DE19710368A1 - Use of water-soluble beta-glucans as active ingredients for the production of therapeutic agents for skin treatment - Google Patents
Use of water-soluble beta-glucans as active ingredients for the production of therapeutic agents for skin treatmentInfo
- Publication number
- DE19710368A1 DE19710368A1 DE1997110368 DE19710368A DE19710368A1 DE 19710368 A1 DE19710368 A1 DE 19710368A1 DE 1997110368 DE1997110368 DE 1997110368 DE 19710368 A DE19710368 A DE 19710368A DE 19710368 A1 DE19710368 A1 DE 19710368A1
- Authority
- DE
- Germany
- Prior art keywords
- glucans
- water
- soluble
- agents
- active ingredients
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Birds (AREA)
- Cosmetics (AREA)
Abstract
Description
Die Erfindung betrifft die Verwendung von wasserlöslichen β-Glucanen als Wirkstoffe zur Bekämpfung der Faltenbildung in der Haut sowie von Hauterkrankungen wie beispielsweise Schuppenflechte, Psoriasis oder UV-Erythemen.The invention relates to the use of water-soluble β-glucans as active substances for combating the formation of wrinkles in the skin and skin diseases such as psoriasis, Psoriasis or UV erythema.
Die altersbedingte Faltenbildung wird durch den Abbau von verschiedenen Makromolekülen wie beispielsweise Elastin und Kollagen hervorgerufen, für den Elastasen im Stratum comeum verant wortlich sind. Auch eine Vielzahl von entzündlichen Hauterkrankungen, wie beispielsweise Schuppen flechte oder UV-Erytheme, lassen sich ursächlich mit einer erhöhten Elastasekonzentration in den obe ren Hautschichten in Verbindung bringen [vgl. R. Voegeli et al. in Cosm. Toil 111, 51 (1996)].Age-related wrinkling is caused by the breakdown of various macromolecules such as For example, elastin and collagen caused for the elastases in the stratum comeum verant are literal. Also a variety of inflammatory skin diseases, such as dandruff Lichen or UV erythema can be caused by an increased concentration of elastase in the upper part connect layers of skin [cf. R. Voegeli et al. in cosm. Toil 111, 51 (1996)].
Der Faltenbildung in der Haut wird in der Regel nicht durch physiologisch wirksame Prinzipien, sondern durch kosmetische Mittel entgegengewirkt. Viele sogenannte "Antiaging Produkte" enthalten mit Wasser oder wäßrigen Wirkstoffen beladene Liposomen, die durch die Fettschicht der Haut in die Epidermis gelangen, sich dort allmählich auflösen und durch die kontinuierliche Wasserabgabe die Hautvertiefungen füllen und den Feuchtigkeitsgehalt der Haut regulieren. Dieser Effekt stellt jedoch keine Bekämpfung der Ursachen dar, sondern hat lediglich einen sogenannten "repair effect", der zudem nur über eine kurze Zeit andauert.The formation of wrinkles in the skin is usually not due to physiologically effective principles, but rather counteracted by cosmetic means. Many so-called "antiaging products" contain Water or aqueous active substances loaded liposomes, which through the fatty layer of the skin in the Epidermis get there, gradually dissolve there and through the continuous release of water Fill skin depressions and regulate the moisture content of the skin. However, this effect poses is not a fight against the causes, but only has a so-called "repair effect", the also only lasts for a short time.
Im Gegensatz zu dieser rein kosmetischen Anwendung dienen der Bekämpfung der Schuppenflechte beispielsweise cytostatische Wirkstoffe, wie etwa Selensulfid, Cadmiumsulfid, Zinkpyrithione oder Corti costeroide, deren medizinische Wirkung z. B. auf einer Reduzierung der Mitoseaktivität in der Basal membran beruht. Wegen der bekannten Nebenwirkungen sollten diese Stoffe jedoch nicht über längere Zeiträume eingesetzt werden. Weiterhin läßt sich die Schuppenflechte durch antiseptische Wirkstoffe, wie beispielsweise Selenoxid, Salicylsäure, Pyrithiondervivate, Hexachlorophen oder quartäre Ammo niumverbindungen bzw. durch zellösende und entfettende Wirkstoffe wie beispielsweise Benzoyl peroxid oder Teerextrakte lindern, jedoch nicht heilen.In contrast to this purely cosmetic application, psoriasis is combated for example cytostatic active ingredients, such as selenium sulfide, cadmium sulfide, zinc pyrithione or corti costeroids, the medical effects of which B. on a reduction in mitotic activity in the basal membrane based. However, because of the known side effects, these substances should not last longer Periods are used. Furthermore, psoriasis can be reduced by antiseptic agents, such as selenium oxide, salicylic acid, pyrithione derivatives, hexachlorophene or quaternary ammo nium compounds or by cell-dissolving and degreasing agents such as benzoyl Alleviate peroxide or tar extracts, but do not cure them.
Auch die Verwendung von speziellen Polysacchariden als Mittel gegen die Hautalterung ist aus dem Stand der Technik bekannt. So wird beispielsweise in der Patentschrift US 5,223,491 vorgeschlagen, ein carboxymethyliertes β-1,3-Glucan, das aus dem Hefepilz Saccharomyces cerevisiae extrahiert wur de, für die topische Anwendung einzusetzen. Das Glucan ist jedoch wasserunlöslich und kann daher nur mit großen Schwierigkeiten formuliert werden.The use of special polysaccharides as an anti-aging agent is also out of the question State of the art known. For example, US Pat. No. 5,223,491 proposes a carboxymethylated β-1,3-glucan extracted from the yeast Saccharomyces cerevisiae de to use for topical application. However, the glucan is water-insoluble and can therefore can only be formulated with great difficulty.
Aus der deutschen Offenlegungsschrift DE-OS 26 04 481 (Ajinomoto) ist der Einsatz von glucanhaltigen Präparaten als Antitumormittel bekannt. In der europäischen Patentanmeldung EP-A1 0463540 (Taito) wird über den Einsatz von Glucanen gegen Viren berichtet. Gemäß der Lehre der beiden Druck schriften DE-A1 37 44 345 (Lomapharm) und EP-B1 0175667 (Larm) eignen sich Glucane zur Stimu lation der Makrophagenaktivität. Die pharmazeutische Wirkung verschiedener Glucane ist des weiteren aus den beiden europäischen Patentanmeldungen EP-A1 0045338 (Debat) und EP-A1 0561408 (Ka ken) bekannt. Lösliche phosphorylierte Glucane sind schließlich Gegenstand der europäischen Patent schrift EP-B1 0232405 (Tulane Educational Fund).From the German published application DE-OS 26 04 481 (Ajinomoto) the use of glucan is Preparations known as anti-tumor agents. In European patent application EP-A1 0463540 (Taito) reports on the use of glucans against viruses. According to the teaching of the two pressure Writings DE-A1 37 44 345 (Lomapharm) and EP-B1 0175667 (Larm) are suitable for stimulating glucans macrophage activity. The pharmaceutical effect of various glucans is further from the two European patent applications EP-A1 0045338 (Debat) and EP-A1 0561408 (Ka ken) known. Soluble phosphorylated glucans are the subject of the European patent publication EP-B1 0232405 (Tulane Educational Fund).
