DE1692444C3 - Feed to increase the speed of growth - Google Patents

Description

feed in piglets, cokes and calves an increase the effects of weight gain, the following tests were carried out:

1.40 bull calves were born over a period of 4 weeks with a commercially available antibiotic & egg Milk replacer supplied 20 animals served as controls, 20 animals received per liter of the finished product Exchanger 10 ^ L-thyroxine-Na and 1 mg sorbitol AQe calves tied up in egg housing Slatted frames and were individually watered twice a day. The feed allocation was in each case adapted to the weight development of the animals. The weight development and feed conversion during the The ten-week trial period results from the Table 1.

Table 1

Change in weight gain due to the active ingredient combination L-thyroxine-Na + sorbitol (10 μg or 1 mg / kg milk replacer) in calves
(Relative numbers in brackets)

Animal number

Initial weight (kg) ..

Final weight (kg)

increase

kg feed / kg gain

Control group

20th
64.1
138.7
74.6
(100)
1.58

Experimental group

20th
63.8

141.2
77.4

(104)
1.56

Table 2
Weight development in the piglet trial

with sorbitol. + L-thyroxine-Na

(1 mg or 10 μ ^ / kg finished feed)

(Relative values in brackets)

2. A similar experiment was set up with piglets. Twice 40 piglets were tested according to weight and weight Gender split into two groups and up to a final weight of. 100 kg fed (automatic feeding). A standard ration was used (starting fattening 16.3, finishing fattening 15.3% crude protein), completed with vitamins and minerals. The diet of the experimental group was also 1 mg Sorbitol + 10 μg L-thyroxine-Na / kg final feed mixture been enriched. The feeding took place with the help of automatic feeders. There was water at all times available ad libitum. The weight increases and utilization numbers are compiled in Table 2

control Vecsuchs-
group 40
16.8
107.4
90.6
(100)
3.36
(100) 40
16.6
111.7
95.1
(105)
3.25
(97) Initial weight (kg)
Bundle weight (kg)
Increase (kg)
kg feed / kg gain ...

3. A third growth experiment was carried out with chicks. Twice 210 Lohmann broiler chicks (<J $

ao = 1: 1) were fed a standard diet (21.5% crude protein) (cage) for a total of 50 days. 1 mg sorbitol and 10 μ§ L-thyroxine-Na / kg final feed mixture were added to the test feed. Food and water could be consumed ad libitum.

a ₅ can be taken. The weight gains and the feed conversion were monitored over 50 days and the overall result is compiled in Table 3. The mortality rate was the same in the test and control group (2.1%).

Table 3

Weight development and feed conversion

in the broiler experiment with sorbitol + L-thyroxine-Na

(1 mg or 10 μg / kg finished feed)

(Relative values in brackets)

35

Animal number

Body weight according to
50 days (g)

kg feed / kg gain ...

control

210

1453
(100)

2.02
(100)

Experimental group

210

1484
(102)

1.94
(94)

According to these results, the combination of 1 mg L-thyroxine-Na + Ig sorbitol per ton of ready-made feed shown positive effects in both calf and pork and broiler fattening.

The exploitation of the invention can be made possible by legal provisions, in particular by the Feed Act, be limited.

Claims (1)

