 1
239000000725 suspension Substances 0.000 description 1
239000006188 syrup Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
229940124597 therapeutic agent Drugs 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
HNKJADCVZUBCPG-UHFFFAOYSA-N thioanisole Chemical compound CSC1=CC=CC=C1 HNKJADCVZUBCPG-UHFFFAOYSA-N 0.000 description 1
125000000341 threoninyl group Chemical group [H]OC([H])(C([H])([H])[H])C([H])(N([H])[H])C(*)=O 0.000 description 1
239000000196 tragacanth Substances 0.000 description 1
235000010487 tragacanth Nutrition 0.000 description 1
229940116362 tragacanth Drugs 0.000 description 1
102000027257 transmembrane receptors Human genes 0.000 description 1
108091008578 transmembrane receptors Proteins 0.000 description 1
229960002622 triacetin Drugs 0.000 description 1
YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1
230000001960 triggered effect Effects 0.000 description 1
238000001665 trituration Methods 0.000 description 1
125000000430 tryptophan group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12 0.000 description 1
210000004881 tumor cell Anatomy 0.000 description 1
OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 1
125000005500 uronium group Chemical group 0.000 description 1
239000004474 valine Substances 0.000 description 1
230000002792 vascular Effects 0.000 description 1
235000015112 vegetable and seed oil Nutrition 0.000 description 1
239000008158 vegetable oil Substances 0.000 description 1
239000013603 viral vector Substances 0.000 description 1
239000011782 vitamin Substances 0.000 description 1
229940088594 vitamin Drugs 0.000 description 1
235000013343 vitamin Nutrition 0.000 description 1
229930003231 vitamin Natural products 0.000 description 1
239000000080 wetting agent Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Physical Education & Sports Medicine (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Rheumatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Orthopedic Medicine & Surgery (AREA)
Diabetes (AREA)
Oncology (AREA)
Neurology (AREA)
Hematology (AREA)
Heart & Thoracic Surgery (AREA)
Pulmonology (AREA)
Dermatology (AREA)
Pain & Pain Management (AREA)
Communicable Diseases (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

DE19929410A 1999-06-26 1999-06-26 Inhibitoren des Integrins avß6 Withdrawn DE19929410A1 (de)

Priority Applications (17)

Application Number	Priority Date	Filing Date	Title
DE19929410A DE19929410A1 (de)	1999-06-26	1999-06-26	Inhibitoren des Integrins avß6
HU0201729A HUP0201729A3 (en)	1999-06-26	2000-06-13	Inhibitors of the integrin alpha v betha 6
CN00809493A CN1358195A (zh)	1999-06-26	2000-06-13	整联蛋白αvβ6抑制剂
BR0011954-7A BR0011954A (pt)	1999-06-26	2000-06-13	Inibidores da integrina alfavbeta6
CZ20014484A CZ20014484A3 (cs)	1999-06-26	2000-06-13	Inhibitory integrinu alfa v beta 6
EP00949177A EP1189930A1 (de)	1999-06-26	2000-06-13	Inhibitoren des integrins alpha v beta 6
MXPA01013247A MXPA01013247A (es)	1999-06-26	2000-06-13	Inhibidores de la integrina alfa-v-beta-6.
JP2001507066A JP2003503422A (ja)	1999-06-26	2000-06-13	インテグリンαｖβ６の阻害剤
KR1020017016580A KR20020015704A (ko)	1999-06-26	2000-06-13	인테그린 α브이β6의 저해제
CA002377224A CA2377224A1 (en)	1999-06-26	2000-06-13	Inhibitors of the integrin .alpha.v.beta.6
AU62630/00A AU771099B2 (en)	1999-06-26	2000-06-13	Inhibitors of the integrin alphavbeta6
SK1872-2001A SK18722001A3 (sk)	1999-06-26	2000-06-13	Inhibítory integrínu ALFAvBETA6
PCT/EP2000/005404 WO2001000660A1 (de)	1999-06-26	2000-06-13	INHIBITOREN DES INTEGRINS αv$(g)b¿6?
PL00352374A PL352374A1 (en)	1999-06-26	2000-06-13	Inhibitors of integrine o v beta 6
ARP000103177A AR024472A1 (es)	1999-06-26	2000-06-23	Inhibidores de la integrina alfav beta6.
NO20016341A NO20016341L (no)	1999-06-26	2001-12-21	Inhibitorer for integrinet <alfa>v<beta>6
ZA200200673A ZA200200673B (en)	1999-06-26	2002-01-24	Inhibitors of the integrin avbeta6.

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19929410A DE19929410A1 (de)	1999-06-26	1999-06-26	Inhibitoren des Integrins avß6

Publications (1)

Publication Number	Publication Date
DE19929410A1 true DE19929410A1 (de)	2000-12-28

Family

ID=7912712

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE19929410A Withdrawn DE19929410A1 (de)	1999-06-26	1999-06-26	Inhibitoren des Integrins avß6

Country Status (17)

Country	Link
EP (1)	EP1189930A1 (no)
JP (1)	JP2003503422A (no)
KR (1)	KR20020015704A (no)
CN (1)	CN1358195A (no)
AR (1)	AR024472A1 (no)
AU (1)	AU771099B2 (no)
BR (1)	BR0011954A (no)
CA (1)	CA2377224A1 (no)
CZ (1)	CZ20014484A3 (no)
DE (1)	DE19929410A1 (no)
HU (1)	HUP0201729A3 (no)
MX (1)	MXPA01013247A (no)
NO (1)	NO20016341L (no)
PL (1)	PL352374A1 (no)
SK (1)	SK18722001A3 (no)
WO (1)	WO2001000660A1 (no)
ZA (1)	ZA200200673B (no)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2004069861A1 (de) *	2003-02-06	2004-08-19	Merck Patent Gmbh	Peptidische sulfonamide

