DE1566539A1 - Device for forming a liquid containing radioactive components, in particular for medical purposes - Google Patents

Description

Akfa:? ^T " ^T - 1670" dJo / Sr

Device for the formation of a radioactive constituent Liquids, in particular for medical purposes.

The invention relates to a device with a removable Holder for a substance containing radioactive components ^ which holder in operation of the device on the upper side a Rinsing liquid is supplied with on the lower oeite of the holder a liquid containing radioactive components, particularly suitable for medical purposes, is collected in a vessel.

In such a device, the holder can contain a radioactive parent substance connected, for example, to an ion exchanger, such as I.'oly-Klän-99 or (Jermanium-68, which by radiation with the Z ^ it into a radioactive daughter substance with a lower half value than parent substance eg Technicium-99m or gallium-68 disintegrates, liese daughter substances are suitable for various medical purposes. in a liquid, they can be eg _f injected into the blood vessels of the human body, they followed through their

otrahlung measurable data regarding Ko'rperprozeese and states of Kö'rp <iror _r; can grant anen.

By the contents of the holder with a BpülflUesi _t »is washed ness which guides the Tochtersubstariz with it, is obtained diis desired product of the apparatus in the form of a liquid with 'Tnohtersubötanz.

Known devices dioiior type have a holder with

ooäWogot

'- 2 - PHN. 1670

Kuttersubetanz, also called generator, which is open on the lower side and its closure on the upper side for introducing the rinsing liquid Will get removed. Under the holder there will be an open Oefa'ss arranged. In operation of the device of this type, the holder and the collecting vessel are mostly at least partially, e.g. Shielded lead jacket. When rinsing, that is, when singing the rinsing fluid and when collecting the product, the upper and lower side of the holder and also the collecting vessel are open. These well-known Devices have the advantage that they can be proceeded quickly can, which is important in order to prevent the operator or the person in the vicinity from absorbing a harmful dose of radiation. This advantage essentially applies when finishing of the device, e.g., when the generator is removed from the package and inserted into the device and when flushing. The product of the device, the liquid with the toothersubstance, With regard to the medical application, the requirement is made that it should be sterile and pyrogen-free. the known devices have the disadvantage that they meet this requirement can not easily meet. Through the opened during rinsing Holder and through the opening of the collecting vessel can infectious Substances or organisms can enter the product freely. Bs is therefore necessary to subject the product of these known devices to a sterilization before it can be used. This can beaomlera disadvantageous no if the half-life zoite of the radioactive Product only wnni <; longer μIb «He eats to the oteriliaiaren of the product

009818/0802

BATH

- 3 - PHH, iC> 70

required "ie it duration, ^ s is even impossible, the radioactivity to utilize the daughter substances obtained in the known devices for medical purposes, if these daughter substances have a half-life approximately equal to that required Sterilization time or less than this.

The invention aims to improve the design of a device for Formation of a radioactive one particularly suitable for medical purposes To create the liquid contained in the components the disadvantages of the described, known devices avoided while maintaining the advantages mentioned. According to the present invention, a device is mentioned in the opening paragraph Type characterized in that the holder is provided on the upper and lower oeite with a part of a sonell coupling and that during operation of the device there is an Oefä's on the upper part for the flushing liquid and to the lower part of the quick coupling the collecting vessel for the liquid is connected.

When using the quick coupling, the device according to the invention the advantage of a convenient and fast

Maintain treatment. Another advantage of the device according to the invention is that when flushing the holder and the Connect vessels to one another so that the liquid and the Contents of the holder not sufficient for infectious particles in the environment sinU This means that - of course, taking into account the usual measures such as the use of previously sterilized, p; Roe-free öpülflüseigkeit, Oefäflse and here auoh

BATH ORIGINAL 009818/0802

1568539

- 4 - PHN. 1670

Coupling parts - with this device from a sterile, pyrogen-free Generator is a sterile, directly suitable for medical purposes, pyrogen-free product is obtained. Subsequent sterilization The product is therefore unnecessary. So it can also be daughter substances can be used with a very short half-life.

An embodiment of the device according to the invention is characterized in that a coupling part of the holder through a pierceable wall part of the holder and one that can be connected to it Coupling part are formed by a hollow needle. The pierceable one Wall part can be a Qummipplug, which on the ε.H. glassy Holder attached and sealed at the edges by a Fälzkapael is. The needle can be an injection needle. Such items are known from medical device technology. With these items can be a quick coupling between the holder and in a very simple way Vessel are produced. Of course, others can do the same Types of quick-release couplings can be used, e.g. those for the detachable Connection of an injection needle to the body of a syringe known type.