Aus dem Stand der Technik sind also für die Glättung der Haut und die Stärkung der Barrierefunktion, sei es aus kosmetischer oder medizinischer Sicht, sehr unterschiedliche Lösungen bekannt, die jeweils aber nur eine Teilaufgabe lösen und zudem noch mit starken Nebenwirkungen verbunden sein können. Die komplexe Aufgabe der Erfindung hat demnach darin bestanden, Wirkstoffe zur Verfügung zu stel len, die gleichzeitig gegen die Faltenbildung in der Haut (kosmetische Wirkung) und Hauterkrankungen (medizinische Wirkung) eingesetzt werden können und dabei eine hohe dermatologische und toxikolo gische Verträglichkeit besitzen.From the prior art, for smoothing the skin and strengthening the barrier function, be it from a cosmetic or medical point of view, very different solutions known, each but only solve a subtask and can also be associated with strong side effects. The complex object of the invention was therefore to provide active ingredients len, at the same time against wrinkling in the skin (cosmetic effect) and skin diseases (medical effect) can be used and a high dermatological and toxicolo have compatibility.
Gegenstand der Erfindung ist die Verwendung von wasserlöslichen β-Glucanen als Wirkstoffe zur Herstellung von therapeutischen Mitteln zur Hautbehandlung, insbesondere zur Herstellung von Mitteln, die gleichzeitig der Hautalterung und Faltenbildung sowie Erythemen entgegenwirken. Durch einen signifikanten Beitrag zum UV-Schutz eignen sich die β-Glucane vor allem auch für den Einsatz in Sonnenschutzmitteln.The invention relates to the use of water-soluble β-glucans as active ingredients for Production of therapeutic agents for skin treatment, in particular for the production of agents, which counteract skin aging and wrinkling as well as erythema. Through a The β-glucans are particularly suitable for use in UV protection Sunscreens.
Überraschenderweise wurde gefunden, daß wasserlösliche β-Glucane, vorzugsweise solche, die durch Extraktion von Basidiomyceten und/oder Ascomyceten erhalten werden, in den Langerhans-Zellen der tieferen Hautschichten eine Immunmodulation hervorrufen, durch die spezielle Cytokine produziert werden. β-Glucane sind zudem toxikologisch unbedenklich.Surprisingly, it has been found that water-soluble β-glucans, preferably those which are by Extraction of Basidiomycetes and / or Ascomycetes can be obtained in the Langerhans cells cause deeper skin layers to have an immune modulation that produces special cytokines will. β-glucans are also toxicologically safe.
Unter der Bezeichnung Glucane werden Homopolysaccharide auf Basis der Glucose verstanden. Je nach sterischer Verknüpfung unterscheidet man zwischen β-1,3-, β-1,4- und β-1,6-Glucanen. β-1,3- Glucane weisen meist eine helicale Struktur auf, während Glucane mit einer 1,4-Verknüpfung im allgemeinen eine lineare Struktur besitzen. Die β-Glucane der Erfindung lassen sich beispielsweise durch Extraktion höherer Pilze, wie beispielsweise den Basidiomyceten Schizophyllum Commune oder Conolosus versicolor oder durch Extraktion von Schlauchpilzen, wie z. B. Ascomyceten vom Typ Sclero ticum glucanium herstellen. In diesen Fällen werden technische Gemische von unsubstituierten β-1,3-, β-14, und β-1,6-Glucanen erhalten, die über eine ausgezeichnete Wasserlöslichkeit verfügen. Typische Beispiele für geeignete wasserlösliche β-Glucangemische sind Schizophyllan (I) und Krestin (II).The term glucans is understood to mean homopolysaccharides based on glucose. Each After steric linkage, a distinction is made between β-1,3-, β-1,4- and β-1,6-glucans. β-1,3- Glucans usually have a helical structure, while glucans with a 1,4-linkage in the generally have a linear structure. The β-glucans of the invention can be, for example by extracting higher fungi, such as the Basidiomycetes Schizophyllum Commune or Conolosus versicolor or by extraction of tubular mushrooms, such as. B. Ascomycetes of the Sclero type Make ticum glucanium. In these cases, technical mixtures of unsubstituted β-1,3-, β-14, and β-1,6-glucans, which have excellent water solubility. Typical Examples of suitable water-soluble β-glucan mixtures are schizophyllan (I) and krestin (II).
Besonders bevorzugt ist der Einsatz von β-Glucanen bzw. deren technischen Gemischen, die einen Anteil von mindestens 50, vorzugsweise 60 bis 100 und insbesondere 70 bis 90 Gew.-% einer β-1,3- Grundstruktur aufweisen. Weiterhin vorteilhaft ist, wenn die Glucane eine Tripelhelix-Feinstruktur und Molekulargewichte im Bereich oberhalb von 50.000, vorzugsweise 100.000 bis 1.000.000 Dalton besitzen. Weiterhin vorteilhaft kann es sein, wenn man Glucane einsetzt die am C-6 eine Verzwei gung, vorzugsweise mit einem weiteren Saccharid wie beispielsweise Glucose, Arabinose oder Xylose aufweisen.The use of β-glucans or their technical mixtures is particularly preferred Proportion of at least 50, preferably 60 to 100 and in particular 70 to 90% by weight of a β-1,3- Have basic structure. It is also advantageous if the glucans have a triple helix fine structure and Molecular weights in the range above 50,000, preferably 100,000 to 1,000,000 daltons have. It can also be advantageous if glucans are used which have a branch on the C-6 tion, preferably with another saccharide such as glucose, arabinose or xylose exhibit.
Die Extraktion der Pilze kann in an sich bekannter Weise nach den Verfahren des Stands der Technik erfolgen und verlangt vom Fachmann nicht erfinderisch tätig zu werden, zumal beispielsweise Extrakte auf Basis verschiedener Hefepilze unter der Bezeichnung "CM-Glucan" im Handel erhältlich sind. Üb licherweise werden die Extrakte als wäßrige oder wäßrig-alkoholische Lösungen mit einem Aktivsub stanzgehalt im Bereich von 0,1 bis 5, vorzugsweise 0,5 bis 3 eingesetzt.The extraction of the mushrooms can be carried out in a manner known per se according to the methods of the prior art take place and requires the person skilled in the art not to be inventive, especially since extracts, for example based on various yeasts are commercially available under the name "CM-Glucan". Practice Licher are the extracts as aqueous or aqueous-alcoholic solutions with an active ingredient Punch content in the range of 0.1 to 5, preferably 0.5 to 3 used.