I. Q 2 'I catabolic drascafunctionaen (adrenal cortex, Claim: Thyroid). By investigations of the biochemi The principle could explain how the hormones work Feed to increase the growth- are made probable, which is based on this speed of change, characterized by it- Sungea: The growth-promoting net that there are in addition to the usual constituents substances restrict the activity of a certain an anabolic substance in a concentration of the Fennent group, the flavin enzymes of the large cells between 1 and 500 g per ton of end feed particles (mitochondria), which catabolic substance mixture and thyroxine and / or a thyroxine initiate alternation cycles and end oxidation, derivative and / or iodine casein in a concentration, ίο The L-amino acid oxidase, which is predominantly essential which oxidizes an amount of i-thyroxine of 10 to 1000 mg amino acids, is particularly strongly inhibited, The result is a saving effect for this particularly valuable nutrient group. At the same time, however, there are also inhibitory effects on the endoxidation initiated by a flavin enzyme on, which appears to be indispensable for the energy supply of the cell. It has now been shown that the Adrenal cortex hormones catalyze exactly the opposite reaction, namely activity ao increase the same flavin enzymes. The thyroxine The invention relates to a feedstuff for climbing, finally, the last stage of endoxidation tion of the growth rate, which thereby stimulate, whereby the energy production increases is marked that it is next to the usual loading. The inhibition of the energy supply • If an anabolic substance is included in a concentration, the necessary flavin enzyme probably has the effect tration between 100 and 500 g per tonne of end-as necessarily an increased delivery of the feed mixture and thyroxine and / or a thyroxine antagonist (adrenal cortex hormone) and leads derivative and / or iodine casein in a concentration that simultaneously leads to an increased distribution of an amount of L-thyroxine of 10 mg to 1000 mg per thyroid hormone. The anabolic effect of the wax bin corresponds to the final feed mixture, contains substances that promote growth, so it probably results in the The following anabolic substances are preferred: 30 essential from a closure of catabolic substance-Vitamins A and E, orotic acid, T-vitamin changeover valves, especially the essential oxidation (GÖTSCH), a through breakdown of casein with trypsin amino acids, and a simultaneous increase of the formed peptide, anabolic sex hormones (natural thyroxine level, which increases the energy supply and synthetic), polyhydric alcohols (1,3-butanedene required for weight gain processes diol, meso-erythritol, sorbitol), anabolically effective upper 35 surface-active substances, alkylphenol polyglycol ethers, investigations made it probable, d? JJ Alkylbenzenesulfonate, alkylarylsulfonate and heavy- all growth-effective substances mentioned metal compounds (organic arsenic preparations, copper) become effective on the same principle ferrous and cobalt sulfate). simultaneous thyroxine supply is then * ignet, The fodder according to the invention is intended for the easily occurring inhibition of the energy stimulation to compensate moderately by mixing an active ingredient concentrate by intensifying the end oxidation with the other components of the end feed mixture. Experience shows that with simultaneous produced, whereby as a suitable active ingredient concentrate thyroxine administration, a premix of an inert feedstuff can actually be achieved with a significantly larger wax rate than with »^ lock such as z. B. a cereal product, as a carrier for additional feeding "- '. ^ Synthesis-promoting substance, come with an anabolic substance in a lot because it gives the anabolic effects and at the same time from 1 to 500 g / kg feed and thyroxine or the counter-regulatory ones that are difficult to control Thyroxine derivative or iodine casein can set in one effect. Especially in the second and L-thyroxine content of 10 mg to 1 g / kg feed third fattening period (middle and final fattening), if the Experience has shown that the appropriate amount has proven to have a growth-promoting effect The effect is based on an increase in the one that increases continuously with age Growth rate is overlaid too much with simultaneous adrenal cortex function, improvement of feed conversion. The observed so that the increased increases are smaller, can Effects is presumably the following principle of action the anabolic and catabolic growth factors like this based on: 55 combine that the growth acceleration up to The above-mentioned growth-promoting substance · is retained at the end of fattening and is even larger th are anabolic effects with the appropriate dosage. itoffees that are in the metabolism like synthesis-promoting The following examples explain the application Hormones behave, only that they - apart from the feed additive according to the invention and the fat-soluble vitamins and sex hormones - 60 show the advantage over previously known feeds no tissue specificity The listed additives. Vitamins and sex hormones that are in physiological Dosage affect specific tissues, stretch their examples Effective range at high dosage on all body . _t . ,. . «,, _V ",. ".,. cells, so that the mast ₅ 6 experiments can be stimulated körperwachstuin chicks in piglets and calves in this fthe the said-. The grow- ^{mt Sorblt} + ^ -Thyroxin-Na do «accelerating effect of the mentioned compounds. To examine the question of whether a combination of active ingredients is related to an increase in nation of 10 mg thyroxine + 1 g sorbitol / tonne of finished products