The possibility of rapid treatment, especially of the radioactive individual parts of the device, is demonstrated in a further embodiment. promoted the invention is that log angeechloeeener to a coupling part of the holder coupling part is fixed to a front wall of a nearly box-like elements which open iet on one side and at least partially surrounds the cold with slight clearance in operation of the device. Of course

009818/0802

BATH ORIGINAL

- 5 - PHN. ΐ6γο

box-like element which has previously been normally sterilized can be placed in the device attached or inserted into this (e.g. in the opening of a possible lead jacket), whereupon the generator simply fits into the element can be introduced, and also the connection of the relevant Coupling can be made quickly. The device according to the invention is then preferably also characterized in that in operation of the device the holder of two box-shaped elements is surrounded, with little clearance around the holder, into one another and fit into any Absohirmantel and each with one Coupling part are provided, which can be connected to a coupling part of the holder. It is possible to use both sides of the Halters quickly in the manner described, with the second box-shaped element pushed over the former like a lid will.

A favorable embodiment of the invention has the feature dus8 in the connection of a vessel with a part of the Holder coupling anachliessbaren coupling part a further, detachable Coupling is added, of which a first part on the vessel and a second part on the coupling part that can be connected to the holder are attached. In this way it is achieved that one vessel and one box-like clement can be treated as separate parts You can therefore have it sterilized separately. The advantage of this » The main thing is that the once produced, sterile Johnell closures of the holder during the entire service life need not be interrupted by the cutter. Permanent

BATH ORIGINAL 0 09818/0802

- 6 - PHH. 1670

Box-like elements remain during this time in which the Generator may be washed repeatedly, returned to the device while the vessels of the rinsing liquid and for collection after Required with every washing process or more often through similar vessels can be replaced

Another coupling between a quick coupling of a holder and a vessel can be one from medical technology Devices or coupling known for other reasons that can be supplied easily preferably by means of a quick coupling. In a further advantageous embodiment, the device according to the invention can also be characterized in that a coupling part fastened to a vessel is penetrated by a part of the vessel wall that can be drilled through a coupling part to be attached to it is formed by a hollow needle · To vent the vessel in question, a second hollow needle can be passed through a pierceable part of the vessel wall.

In a further advantageous embodiment of the device according to the invention, the vessel does not need to be vented. This embodiment is characterized in that «in GefSsa is designed essentially zy} inderfb * rraig, in which a piston is movably arranged. When using such a vessel both under than auoh over the holder, so for the rinsing liquid and for the product is obtained a device in which the Jefgsse and The holder forms a closed system during washing, in which no air at all is let in via the flushing liquid or no air at all needs to be removed from the collecting vessel. This training

009818/0802

BATH ORIGINAL

- 7 - PHN. 1670

the device thus comes to the ideal of a completely sterile product very close.

jin -Jevessel with a piston can go through the body of one for medical: .- awaken usual hypodermic syringe to be formed.

The invention is explained in more detail below with reference to the drawing arla'utert, in which a device according to the invention schematically and is shown in cross section.

In the illustrated state of this device is the Holders attached to the substance containing radioactive components and are attached to these the vessels for the rinsing liquid and for the product to be collected is connected.

The holder 1 of the device can contain, for example, certain resins or aluminum oxide bound radioactive cutting substance such as molybdenum-99 or oermanium-68, for example on an ion changer. Binding substance and parent substance are denoted by 2 | they are in holder 1 above a filter?,. The holder 1, which is cylindrical here, can be made essentially of glass and has a hopper at the top and bottom that are closed by rubber stoppers 4. The edges of the plug 4 are also sealed by flange caps 5, which leave the cement of the plug 4 free. In the illustrated state, the holder 1 of two mating, schachtelartijen Slementen 6 with low üpiel- is, space surrounded am zylinderfömigeii elements 6 are open at one end and have on the opposite side of an extension 8 on the end walls 7 in the ends of the extensions 8 is a

009818/0802

BATH ORIGINAL

- 8 - prm, 1670

9 detachably fastened by means of a thread to a mechanical 3 without 3 coupling. The parts 9 also form the fits of the hollow needles 10, which can be soldered in the parts 9.

The feet 11 and 12 each contain a cylindrical one Body 13 made of glass, for example, on which rings 14 are cemented. To the Rings 14 close the cover 15. The other ends of the vessels 11 and 12 are closed by covers 16. By Qeffnutigen The piston rods 17 of the pistons 18 protrude in the covers 15. The covers 16 contain the parts 19 of a mechanical ochnel! Coupling, which in the position shown are connected to the mentioned parts 19 of this coupling. The OefKss 11 contains a rinsing liquid 20, ... which a physiological saline solution can be

The holder 1 and the ■ element β 6 are essentially surrounded by a protective jacket 21 made of lead, for example. Through the protective sheath Bolts 22 can be guided through which the elements 6 can be clamped in the jacket 21. The jacket 21 is closed at the top by a cover 23, e.g. also made of lead. The serving to collect the radioactive liquid Oefäß 12 is from a Surrounding the shield, consisting of a cylindrical which is halved in the longitudinal direction Sheath 24 ssueammen is built, with the halves by a Slid-on tube 25 are held, which is closed by a Deokel 26 · The jacket 241 consists of the tube 25 and the cover 26 e.B. also made of lead »The GefSeee 11 and 12 can be made from injection fuel een content sufficient for medical purposes be lefüese, e.g. with a content of 30 or 50 ml

009818/0802

- 9 - 'PHN. 1670

The protective jacket 21 rests on a support 27 which has an upper plate _for columns 29 and a base plate 30.