Im Sinne der Erfindung können die wasserlöslichen β-Glucane als Wirkstoffe zur Herstellung von kosmetischen und/oder pharmazeutischen Zubereitungen eingesetzt werden. Typische Beispiele für solche Mittel sind Hautpflegemittel wie beispielsweise Antifaltencremes, Anticellulitiscremes oder Sonnenschutzlotionen sowie Salben zur Behandlung von Hauterkrankungen wie beispielsweise Cradle Cap, Schuppenflechte, Seborrhoische Dermatitis, Seborrhoe Sicca, Seborrhoe Oleosa, Psoriasis vulgaris, Ichtyosen oder UV-Erythemen. Üblicherweise können die wasserlöslichen β-Glucane in Mengen von 0,0001 bis 5, vorzugsweise 0,001 bis 1 und insbesondere 0,01 bis 0,1 Gew.-% - bezogen auf die Mittel - eingesetzt werden.For the purposes of the invention, the water-soluble β-glucans can be used as active ingredients for the production of cosmetic and / or pharmaceutical preparations are used. Typical examples of such agents are skin care agents such as anti-wrinkle creams, anti-cellulite creams or Sun protection lotions and ointments for the treatment of skin diseases such as cradle Cap, psoriasis, seborrheic dermatitis, seborrhea sicca, seborrhea oleosa, psoriasis vulgaris, ichthyoses or UV erythema. Usually the water-soluble β-glucans in Amounts of 0.0001 to 5, preferably 0.001 to 1 and in particular 0.01 to 0.1 wt .-% - based on the means - be used.
Die Zubereitungen können in untergeordneten Mengen mit den anderen Inhaltsstoffen kompatible anionische, nichtionische, kationische und/oder amphotere bzw. zwitterionische Tenside enthalten. Typische Beispiele für anionische Tenside sind Seifen, Alkylbenzolsulfonate, Alkansulfonate, Olefinsulfonate, Alkylethersulfonate, Glycerinethersulfonate, α-Methykestersulfonate, Sulfofettsäuren, Alkylsulfate, Fettalkoholethersulfate, Glycerinethersulfate, Hydroxymischethersulfate, Monoglycerid- (ether)sulfate, Fettsäureamid(ether)sulfate, Mono- und Dialkylsulfosuccinate, Mono- und Dialkylsulfo succinamate, Sulfotriglyceride, Amidseifen, Ethercarbonsäuren und deren Salze, Fettsäureisethionate, Fettsäuresarcosinate, Fettsäuretauride, N-Acylaminosäuren wie beispielsweise Acyllactylate, Acyl tartrate, Acylglutamate und Acylaspartate, Alkyloligoglucosidsulfate, Proteinfettsäurekondensate (insbe sondere pflanzliche Produkte auf Weizenbasis) und Alkyl(ether)phosphate. Sofern die anionischen Tenside Polyglycoletherketten enthalten, können diese eine konventionelle, vorzugsweise jedoch eine eingeengte Homologenverteilung aufweisen. Typische Beispiele für nichtionische Tenside sind Fett alkoholpolyglycolether, Alkylphenolpolyglycolether, Fettsäurepolyglycolester, Fettsäureamidpolyglycol ether, Fettaminpolyglycolether, alkoxylierte Triglycende, Mischether bzw. Mischformale, Alk(en)yloligo glykoside, Fettsäure-N-alkylglucamide, Proteinhydrolysate (insbesondere pflanzliche Produkte auf Wei zenbasis), Polyolfettsäureester, Zuckerester, Sorbitanester, Polysorbate und Aminoxide. Sofern die nichtionischen Tenside Polyglycoletherketten enthalten, können diese eine konventionelle, vorzugs weise jedoch eine eingeengte Homologenverteilung aufweisen. Typische Beispiele für kationische Tenside sind quartäre Ammoniumverbindungen und Esterquats, insbesondere quaternierte Fettsäu retrialkanolaminestersalze. Typische Beispiele für amphotere bzw. zwitterionische Tenside sind Alkylbetaine, Alkylamidobetaine, Aminopropionate, Aminoglycinate, Imidazoliniumbetaine und Sulfo betaine. Bei den genannten Tensiden handelt es sich ausschließlich um bekannte Verbindungen. Hin sichtlich Struktur und Herstellung dieser Stoffe sei auf einschlägige Übersichtsarbeiten beispielsweise J. Falbe (ed.), "Surfactants in Consumer Products", Springer Verlag, Berlin, 1987, S. 54-124 oder J. Falbe (ed.), "Katalysatoren, Tenside und Mineralöladditive", Thieme Verlag, Stuttgart, 1978, S. 123-217 verwiesen.The preparations can be compatible with the other ingredients in minor amounts contain anionic, nonionic, cationic and / or amphoteric or zwitterionic surfactants. Typical examples of anionic surfactants are soaps, alkylbenzenesulfonates, alkanesulfonates, Olefin sulfonates, alkyl ether sulfonates, glycerol ether sulfonates, α-methyl ester sulfonates, sulfo fatty acids, Alkyl sulfates, fatty alcohol ether sulfates, glycerol ether sulfates, hydroxy mixed ether sulfates, monoglyceride (ether) sulfates, fatty acid amide (ether) sulfates, mono- and dialkyl sulfosuccinates, mono- and dialkyl sulfo succinamates, sulfotriglycerides, amide soaps, ether carboxylic acids and their salts, fatty acid isethionates, Fatty acid sarcosinates, fatty acid taurides, N-acylamino acids such as acyl lactylates, acyl tartrate, acyl glutamate and acyl aspartate, alkyl oligoglucoside sulfate, protein fatty acid condensate (esp special vegetable products based on wheat) and alkyl (ether) phosphates. Unless the anionic If surfactants contain polyglycol ether chains, these can be conventional, but preferably one have narrow homolog distribution. Typical examples of nonionic surfactants are fat alcohol polyglycol ether, alkylphenol polyglycol ether, fatty acid polyglycol ester, fatty acid amide polyglycol ether, fatty amine polyglycol ether, alkoxylated triglycene, mixed ethers or mixed formals, alk (en) yloligo glycosides, fatty acid-N-alkylglucamides, protein hydrolyzates (especially vegetable products on Wei zen basis), polyol fatty acid esters, sugar esters, sorbitan esters, polysorbates and amine oxides. If the nonionic surfactants containing polyglycol ether chains, these can be a conventional, preferred however, have a narrow homolog distribution. Typical examples of cationic Surfactants are quaternary ammonium compounds and ester quats, especially quaternized fatty acids retrialkanolamine ester salts. Typical examples of amphoteric or zwitterionic surfactants are Alkyl betaines, alkyl amido betaines, aminopropionates, aminoglycinates, imidazolinium betaines and sulfo betaine. The surfactants mentioned are exclusively known compounds. There Visible structure and production of these substances is for example on relevant reviews J. Falbe (ed.), "Surfactants in Consumer Products", Springer Verlag, Berlin, 1987, pp. 54-124 or J. Falbe (ed.), "Catalysts, surfactants and mineral oil additives", Thieme Verlag, Stuttgart, 1978, p. 123-217.
Ferner können die Mittel als weitere Hilfs- und Zusatzstoffe Ölkörper, Emulgatoren, Überfettungsmittel, Stabilisatoren, Wachse, Konsistenzgeber, Verdickungsmittel, Kationpolymere, Siliconverbindungen, biogene Wirkstoffe, Antischuppenmittel, Filmbildner, Konservierungsmittel, Hydrotrope, Solubilisatoren, UV-Lichtschutzfilter, Farb- und Duftstoffe enthalten.Furthermore, the agents can be used as further auxiliaries and additives, oil bodies, emulsifiers, superfatting agents, Stabilizers, waxes, consistency agents, thickeners, cation polymers, silicone compounds, biogenic agents, antidandruff agents, film formers, preservatives, hydrotropes, solubilizers, UV light protection filters, dyes and fragrances included.
