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DE122009000010I2 - Krampflösende, enantiomere aminosäure-derivate - Google Patents

Krampflösende, enantiomere aminosäure-derivate

Info

Publication number
DE122009000010I2
DE122009000010I2 DE122009000010C DE122009000010C DE122009000010I2 DE 122009000010 I2 DE122009000010 I2 DE 122009000010I2 DE 122009000010 C DE122009000010 C DE 122009000010C DE 122009000010 C DE122009000010 C DE 122009000010C DE 122009000010 I2 DE122009000010 I2 DE 122009000010I2
Authority
DE
Germany
Prior art keywords
enantiomic
crampoles
amino acid
acid derivatives
animal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE122009000010C
Other languages
English (en)
Other versions
DE122009000010I1 (de
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Research Corp Technologies Inc
Original Assignee
Research Corp Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21760388&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE122009000010(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Research Corp Technologies Inc filed Critical Research Corp Technologies Inc
Publication of DE122009000010I1 publication Critical patent/DE122009000010I1/de
Publication of DE122009000010I2 publication Critical patent/DE122009000010I2/de
Active legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE122009000010C 1996-03-15 1997-03-17 Krampflösende, enantiomere aminosäure-derivate Active DE122009000010I2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1352296P 1996-03-15 1996-03-15
PCT/US1997/004579 WO1997033861A1 (en) 1996-03-15 1997-03-17 Anticonvulsant enantiomeric amino acid derivatives

Publications (2)

Publication Number Publication Date
DE122009000010I1 DE122009000010I1 (de) 2009-05-20
DE122009000010I2 true DE122009000010I2 (de) 2010-10-21

Family

ID=21760388

Family Applications (3)

Application Number Title Priority Date Filing Date
DE69705210T Expired - Lifetime DE69705210T2 (de) 1996-03-15 1997-03-17 Krampflösende, enantiomere aminosäure-derivate
DE69729392T Expired - Lifetime DE69729392T2 (de) 1996-03-15 1997-03-17 Krampfhemmende enantiomere Aminosäurederivate
DE122009000010C Active DE122009000010I2 (de) 1996-03-15 1997-03-17 Krampflösende, enantiomere aminosäure-derivate

Family Applications Before (2)

Application Number Title Priority Date Filing Date
DE69705210T Expired - Lifetime DE69705210T2 (de) 1996-03-15 1997-03-17 Krampflösende, enantiomere aminosäure-derivate
DE69729392T Expired - Lifetime DE69729392T2 (de) 1996-03-15 1997-03-17 Krampfhemmende enantiomere Aminosäurederivate

Country Status (12)

Country Link
EP (2) EP0888289B1 (de)
JP (1) JP3145414B2 (de)
AT (2) ATE202079T1 (de)
AU (1) AU718577B2 (de)
CA (1) CA2248317C (de)
DE (3) DE69705210T2 (de)
DK (2) DK0888289T3 (de)
ES (2) ES2218024T3 (de)
FR (1) FR09C0006I2 (de)
NL (1) NL300376I1 (de)
PT (2) PT888289E (de)
WO (1) WO1997033861A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6048899A (en) * 1997-03-17 2000-04-11 Research Corporation Tech., Inc. Anticonvulsant enantiomeric amino acid derivatives
EP1642889A1 (de) 2004-10-02 2006-04-05 Schwarz Pharma Ag Verbessertes Syntheseschema für Lacosamid
EP1873527A1 (de) 2006-06-30 2008-01-02 Schwarz Pharma Ag Verfahren zur Identifizierung von CRMP-Modulatoren
US8093426B2 (en) 2007-12-04 2012-01-10 Ranbaxy Laboratories Limited Intermediate compounds and their use in preparation of lacosamide
DE102008059155A1 (de) 2008-11-27 2010-06-02 Ratiopharm Gmbh Trockenverarbeitung und neue Formen von Lacosamid
CN102596897A (zh) 2009-08-06 2012-07-18 麦迪凯姆股份公司 一种n-(苯基甲基)丙酰胺衍生物的多种固体形态及制备方法
WO2011039781A1 (en) * 2009-09-25 2011-04-07 Cadila Healthcare Limited Processes for the preparation of lacosamide and intermediates thereof
IT1398044B1 (it) * 2010-01-29 2013-02-07 Archimica Srl Processo per la preparazione della lacosamide
WO2011095995A1 (en) 2010-02-08 2011-08-11 Natco Pharma Limited A process for the preparation of lacosamide
US8907132B2 (en) 2010-02-09 2014-12-09 Msn Laboratories Private Limited Process for preparing (R)-2-acetamido-N-benzyl-3-methoxy-propionamide
EP2399901A1 (de) 2010-06-23 2011-12-28 Archimica GmbH Zwischenprodukt zur Herstellung von Lacosamid und Verfahren zu dessen Herstellung und Umwandlung zu Lacosamid
EP2621893A1 (de) 2010-10-01 2013-08-07 UCB Pharma GmbH Verfahren zur herstellung von aminosäurederivaten
US9226971B2 (en) 2010-10-15 2016-01-05 Nektar Therapeutics N-optionally substituted aryl-2-oligomer-3-alkoxypropionamides
PL2444390T3 (pl) 2010-10-19 2017-06-30 Euticals Gmbh Sposób wytwarzania Lakozamidu
EP2468261A1 (de) 2010-12-02 2012-06-27 UCB Pharma GmbH Formulierung von Lacosamid
EP2646001A2 (de) 2010-12-02 2013-10-09 UCB Pharma GmbH Formulierung von lacosamid
CN104771356A (zh) * 2014-01-09 2015-07-15 山东方明药业集团股份有限公司 一种拉科酰胺注射液及其制备方法
US11278634B1 (en) 2021-02-12 2022-03-22 Extrovis Ag Stable parenteral composition of lacosamide

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5378729A (en) * 1985-02-15 1995-01-03 Research Corporation Technologies, Inc. Amino acid derivative anticonvulsant
CA1340902C (en) * 1985-02-15 2000-02-22 Harold L. Kohn Amino acid derivative anticonvulsant

Also Published As

Publication number Publication date
DK1038522T3 (da) 2004-10-11
FR09C0006I2 (fr) 2009-12-18
ES2157567T3 (es) 2001-08-16
DE69705210D1 (de) 2001-07-19
ATE202079T1 (de) 2001-06-15
EP1038522B1 (de) 2004-06-02
DE69729392T2 (de) 2005-06-02
AU2539497A (en) 1997-10-01
DE122009000010I1 (de) 2009-05-20
DE69729392D1 (de) 2004-07-08
NL300376I1 (nl) 2009-05-06
EP1038522A3 (de) 2003-01-15
FR09C0006I1 (de) 2009-04-17
WO1997033861A1 (en) 1997-09-18
CA2248317C (en) 2003-12-02
ES2218024T3 (es) 2004-11-16
EP1038522A2 (de) 2000-09-27
DK0888289T3 (da) 2001-09-03
PT1038522E (pt) 2004-10-29
JP3145414B2 (ja) 2001-03-12
CA2248317A1 (en) 1997-09-18
EP0888289A1 (de) 1999-01-07
PT888289E (pt) 2001-09-28
EP0888289B1 (de) 2001-06-13
DE69705210T2 (de) 2001-09-20
JP2000505476A (ja) 2000-05-09
ATE268169T1 (de) 2004-06-15
AU718577B2 (en) 2000-04-13

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