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6972296B2 (en)	1999-05-07	2005-12-06	Encysive Pharmaceuticals Inc.	Carboxylic acid derivatives that inhibit the binding of integrins to their receptors
GB0520068D0 (en) *	2005-10-03	2005-11-09	Cancer Res Technology	av peptide ligand
CN103524619B (zh)	2006-08-03	2016-10-05	阿斯利康(瑞典)有限公司	针对αVβ6的抗体及其应用
IL305158A (en) *	2016-11-01	2023-10-01	Arrowhead Pharmaceuticals Inc	Ligands of alpha-V beta-6 integrin and their uses
EP3703700A4 (en)	2017-11-01	2021-08-04	Arrowhead Pharmaceuticals, Inc.	INTEGRIN LIGANDS AND USES OF THESE LATEST
JP2024516096A (ja)	2021-04-08	2024-04-12	アローヘッドファーマシューティカルズインコーポレイテッド	終末糖化産物受容体の発現を阻害するためのＲＮＡｉ剤、その組成物、及び使用方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2103139A1 (en) *	1991-05-14	1992-11-15	George A. Heavner	Peptide inhibitors of inflammation
EP1504764B1 (en) *	1997-08-08	2008-10-08	The Regents Of The University Of California	Treatment of liver fibrosis with antibodies against alpha V beta 6 integrin
BR9916323A (pt) *	1998-12-19	2001-10-30	Merck Patent Gmbh	Inibidores da integrina alfavbeta6

1999
- 1999-06-26 DE DE19929410A patent/DE19929410A1/de not_active Withdrawn
2000
- 2000-06-13 EP EP00949177A patent/EP1189930A1/de not_active Withdrawn
- 2000-06-13 PL PL00352374A patent/PL352374A1/xx unknown
- 2000-06-13 CN CN00809493A patent/CN1358195A/zh active Pending
- 2000-06-13 KR KR1020017016580A patent/KR20020015704A/ko not_active Withdrawn
- 2000-06-13 BR BR0011954-7A patent/BR0011954A/pt not_active IP Right Cessation
- 2000-06-13 WO PCT/EP2000/005404 patent/WO2001000660A1/de not_active Ceased
- 2000-06-13 SK SK1872-2001A patent/SK18722001A3/sk unknown
- 2000-06-13 MX MXPA01013247A patent/MXPA01013247A/es unknown
- 2000-06-13 JP JP2001507066A patent/JP2003503422A/ja active Pending
- 2000-06-13 HU HU0201729A patent/HUP0201729A3/hu unknown
- 2000-06-13 AU AU62630/00A patent/AU771099B2/en not_active Ceased
- 2000-06-13 CA CA002377224A patent/CA2377224A1/en not_active Abandoned
- 2000-06-13 CZ CZ20014484A patent/CZ20014484A3/cs unknown
- 2000-06-23 AR ARP000103177A patent/AR024472A1/es not_active Application Discontinuation
2001
- 2001-12-21 NO NO20016341A patent/NO20016341L/no not_active Application Discontinuation
2002
- 2002-01-24 ZA ZA200200673A patent/ZA200200673B/en unknown

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2004069861A1 (de) *	2003-02-06	2004-08-19	Merck Patent Gmbh	Peptidische sulfonamide
US7759302B2 (en)	2003-02-06	2010-07-20	Merck Patent Gmbh	Peptidic sulfonamides

Also Published As

Publication number	Publication date
MXPA01013247A (es)	2002-07-02
HUP0201729A3 (en)	2005-01-28
KR20020015704A (ko)	2002-02-28
EP1189930A1 (de)	2002-03-27
NO20016341L (no)	2002-02-25
CA2377224A1 (en)	2001-01-04
HUP0201729A2 (en)	2002-08-28
AU771099B2 (en)	2004-03-11
SK18722001A3 (sk)	2002-05-09
ZA200200673B (en)	2003-04-24
CZ20014484A3 (cs)	2002-04-17
NO20016341D0 (no)	2001-12-21
AU6263000A (en)	2001-01-31
AR024472A1 (es)	2002-10-02
CN1358195A (zh)	2002-07-10
WO2001000660A1 (de)	2001-01-04
JP2003503422A (ja)	2003-01-28
BR0011954A (pt)	2002-05-07
PL352374A1 (en)	2003-08-25

Publication	Publication Date	Title
EP1196433B1 (de)	2006-09-27	CYCLISCHE PEPTIDDERIVATE ALS INHIBITOREN DES INTEGRINS ALPHA v BETA 6
EP0770622B1 (de)	2000-02-02	Cyclische Adhäsionsinhibitoren
EP0683173B1 (de)	1999-08-11	Cyclische Adhäsioninhibitoren
EP0904285B1 (de)	2002-09-18	Cyclische adhäsionsinhibitoren
EP1140989A1 (de)	2001-10-10	Inhibitoren des integrins alpha(v) beta(6)
DE4310632A1 (de)	1994-10-06	Lineare Adhäsionsinhibitoren
DE19929410A1 (de)	2000-12-28	Inhibitoren des Integrins avß6
DE19728524A1 (de)	1999-01-07	Cyclische Azapeptide
EP0655462B1 (de)	1998-05-06	Lineare Adhäsionsinhibitoren
EP0771818B1 (de)	2002-04-03	Biotinderivate
EP1590366B1 (de)	2008-05-07	Peptidische sulfonamide
HUP0104071A2 (hu)	2002-03-28	Az alfavbéta6-integrint gátló vegyületek
HK1047946A (en)	2003-03-14	INHIBITORS OF THE INTEGRIN αVβ6
MXPA01006229A (en)	2002-05-09	&agr;v

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