Als Ölkörper kommen beispielsweise Guerbetalkohole auf Basis von Fettalkoholen mit 6 bis 18, vorzugsweise 8 bis 10 Kohlenstoffatomen, Ester von linearen C6-C20Fettsäuren mit linearen C6-C20- Fettalkoholen, Ester von verzweigten C6-C13-Carbonsäuren mit linearen C6-C20-Fettalkoholen, Ester von linearen C6-C18-Fettsäuren mit verzweigten Alkoholen, insbesondere 2-Ethylhexanol, Ester von linearen und/oder verzweigten Fettsäuren mit mehrwertigen Alkoholen (wie z. B. Dimerdiol oder Trimertriol) und/oder Guerbetalkoholen, Triglyceride auf Basis C6-C10Fettsäuren, pflanzliche Öle, ver zweigte primäre Alkohole, substituierte Cyclo-hexane, Guerbetcarbonate, Dialkylether, Siliconöle und/oder aliphatische bzw. naphthenische Kohlenwasserstoffe in Betracht.Guerbet alcohols based on fatty alcohols with 6 to 18, preferably 8 to 10 carbon atoms, esters of linear C 6 -C 20 fatty acids with linear C 6 -C 20 fatty alcohols, esters of branched C 6 -C 13 carboxylic acids are used as oil bodies, for example linear C 6 -C 20 fatty alcohols, esters of linear C 6 -C 18 fatty acids with branched alcohols, in particular 2-ethylhexanol, esters of linear and / or branched fatty acids with polyhydric alcohols (such as dimer diol or trimer triol) and / or Guerbet alcohols, triglycerides based on C 6 -C 10 fatty acids, vegetable oils, branched primary alcohols, substituted cyclo-hexanes, Guerbet carbonates, dialkyl ethers, silicone oils and / or aliphatic or naphthenic hydrocarbons.
Als Emulgatoren kommen beispielsweise nichtionogene Tenside aus mindestens einer der folgenden
Gruppen in Frage:
Examples of suitable emulsifiers are nonionic surfactants from at least one of the following groups:
- (1) Anlagerungsprodukte von 2 bis 30 Mol Ethylenoxid und/oder 0 bis 5 Mol Propylenoxid an lineare Fettalkohole mit 8 bis 22 C-Atomen, an Fettsäuren mit 12 bis 22 C-Atomen und an Alkylphenole mit 8 bis 15 C-Atomen in der Alkylgruppe;(1) Addition products of 2 to 30 moles of ethylene oxide and / or 0 to 5 moles of propylene oxide with linear Fatty alcohols with 8 to 22 carbon atoms, on fatty acids with 12 to 22 carbon atoms and on alkylphenols with 8 to 15 carbon atoms in the alkyl group;
- (2) C12/18-Fettsäuremono- und -diester von Anlagerungsprodukten von 1 bis 30 Mol Ethylenoxid an Glycerin;(2) C 12/18 fatty acid monoesters and diesters of adducts of 1 to 30 moles of ethylene oxide with glycerol;
- (3) Glycerinmono- und -diester und Sorbitanmono- und -diester von gesättigten und ungesättigten Fettsäuren mit 6 bis 22 Kohlenstoffatomen und deren Ethylenoxid-anlagerungsprodukte;(3) glycerol monoesters and diesters and sorbitan monoesters and diesters of saturated and unsaturated Fatty acids with 6 to 22 carbon atoms and their ethylene oxide addition products;
- (4) Alkylmono- und -oligoglycoside mit 8 bis 22 Kohlenstoffatomen im Alkylrest und deren ethoxy lierte Analoga; (4) Alkyl mono- and oligoglycosides with 8 to 22 carbon atoms in the alkyl radical and their ethoxy analogs;
- (5) Anlagerungsprodukte von 15 bis 60 Mol Ethylenoxid an Ricinusöl und/oder gehärtetes Ricinusöl;(5) adducts of 15 to 60 moles of ethylene oxide with castor oil and / or hardened castor oil;
- (6) Polyol- und insbesondere Polyglycerinester wie z. B. Polyglycerinpolyricinoleat oder Polyglycerinpoly-12-hydroxystearat. Ebenfalls geeignet sind Gemische von Verbindungen aus mehreren dieser Substanzklassen;(6) polyol and especially polyglycerol esters such. B. polyglycerol polyricinoleate or Polyglycerol poly-12-hydroxystearate. Mixtures of compounds are also suitable several of these classes of substances;
- (7) Anlagerungsprodukte von 2 bis 15 Mol Ethylenoxid an Ricinusöl und/oder gehärtetes Ricinusöl;(7) adducts of 2 to 15 moles of ethylene oxide with castor oil and / or hardened castor oil;
- (8) Partialester auf Basis linearer, verzweigter, ungesättigter bzw. gesättigter C12/22-Fettsäuren, Ricinolsäure sowie 12-Hydroxystearinsäure und Glycerin, Polyglycerin, Pentaerythrit, Dipenta erythrit, Zuckeralkohole (z. B. Sorbit) sowie Polyglucoside (z. B. Cellulose);(8) Partial esters based on linear, branched, unsaturated or saturated C 12/22 fatty acids, ricinoleic acid and 12-hydroxystearic acid and glycerol, polyglycerol, pentaerythritol, dipentaerythritol, sugar alcohols (e.g. sorbitol) and polyglucosides (e.g. Cellulose);
- (9) Trialkylphosphate;(9) trialkyl phosphates;
- (10) Wollwachsalkohole;(10) wool wax alcohols;
- (11) Polysiloxan-Polyalkyl-Polyether-Copolymere bzw. entsprechende Derivate;(11) polysiloxane-polyalkyl-polyether copolymers or corresponding derivatives;
- (12) Mischester aus Pentaerythrit, Fettsäuren, Citronensäure und Fettalkohol gemäß DE-PS 11 65 574 sowie(12) Mixed esters of pentaerythritol, fatty acids, citric acid and fatty alcohol according to DE-PS 11 65 574 such as
- (13) Polyalkylenglycole.(13) Polyalkylene glycols.
Die Anlagerungsprodukte von Ethylenoxid und/oder von Propylenoxid an Fettalkohole, Fettsäuren, Alkylphenole, Glycerinmono- und -diester sowie Sorbitanmono- und -diester von Fettsäuren oder an Ricinusöl stellen bekannte, im Handel erhältliche Produkte dar. Es handelt sich dabei um Homologengemische, deren mittlerer Alkoxylierungsgrad dem Verhältnis der Stoffmengen von Ethylen oxid und/oder Propylenoxid und Substrat, mit denen die Anlagerungsreaktion durchgeführt wird, entspricht. C12/18-Fettsäuremono- und -diester von Anlagerungsprodukten von Ethylenoxid an Glycerin sind aus DE-PS 20 24 051 als Rückfettungsmittel für kosmetische Zubereitungen bekannt.The adducts of ethylene oxide and / or of propylene oxide with fatty alcohols, fatty acids, alkylphenols, glycerol mono- and diesters and sorbitan mono- and diesters of fatty acids or with castor oil are known, commercially available products. These are mixtures of homologs, the middle of which Degree of alkoxylation corresponds to the ratio of the amounts of ethylene oxide and / or propylene oxide and substrate with which the addition reaction is carried out. C 12/18 fatty acid monoesters and diesters of adducts of ethylene oxide with glycerol are known from DE-PS 20 24 051 as refatting agents for cosmetic preparations.