The device is put into operation as follows. The holder closed by the plug 5 is in the previously in the Sheath guided, sterilized, lower element 6 inserted, wherein the lower plug 5 can be pierced with the lower needle "10 The lower coupling part 9 can be closed with a suitable plug. The upper element 6 with the needle 10 and the coupling part 9 is then attached, whereupon the shielding cover 23 is applied will. The two plugs 5 of the holder 1 are then with the needles 10 pierced. The upper coupling part 9 can also be fitted with a suitable Plug to be closed. The elements 6 can through the bolts 22 can be fixed.

Then, if necessary after removing the caps of the coupling parts 9 and / or 191, the tubes 12 and 1t are connected, the tube 12 being empty and its piston 18 being in the upper position and the tube 11 being filled with flushing fluid 20 under its piston 18 is. Rinsing can begin under the action of gravity. If necessary, a certain pressure can be exerted on the upper piston rod 17, aB means of "one" weight. The piston 18 of the "Oefa'eeee M in particular must be easily movable in the 2yHn4tl * JJ of this OefKese"

The liquid 20 durohflies the cold «» t> woljti 44 * radioactive parent substance remains bound to the binding substance while the "radioactive Toohtereubetani" formed from the mother substance

009818/0802 _:

- 10 - PHN. 1670

is passed down through the filter 3 to the collecting vessel 12.

The vessels 11 and 12 and the holder 1 form when rinsing a closed system into which no air is admitted and that does not need to be vented. In this way, a sterile, pyrogen-free liquid with radioactive Toohtersubstanz is in the Qefäss 12 collected, after which no more sterilization is necessary is.

On the upper plate 28 of the support 27 are in this Ausünssform Holder 31 with awei öohnellkupplungstteile 32 attached. For example, a filled vessel 12 and one after the other can be attached to the parts 32 Smaller volume injection syringes to be precipitated from this 3 vial * be connected.

The drawing shows only one possible form of the bar counter the device according to the invention. Of course many of the construction are different in details the invention conceivable.

009818/0802 bad original

j. ΐ

t Al

Claims (1)

- 11 - PHN. 1670 fat 'VT?: - tnpnT-scire t' 1. A device with a holder for a loenehmbaren radioactive components containing substance, wherein DER device is inserted into the holder above a rinsing liquid during operation and ⁴ • tuf the lower 3 * · it β of the holder a wake for medical "suitable radioactive constituents containing liquid is collected in a vessel, characterized »that the holder is provided on the upper and lower side with a part of a quick coupling and that during operation of the device on the upper part of the sonell coupling a vessel for the rinsing liquid and on the lower part a container for the liquid to be collected is connected to the quick coupling, 2 · Device according to claim 1, characterized in that a coupling part of the holder through a pierceable part of the HaI-terwani and a coupling part that can be connected to it through a hollow needle be area. 3. Device according to claim 1 or 2, characterized in that a coupling part that can be connected to a coupling part of the holder is attached to the end wall of an almost box-like element which eats open on one side and at least partially surrounds the holder with little clearance when the device is in operation , 4 · Device according to claim 3i wherein the holder and optionally the collecting vesselB · Β «are shielded by a lead jacket, characterized in that, when the device is in operation, the holder is surrounded by two box-like elements _t which are - 1? - PHN. 1670 riivjem "piel around the holder, inside each other and in a protective jacket, if any grasp and the π · 5 i each to a coupling part of the holder attachable coupling part are provided. Device according to one of the preceding claims, characterized in that a further, loose coupling is inserted into the connection of a u'iil - ¹ In the second part trti 1 Λ-eft- »are attached to the couplings that can be connected to the holder. 6. Device according to one of the preceding claims, characterized gekennaoichrwt that a coupling part attached to a vessel through oine-i drilled part of the Oefä'sswand and one to be connected to it Coupling part can be formed by a hollow needle. 7 “Performing according to one of the preceding claims, characterized” indicates that a vessel is essentially cylindrical in shape, in which a Y 1st is movably arranged. P. Vor · ¹ i-: l.lung according to claim 7 »characterized in that the ΊθΓηηρ for the '; ήΠfluid and the vessel for the" lÜRsijk-ftJt lurch j> - a body of an injection syringe is formed. \, ■ 1 Mm ΐ "fin is movable. 0098 18/0802 öad original