DE148819T1 - METHOD AND DEVICE FOR DIAGNOSIS OF DISEASES OF THE CORONARY ARTERIES. - Google Patents

Claims (25)

Claims 1. Procedure for the detection of coronary artery disease of a patient full: Obtaining measurements of the systolic slope of a patient's arterial blood pressure wave, and Use of differences in incline measurements compared to incline measurements from people without coronary artery disease as an indication of coronary artery disease in the patient. 2. The method of claim 1, wherein the measurements are obtained when the patient is at rest and a systolic Resting state slope that is smaller than that of people without coronary artery disease, an indication a coronary artery disease. 3. The method of claim 2, wherein a systolic resting state slope of substantially 0.5 mm Hg / ms and serves less as an indication of coronary artery disease. 4. The method of claim 1, wherein the measurements are obtained repeatedly while the patient is physically is stressed, and with a systolic slope, which increases and then during physical exertion decreases, serves as an indication of coronary artery disease in the patient. 5. The method of claim 1, wherein the measurements are repeated prior to physical exertion of the patient and can be obtained during a period immediately following the loading period, with one after 0U8819 systolic slope obtained after exercise, which is smaller than the systolic slope obtained before exercise is, as an indication of coronary artery disease Serves patient.
5 6. The method of claim 1, wherein measurements are repeated before and during exercise as well as in the resting phase after of the load can be obtained, with a systolic preload slope which is smaller than that of Individuals without coronary artery disease have a systolic slope that increases and decreases first during exercise then decreases, and a systolic slope during the rest phase following exertion which is smaller than that before the load is, as an indication of a wreath serve arterial disease of the patient. 7. The method of claim 1 comprising Obtaining a measure of the beats per minute while obtaining the systolic slope measurements and Plot the systolic slope readings relative to the heartbeats per minute to obtain a record these values. 8. The method of claim 1 comprising Plot of systolic measurements obtained during a patient exercise protocol Slope versus time. 9. A method for detecting a coronary ^{artery disease ΰ in} a patient, comprising Obtained from repeated measurements of the systolic slope of an arterial blood pressure waveform of the patient during a stress cycle comprising a rest portion in front of the load, a load portion and a silent portion ³ ^ after challenge, 3 0H88T9 10. The method of claim 9, wherein repeated measurements of the systolic slope are obtained non-invasively are made using an inflatable cuff which has a transducer responsive to the cuff pressure, an R-peak recorder and a Korotkoff Has noise detector, with the transducer and the detectors, blood pressure, R-peak and Korotkoff sound signals can be derived, and wherein the signals are repeatedly processed to form signals which are related to the slope a straight line that balances R-spike / Korotkoff noise intervals versus cuff pressure while deflating the cuff between systolic and diastolic blood pressure produces, with the slope-related signals a 15 Relationship to the systolic slope of blood pressure waves during cuff deflation exhibit. 11. The method according to claim 10, wherein the drawn signals versus the patient's heartbeat per minute, derived from the processing of the R-peak signals, to be recorded. 12. Device for use in diagnosis and / or screening patients for coronary artery disease, characterized by an inflatable cuff that wraps around a patient's arm, Means for inflating the cuff and deflating Air from it within a range of pressures at which Korotkoff noise is generated, a pressure transducer that responds to the cuff pressure responds and forms a corresponding output signal, electrodes for detecting electrocardiographic Signals from the patient, QU8819 an R-tip detector, which is the apex of the R-tip detected in the electrocardiographic signals, a transducer that operates during deflation picks up Korotkoff noises from the cuff, 5 a Korotkoff noise detector which detects Korotkoff noises in the output signal of the Korotkoff noise transducer,
on the output signals of the pressure transducer, the R-peak peak detector and the Korotkoff noise Detector responsive means that a the systolic Generate a signal indicative of the slope of blood pressure waves during deflation of the cuff, and Means of repeatedly obtaining the systolic Signals indicative of slope during different Periods of an exercise cycle performed by the patient, of which slope changes during the exercise cycle for the diagnosis and / or verification of patients be used with coronary artery disease. 20th 13. Device according to claim 12, wherein means for display the signals indicative of the systolic slope are provided. 14. Device according to claim 13, wherein the of the display means The display generated shows a graph of the signals indicative of the systolic slope versus the Includes patient heart rate per minute. 15. Device according to claim 13, wherein the of the display means The display generated a graph of the signals indicative of the systolic slope versus time includes. 16. The device of claim 12, wherein the means for generating a signal corresponding to the systolic Slope of blood pressure waves include: ₅ 0U8819 Means for storing a plurality of cuff pressure values and associated RK intervals including the time between occurrence of an output signal of the R-peak apex detector and the associated Korotkoff noise signal of the Korotkoff noise detector, and
Means for adapting a straight line to the RK intervals
and associated cuff pressure values obtained during deflation of the cuff,
where is the slope of the straight line of the systolic slope is inversely proportional to the blood pressure wave.
10 17. Device according to claim 16, comprising display means, which show a graph of the slope of the straight line versus the number of heartbeats per minute. 18. procedures for screening individuals for coronary artery disease; marked by repeatedly obtaining a measure of the systolic slope of a person's humeral artery blood pressure wave, Creation of a diagram that is obtained over a period of time ^ΔΚ) ten slope measurements, during which the person enters
Exercise protocol, including rest before exercise, exercise and rest after exercise,
Evaluating the diagram on the basis of a plurality of different parameters, and ° Weighting of values obtained from these evaluations
and summing the weighted values, one outside of a predetermined separating node
Sum is used to identify people with coronary artery disease. 19. The method of claim 18, wherein the plurality of parameters are those during the person's rest period prior to exercise obtained slope measurement includes. 0H8819 20. The method of claim 18, wherein the plurality of parameters includes the rate of change of slope measurements during the beginning of the exercise log. 21. The method of claim 18, wherein the plurality of parameters include the slope of the curve at the beginning of the exercise log. 22. The method according to claim 18, wherein the plurality of parameters is the detection of a change in direction of the slope measurement included during the exercise protocol. 23. The method of claim 18, wherein the plurality of parameters the amount of change in the slope measurements for includes the duration of a post-exercise period during the exercise protocol. 24. The method of claim 18, wherein the plurality of parameters include the rate of change of the slope measurement, the occurs during a post-exercise period during the exercise protocol. 25. The method of claim 18, wherein the plurality of parameters include the maximum value of the slope measurement that occurs after exercise during the exercise protocol.