C8/18-Alkylmono- und oligoglycoside, ihre Herstellung und ihre Verwendung als oberflächenaktive Stoffe sind beispielsweise aus US 3,839,318, US 3,707,535, US 3,547,828, DE-OS 19 43 689, DE-OS 20 36 472 und DE-A1 30 01 064 sowie EP-A 0077167 bekannt. Ihre Herstellung erfolgt insbesondere durch Umsetzung von Glucose oder Oligosacchariden mit primären Alkoholen mit 8 bis 18 C-Atomen. Bezüglich des Glycosidrestes gilt, daß sowohl Monoglycoside, bei denen ein cyclischer Zuckerrest glycosidisch an den Fettalkohol gebunden ist, als auch oligomere Glycoside mit einem Oligomerisa tionsgrad bis vorzugsweise etwa 8 geeignet sind. Der Oligomerisierungsgrad ist dabei ein statistischer Mittelwert, dem eine für solche technischen Produkte übliche Homologenverteilung zugrunde liegt.C 8/18 alkyl mono- and oligoglycosides, their preparation and their use as surface-active substances are, for example, from US 3,839,318, US 3,707,535, US 3,547,828, DE-OS 19 43 689, DE-OS 20 36 472 and DE-A1 30 01 064 and EP-A 0077167 known. They are produced in particular by reacting glucose or oligosaccharides with primary alcohols with 8 to 18 carbon atoms. Regarding the glycoside residue, both monoglycosides, in which a cyclic sugar residue is glycosidically bound to the fatty alcohol, and oligomeric glycosides with a degree of oligomerization of up to approximately 8 are suitable. The degree of oligomerization is a statistical mean value which is based on a homolog distribution customary for such technical products.
Weiterhin können als Emulgatoren zwitterionische Tenside verwendet werden. Als zwitterionische Tenside werden solche oberflächenaktiven Verbindungen bezeichnet, die im Molekül mindestens eine quartäre Ammoniumgruppe und mindestens eine Carboxylat- und eine Sulfonatgruppe tragen. Besonders geeignete zwitterionische Tenside sind die sogenannten Betaine wie die N-Alkyl-N,N- dimethylammoniumglycinate, beispielsweise das Kokosalkyldimethylammoniumglycinat, N-Acylamino propyl-N,N-dimethylammoniumglycinate, beispielsweise das Kokosacylaminopropyldimethylammo niumglycinat, und 2-Alkyl-3-carboxylmethyl-3-hydroxyethylimidazoline mit jeweils 8 bis 18 C-Atomen in der Alkyl- oder Acylgruppe sowie das Kokosacylaminoethylhydroxyethylcarboxymethylglycinat. Beson ders bevorzugt ist das unter der CTFA-Bezeichnung Cocamidopropyl Betaine bekannte Fettsäureamid- Derivat. Ebenfalls geeignete Emulgatoren sind ampholytische Tenside. Unter ampholytischen Tensiden werden solche oberflächenaktiven Verbindungen verstanden, die außer einer C8/18-Alkyl- oder -Acyl gruppe im Molekül mindestens eine freie Aminogruppe und mindestens eine -COOH- oder -SO3H- Gruppe enthalten und zur Ausbildung innerer Salze befähigt sind. Beispiele für geeignete ampho lytische Tenside sind N-Alkylglycine, N-Alkylpropionsäuren, N-Alkylaminobuttersäuren, N-Alkyliminodi propionsäuren, N-Hydroxyethyl-N-alkylamidopropylglycine, N-Alkyltaurine, N-Alkylsarcosine, 2-Alkyl aminopropionsäuren und Alkylaminoessigsäuren mit jeweils etwa 8 bis 18 C-Atomen in der Alkyl gruppe. Besonders bevorzugte ampholytische Tenside sind das N-Kokosalkylaminopropionat, das Kokosacylaminoethylaminopropionat und das C12/18-Acylsarcosin. Neben den ampholytischen kommen auch quartäre Emulgatoren in Betracht, wobei solche vom Typ der Esterquats, vorzugsweise methyl quaternierte Difettsäuretriethanolaminester-Salze, besonders bevorzugt sind.Zwitterionic surfactants can also be used as emulsifiers. Zwitterionic surfactants are surface-active compounds that contain at least one quaternary ammonium group and at least one carboxylate and one sulfonate group in the molecule. Particularly suitable zwitterionic surfactants are the so-called betaines such as the N-alkyl-N, N-dimethylammonium glycinate, for example coconut alkyldimethylammonium glycinate, N-acylamino propyl-N, N-dimethylammonium glycinate, for example coconut acylaminopropyldimethylammonium glycinate, and 2-alkyl-3-carboxylate -hydroxyethylimidazolines each having 8 to 18 carbon atoms in the alkyl or acyl group and the cocoacylaminoethylhydroxyethylcarboxymethylglycinate. The fatty acid amide derivative known under the CTFA name of Cocamidopropyl Betaine is particularly preferred. Suitable emulsifiers are ampholytic surfactants. Ampholytic surfactants are surface-active compounds which, in addition to a C 8/18 alkyl or acyl group, contain at least one free amino group and at least one -COOH or -SO 3 H group in the molecule and are capable of forming internal salts . Examples of suitable ampholytic surfactants are N-alkylglycine, N-alkylpropionic acid, N-alkylaminobutyric acid, N-alkyliminodipropionic acid, N-hydroxyethyl-N-alkylamidopropylglycine, N-alkyltaurine, N-alkyl sarcosine, 2-alkyl aminopropionic acid and alkyl amino acetic acid each with about 8 up to 18 carbon atoms in the alkyl group. Particularly preferred ampholytic surfactants are N-cocoalkylaminopropionate, cocoacylaminoethylaminopropionate and C 12/18 acylsarcosine. In addition to the ampholytic emulsifiers, quaternary emulsifiers are also suitable, those of the esterquat type, preferably methyl-quaternized difatty acid triethanolamine ester salts, being particularly preferred.
Als Überfettungsmittel können Substanzen wie beispielsweise Lanolin und Lecithin sowie polyethoxylierte oder acylierte Lanolin- und Lecithinderivate, Polyolfettsäureester, Monoglyceride und Fettsäurealkanolamide verwendet werden, wobei die letzteren gleichzeitig als Schaumstabilisatoren dienen. Als Konsistenzgeber kommen in erster Linie Fettalkohole mit 12 bis 22 und vorzugsweise 16 bis 18 Kohlenstoffatomen in Betracht. Bevorzugt ist eine Kombination dieser Stoffe mit Alkyloligo glucosiden und/oder Fettsäure-N-methylglucamiden gleicher Kettenlänge und/oder Polyglycerinpoly-12- hydroxystearaten. Geeignete Verdickungsmittel sind beispielsweise Polysaccharide, insbesondere Xanthan-Gum, Guar-Guar, Agar-Agar, Alginate und Tylosen, Carboxymethylcellulose und Hydroxy ethylcellulose, ferner höhermolekulare Polyethylenglycolmono- und -diester von Fettsäuren, Polyacry late, Polyvinylalkohol und Polyvinylpyrrolidon, Tenside wie beispielsweise ethoxylierte Fettsäuregly ceride, Ester von Fettsauren mit Polyolen wie beispielsweise Pentaerythrit oder Trimethylolpropan, Fettalkoholethoxylate mit eingeengter Homologenverteilung oder Alkyloligoglucoside sowie Elektrolyte wie Kochsalz und Ammoniumchlorid.Substances such as lanolin and lecithin as well as polyethoxylated or acylated lanolin and lecithin derivatives, polyol fatty acid esters, monoglycerides and Fatty acid alkanolamides are used, the latter at the same time as foam stabilizers to serve. The main consistency agents are fatty alcohols with 12 to 22 and preferably 16 up to 18 carbon atoms. A combination of these substances with alkyl oligo is preferred glucosides and / or fatty acid N-methylglucamides of the same chain length and / or polyglycerol poly-12- hydroxystearates. Suitable thickeners are, for example, polysaccharides, in particular Xanthan gum, guar guar, agar agar, alginates and tyloses, carboxymethyl cellulose and hydroxy ethyl cellulose, also higher molecular weight polyethylene glycol monoesters and diesters of fatty acids, polyacrylics latex, polyvinyl alcohol and polyvinyl pyrrolidone, surfactants such as ethoxylated fatty acid gly cerides, esters of fatty acids with polyols such as pentaerythritol or trimethylolpropane, Fatty alcohol ethoxylates with a narrow homolog distribution or alkyl oligoglucosides as well as electrolytes like table salt and ammonium chloride.
Geeignete kationische Polymere sind beispielsweise kationische Cellulosederivate, kationische Starke, Copolymere von Diallylammoniumsalzen und Acrylamiden, quaternierte Vinylpyrrolidon/Vinyl imidazol Polymere wie z. B. Luviquat® (BASF AG, Ludwigshafen/FRG), Kondensationsprodukte von Polyglycolen und Aminen, quaternierte Kollagenpolypeptide wie beispielsweise Lauryldimonium hydroxypropyl hydrolyzed collagen (Lamequat®L, Grunau GmbH), quaternierte Weizenpolypeptide, Polyethylenimin, kationische Siliconpolymere wie z. B. Amidomethicone oder Dow Corning, Dow Cor nin g Co./US, Copolymere der Adipinsaure und Dimethylaminohydroxypropyldiethylentriamin (Cartaretine®, Sandoz/CH), Polyaminopolyamide wie z. B. beschrieben in der FR-A 22 52 840 sowie deren vernetzte wasserloslichen Polymere, kationische Chitindenvate wie beispielsweise quaterniertes Chitosan, gegebenenfalls mikrokristallin verteilt, Kondensationsprodukte aus Dihalogenalkylen wie z. B. Dibrombutan mit Bisdialkylaminen wie z. B. Bis-Dimethylamino-1,3-propan, kationischer Guar-Gum wie z. B. Jaguar® CBS, Jaguar® C-17, Jaguar® C-16 der Celanese/US, quaternierte Ammoniumsalz- Polymere wie z. B. Mirapol® A-15, Mirapol® AD-1, Mirapol® AZ-1 der Miranol/US.Suitable cationic polymers are, for example, cationic cellulose derivatives, cationic Strong, copolymers of diallyl ammonium salts and acrylamides, quaternized vinyl pyrrolidone / vinyl imidazole polymers such as B. Luviquat® (BASF AG, Ludwigshafen / FRG), condensation products from Polyglycols and amines, quaternized collagen polypeptides such as lauryldimonium hydroxypropyl hydrolyzed collagen (Lamequat®L, Grunau GmbH), quaternized wheat polypeptides, Polyethyleneimine, cationic silicone polymers such as B. Amidomethicone or Dow Corning, Dow Cor nin g Co./US, copolymers of adipic acid and dimethylaminohydroxypropyldiethylenetriamine (Cartaretine®, Sandoz / CH), polyaminopolyamides such as B. described in FR-A 22 52 840 and their crosslinked water-soluble polymers, cationic chitindenes such as quaternized Chitosan, optionally microcrystalline, condensation products from dihaloalkylene such. B. Dibromobutane with bisdialkylamines such as. B. bis-dimethylamino-1,3-propane, cationic guar gum such as e.g. B. Jaguar® CBS, Jaguar® C-17, Jaguar® C-16 from Celanese / US, quaternized ammonium salt Polymers such as B. Mirapol® A-15, Mirapol® AD-1, Mirapol® AZ-1 from Miranol / US.
Geeignete Siliconverbindungen sind beispielsweise Dimethylpolysiloxane, Methyl-phenylpolysiloxane, cyclische Silicone sowie amino-, fettsäure-, alkohol-, polyether-, epoxy-, fluor- und/oder alkylmodifizierte Siliconverbindungen, die bei Raumtemperatur sowohl flüssig als auch harzförmig vorliegen können. Typische Beispiele für Fette sind Glyceride, als Wachse kommen u. a. Bienenwachs, Paraffinwachs oder Mikrowachse gegebenenfalls in Kombination mit hydrophilen Wachsen, z. B. Cetylstearylalkohol in Frage. Als Perlglanzwachse können insbesondere Mono- und Difettsäureester von Polyalkylen glycolen, Partialglyceride oder Ester von Fettalkoholen mit mehrwertigen Carbonsäuren bzw. Hydroxycarbonsäuren verwendet werden. Als Stabilisatoren können Metallsalze von Fettsäuren wie z. B. Magnesium-, Aluminium- und/oder Zinkstearat eingesetzt werden. Unter biogenen Wirkstoffen sind beispielsweise Bisabolol, Allantoin, Phytantriol, Panthenol, AHA-Säuren, Pflanzenextrakte und Vitaminkomplexe zu verstehen. Als Antischuppenmittel können Climbazol, Octopirox und Zink pyrethion eingesetzt werden. Gebräuchliche Filmbildner sind beispielsweise Chitosan, mikrokristallines Chitosan, quaterniertes Chitosan, Polyvinylpyrrolidon, Vinylpyrrolidon-Vinylacetat-Copolymerisate, Poly mere der Acrvlsäurereihe, quaternäre Cellulose-Derivate, Kollagen, Hyaluronsäure bzw. deren Salze und ähnliche Verbindungen. Zur Verbesserung des Fließverhaltens können ferner Hydrotrope wie beispielsweise Ethanol, Isopropylalkohol, Propylenglycol oder Glucose eingesetzt werden. Als Kon servierungsmittel eignen sich beispielsweise Phenoxyethanol, Formaldehydlösung, Parabene, Pentandiol oder Sorbinsäure.Suitable silicone compounds are, for example, dimethylpolysiloxanes, methylphenylpolysiloxanes, Cyclic silicones as well as amino, fatty acid, alcohol, polyether, epoxy, fluorine and / or alkyl modified Silicone compounds that can be both liquid and resinous at room temperature. Typical examples of fats are glycerides. a. Beeswax, paraffin wax or micro waxes optionally in combination with hydrophilic waxes, e.g. B. Cetylstearyl alcohol in Question. Mono and difatty acid esters of polyalkylene can in particular be used as pearlescent waxes glycols, partial glycerides or esters of fatty alcohols with polyvalent carboxylic acids or Hydroxycarboxylic acids are used. Metal salts of fatty acids such as e.g. B. magnesium, aluminum and / or zinc stearate can be used. Among biogenic agents are, for example, bisabolol, allantoin, phytantriol, panthenol, AHA acids, plant extracts and Understand vitamin complexes. Climbazole, octopirox and zinc can be used as antidandruff agents pyrethione can be used. Common film formers are, for example, chitosan, microcrystalline Chitosan, quaternized chitosan, polyvinylpyrrolidone, vinylpyrrolidone-vinyl acetate copolymers, poly mers of the acrylic acid series, quaternary cellulose derivatives, collagen, hyaluronic acid or salts thereof and similar compounds. To improve the flow behavior, hydrotropes such as for example ethanol, isopropyl alcohol, propylene glycol or glucose can be used. As a con Serving agents are, for example, phenoxyethanol, formaldehyde solution, parabens, Pentanediol or sorbic acid.
Typische Beispiele für UV-Lichtschutzfilter sind 4-Aminobenzoesäure sowie ihre Ester und Derivate (z. B. 2-Ethylhexyl-p-dimethylaminobenzoat oder p-Dimethylaminobenzoesäureoctylester), Methoxy zimtsäure und ihre Derivate (z. B. 4-Methoxyzimtsäure-2-ethylhexylester), Benzophenone (z. B. Oxyben zon, 2-Hydroxy-4-methoxy-benzophenon), Dibenzoylmethane, Salicylatester, 2-Phenylbenzimadozol- 5-sulfonsaure, 1-(4-tert.Butylphenyl)-3-(4'-methoxyphenyl)propan-1,3-dion, 3-(4-Methyl)benzyliden boman-2-on, Methyl-benzylidencampher und dergleichen. Weiterhin geeignet sind auch feindisperse Metalloxide bzw. Salze, wie beispielsweise Titandioxid, Zinkoxid, Eisenoxid, Aluminiumoxid, Ceroxid, Zirkoniumoxid, Silicate (Talk) und Banumsulfat. Schließlich kommen auch sekundäre Lichtschutzmittel vom Typ der Antioxidantien in Betracht, wie etwa Superoxid-Dismutase, Tocopherole (Vitamin E) und Ascorbinsäure (Vitamin C).Typical examples of UV light protection filters are 4-aminobenzoic acid and its esters and derivatives (e.g. 2-ethylhexyl p-dimethylaminobenzoate or p-dimethylaminobenzoic acid octyl ester), methoxy cinnamic acid and its derivatives (e.g. 2-ethylhexyl 4-methoxycinnamate), benzophenones (e.g. oxybene zon, 2-hydroxy-4-methoxy-benzophenone), dibenzoylmethane, salicylate ester, 2-phenylbenzimadozole 5-sulfonic acid, 1- (4-tert-butylphenyl) -3- (4'-methoxyphenyl) propane-1,3-dione, 3- (4-methyl) benzylidene boman-2-one, methyl benzylidene camphor and the like. Finely dispersed are also suitable Metal oxides or salts, such as titanium dioxide, zinc oxide, iron oxide, aluminum oxide, cerium oxide, Zirconium oxide, silicates (talc) and barium sulfate. Finally, there are also secondary light stabilizers of the type of antioxidants such as superoxide dismutase, tocopherols (vitamin E) and Ascorbic acid (vitamin C).
Als Farbstoffe können die für kosmetische Zwecke geeigneten und zugelassenen Substanzen ver wendet werden, wie sie beispielsweise in der Publikation Kosmetische Färbemittel der Farbstoff kommission der Deutschen Forschungsgemeinschaft, Verlag Chemie, Weinheim, 1984, S. 81-106 zusammengestellt sind. Diese Farbstoffe werden üblicherweise Konzentrationen von 0,001 bis 0,1 Gew.-%, bezogen auf die gesamte Mischung, eingesetzt.As dyes, the substances suitable and approved for cosmetic purposes can be used be used, such as the dye in the publication Cosmetic Colorants Commission of the German Research Foundation, Verlag Chemie, Weinheim, 1984, pp. 81-106 are put together. These dyes usually have concentrations of 0.001 to 0.1 % By weight, based on the mixture as a whole.
Der Gesamtanteil der Hilfs- und Zusatzstoffe kann 1 bis 50, vorzugsweise 5 bis 40 Gew.-% - bezogen auf die Mittel - betragen. Die Herstellung der Mittel kann durch übliche Kalt- oder Heißprozesse erfolgen; vorzugsweise arbeitet man nach der Phaseninversionstemperatur-Methode.The total proportion of auxiliaries and additives can be 1 to 50, preferably 5 to 40% by weight on the middle - amount. The agents can be produced by customary cold or hot processes respectively; the phase inversion temperature method is preferably used.
Ein Panel bestehend aus 15 weiblichen Probanden im Alter zwischen 35 und 50 Jahren wurde über
einen Zeitraum von 28 Tagen einer täglichen Exposition mit verschiedenen Glucanen ausgesetzt. Hier
zu wurden O/W-Hautcremes der folgenden Zusammensetzung durch Vermischen der Phasen I und II
bei 95°C hergestellt:
A panel consisting of 15 female volunteers between the ages of 35 and 50 years was exposed to a daily exposure to various glucans over a period of 28 days. O / W skin creams of the following composition were produced by mixing phases I and II at 95 ° C:
Die Probanden wendeten die Hautcremes täglich vor dem Zubettgehen an. Im Abstand von 7 Tagen wurde jeweils am darauffolgenden Morgen die Zahl, Tiefe und Länge der Hauffalten mittels Profilome trie einer ausgesuchten Hautpartie bestimmt, nämlich eines vertikalen Streifens von 2 cm Breite und 5 cm Länge, dessen obere linke und rechte Begrenzung sich ergibt, wenn man von der Nasenwurzel eine Horizontale zieht, von dieser zum rechten Auge hin 2 bzw. 4 cm abträgt und die beiden resultierenden Punkte im Winkel von 270° jeweils 2 cm verlängert. Das dimensionslose Produkt aus Tiefe, Anzahl und Länge der Hauffalten am Tage vor dem Beginn der Exposition wurde als Standard (= 100%) gesetzt und alle folgenden Messungen darauf bezogen. Gleichzeitig wurde die Hautrauhigkeit von den Pro banden subjektiv auf einer Skala von 0 = "unverändert" bis 3: "stark verbessert" bewertet. Die Ergeb nisse sind in Tabelle 1 zusammengefaßt. Die Beispiele 1 bis 3 sind erfindungsgemäß, die Beispiele V1 bis V4 dienen zum Vergleich.The subjects applied the skin creams daily before going to bed. Every 7 days the following morning the number, depth and length of the creases were determined using profilomas determined a selected area of skin, namely a vertical strip of 2 cm wide and 5 cm length, the upper left and right border of which results when one of the nasal roots Horizontal draws, removes 2 or 4 cm from the right eye and the two resulting Dots extended by 2 cm each at an angle of 270 °. The dimensionless product of depth, number and The length of the wrinkles on the day before the start of exposure was set as the standard (= 100%) and all subsequent measurements related to it. At the same time, the skin roughness from the Pro tied subjectively on a scale from 0 = "unchanged" to 3: "greatly improved". The results nisse are summarized in Table 1. Examples 1 to 3 are according to the invention, examples V1 up to V4 are used for comparison.
Man erkennt, daß die wasserlöslichen β-Glucane der Erfindung nicht nur den Vorteil der besseren Formulierbarkeit besitzen, sondern zudem auch eine höhere Wirksamkeit als bekannte Glucane des Stands der Technik aufweisen. It can be seen that the water-soluble β-glucans of the invention not only have the advantage of the better Can be formulated, but also have a higher potency than known glucans Have state of the art.
Hautalterung und HautrauhigkeitSkin aging and roughness
Hautalterung und HautrauhigkeitSkin aging and roughness
Claims (8)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE1997110368 DE19710368A1 (en) | 1997-03-13 | 1997-03-13 | Use of water-soluble beta-glucans as active ingredients for the production of therapeutic agents for skin treatment |
| PCT/EP1998/001202 WO1998040082A1 (en) | 1997-03-13 | 1998-03-04 | THE USE OF WATER-SOLUBLE β-GLUCANS AS ACTIVE SUBSTANCES IN THE PRODUCTION OF THERAPEUTIC AGENTS IN SKIN TREATMENT |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE1997110368 DE19710368A1 (en) | 1997-03-13 | 1997-03-13 | Use of water-soluble beta-glucans as active ingredients for the production of therapeutic agents for skin treatment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE19710368A1 true DE19710368A1 (en) | 1998-09-17 |
Family
ID=7823230
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|---|---|---|---|
| DE1997110368 Withdrawn DE19710368A1 (en) | 1997-03-13 | 1997-03-13 | Use of water-soluble beta-glucans as active ingredients for the production of therapeutic agents for skin treatment |
Country Status (2)
| Country | Link |
|---|---|
| DE (1) | DE19710368A1 (en) |
| WO (1) | WO1998040082A1 (en) |
Cited By (5)
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| DE19911057A1 (en) * | 1999-03-12 | 2000-09-21 | Cognis Deutschland Gmbh | Hair cosmetic preparations |
| DE10145008A1 (en) * | 2001-09-12 | 2003-03-27 | Odenco Kosmetik Gmbh | Cosmetic composition e.g. useful for skin treatment, comprises a ubiquinone or plastoquinone, beta-glucan, Dead Sea water and a solubilizing agent |
| WO2007001904A3 (en) * | 2005-06-21 | 2007-05-18 | Procter & Gamble | Personal care compositions comprising alpha-glucans and/or beta-glucans |
| CN103735566A (en) * | 2013-12-26 | 2014-04-23 | 南京理工大学 | Application of soracan gum in inhibiting skin injury of ultraviolet ray |
| CN105106032A (en) * | 2015-09-10 | 2015-12-02 | 南京理工大学 | Application of soracan gum in hair washing and caring |
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| EP1197216B1 (en) * | 1996-07-19 | 2004-06-23 | Mibelle AG Cosmetics | Pharmaceutical or cosmetic composition containing polyglucan ether derivatives |
| US6251877B1 (en) * | 1998-03-24 | 2001-06-26 | Pacific Corporation | Composition for external application containing a β-1,6-branched-β-1,3-glucan |
| KR100543124B1 (en) * | 1998-12-30 | 2006-04-28 | 주식회사 태평양 | Pharmaceutical Composition for Reducting or Preventing Sking Irritation or Sensitization by Drugs |
| DE19911052A1 (en) * | 1999-03-12 | 2000-09-21 | Cognis Deutschland Gmbh | Sunscreen |
| DE19911056B9 (en) * | 1999-03-12 | 2005-09-08 | Biotec Asa | Cosmetic preparations and their use |
| AU3657100A (en) | 1999-03-12 | 2000-10-04 | Biotec Asa | Use of water-soluble beta-(1,3) glucans as agents for producing therapeutic skintreatment agents |
| DE19911053B4 (en) * | 1999-03-12 | 2004-10-28 | Biotec Asa | Cosmetic and / or pharmaceutical preparations |
| DE19911058B4 (en) * | 1999-03-12 | 2004-09-30 | Biotec Asa | Use of nanoscale water-soluble β- (1,3) -glucans |
| JP3885204B2 (en) * | 2002-04-16 | 2007-02-21 | 株式会社Ｃａｃ | External agent for promoting cell activity |
| JP3820577B2 (en) | 2002-06-03 | 2006-09-13 | 株式会社Ｃａｃ | External treatment for dermatitis |
| CN112079938A (en) * | 2020-08-18 | 2020-12-15 | 周银根 | Highland barley polysaccharide extraction method, highland barley polysaccharide extract and application thereof |
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| JP2681527B2 (en) * | 1990-02-15 | 1997-11-26 | ジャパンファインケミカル株式会社 | Topical for promoting cell activity |
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| US5576015A (en) * | 1995-03-02 | 1996-11-19 | Donzis; Byron A. | Substantially purified beta (1,3) finely ground yeast cell wall glucan composition with dermatological and nutritional uses |
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| WO1996028476A1 (en) * | 1995-03-13 | 1996-09-19 | Novogen Research Ltd. | Process for glucan preparation and therapeutic uses of glucan |
| DE19537509A1 (en) * | 1995-09-27 | 1997-04-10 | Egsto Pharm Pharmazeutische Pr | Prods. for treating irritated skin |
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|---|---|---|---|---|
| DE19911057A1 (en) * | 1999-03-12 | 2000-09-21 | Cognis Deutschland Gmbh | Hair cosmetic preparations |
| DE19911057C2 (en) * | 1999-03-12 | 2001-01-25 | Cognis Deutschland Gmbh | Hair cosmetic preparations |
| DE10145008A1 (en) * | 2001-09-12 | 2003-03-27 | Odenco Kosmetik Gmbh | Cosmetic composition e.g. useful for skin treatment, comprises a ubiquinone or plastoquinone, beta-glucan, Dead Sea water and a solubilizing agent |
| WO2007001904A3 (en) * | 2005-06-21 | 2007-05-18 | Procter & Gamble | Personal care compositions comprising alpha-glucans and/or beta-glucans |
| CN103735566A (en) * | 2013-12-26 | 2014-04-23 | 南京理工大学 | Application of soracan gum in inhibiting skin injury of ultraviolet ray |
| CN105106032A (en) * | 2015-09-10 | 2015-12-02 | 南京理工大学 | Application of soracan gum in hair washing and caring |
Also Published As
| Publication number | Publication date |
|---|---|
| WO1998040082A1 (en) | 1998-09-17 |
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